The future of medicine and health
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'Body on a chip' used for drug tests

'Body on a chip' used for drug tests | The future of medicine and health | Scoop.it
A technology which puts miniature human organs made with a 3D printer on a microchip is being used to test new drugs and vaccines.
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How ketamine relieves depression by suppressing the brain's "anti-reward" center

How ketamine relieves depression by suppressing the brain's "anti-reward" center | The future of medicine and health | Scoop.it
The anti-depressant qualities of ketamine, initially developed as an anesthetic before drifting into recreational circles due to its hallucinogenic properties, have been a booming topic of research over the past few years. Anecdotal evidence of the drug's effects have been so strong that "ketamine clinics" have popped up all over the US, delivering experimental treatments to patients for hundreds of dollars a dose. Researchers at Zhejiang University in China have now uncovered exciting new insights into a mechanism that may finally explain how ketamine has such a rapid anti-depressant effect.

Research from Columbia University Medical Center has recently clinically verified the drug's ability to rapidly reduce major depressive symptoms in a matter of hours, but the actual mechanism underlying these effects has been unclear. It's been known for some time that ketamine blocks a protein receptor in the brain called N-methyl-D-aspartate (NMDA), and it is this process that some have suspected is the cause of the drug's fast-acting anti-depressant qualities. But until now it hasn't been clear where in the brain this process is occurring.

The new research focused on a very small area deep in the center of the brain called the lateral habenula. This area is commonly referred to by researchers as the "anti-reward center," as it's known for suppressing nearby reward areas of the brain that release dopamine and serotonin. Following growing evidence suggesting that overactivity in the lateral habenula is related to depression, the researchers examined how ketamine directly affects activity in that region of the brain.

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Here's why it's better to be single, according to science

Here's why it's better to be single, according to science | The future of medicine and health | Scoop.it
Give Tinder a break and take yourself on a date tonight.

Being single has a handful of benefits, scientific research has found. Alone time is one of them.

Single people are more likely to not only embrace solitude, but benefit from it, recent studies have suggested.

Bella DePaulo, a psychologist at the University of California Santa Barbara, advocates the single life and travels the nation to present these findings, which she says are too often dismissed by the larger psychology community.

In a TEDx Talk she gave last spring, she called living single her "happily ever after."

Studies suggest she's onto something.

Single people tend to have stronger social networks

In 2015, social scientists named Natalia Sarkisian and Naomi Gerstel set out to explore how ties to relatives, neighbours, and friends varied among single and married American adults.

They found that singles were not only more likely to frequently reach out to their social networks, but also tended to provide and receive help from these people more than their married peers.

Their results held steady even when they accounted for factors like race, gender, and income levels.

Put simply, "being single increases the social connections of both women and men," Sarkisian and Gerstel wrote in their paper.

Fostering friendship is key to ageing well and boosting happiness, several recent studies have suggested.

One of them, published in 2008 in the British Medical Journal, found that people who had regular contact with 10 or more others were significantly happier than those who did not, and that people with fewer friends were less happy overall.

Friends who are not your family may be especially important.

In a pair of studies involving nearly 280,000 people, William Chopik, an assistant professor of psychology at Michigan State University, found that friendships become increasingly important as we age.

In older people, friendships were a stronger predictor of both health and happiness than relationships with family members.

"Keeping a few really good friends around can make a world of difference for our health and well-being," Chopik said in a statement. "So it's smart to invest in the friendships that make you happiest."

Singles also tend to be fitter

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We Should Consider Obesity as a Kind of Contagious Disease, Study Shows

We Should Consider Obesity as a Kind of Contagious Disease, Study Shows | The future of medicine and health | Scoop.it
It's often described as an epidemic, but rising obesity figures might have more in common with infectious diseases than we ever realised.

New research has added evidence to the idea that being in a social network with a higher level of obesity puts us more at risk of increasing our body mass index (BMI), almost as if we were 'catching' behaviours that make us put on weight.

A study conducted by a pair of US economists on families living on military bases has found that exposure to communities with higher rates of obesity is associated with an increase in BMI in parents and children.

There's been increasing interest over the past decade in understanding the way health-related behaviours spread through social networks.

Smoking is perhaps one of the more obvious examples, but studies have also explored the question of whether we are influenced to gain weight through our social ties.

Finding evidence one way or another is harder than you might think; it's hard to tease apart inherited factors from learned ones inside families, for one thing.

There's also the 'birds of a feather' factor, where we tend to associate with like-minded individuals. In other words, to what extent are we influenced by those in our social networks, compared with our choosing networks based on common behaviours?

That's what Ashlesha Datar of University of Southern California and Nancy Nicosia of the RAND Corporation set out to find.

To get around the problem of choosing social groups, the pair turned to a rather special type of community that assigns families to live close together from far and wide – the military base.

Using data from the Military Teenagers' Environments, Exercise, and Nutrition Study (M-TEENS), the researchers combined details on 1,111 young adolescents and more than 1,300 parents who had been assigned to one of 12 military bases in the US.
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Neuroscientists Have Followed a Thought as It Moves Through The Brain

Neuroscientists Have Followed a Thought as It Moves Through The Brain | The future of medicine and health | Scoop.it
A study using epilepsy patients undergoing surgery has given neuroscientists an opportunity to track in unprecedented detail the movement of a thought through the human brain, all the way from inspiration to response.

The findings confirm the role of the prefrontal cortex as the coordinator of complex interactions between different regions, linking our perception with action and serving as what can be considered the "glue of cognition".

Previous efforts to measure the passing of information from one area to the other have relied on processes such as electroencephalography (EEG) or functional magnetic resonance imaging (fMRI), which, whilenon-invasive, offer less than perfect resolution.

The study led by researchers from the University of California, Berkley, recorded the electrical activity of neurons using a precise technique called electrocorticograhy (ECoG).

This required hundreds of tiny electrodes to be placed right up against the cortex, providing more spatial detail than EEG and improving the resolution in time of fMRI.

While this poses an unethical level of risk for your average volunteer, patients undergoing surgery for epilepsy have their brain activity monitored in this very way, giving the researchers a perfect chance to conduct a few tests.

Each of the 16 test subjects performed a number of tasks varied to suit their individual arrangement of electrodes, all while having their neural activity monitored and tracked.

Participants were required to listen to a stimulus and respond, or watch images of faces or animals on a screen and asked to perform an action.

Some tasks were more complex than others; for example, a simple action involved simply repeating a word, while a more complex version was to think of its antonym.

Researchers monitored the split-second movement of electrical activity from one area – such as areas associated with interpreting auditory stimuli – to the prefrontal cortex, to areas required to shape an action, such as the motor cortex.
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Fat fighting drug could let you lose weight without dieting

Fat fighting drug could let you lose weight without dieting | The future of medicine and health | Scoop.it
You want to lose weight, but you don't want to eat less – right? Well, when and if a new drug makes it to market, you may get your wish. Scientists from The University of Texas Medical Branch at Galveston are developing a medication that has already lowered body weight in obese mice, even though they kept eating the same amount.

Fat cells begin to overexpress a protein known as nicotinamide-N-methyltransferase (NNMT), as they get larger. NNMT acts as a metabolic brake which slows down fat cell metabolism, so the more of it that's expressed, the harder it is for the cells to burn fat – it's a vicious circle.

That's where the experimental new drug comes in. It blocks NNMT from operating in obese white fat cells, allowing their fat-burning metabolism to increase.

The researchers tested it by placing mice on a high-fat diet until they became obese, after which the animals received either the drug or a placebo. After 10 days of treatment, the drugged mice experienced a 7 percent loss in total body weight, plus their white fat tissue mass and cell size decreased by 30 percent compared to the placebo group. Their blood cholesterol levels also returned to normal levels.

By contrast, mice in the placebo group continued to gain weight. Both they and the mice that received the actual drug continued to consume the same amount of food throughout the study.
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Here's Why You Really Shouldn't Clean The Wax From Your Ears

Here's Why You Really Shouldn't Clean The Wax From Your Ears | The future of medicine and health | Scoop.it
Earwax can feel a lot like the stuff inside pimples: It's gross, and cleaning it out feels satisfying. Even watching other people's earwax get cleaned out feels satisfying.

So you might be surprised to learn that earwax serves an important purpose - and doctors say that most of us should not be trying to remove it at all.

This is the official decree of the American Academy of Otolaryngology (AAO), which released official earwax guidelines earlier this year.

The guidelines make it clear : "Earwax that does not cause symptoms or block the ear canal should be left alone."

No ear candling. No syringes full of water. And especially no Q-tips.

As earwax removal extraordinaire Dr. Mark Vaughan told INSIDER in August, Q-tips are too big and too blunt to actually scoop out wax from your ears. "All you can do is push [wax] in," he said.

Besides, as the guidelines explain, earwax is there for a reason. It helps to trap dirt and dust, preventing them from traveling further into the ear.

It also cleans itself: Chewing, jaw motion, and the growth of new skin continuously push old wax out of the ear canal. Then it just flakes off or falls away in the shower.

It's a natural process that helps keep your ears healthy, and there's no good reason to mess with it.
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From Ayurveda to biomedicine: understanding the human body

From Ayurveda to biomedicine: understanding the human body | The future of medicine and health | Scoop.it
What is a human body? This may seem a facetious question, but the answer will be very different according to which medical tradition you consult. Take Ayurveda, a traditional system of medical knowledge from India which has enjoyed a renaissance of popularity in the West since the 1980s – and is the subject of a new exhibition at London’s Wellcome Collection.

Walking round the show, one is encouraged to explore different ways of understanding and visualising the human body. The Ayurvedic body differs significantly from that of European biomedicine, which is based on dissection. The Ayurvedic body is a body of systems. It is conceptualised as being composed of five constituent parts (mahābūta), seven body substances (dhātu) and three regulating qualities (doṣa). According to Ayurvedic theory, by attending to imbalances between these principles in a body, health might be promoted and illness avoided. The Ayurvedic concepts of the doṣas – vata, pitta and kapha can be seen in the West today promoting teas, soaps and massages.
But of course, there are many other different conceptions of the human body. There is the tantric understanding, often conflated with that of Ayurveda. Tantra focuses on the concept of energy channels (nāḍīs) which have particular centres of concentration along a line in the centre of the body (chakras). The traditional Chinese model, on the other hand, emphasises the dynamic principles of ying and yang as being paramount for ensuring health. Meanwhile, indigenous healing in many traditional cultures identifies problems between the individual and the greater social and metaphysical context as the cause of illness.
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Scientists Have Tried First-Ever Gene Editing Directly Inside a Patient's Body

Scientists Have Tried First-Ever Gene Editing Directly Inside a Patient's Body | The future of medicine and health | Scoop.it
In a bold first-of-its-kind experiment, scientists have edited a person's genes directly inside living tissue in an ambitious bid to cure a man of a rare, crippling genetic disorder.

While CRISPR has broken ground in things like editing human embryos and injecting patients with genetically edited cells, this alternative technique pioneers a new real-time approach to infusing a person's blood with a gene-editing virus.

"For the first time, a patient has received a therapy intended to precisely edit the DNA of cells directly inside the body," says CEO of Sangamo Therapeutics, Sandy Macrae, whose company is testing the experimental procedure.

"We are at the start of a new frontier of genomic medicine."

The patient on the edge of that frontier is 44-year-old Brian Madeux from Arizona, who has Hunter syndrome (aka mucopolysaccharidosis II) – a serious, progressively debilitating genetic disease caused by the deficiency of an enzyme called iduronate–2-sulfatase (I2S).
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The firm that can 3D print human body parts

The firm that can 3D print human body parts | The future of medicine and health | Scoop.it
Erik Gatenholm grins widely as he presses the start button on a 3D printer, instructing it to print a life-size human nose.

It sparks a frenzied 30-minute burst of energy from the printer, as its thin metal needle buzzes around a Petri dish, distributing light blue ink in a carefully programmed order.

The process looks something like a hi-tech sewing machine weaving an emblem onto a garment.

But soon the pattern begins to rise and swell, and a nose, constructed using a bio-ink containing real human cells, grows upwards from the glass, glowing brightly under an ultraviolet light.

This is 3D bioprinting, and it's almost too obvious to point out that its potential reads like something from a science fiction novel.

Currently focused on growing cartilage and skin cells suitable for testing drugs and cosmetics, Erik, 28, believes that within 20 years it could be used to produce organs that are actually fit for human implantation.

Erik is the chief executive and co-founder of a small Swedish company called Cellink. Founded in Gothenburg only a year ago, it is a world leader in bioprinting, and Erik has big ambitions.
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Compound found in berries and red wine can rejuvenate cells, suggests new study

By the middle of this century the over 60s will outnumber the under 18s for the first time in human history. This should be good news, but growing old today also means becoming frail, sick and dependent. A healthy old age is good for you and a remarkably good deal for society. Improving the overall health of older Americans could save the US alone enough money to pay for clean drinking water for everyone on Earth for the next 30 years.

But if we want people to be healthy in old age we have to understand the mechanisms underlying the deterioration of our bodies over time. Doing so – and learning how we can prevent it – has been the goal of ageing research for more than 60 years.

There has been astonishing progress made over the last decade. In 2009, it was shown that the drug rapamcyin extended the lifespans of mice by 10-15%. Two years later a landmark study showed that experimental clearance of “senescent” cells – dysfunctional cells which build up as we age and cause damage to tissue – improved healthy lifespan in laboratory mice. These results delighted those of us who had argued for decades that senescent cells were a major cause of late life problems and should therefore be therapeutic targets.
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Why saunas really are good for your health

Why saunas really are good for your health | The future of medicine and health | Scoop.it

They provide more than warmth.


Things are hotting up in the world of sauna research. Previously, anecdotal claims of possible benefits were rarely backed up by medical evidence. But recent studies have shown that taking a regular sauna can be extremely good for your health – alleviating and preventing the risk of common acute and chronic conditions. Sauna “bathing” is a form of passive heat therapy which originates from Finland and is mostly associated with Nordic countries. It is used mainly for pleasure and relaxation, and involves spending short periods of time (usually five to 20 minutes) in temperatures of 80°C to 100°C, interspersed with moments of cooling-off in a pool or shower. Although there are other forms of heat therapy such as Turkish baths, infrared saunas, and Waon therapy, the traditional Finnish sauna is the most examined to date. In a 2015 study, scientists from the University of Eastern Finland recorded the sauna bathing habits of 2,300 men, and tracked their health for more than two decades. They found that those who used saunas regularly suffered from dramatically fewer deaths from heart disease or stroke. In a follow-up study by the same group the following year, regular sauna sessions were found to substantially reduce the risk of dementia. Our latest research this year involved recording the habits and health of 1,621 men over 22 years. Having regular saunas (four to seven times a week) was shown to slash the risk of high blood pressure by almost 50%. Scientists are not certain how saunas reduce heart disease, but one theory is that they contribute to a reduction in high blood pressure, one of the condition’s major risk factors. Additionally, the heat from the sauna causes an increase in heart rate and widening of blood vessels in the skin. This leads to increased blood flow, which improves cardiovascular function and subsequently reduces the risk of heart disease.

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People With Chronic Fatigue Syndrome Are Exhausted at a Cellular Level, Study Shows

People With Chronic Fatigue Syndrome Are Exhausted at a Cellular Level, Study Shows | The future of medicine and health | Scoop.it
If you're one of the millions of people worldwide who deals with the symptoms of CFS (chronic fatigue syndrome, sometimes also called myalgic encephalomyelitis, ME), it can often feel like your entire body is drained of energy.

New research has found immune cells taken from the blood of volunteers diagnosed with the condition show clear signs of low energy production, not only adding details to a complex and confusing condition, but demonstrating once again that it's not a disease that can be fixed with willpower alone.

Researchers from Newcastle University in the UK investigated how white blood cells taken from healthy patients differed to those taken from individuals with a history of CFS.

For one of the scientists involved, it was more than just an academic question. Biomedical researcher and PhD student Cara Tomas knows from personal experience what the condition is capable of, and how often it is seen as poor mental health.

"A lot of people dismiss it as a psychological disease, which is a big frustration," Tomas told Andy Coghlan at New Scientist.

Derisively referred to as "Yuppy Flu" just a few short decades ago, CFS has been dismissed as a fashionable condition that reflects a lazy, unmotivated generation of layabouts.

For half a century researchers have debated underlying mechanisms of the syndrome, leading many to speculate whether it has a psychological basis.

To some, this sounds awfully like CFS is 'all in the mind', making it feel like weak willpower rather than something rooted in biology. Poorly conducted studies have made a mess of recommended treatments in recent years, continuing to leave those suffering from CFS with a stigma and few options.

Thankfully the trend is slowly changing as scientists have begun to identify stark distinctions in immune cells, gut bacteria, and blood biomarkers among those diagnosed with the disease.
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Your Weird Tastebuds Are to Blame For Your Huge Love of Carbs, Says New Study

Your Weird Tastebuds Are to Blame For Your Huge Love of Carbs, Says New Study | The future of medicine and health | Scoop.it

More than sweet.


If you've gone for seconds, or even thirds, on your housemate's rather average homemade pasta, there's a chance your taste for starch might have more to do with your freaky tastebuds than their culinary skills. Following up on earlier discoveries of an additional gustatory sense specific to complex carbohydrates, researchers have now found some of us more sensitive to the taste than others, which could be helping to fill out some of our waistlines. Scientists are now pretty certain our tastebuds can actually detect the long chains of sugar making up the complex starches found in food items such as bread, pasta, and rice. So even though we still only have five 'official' tastes, we can actually list the sensations caused by chemicals dissolving in our mouth as sweet, salty, umami (savoury, meaty flavours), bitter, fat, sour, and... starchy. While we're on the subject, forget that tongue map nonsense you might have learned as a kid, too. Even though most of us might be able to detect bitter flavours better down the throat, our entire tongue reacts to all of these sensations. That said, taste sensitivity varies significantly across the population. So-called 'supertasters' experience far more intense flavour sensations. And a little more than a quarter of us – depending on our genetic background – can't even taste a compound called phenylthiourea. Since our individual tasting talents vary, researchers from Deakin University in Australia were keen to put the discovery about starchy tastes to the population test.

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Transgender woman is first to be able to breastfeed her baby

Transgender woman is first to be able to breastfeed her baby | The future of medicine and health | Scoop.it
An experimental treatment regimen has enabled a transgender woman to exclusively breastfeed her baby for six weeks, during which time the baby grew healthily
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Video camera sees your heartbeat in your skin

Video camera sees your heartbeat in your skin | The future of medicine and health | Scoop.it
Are stethoscopes on their way to becoming obsolete? It's possible, as scientists from Utah State University have developed a no-contact method of measuring a person's heartbeat utilizing a video camera and custom software.

The system is based on the fact that our skin subtly changes color as our heart beats, in a manner that can't be seen by the human eye but that can be detected by a camera.

"Hemoglobin in the blood has an absorption peak for green light," says Dr. Jake Gunther, who teamed up with his former student Nate Ruben to create the technology. "So when the heart pushes blood into arteries near the skin, more green light is absorbed and less is reflected. This means we see fewer green values in the images from the camera."

The software not only processes the color data, but it also computes an average over regions of the body where the skin is visible, such as the face, neck or arms. It is hoped that the patented system could find use in applications such as baby monitors, exercise equipment and even hospital settings.
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Wound monitoring app may keep patients out of hospitals

Wound monitoring app may keep patients out of hospitals | The future of medicine and health | Scoop.it
According to recent studies, surgical site infections (SSIs) are the leading cause of hospital readmission following an operation. In hopes of catching those SSIs before readmission is necessary, scientists from the University of Wisconsin, Madison have developed an experimental app known as WoundCare.

In a test of the app, 40 vascular surgery patients were instructed to regularly upload photos of their wound sites to a server, along with answering a few onscreen questions regarding any symptoms they might be experiencing. They were instructed to do so daily for two weeks.

Nurses reviewed each submission within an average of 9.7 hours – throughout the course of the study, they detected seven wound complications, and one false negative was found.
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Limiting dietary fat could help prevent prostate cancer’s fatal metastatic progression

Limiting dietary fat could help prevent prostate cancer’s fatal metastatic progression | The future of medicine and health | Scoop.it
A team from the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) has been studying the mechanisms behind the metastatic progression of prostate cancer. They've found that a high-fat diet could play a major role in promoting metastasis of what is generally an "indolent" disease.

Indolent cancers are low-risk, slow-growing tumors that can progress so slowly that often no treatment is ever needed. Thyroid, lung and breast cancers can be classified as indolent, as can many cases of prostate cancer. The key thing for a physician trying to plan a treatment after a cancer has been identified is to understand what factors can cause it to metastasize and move to other parts of the body, often with fatal results.

The BIDMC team initially discovered that the absence of two specific genes, PTEN and PML, was linked with the metastatic progression of prostate tumors. But the absence of these two genes in the tumors was not enough to completely drive metastasis, there was still an unknown mechanism at play. It was here the researchers discovered that the metastatic prostate tumors being studied were producing incredible amounts of lipids, or fats. In concert with the absence of the two tumor suppressing genes, it seemed the cells' fat production processes were key to triggering a metastatic progression in the cancer.
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15 'Health Foods' That Aren't Actually That Good For You

15 'Health Foods' That Aren't Actually That Good For You | The future of medicine and health | Scoop.it
Eating healthy can often feel like torture in a country whose crowning achievement in food is the Crunchwrap Supreme.

To make matters worse, a lot of supposedly healthy foods aren't actually very good for you.

With that in mind, Business Insider asked Andy Bellatti, a registered dietitian and the cofounder of Dietitians for Professional Integrity, which "health foods" you should skip on your next trip to the grocery store.

1. Juice

When you juice fresh fruits and veggies, you remove their fibre, the key ingredient that keeps you feeling full and satisfied until your next meal.

What you keep is the sugar. In the short term, a high-sugar, low-protein diet means hunger pangs, mood swings, and low energy. In the long term, you can lose muscle mass, since muscles rely on protein.

2. Coconut oil

Coconut oil is roughly identical to olive oil in overall calorie and fat content.

But as opposed to a tablespoon of olive oil, which has just 1 gram of saturated fat and more than 10 grams of healthy mono- or polyunsaturated fats, a tablespoon of coconut oil has a whopping 12 grams of saturated fat and just 1 gram of healthy fat.

Experts suggest avoiding saturated fats because they have been linked with high cholesterol and a risk of Type 2 diabetes.

3. Agave nectar

Once upon a time, many health proponents (including Dr. Oz) suggested swapping your sugar for agave, since it has a low-glycemic index and doesn't lead to the impromptu spikes in blood sugar (aka glucose) that happen after consuming plain white sugar.

But while agave isn't high in glucose, it is high in another type of sweetener – fructose (the same stuff in high-fructose corn syrup). Some recent studies suggest that diets high in fructose are linked with several health problems, including heart disease.

It doesn't so much matter which sweetener you use as how much you're using. "Sugar is sugar is sugar," says Bellatti.

4. Egg whites
5. Low-fat products6. Granola7. Almond butter8. Multivitamins9. Gluten-free bread

Unless you're one of the 1 percent of Americans who suffer from celiac disease, gluten probably won't have a negative effect on you.

In fact, studies show that most people suffer from slight bloating and gas when they eat, whether they consume wheat or not. So go ahead and eat that bagel.

10. Almond milk11. Bottled water12. Detoxes13. Himalayan salt14. Coconut water15. Sports drinks
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How the sugar industry tried to hide the health effects of its product 50 years ago

How the sugar industry tried to hide the health effects of its product 50 years ago | The future of medicine and health | Scoop.it
About 50 years ago, the sugar industry stopped funding research that began to show something they wanted to hide: that eating lots of sugar is linked to heart disease. A new study exposes the sugar industry’s decades-old effort to stifle that critical research.

Researchers at the University of California, San Francisco, recently analyzed historical documents regarding a rat study called Project 259 that was launched in 1968. The study was funded by a sugar industry trade group called the International Sugar Research Foundation, or ISRF, and conducted by W. F. R. Pover at the University of Birmingham. When the preliminary findings from that study began to show that eating lots of sugar might be associated with heart disease, and even bladder cancer, the ISRF pulled the plug on the research. Without additional funding, the study was terminated and the results were never published, according to a study published today in PLOS Biology.
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Choosy Eggs May Pick Sperm for Their Genes, Defying Mendel’s Law | Quanta Magazine

Choosy Eggs May Pick Sperm for Their Genes, Defying Mendel’s Law | Quanta Magazine | The future of medicine and health | Scoop.it
In the winner-takes-all game of fertilization, millions of sperm race toward the egg that’s waiting at the finish line. Plenty of sperm don’t even make it off the starting line, thanks to missing or deformed tails and other defects. Still others lack the energy to finish the long journey through the female reproductive tract, or they get snared in sticky fluid meant to impede all but the strongest swimmers. For the subset of a subset of spermatozoa that reach their trophy, the final winner would be determined by one last sprint to the end. The exact identity of the sperm was random, and the egg waited passively until the Michael Phelps of gametes finally arrived. Or so scientists have thought.

Joe Nadeau, principal scientist at the Pacific Northwest Research Institute, is challenging this dogma. Random fertilization should lead to specific ratios of gene combinations in offspring, but Nadeau has found two examples just from his own lab that indicate fertilization can be far from random: Certain pairings of gamete genes are much more likely than others. After ruling out obvious alternative explanations, he could only conclude that fertilization wasn’t random at all.

“It’s the gamete equivalent of choosing a partner,” Nadeau said.

His hypothesis – that the egg could woo sperm with specific genes and vice versa – is part of a growing realization in biology that the egg is not the submissive, docile cell that scientists long thought it was. Instead, researchers now see the egg as an equal and active player in reproduction, adding layers of evolutionary control and selection to one of the most important processes in life.
“Female reproductive anatomy is more cryptic and difficult to study, but there’s a growing recognition of the female role in fertilization,” said Mollie Manier, an evolutionary biologist at George Washington University.
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Blame these bacteria for itchy eczema skin - Futurity

Blame these bacteria for itchy eczema skin - Futurity | The future of medicine and health | Scoop.it
Researchers may have found why our skin can become itchy and inflamed due to conditions like eczema, also known as atopic dermatitis.

A common bacterium called Staphylococcus aureus sometimes stimulates production of a protein that causes our own cells to react and cause the inflammation, the researchers report.

“Our skin is covered with bacteria as part of our normal skin microbiome and typically serves as a barrier that protects us from infection and inflammation,” says Lloyd Miller, associate professor of dermatology at the Johns Hopkins University School of Medicine. “However, when that barrier is broken, the increased exposure to certain bacteria really causes problems.”

S. aureus is an important human pathogen, already known as the most common cause of skin infections in people. In the United States, 20 to 30 percent of the population has it living on the skin or in the nose, Miller adds, and over time, up to 85 percent of people come into contact with it.

Eczema is an inflammatory skin disease that affects 20 percent of children and about 5 percent of adults. Ninety percent of patients with eczema have exceedingly high numbers of S. aureus bacteria on their inflamed skin.

Untreated eczema can lead to other allergic conditions, including asthma, food allergies, seasonal allergies, and conjunctivitis. Blocking the skin inflammation in eczema has the potential to prevent these unwanted conditions.

“We don’t really know what causes atopic dermatitis, and there aren’t many good treatments for it,” Miller says.
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For The First Time Ever Scientists Have Boosted Human Memory With a Brain Implant

For The First Time Ever Scientists Have Boosted Human Memory With a Brain Implant | The future of medicine and health | Scoop.it
With everyone from Elon Musk to MIT to the US Department of Defense researching brain implants, it seems only a matter of time before such devices are ready to help humans extend their natural capabilities.

Now, a professor from theUniversity of Southern California (USC) has demonstrated the use of a brain implant to improve the human memory, and the device could have major implications for the treatment of one of the US's deadliest diseases.

Dong Song is a research associate professor of biomedical engineering at USC, and he recently presented his findings on a "memory prosthesis" during a meeting of the Society for Neuroscience in Washington D.C. According to a New Scientist report, the device is the first to effectively improve the human memory.

To test his device, Song's team enlisted the help of 20 volunteers who were having brain electrodes implanted for the treatment of epilepsy.

Once implanted in the volunteers, Song's device could collect data on their brain activity during tests designed to stimulate either short-term memory or working memory.

The researchers then determined the pattern associated with optimal memory performance and used the device's electrodes to stimulate the brain following that pattern during later tests.

Based on their research, such stimulation improved short-term memory by roughly 15 percent and working memory by about 25 percent. When the researchers stimulated the brain randomly, performance worsened.

As Song told New Scientist, "We are writing the neural code to enhance memory function. This has never been done before."
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Your 'Gluten Sensitivity' Could Be Explained by Something Else Found in Wheat

Your 'Gluten Sensitivity' Could Be Explained by Something Else Found in Wheat | The future of medicine and health | Scoop.it

Sharing the science that matters.


If you're one of those people who don't have coeliac disease but still think gluten is causing your gut problems, scientists may finally have a clue as to what's going on. Studies have been pointing towards 'gluten sensitivity' not being a real thing. But plenty of people seem to have stomach upsets when they eat bread - and now a study shows that it's probably nothing to do with gluten, but there's another wheat component to blame. Coeliac disease manifests as an immune response to gluten, a family of proteins found in grains such as wheat, rye, barley and oats. Based on various studies, prevalence of coeliac disease in an average population can be up to around 1.3 percent. Yet the percentage of people who report adverse symptoms when they eat wheat is significantly higher. The exact prevalence of non-coeliac gluten sensitivity (NCGS) as it is called, is unknown, although a recent study suggests it could be as high as 13 percent. And because gluten has been turning out to be an unlikely culprit, a growing body of research has been looking at what's actually going on. Peter Gibson of Monash University and his team have performed extensive research into NCGS, and discovered that short-chain carbohydrates (Fermentable Oligosaccharides, Disaccharides, Monosaccharides and Polyols - also known as FODMAPs) - could be responsible. These ferment in the gut, causing bloating and other unpleasant symptoms. A study published in 2014 showed that a diet low in FODMAPs can reduce the symptoms of irritable bowel disease. Now Gibson's team has drawn a correlation between adverse gastrointestinal symptoms and a type of FODMAP carbohydrate called fructan.

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Plagued by unwanted thoughts? You may be low on hippocampal GABA

Plagued by unwanted thoughts? You may be low on hippocampal GABA | The future of medicine and health | Scoop.it

Recurrent unwanted thoughts are a key feature of conditions such as anxiety, post-traumatic stress disorder (PTSD), depression and schizophrenia. Now, in a step towards better-treating these disorders, scientists have identified a chemical in the brain that lets most people suppress such thoughts.


Whether they take the form of worries, unpleasant memories or hallucinations, recurrent unwanted thoughts are a key feature of conditions such as anxiety, post-traumatic stress disorder (PTSD), depression and schizophrenia. Now, in a step towards better-treating these disorders, scientists from Britain's University of Cambridge have identified a chemical in the brain that lets most people suppress such thoughts. Led by Prof. Michael Anderson and Dr. Taylor Schmitz, the researchers submitted a group of healthy test subjects to what's known as a Think/No-Think procedure. This involved first teaching the subjects to associate a series of words with other unrelated words, such as associating the word "ordeal" with "roach." Next, they were asked to recall the associated word when shown the first word, but only if the letters of that first word were colored green. If the letters were red, they were instead supposed to suppress any thoughts of the associated word. Utilizing both functional magnetic resonance imaging (fMRI) and magnetic resonance spectroscopy, the activity and chemistry of the subjects' brains were monitored as they performed this exercise. It was already known that the prefrontal cortex – the "command center" of the brain – played a role. What was found, however, was that a chemical known as GABA was more directly responsible for suppressing the unwanted thoughts. 

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'Incredible' editing of life's building blocks

'Incredible' editing of life's building blocks | The future of medicine and health | Scoop.it
Scientists have demonstrated an "incredibly powerful" ability to manipulate the building blocks of life in two separate studies.

One altered the atoms in DNA to rewrite the human genetic code and the instructions for life.

The other edited RNA, which is a chemical cousin of DNA and unlocks the information in the genetic code.

The studies - which could eventually treat diseases - have been described as clever, important and exciting.

Cystic fibrosis, inherited blindness and other diseases caused by a single typo in the genetic code could ultimately be prevented or treated with such approaches.

Both studies were performed at the Broad Institute of MIT and Harvard.
Base editing

The first, published in the journal Nature, developed tools called base editors.

DNA is built out of the four bases: adenine (A), cytosine (C), guanine (G) and thymine (T). If a single one of them is in the wrong place, it can cause disease.

Base editors alter the atomic structure of one base to convert it into another. Researchers can now manipulate the four bases.

And the team used base editing to correct an inherited disease that leads to dangerously high levels of iron in the blood.

Prof David Liu of the Broad Institute said: "We are hard at work trying to translate base editing technology into human therapeutics."
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