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Systems and synthetic biology approaches to cell division

Systems and synthetic biology approaches to cell division | SynBioFromLeukipposInstitute | Scoop.it
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by
Alireza Mashaghi • Cees Dekker

"Cells proliferate by division into similar daughter cells, a process that lies at the heart of cell biol- ogy. Extensive research on cell division has led to the identification of the many components and control ele- ments of the molecular machinery underlying cellular division. Here we provide a brief review of prokaryotic and eukaryotic cell division and emphasize how new approa- ches such as systems and synthetic biology can provide valuable new insight."

http://bit.ly/1aZrcI6

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Microsoft commits to the Open Science movement

Microsoft commits to the Open Science movement | SynBioFromLeukipposInstitute | Scoop.it
Microsoft Research's Andy Wilson demonstrates a 'touch-screen' projector on Joshua Topolsky's back.
Microsoft will aim to make all of its scientific research publicly accessible in a move to...
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Synthetic biology of avermectin for production improvement and structure diversification

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http://bit.ly/Mqsu3k

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DNA designer software

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Gerd Moe-Behrens's insight:

via @RKelwick Create biologically neutral sequences using this tool developed at Imperial College London http://bit.ly/LIhgah

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Self-aligning DNA wires for application in nanoelectronics

Self-aligning DNA wires for application in nanoelectronics | SynBioFromLeukipposInstitute | Scoop.it
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http://bit.ly/1bHMncf

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syntechbio | Biologia sintética brasil | synthetic biology brazil

syntechbio | Biologia sintética brasil | synthetic biology brazil | SynBioFromLeukipposInstitute | Scoop.it
Syntechbio is a biohacker's Space and Technology Channel, focus on: Genomics; Reverse Bioinformatics; Synthetic Biology; Nanotechnology.
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Synthetic Biology and Arts http://bit.ly/1lpNcAe

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The Internet of Vegetables: How Cyborg Plants Can Monitor Our World

The Internet of Vegetables: How Cyborg Plants Can Monitor Our World | SynBioFromLeukipposInstitute | Scoop.it
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by
KLINT FINLEY

"In the not too distant future, we could see cyborg plants that tell us when they need more water, what chemicals they’ve been exposed to, and what parasites are eating their roots. These part-organic, part-electronic creations may even tell us how much pollution is in the air. And yes, they’ll plug into the network.

That’s right: We’re on our way to the Internet of Plants.
That’s the message from Andrea Vitaletti, the head of a blue-sky research group working on this very thing at a lab in Italy. The project is called PLEASED, short for “PLants Employed As SEnsing Devices.” Though the project is still in the early stages, Vitaletti believes plants could serve as ideal sensors, monitoring so many aspects of our environment. Plants are cheap and resilient, he argues, and they could potentially monitor many different things simultaneously.
“Plants have millions of years of evolution. They are robust. They want to survive,” Vitaletti says...."


 http://wrd.cm/LtBkwU

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Stimulus-triggered fate conversion of somatic cells into pluripotency

Stimulus-triggered fate conversion of somatic cells into pluripotency | SynBioFromLeukipposInstitute | Scoop.it
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an important cellular reprogramming paper: "which requires neither nuclear transfer nor the introduction of transcription factors"

*Stimulus-triggered fate conversion of somatic cells into pluripotency*

by
Haruko Obokata,Teruhiko Wakayama,Yoshiki Sasai,Koji Kojima,Martin P. Vacanti,Hitoshi Niwa,Masayuki Yamato& Charles A. Vacanti

"Here we report a unique cellular reprogramming phenomenon, called stimulus-triggered acquisition of pluripotency (STAP), which requires neither nuclear transfer nor the introduction of transcription factors. In STAP, strong external stimuli such as a transient low-pH stressor reprogrammed mammalian somatic cells, resulting in the generation of pluripotent cells. Through real-time imaging of STAP cells derived from purified lymphocytes, as well as gene rearrangement analysis, we found that committed somatic cells give rise to STAP cells by reprogramming rather than selection. STAP cells showed a substantial decrease in DNA methylation in the regulatory regions of pluripotency marker genes. Blastocyst injection showed that STAP cells efficiently contribute to chimaeric embryos and to offspring via germline transmission. We also demonstrate the derivation of robustly expandable pluripotent cell lines from STAP cells. Thus, our findings indicate that epigenetic fate determination of mammalian cells can be markedly converted in a context-dependent manner by strong environmental cues."

http://bit.ly/1mYk3aM

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Crowdsourced RNA designs outperform computer algorithms

Crowdsourced RNA designs outperform computer algorithms | SynBioFromLeukipposInstitute | Scoop.it
An enthusiastic group of non-experts, working through an online interface and receiving feedback from lab experiments, has produced designs for RNA molecules that are consistently more successful than those generated by the best computerized design algorithms, researchers report.
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http://bit.ly/1ib1YWD

 

see also

ONLINE GAME BEATS ALGORITHM FOR RNA DESIGN http://bit.ly/1byCMEu

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Synthetic Biology: opportunities for Chilean bioindustry and education

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http://bit.ly/1hITTro

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Learning from nature – novel synthetic biology approaches for biomaterial design

Learning from nature – novel synthetic biology approaches for biomaterial design | SynBioFromLeukipposInstitute | Scoop.it
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 http://bit.ly/1i7pILe

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IBM DNA Transistor

IBM DNA Transistor | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

by
futurepredictions

"In an effort to build a nanoscale DNA sequencer, IBM scientists are drilling nano-sized holes in computer-like chips and passing DNA strands through them in order to read the information contained within their genetic code.

This research effort is to design a silicon-based DNA Transistor that could help pave the way to easily and quickly read human DNA, generating advancements in health condition diagnosis and treatment. The challenge in the effort is to slow the flow of the DNA through the hole so the reader can accurately decode what is in the DNA. If successful, the project could improve throughput and reduce cost to achieve the vision of personalized genome analysis at a cost of $100 to $1,000. In comparison, the first sequencing ever done by the Human Genome Project (HGP) cost $3 billion.A human genome sequencing capability affordable for individuals is the ultimate goal of the DNA sequencing and is commonly referred to as $1,000 genome. Ultimately, it can improve the quality of medical care by identifying patients who will gain the greatest benefit from a particular medicine and those who are most at risk of adverse reactions."



http://bit.ly/19XqMRA

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Craig Venter discusses creation of synthetic life | Machines Like Us

Craig Venter discusses creation of synthetic life | Machines Like Us | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

"Life is a DNA software system" says J. Craig Venter, PhD, and biology can be digitized, the information sent via the Internet, and viruses and other life forms recreated using the emerging tools of synthetic biology. Dr. Venter describes his vision for applying biological teleportation to send digitized biological information around the world and from Mars to Earth in an interview in Industrial Biotechnology, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available on the Industrial Biotechnology website.

Dr. Venter, Founder, Chairman, and CEO of the J. Craig Venter Institute, and CEO of Synthetic Genomics, Inc. (La Jolla, CA), delivered the Plenary Lecture at the 2013 BIO Pacific Rim Summit, December 10th, in San Diego, CA, in which he described the recent successful application of digital biology and synthetic genomics technology for the rapid development of a vaccine against a meningitis type B virus that has caused outbreaks this year.

In "IB Interview: A Conversation with J. Craig Venter, PhD," Dr. Venter discusses the work leading up to his group's creation of the first synthetic genome and new life form, the role that synthetic biology will have in sustainable human development, his current interest and activities in space exploration and the search for extraterrestrial life, and his views on bioenergy, future technology development, and policy and funding needs to support R&D in industrial biotechnology. Following the interview are excerpts of Dr. Venter's Plenary Lecture.

"Synthetic biology is not just an evolutionary step in industrial biotechnology, it is a quantum leap, and there is no better person than Craig Venter to help us look over the horizon and anticipate the future path and benefits of that continuing evolution," says Brent Erickson, Consulting Editor of Industrial Biotechnology and Executive Vice President, Industrial & Environmental Section, Biotechnology Industry Organization (BIO), Washington, DC. "The biotech tools Dr. Venter and his industry colleagues are developing enable us to tackle problems that humankind has found intractable for centuries. That should inspire all of us in the industry."


 http://bit.ly/1mWl3yR

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Orthogonal logic gates

A set of 16 TetR proteins specific for their synthetic promoters will allow the construction of complex genetic circuits.
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Designing Life: The Ethics of Synthetic Biology, with Professor Drew Endy of Stanford University - YouTube

As part of a major new initiative by President Michael D. Higgins, Science Gallery at Trinity College Dublin will explore the ethics and future directions of...
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BioCoder: Issue 2

BioCoder: Issue 2 | SynBioFromLeukipposInstitute | Scoop.it
RT @simonbayly: RT @liaonet: Please retweet to anyone wanting to do a synthetic biology startup. http://t.co/aLbgGeZuAq #synbio
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Reinventing Explanation | Michael Nielsen

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 - essay on the use of digital media to explain scientific ideas http://bit.ly/1j7j8Yn

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GEN | Webinars:CRISPRs: Ushering in a New Age of Gene Editing

GEN | Webinars:CRISPRs: Ushering in a New Age of Gene Editing | SynBioFromLeukipposInstitute | Scoop.it
Get the latest in biotechnology through daily news coverage as well as analysis, features, tutorials, webinars, podcasts, and blogs. Learn about the entire bioproduct life cycle from early-stage R&D, to applied research including omics, biomarkers, as well as diagnostics, to bioprocessing and commercialization.
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Laurie Garrett on Synthetic Biology

Gideon Rose, Editor of Foreign Affairs, interviews Laurie Garrett, senior fellow at the Council on Foreign Relations, on the promise and perils of synthetic ...
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OpenPlant - major boost for synthetic biology | University of Cambridge

OpenPlant - major boost for synthetic biology | University of Cambridge | SynBioFromLeukipposInstitute | Scoop.it
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Application of nucleic acid–lipid conjugates for the programmable organisation of liposomal modules

Application of nucleic acid–lipid conjugates for the programmable organisation of liposomal modules | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

by
Beales PA, Vanderlick TK

"We present a critical review of recent work related to the assembly of multicompartment liposome clusters using nucleic acids as a specific recognition unit to link liposomal modules. The asymmetry in nucleic acid binding to its non-self complementary strand allows the controlled association of different compartmental modules into composite systems. These biomimetic multicompartment architectures could have future applications in chemical process control, drug delivery and synthetic biology. We assess the different methods of anchoring DNA to lipid membrane surfaces and discuss how lipid and DNA properties can be tuned to control the morphology and properties of liposome superstructures. We consider different methods for chemical communication between the contents of liposomal compartments within these clusters and assess the progress towards making this chemical mixing efficient, switchable and chemically specific. Finally, given the current state of the art, we assess the outlook for future developments towards functional modular networks of liposomes."

http://bit.ly/1fnjVkr

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Synthetic mammalian gene circuits for biomedical applications

Synthetic mammalian gene circuits for biomedical applications | SynBioFromLeukipposInstitute | Scoop.it
Gerd Moe-Behrens's insight:

by
Ye H, Aubel D, Fussenegger M.

"Synthetic biology is the science of reassembling cataloged and standardized biological items in a systematic and rational manner to create and engineer functional biological designer devices, systems and organisms with novel and useful, preferably therapeutic functions. Synthetic biology has significantly advanced the design of complex genetic networks that can reprogram metabolic activities in mammalian cells and provide novel therapeutic strategies for future gene-based and cell-based therapies. Synthetic biology-inspired therapeutic strategies provide new opportunities for improving human health in the 21st century. This review covers the most recent synthetic mammalian circuits designed for therapy of diseases such as metabolic disorders, cancer, and immune disorders. We conclude by discussing current challenges and future perspectives for biomedical applications of synthetic mammalian gene networks."


 http://bit.ly/1jJLY0I

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REWRITING NATURAL PRODUCT DRUG DISCOVERY THROUGH SYNTHETIC 5 BIOLOGY

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 http://bit.ly/1fk50HA

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SSBSS 2014 : Synthetic and Systems Biology Summer School: Biology meets Engineering and Computer Science

SSBSS 2014 : Synthetic and Systems Biology Summer School: Biology meets Engineering and Computer Science | SynBioFromLeukipposInstitute | Scoop.it
SSBSS 2014 : Synthetic and Systems Biology Summer School: Biology meets Engineering and Computer Science
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Modelling success stories (4) Birth of synthetic biology 2000

Modelling success stories (4) Birth of synthetic biology 2000 | SynBioFromLeukipposInstitute | Scoop.it
For the fourth entry in the series, I will not introduce one, but two papers, published back to back in a January 2000 issue of Nature. The particularity of these articles is not that the described...
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