SynBioFromLeukipposInstitute
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Optogenetic Hack Advances Synthetic Morphogenesis

Optogenetic Hack Advances Synthetic Morphogenesis | SynBioFromLeukipposInstitute | Scoop.it
Get the latest in biotechnology through daily news coverage as well as analysis, features, tutorials, webinars, podcasts, and blogs. Learn about the entire bioproduct life cycle from early-stage R&D, to applied research including omics, biomarkers, as well as diagnostics, to bioprocessing and...
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New machine learning approach could accelerate bioengineering

Scientists have developed a way to use machine learning to dramatically accelerate the design of microbes that produce biofuel....
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Journal of Biosensors and Bioelectronics - Open Access Journals

Journal of Biosensors and Bioelectronics - Open Access Journals | SynBioFromLeukipposInstitute | Scoop.it
Journal of Biosensors and Bioelectronics discusses the latest research innovations and important developments in this field.
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CRISPR/dCas9-mediated multiplex gene repression in Streptomyces

Biotechnol J. 2018 Jun 3:e1800121. doi: 10.1002/biot.201800121.[Epub ahead of print]...
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On an algorithmic definition for the components of the minimal cell

On an algorithmic definition for the components of the minimal cell | SynBioFromLeukipposInstitute | Scoop.it
Living cells are highly complex systems comprising a multitude of elements that are engaged in the many convoluted processes observed during the cell cycle. However, not all elements and processes are essential for cell survival and reproduction under steady-state environmental conditions.
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Control Theory for Synthetic Biology: Recent Advances in System Characterization, Control Design, and Controller Implementation for Synthetic Biology

Living organisms are differentiated by their genetic material-millions to billions of DNA bases encoding thousands of genes. These genes are translated into a vast array of proteins, many of which have functions that are still unknown. Previously, it was believed that simply knowing the genetic sequence of an organism would be the key to unlocking all understanding. However, as DNA sequencing technology has become affordable, it has become clear that living cells are governed by complex, multilayered networks of gene regulation that cannot be deduced from sequence alone. Synthetic biology as a field might best be characterized as a learn-by-building approach, in which scientists attempt to engineer molecular pathways that do not exist in nature. In doing so, they test the limits of both natural and engineered organisms.
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Artificial metalloenzyme flips switch in cells

Artificial metalloenzyme flips switch in cells | SynBioFromLeukipposInstitute | Scoop.it
Cell-penetrating assembly uncages hormone, turning on gene circuit...
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Water-Based Digital Fabrication Platforms : fabrication platform

Water-Based Digital Fabrication Platforms : fabrication platform | SynBioFromLeukipposInstitute | Scoop.it
fabrication platform - In her water-based digital fabrication platform project, architect and professor Neri Oxman embraces water as nature’s architectural tool and...
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neri oxman and MIT develop digitally produced water-based renewable material

neri oxman and MIT develop digitally produced water-based renewable material | SynBioFromLeukipposInstitute | Scoop.it
neri oxman and the MIT mediated matter group have developed a water-based digital fabrication platform using a renewable polymer from the ocean.
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Construction and Integration of a Synthetic MicroRNA Cluster for Multiplex RNA Interference in Mammalian Cells

Methods Mol Biol. 2018;1772:347-359. doi: 10.1007/978-1-4939-7795-6_19.
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At GP-write, scientists take first steps on way to synthetic human genome

At GP-write, scientists take first steps on way to synthetic human genome | SynBioFromLeukipposInstitute | Scoop.it
At the third meeting of GP-write, researchers decide to create virus-resistant human cells...
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Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast

Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast | SynBioFromLeukipposInstitute | Scoop.it
Robust Synthetic Circuits for Two-Dimensional Control of Gene Expression in Yeast...
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Biology Will Be the Next Great Computing Platform

Biology Will Be the Next Great Computing Platform | SynBioFromLeukipposInstitute | Scoop.it
BIOLOGY WILL BE THE NEXT GREAT COMPUTING PLATFORM
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MIT engineers recruit microbes to help fight cholera

MIT engineers recruit microbes to help fight cholera | SynBioFromLeukipposInstitute | Scoop.it
MIT engineers have developed a probiotic mix of natural and engineered bacteria to diagnose and treat cholera, an intestinal infection that causes severe dehydration.
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Genetic tool development and systemic regulation in biosynthetic technology

Biotechnol Biofuels. 2018 Jun 1;11:152. doi: 10.1186/s13068-018-1153-5. eCollection 2018.Review...
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Developing a Synthetic Biology Toolkit for Comamonas testosteroni, an Emerging Cellular Chassis for Bioremediation

ACS Synth Biol. 2018 Jun 3. doi: 10.1021/acssynbio.7b00430.[Epub ahead of print]...
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Bio Art | SVA Bio Art Lab, BFA Fine Arts – New York City

Bio Art | SVA Bio Art Lab, BFA Fine Arts – New York City | SynBioFromLeukipposInstitute | Scoop.it
SCALE Studies in Bio Art Wednesday June 13, 2018 6-8PM SVA BFA Fine Arts 335 W 16th St, New York, NY 10011   Participants: Clare Benson  Magdalena Dukiewicz Ryan Greer  Jane Hsi  Keika Okamoto E.R. Saba      Bio Art SVA Art and Science Laboratory Bio Art Lab. SVA BFA Fine Arts School of Visual Arts, New York The Bio Art Lab was founded in 2011 as part of the SVA’s BFA Fine Arts new facility consisting of 54,000 square feet in the heart of Chelsea, NYC.  The Lab was founded and is directed by Suzanne Anker, Chair of the BFA Fine Arts Department.  Conceived as a place where scientific tools and techniques become tools and techniques in art practice, the Lab is the result of many people’s expertise, research and sustained effort. Such deftness and collaborative efforts continue to remain crucial in developing this facility to its full potential. Joe Tekippe and Luis Navarro were responsible for all high-tech computer access including our full range of hardware and software installation and maintenance. More recently Michael Falk has coordinated, experimented with and set up the necessary photographic resources we need in place for our microscopic image making. Daniel Wapner and Sung Jin Choi used their skills to seamlessly build both stainless steel and aluminum stands housing our fish and plants. Mark Rosen set up a check-in check-out system for our library.  Brandon Ballengée added his knowledge concerning fresh water fish and frog tanks in addition to the acquisition of a chemical hood where the preservation of specimens and cleaning and staining of aquatic animals could take place. Dr. Ignacio Lopez-Coviella was a great consultant in developing our microscopic practices, pointing us in the direction of three types of microscopes: a compound microscope, a dissecting microscope and an inverted microscope.  Marine biologist Joe Di Giorgis expanded our collection of microscopes by loaning us a full array of dissecting microscopes and analyzing the camera requirements for each.  Molecular scientists, Oliver Medvedik and Ellen Jorgensen from Genspace consulted in regard to our incubators, HEPA filter and autoclave as well as helping to design projects relevant to Bio  Art practice. Ellen and Oliver are also our current “scientists in residence” working with students on the use of bio-materials for art projects and the barcoding of plants from the surrounding environment.  Tarah Rhoda researched labware, lab rules and formats for molecular cuisine and tissue culturing as well as lighting systems for plants and lab protocol, safety and workflow. Many student workers were instrumental in maintaining the live plants and organisms in the Lab with care, integrity, and enthusiasm. And I say the same for the various visiting artists who have shared their expertise with us (see separate link.) Scott Vaughn of  NY Aquarium in NYC manages our salt water aquarium which houses coral, an anemone, hermit crabs and starfish. Sebastian Cocioba from NY Botanics, introduced techniques for plant tissue culturing of African violets and venus fly-traps. He is also developing an “SVA” palette for painting with bacteria. Sebastian and Sung  have been helping us develop a molecular biology component  of our lab employing PCR practices, synthetic biology and forensics in analyzing molecular data. Raul Gomez Valverde has designed our micro website, www.bioart.sva.edu, and has produced outstanding pictures of student works produced in situ.  George Boorujy has donated marvelous taxidermied duck specimens which appear as if in flight.  And of course our great thanks to President David Rhodes and Provost Jeff Nesin for allowing us to go forward with this great resource.
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Programming self-organizing multicellular structures with synthetic cell-cell signaling

A common theme in the self-organization of multicellular tissues is the use of cell-cell signaling networks to induce morphological changes. We used the modular synNotch juxtacrine signaling platform to engineer artificial genetic programs in which specific cell-cell contacts induced changes in cadherin cell adhesion. Despite their simplicity, these minimal intercellular programs were sufficient to yield assemblies with hallmarks of natural developmental systems: robust self-organization into multi-domain structures, well-choreographed sequential assembly, cell type divergence, symmetry breaking, and the capacity for regeneration upon injury. The ability of these networks to drive complex structure formation illustrates the power of interlinking cell signaling with cell sorting: signal-induced spatial reorganization alters the local signals received by each cell, resulting in iterative cycles of cell fate branching. These results provide insights into the evolution of multi-cellularity and demonstrate the potential to engineer customized self-organizing tissues or materials.
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The Global Synthetic Biology Summit

The Global Synthetic Biology Summit | SynBioFromLeukipposInstitute | Scoop.it
SynBioBeta 2018 comes to San Francisco on October 1-3, uniting biological engineers, entrepreneurs and investors for the Global Synthetic Biology Summit. Meet over 1000 attendees and 100 speakers, sponsors and exhibitors.
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Do-it-yourself CRISPR genome editing kits bring genetic engineering to your kitchen bench

A synthetic biologist from NASA plans to make CRISPR-based genetic engineering as accessible as a home science kit, so you can bio-hack yeast and bacteria on your kitchen bench.​...
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Single-step Precision Genome Editing in Yeast Using CRISPR-Cas9

Bio Protoc. 2018 Mar 20;8(6). pii: e2765. doi: 10.21769/BioProtoc.2765.
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Bio-Algorithmic Workflows for Standardized Synthetic Biology Constructs

Methods Mol Biol. 2018;1772:363-372. doi: 10.1007/978-1-4939-7795-6_20.
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CRISPR-Cas9-Mediated Genome Editing and Transcriptional Control in Yarrowia lipolytica

Methods Mol Biol. 2018;1772:327-345. doi: 10.1007/978-1-4939-7795-6_18.
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Tools for Biohackers: Here Come 3 Mini-Labs

Tools for Biohackers: Here Come 3 Mini-Labs | SynBioFromLeukipposInstitute | Scoop.it
These desktop gadgets should make DIY genetic engineering much easier...
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CRISPR Cas9 Nuclease Recruitment for Targeted Mutagenesis using Oligo SgRNA in Soybean (Glycine Max L) | SciTechnol

CRISPR Cas9 Nuclease Recruitment for Targeted Mutagenesis using Oligo SgRNA in Soybean (Glycine Max L) | SciTechnol | SynBioFromLeukipposInstitute | Scoop.it
The Modern era of genome engineering via targeted mutagenesis is now bringing further innovations in the field of Plant biology and biomedicines. RNA-guided endonucleases..
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