Stems cells and Regenerative Medicine
1.5K views | +0 today
Follow
Stems cells and Regenerative Medicine
Evidence-based research and developments in regenerative medicine to maintain optimal health and function.
Your new post is loading...
Your new post is loading...
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Drug perks up old muscles and aging brains

Drug perks up old muscles and aging brains | Stems cells and Regenerative Medicine | Scoop.it
We age, in part, because the adult stem cells in our tissues are surrounded by chemicals that prevent them from replacing damaged cells. One of these chemicals is TGF-beta1, known to depress stem cell activity. A new study shows that a drug that blocks TGF-beta1, which is now being tested for its anticancer properties, makes brain and muscle tissue more youthful. This is a step toward a drug cocktail that could rejuvenate aging tissue.
Richard D. Hammer, M.D.'s insight:

We are just beginning to understand the complex role of cytokines like TGF-beta1 on health.  One of the problems is  these cytokines have widespread effects in the body.  TGF-beta1 is a common cytokine included in skin therapies for rejuvenation. So does it depress stem cells?  Maybe it depends where they are.  So don't hold your breath for the new drug that will reverse aging. Stick to things that we know will work, exercise, good nutrition and a healthy lifestyle.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Missouri Cures – Stem Cells Halt MS for Two Years

Missouri Cures – Stem Cells Halt MS for Two Years | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

So maybe a bone marrow transplant can cure MS?  A procedure that is well established, although not without significant risks.  

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Human Neural Precursor Cells Promote Neurologic Recovery in a Viral Model of Multiple Sclerosis

Human Neural Precursor Cells Promote Neurologic Recovery in a Viral Model of Multiple Sclerosis | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

Further work demonstrating the potential of stem cells in treatment of MS.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Can Tai Chi Really Slow Aging? A New Study Has The Answer

Can Tai Chi Really Slow Aging? A New Study Has The Answer | Stems cells and Regenerative Medicine | Scoop.it
Seeking to roll back the clock? Tai Chi, an ancient Chinese martial art, may be the answer.

A new study published in Cell Transplantation found that Tai Chi can help raise the numbers of a stem cell -- CD34 cells -- important to a number of the bo...
Richard D. Hammer, M.D.'s insight:

It would have been more informative to do this in an older population group.  However, this is encouraging.

more...
No comment yet.
Rescooped by Richard D. Hammer, M.D. from Optimal Health and Aging-An Evidence-Based Medicine Approach
Scoop.it!

Harvard researchers find protein that could reverse the aging process

Harvard researchers find protein that could reverse the aging process | Stems cells and Regenerative Medicine | Scoop.it
Researchers from the Harvard Stem Cell Institute (HSCI) have shown that injections of a protein dubbed GDF11, when administered to older mice, appear to cau...
more...
Richard D. Hammer, M.D.'s curator insight, May 9, 2014 9:15 AM

Pretty dramatic findings.  So far GDF11 has been shown to increase muscle stem cell activity, improve neurologic parameters, and reverse cardiac hypertrophy.  Of course, though a recombinant protein is available now (which was used in the study) , we have to wait for pharma to develop a patentable analog.   

Scooped by Richard D. Hammer, M.D.
Scoop.it!

Scientists Transform Skin Cells into Functioning Liver Cells | Gladstone Institutes

Scientists Transform Skin Cells into Functioning Liver Cells | Gladstone Institutes | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

This is hopeful for the transplant industry.  

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Stem Cells Used in Knee Cartilage Regeneration

Stem Cells Used in Knee Cartilage Regeneration | Stems cells and Regenerative Medicine | Scoop.it
Imagine having stem cells taken from your marrow and quickly being transplanted into your worn-out knee cartilage, quicker than your pizza gets delivered. After...
Richard D. Hammer, M.D.'s insight:

Although, the FDA has currently effectively shut down the use of autologous stem cells. the rest of the world moves on.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles.

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles. | Stems cells and Regenerative Medicine | Scoop.it
In two new studies, Helen Blau and Bradley Olwin and their colleagues show that muscle stem cells in aged mice have an intrinsic defect in their stem cell capacity, contributing to age-related sarcopenia. They also provide mechanistic insight to explain this phenomenon and show that biochemical and biophysical manipulations can overcome the defect, suggesting a possible future route of therapy.
Richard D. Hammer, M.D.'s insight:

Aging muscle has an intrinsic decreased function of muscle stem cells that can be overcome.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Early Success in a Human Embryonic Stem Cell Trial to Treat Blindness | TIME.com

Early Success in a Human Embryonic Stem Cell Trial to Treat Blindness | TIME.com | Stems cells and Regenerative Medicine | Scoop.it
The first patients to receive human embryonic stem cell transplants say their lives have been transformed by the experimental procedure.
Richard D. Hammer, M.D.'s insight:

THis may be one of the first success stories to become a valid therapy.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Human adipose derived stromal/stem cells (hASCs) protect against STZ-induced hyperglycemia; analysis of hASC-derived paracrine effectors

Human adipose derived stromal/stem cells (hASCs) protect against STZ-induced hyperglycemia; analysis of hASC-derived paracrine effectors | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

Adipose derived stem cells may have effects in diabetes and glucose control.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Scientists discover a new, simpler way to make stem cells - Boston.com

Scientists discover a new, simpler way to make stem cells - Boston.com | Stems cells and Regenerative Medicine | Scoop.it
A team of Boston and Japanese researchers stunned the scientific world Wednesday by revealing a remarkably simple and unexpected way to create stem cells able to give rise to any tissue in the body. To transform mature cells into powerful stem cells that are a biological blank slate, the team simply bathed them in an acid bath for half an hour. The technique appears to be far easier and faster than current methods for creating these cells, which scientists are racing to develop into therapies for a range of diseases.
Richard D. Hammer, M.D.'s insight:

Wow, so simple yet so logical that environmental stress may intitiate a mechanism of healing.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Groundbreaking stem cell treatment trial for MS patients

Groundbreaking stem cell treatment trial for MS patients | Stems cells and Regenerative Medicine | Scoop.it
Dr. Jon LaPook goes inside the trial and approval process for an experimental treatment using stem cells designed to make Multiple Sclerosis patients better. Current treatments only try to stop the progression of the disease.
Richard D. Hammer, M.D.'s insight:

While CBS site says "approved" this is only the beginning of a phase 1 safety study on 20 patients, none which have been treated yet.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial : The Lancet Respiratory...

Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial. By - Aliaksandr Skrahin...
Richard D. Hammer, M.D.'s insight:

Very interesting to find that MSCs may modulate the immune system in a way that is beneficial to traditional drug therapy.  Larger trials in various situations would be a interesting avenue to explore.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties?

Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties? | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

The case for fresh cells continues to grow. 

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Missouri Cures – A Leap of Faith: Desperate Patients Look to Lab-Grown Organs

Missouri Cures – A Leap of Faith: Desperate Patients Look to Lab-Grown Organs | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

This will eventually be the treatment of choice for organ transplants.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation

The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

There is a significant survival effect related to diversity of bacteria in the intestine.  Are probiotics, a potentially lifesaving treatment in stem cell transplantation?  

more...
Richard D. Hammer, M.D.'s curator insight, June 18, 2014 10:27 AM

Probiotics may be more important in health and stem cells than realized.

Scooped by Richard D. Hammer, M.D.
Scoop.it!

Mice disabled by MS could walk following treatment with human stem cells

Mice disabled by MS could walk following treatment with human stem cells | Stems cells and Regenerative Medicine | Scoop.it
Mice severely disabled by a multiple sclerosis (MS) - like condition could walk less than two weeks following treatment with human stem cells. The finding, which uncovers new avenues for treating MS, will be published online on May 15, 2014, in the journal Stem Cell Reports.
Richard D. Hammer, M.D.'s insight:

Exciting progress illustrating that the cytokines and signals produced by stem cells are likely to be the key.  

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Therapeutic applications of mesenchymal stem cells for amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the neuromuscular system and does not have a known singular cause. Genetic mutations, extracellular factors, non-neuronal support cells, and the immune system have all been shown to play varied roles in clinical and pathological disease progression. The therapeutic plasticity of mesenchymal stem cells (MSCs) may be well matched to this complex disease pathology, making MSCs strong candidates for cellular therapy in ALS. In this review, we summarize a variety of explored mechanisms by which MSCs play a role in ALS progression, including neuronal and non-neuronal cell replacement, trophic factor delivery, and modulation of the immune system. Currently relevant techniques for applying MSC therapy in ALS are discussed, focusing in particular on delivery route and cell source. We include examples from in vitro, preclinical, and clinical investigations to elucidate the remaining progress that must be made to understand and apply MSCs as a treatment for ALS.
Richard D. Hammer, M.D.'s insight:

ALS and MS are major focuses or stem cell research and ultimately will have a therapeutic role.  

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

CIRM Stem Cell Research Updates: Team tricked scar tissue on spinal cord injury into becoming new nerves without stem cell transplant

CIRM Stem Cell Research Updates: Team tricked scar tissue on spinal cord injury into becoming new nerves without stem cell transplant | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

There does appear to be a biologic process where the stem cells of an older person are not as versatile or responsive as younger people.  This has been studies much in mice and there are factors that can restore the youthfulness of stem cells.  Hopefully one day this can be applied in humans. Until then, if considering banking your stem cells, remember the longer you wait, the less responsive or functional they may be.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Stem Cell Therapy and Curcumin Synergistically Enhance Recovery from Spinal Cord Injury

Stem Cell Therapy and Curcumin Synergistically Enhance Recovery from Spinal Cord Injury | Stems cells and Regenerative Medicine | Scoop.it
PLOS ONE: an inclusive, peer-reviewed, open-access resource from the PUBLIC LIBRARY OF SCIENCE. Reports of well-performed scientific studies from all disciplines freely available to the whole world.
Richard D. Hammer, M.D.'s insight:

Curcumin has many benefits and now seems to have an effect on stem cell growth and proliferation.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Researchers rejuvenate stem cell population from elderly mice ...

Researchers rejuvenate stem cell population from elderly mice ... | Stems cells and Regenerative Medicine | Scoop.it
Researchers at the Stanford University School of Medicine have pinpointed why normal aging is accompanied by a diminished ability to regain strength and mobility after muscle injury: Over time, stem cells within muscle ...
Richard D. Hammer, M.D.'s insight:

Important research that has implications in human aging.  Sarcopenia (or muscle weakness) is a component of aging that results in debility and increases chances of falls.  Exercise  has been shown to stimulate stem cell proliferation in-vivo and can be used now, rather than waiting for development of a wonder drug.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Stem cell banking from teeth gains acceptance.

Stem cell banking from teeth gains acceptance. | Stems cells and Regenerative Medicine | Scoop.it
Stem cell banking from teeth gains acceptance
Times of India
LUDHIANA: People with poor health history or those suffering from genetic diseases are going to the dentists in greater numbers for stem cell banking from teeth.
Richard D. Hammer, M.D.'s insight:

Dental pulp is a good source of mesenchymal stem cells that are easily obtained. Several banks offer this option here in the US.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Health News - Stomach cells naturally revert to stem cells

Health News - Stomach cells naturally revert to stem cells | Stems cells and Regenerative Medicine | Scoop.it
Richard D. Hammer, M.D.'s insight:

I wonder if there is an association between the recent demonstration of acid producing stem cells and this phenomenon?

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Pluristem stem cell trial to treat muscle injury meets main goal

Pluristem stem cell trial to treat muscle injury meets main goal | Stems cells and Regenerative Medicine | Scoop.it
TEL AVIV (Reuters) - Pluristem Therapeutics Inc said results from its early/mid-stage clinical trial indicated its placenta-derived stem cells for the treatment of muscle injury were safe and provided...
Richard D. Hammer, M.D.'s insight:

Not much information to go on and truly assess other than the company claims.  However sounds promising.  Another study that also shows more cells doesn't necessarily give a better effect.  This has been seen in other scenarios, so optimal dose is important.

more...
No comment yet.
Scooped by Richard D. Hammer, M.D.
Scoop.it!

Stem Cell Research & Therapy | Abstract | Sera of overweight people promote in vitro adipocyte differentiation of bone marrow stromal cells

Overweight status should not be considered merely an aesthetic concern; rather, it can incur health risks since it may trigger a cascade of events that produce further fat tissue through altered levels of circulating signaling molecules.
Richard D. Hammer, M.D.'s insight:

A provocative pilot study showing that serum of obese people promotes further differentiation of stem cells into fat.  The factor is as yet unknown.  Also a good summary of the many deleterious effects of obesity.

more...
No comment yet.