Stem Cell Research
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UCLA stem cell researchers move toward treatment for rare genetic nerve disease / UCLA Newsroom

UCLA stem cell researchers move toward treatment for rare genetic nerve disease / UCLA Newsroom | Stem Cell Research | Scoop.it
UCLA stem cell researchers move toward treatment for rare genetic nerve disease / UCLA Newsroom

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Sean Brazel's curator insight, April 5, 2014 11:16 PM

Provides evidence that if stem cell research is used ethically by scientist's, results of this research can find cures to disease's or improve a person's health.

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Longevity gene tied to nerve stem cell regeneration, say Stanford researchers-scopeblog.stanford.edu

Geneticist Anne Brunet, PhD, thinks a lot about aging. Much of her research focuses on understanding why some people and animals live much longer than their peers. She’s characterized some proteins, including one called FOXO3, that play a role in this process. 


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Jacob Blumenthal's curator insight, July 30, 2013 3:31 AM

In a research, published in Cell Reports, the geneticist Anne Brunet describes how the pro-longevity factor FOXO3 works in stem cells from the adult brain. Her research team successfuly identified FOXO3 direct targets genome-wide in primary cultures of adult neural progenitor cells (NPCs).

http://www.cell.com/cell-reports/fulltext/S2211-1247(13)00327-6

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A molecular ‘switch’ to reprogram control pathways in cells | KurzweilAI

A molecular ‘switch’ to reprogram control pathways in cells | KurzweilAI | Stem Cell Research | Scoop.it

A modular technology that uses three biological components to control a signaling pathway inside a cell: the transducer (left), an RNA-based system that


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Anyone for a stem-cell burger? | Science | The Guardian

Anyone for a stem-cell burger? | Science | The Guardian | Stem Cell Research | Scoop.it
At the unveiling of the world's first lab-grown burger, the crucial question is: how does it taste?
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Image of the Day: Stem Cell Sentinel | The Scientist Magazine®

Image of the Day: Stem Cell Sentinel | The Scientist Magazine® | Stem Cell Research | Scoop.it
An unfertilized egg cell showing a dense cloud of protein called “Ronin,” which contributes to embryonic development and maintains stem cells in their undifferentiated states

 

   

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MSC 2013: Induced tissue regeneration and developmental engineering

MSC 2013: Induced tissue regeneration and developmental engineering | Stem Cell Research | Scoop.it

I’m attending MSC 2013: Adult Stem Cell Therapy and Regenerative Medicine in Cleveland. It has been great meeting so far and I’m learning a lot of new things. The highlights of the first day for me were: a new term, coined by Michael West (CEO of BioTime) – induced tissue regeneration (iTR) and importance of the concept of developmental engineering. These two things intimately interconnected.


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Jacob Blumenthal's curator insight, August 20, 2013 1:49 AM

In this post by ALEXEY BERSENEV, he describes his impressions from the MSC 2013 stem cell meeting first day. Michael West was a keynote speaker and talked about the rationale behing the derivation of embryonic mesenchymal progenitor cells (EMPC) from human embryonic stem (hES) cells. EMPC are adult-like, clonally-purified lines, made of pluripotent stem cells, which can be scaled up and suited for industrial manufacturing. Unlike ES cells, EMPC are mortal, but could go easily 100 doublings in culture. Importantly, these EMPC recapitulating normal embryonic development in vitro. EMPC are very sensitive to environmental cues and can be turned easily into more specific mesenchymal lineages.

 

If you wish to learn more about these EMPC, you can take a look at:

 http://bioreagents.lifemapsc.com/pages/category-purestem

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Developmental on-switch: Substances that convert body cells back into stem cells initially activate all genes in the embryo

Developmental on-switch: Substances that convert body cells back into stem cells initially activate all genes in the embryo | Stem Cell Research | Scoop.it
Researchers have demonstrated for the first time why the molecular cocktail responsible for generating stem cells works.

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Jacob Blumenthal's curator insight, August 19, 2013 6:44 AM

Researchers from Freiburg university found that zebrafish Pou5f1, a homolog of the mammalian pluripotency transcription factor Oct4, occupies SOX-POU binding sites before the onset of zygotic transcription and activates the earliest zygotic genes. 

The paper was published in Science:

http://www.sciencemag.org/content/early/2013/08/14/science.1242527

 

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To learn about stem cells and their related differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/in-vitro-cells

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

 

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Frontiers | Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a...

Frontiers | Cortical region-specific engraftment of embryonic stem cell-derived neural progenitor cells restores axonal sprouting to a subcortical target and achieves motor functional recovery in a... | Stem Cell Research | Scoop.it
Hypoxic–ischemic encephalopathy (HIE) at birth could cause cerebral palsy, mental retardation, and epilepsy, which last throughout the individual’s lifetime. However, few restorative treatments for ischemic tissue are currently available.

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Ella Buzhor's curator insight, August 21, 2013 11:16 AM

This study demonstrates the ability of embryonic stem cell-derived neural progenitor cells (ES-NPCs) to become cortical deep layer neurons and  and to repair brain damage in an Hypoxic-ischemic encephalopathy mouse model.

http://www.frontiersin.org/Cellular_Neuroscience/10.3389/fncel.2013.00128/abstract

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Animal drug testing can be a thing of the past; scientists now 3D-printing embryonic stem cells

Animal drug testing can be a thing of the past; scientists now 3D-printing embryonic stem cells | Stem Cell Research | Scoop.it
Animal drug testing can be a thing of the past; scientists now 3D-printing embryonic stem cells (RT @slone: Animal drug testing can be a thing of the past; scientists now 3D-printing embryonic stem cells http://t.co/UkOmaFvR1y...

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Crucial advance in stem cell research: Conversion of human skin cells directly into immature brain cells

Crucial advance in stem cell research: Conversion of human skin cells directly into immature brain cells | Stem Cell Research | Scoop.it
Scientists at The University of Auckland’s Centre for Brain Research have succeeded in converting human skin cells directly into immature brain cells (or neural precursor cells).

 

The team, assisted by funding from the Neurological Foundation of New Zealand, the Auckland Medical Research Foundation, and the Maurice and Phyllis Paykel Trust , has led the world in developing a fast and efficient means of accomplishing this without having to go through the intermediate stage of conversion to embryonic stem cells.

 

“This is an advance of huge significance to stem cell research on a global level,” says Principal Investigator, Associate Professor Bronwen Connor, who is head of the Neural Repair and Neurogenesis Laboratory at the University. “It has the potential to lead to a new understanding of neurodegenerative diseases such as Huntington’s, Parkinson’s and Alzheimer’s. “We are all very excited about it.”

 

First, it is the only group to have reprogrammed adult human skin cells. Other groups using this technique are working with cells taken from animals’ skin. Second, the Auckland team is using just two genes for the process of reprogramming from skin cells to neural precursor cells. Other international groups are using between five and 11 genes. The direct conversion also overcomes a problem of tumor formation which can arise when embryonic stem cells are used. The elimination of this risk through direct conversion from skin cells to neural precursor cells therefore gives a strong boost to the prospect of cell replacement therapy in the future.


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Stem Cell Discovery Furthers Research on Cell-Based Therapy and Cancer | ucsf.edu

Stem Cell Discovery Furthers Research on Cell-Based Therapy and Cancer | ucsf.edu | Stem Cell Research | Scoop.it

Stem-cell researchers at UC San Francisco have found a key role for a protein called BMI1 that may help scientists direct the development of tissues to replace damaged organs in the human body.


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Jacob Blumenthal's curator insight, July 26, 2013 3:00 PM

A group of scientists from UCSF, lead by Ophir Klein, MD, PhD, have discovered  a general mechanism whereby BMI1-mediated repression of Hox genes is required for the maintenance of adult stem cells and for prevention of inappropriate differentiation.

http://www.nature.com/ncb/journal/v15/n7/abs/ncb2766.html


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Tiny Lab-Grown Heart Beats On Its Own

Tiny Lab-Grown Heart Beats On Its Own | Stem Cell Research | Scoop.it

A growing number of researchers are looking to build hearts, like other organs, from biological tissue. Such hearts have the added benefit of using the patient’s own tissue, reducing the chance of rejection.


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An end to kosher slaughter? Stem cell meat takes on factory farming - Haaretz

An end to kosher slaughter? Stem cell meat takes on factory farming - Haaretz | Stem Cell Research | Scoop.it
Haaretz
An end to kosher slaughter? Stem cell meat takes on factory farming
Haaretz
Stem cell meat takes on factory farming. Cultured meat would avoid cruelty to animals and save our environment.
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The Quest for an Artificial Liver - MIT Technology Review

The Quest for an Artificial Liver                             - MIT  Technology Review | Stem Cell Research | Scoop.it
MIT Technology Review The Quest for an Artificial Liver MIT Technology Review "Together, these papers offer a path forward to solve two of the long-standing challenges in liver tissue engineering—growing a large supply of liver cells outside the...

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Jacob Blumenthal's curator insight, August 21, 2013 2:52 AM

Researchers from MIT performed large-scale, rapid studies of how 12,500 different chemicals affect liver-cell growth and functions, including drug detoxification, energy metabolism, protein synthesis, and bile production. 

They identified 12 compounds that helped the cells divide, maintain their normal functions, or both.

In addition, they examined the ability of the molecules to promote the differentiation of iPS cells toward a hepatic lineage and induce the maturation of iHep cells toward a more adult-like liver phenotype. 

This research will hopefully enable to develope new therapeutical strategies for chronic liver diseases such as hepatitis C.

http://www.nature.com/nchembio/journal/v9/n8/full/nchembio.1270.html


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To learn about liver development:

http://discovery.lifemapsc.com/in-vivo-development/liver

 

Stem cells differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

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Printing Out a Biological Machine

Printing Out a Biological Machine | Stem Cell Research | Scoop.it
Researchers at the University of Illinois have used a 3-D printer to make small hybrid “biobots” — part gel, part muscle cell — that can move on their own.

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Jacob Blumenthal's curator insight, August 20, 2013 1:57 AM

This article describes the generation of tiny "biobots" by combining contracting muscle cells and gells. These contractile muscle cells can be used in the  future to mobilize engineered devices in our bodies.

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FDA Approves Stem Cell Clinical Trial For Multiple Sclerosis

FDA Approves Stem Cell Clinical Trial For Multiple Sclerosis | Stem Cell Research | Scoop.it
NEW YORK, Aug. 14, 2013 /PRNewswire/ --   The Tisch MS Research Center of New York announced today that it has received Investigational New Drug (IND) approval from the Food and Drug Administration (FDA) to commence a Phase 1 trial using autologous neural stem cells in the treatment of multiple sclerosis (MS).  MS is a chronic human autoimmune disease of the central nervous system that leads to myelin damage and neurodegeneration and affects approximately 2.1 million people worldwide.

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Jacob Blumenthal's curator insight, August 18, 2013 3:41 PM

In the approved clinical trial, mesenchymal stem cell-derived neural progenitor cells (MSC-NPs) will be isolated from the patient's bone marrow, expanded and tested prior to injection. Participants will receive three rounds of injections at three month intervals. Safety and efficacy parameters will be evaluated in all participants through regular follow-up visits.The approval of the trial will allow researchers, for the first time to test this treatment strategy in real human patients. Hopefully, this phase I trial will lead to further trials of other stem cells-based potential therapies.

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Information on Phase II Stem Cell Trial: July 2013

Information on Phase II Stem Cell Trial: July 2013 | Stem Cell Research | Scoop.it

This clinical trial will test the safety of increasing doses of stem cells injected into the spinal cord of patients with ALS.  There will be 15 - 18 patients in the study, separated into 5 dosing groups, A-E, with 3 patients in each group.  The first 4 groups will receive injections into the cervical spinal cord in the neck, into the region that controls the breathing muscles.  The subjects will receive either 5 (group A) or 10 (group B-E) injections on both sides of the spinal cord, for a total of either 10 or 20 injections.  The number of cells will increase with each dosing group from 2 million to 8 million cells injected.  Group E subjects will undergo two surgeries, first injections into the lumbar cord (lower spine) followed several weeks later by injections into the cervical spinal cord. 

Eligible participants must all be able to....................


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Human Stem Cells Revive Mouse's Cell-Stripped Heart [VIDEO]

Human Stem Cells Revive Mouse's Cell-Stripped Heart [VIDEO] | Stem Cell Research | Scoop.it
Pittsburgh scientists successfully got a "decellularized" mouse heart beating again via human stem cells, showing the potential of regenerative medicine.
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