Rheumatology-Rhumatologie
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An update on IgG4-related disease

An update on IgG4-related disease | Rheumatology-Rhumatologie | Scoop.it
Purpose of reviewIgG4-related disease (IgG4-RD) is a recently described fibroinflammatory condition that can affect nearly an.
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RHUMATOLOGIE - RHEUMATOLOGY

Obviously a topic of interest for so many people:

for the patient, it includes aching muscles, tendons and joints..

for MDs and researchers, it covers degenerative diseases as well as arthritis, often associated with various autoimmune diseases (see autoimmunity http://www.scoop.it/t/autoimmunity)

fortunately, new diagnostic tools are available

https://www.scoop.it/t/rheumatology-rhumatologie?q=diagnosis

and new biotherapies 

https://www.scoop.it/t/rheumatology-rhumatologie?q=therapy

allowed to improve the prognosis and the quality of life of patients

Gilbert C FAURE's insight:

January 2016

still few viewers (#650) for this topic, but >1280 posts and 2000 views

much less than other immunology topics, but growing!


October 2016 1500 scoops and almost 3K views

January 2018 1700 scoops and #5K views

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JCI Insight - Identification of enhanced IFN-γ signaling in polyarticular juvenile idiopathic arthritis with mass cytometry

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Highlights from EULAR 2018: Current and Future Perspectives in the Cytokine Signalling Blockade

Highlights from EULAR 2018: Current and Future Perspectives in the Cytokine Signalling Blockade | Rheumatology-Rhumatologie | Scoop.it
Increasing the understanding of Cytokine Signalling science and its implications for clinical management of rheumatoid arthritis patients...
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Methotrexate BAFFles anti-drug antibodies

Methotrexate BAFFles anti-drug antibodies | Rheumatology-Rhumatologie | Scoop.it
Combining TNF inhibition with methotrexate treatment is an effective therapeutic approach for patients with rheumatoid arthritis and reduces the likelihood of the patient developing ‘resistance’ to the TNF inhibitor. But how does methotrexate suppress the production of anti-drug antibodies and how can we tell which patients will develop resistance?
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Frontiers | It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells | Immunology

Frontiers | It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells | Immunology | Rheumatology-Rhumatologie | Scoop.it
Innate-like T cells such as invariant natural killer T (iNKT) cells and mucosal associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction towards MHC-like molecules (CD1 and MR1 respectively), are a unique unconventional immune subset acting at the interface of innate and adaptive immunity. Highly represented at barrier sites and capable of rapidly producing substantial amounts of cytokines, they serve a pivotal role as first line responders towards microbial infections. In contrast, it was demonstrated that innate-like T cells can be skewed towards a predominant pro-inflammatory state and consequently are involved in a number of auto-immune and inflammatory diseases, like inflammatory bowel diseases (IBD) and rheumatic disorders such as spondyloarthritis (SpA) and rheumatoid arthritis (RA). Interestingly, there is link between gut and joint disease as they often co-incide and share certain aspects of the pathogenesis such as established genetic risk factors, a critical role for pro-inflammatory cytokines such as TNF-α, IL-23 and IL-17 and therapeutic susceptibility. In this regard dysregulated IL-23/IL-17 responses appear to be crucial in both debilitating pathologies and innate-like T cells likely act as key player. In this review, we will explore the remarkable features of iNKT cells and MAIT cells, and discuss their contribution to immunity and combined gut-joint disease.
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Leukocyte trafficking between stromal compartments: lessons from rheumatoid arthritis | Nature Reviews Rheumatology

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Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission

Multi-omics monitoring of drug response in rheumatoid arthritis in pursuit of molecular remission | Rheumatology-Rhumatologie | Scoop.it
Little information is available on molecular changes in response to treatment of rheumatoid arthritis (RA). Here the authors report a multi-omics study collecting patients' transcriptome, proteome, and immunophenotype data to help understand the impact of drug treatments on RA molecular phenotypes.

Via Krishan Maggon
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Rescooped by Gilbert C FAURE from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Ability of disease-modifying antirheumatic drugs to prevent or delay rheumatoid arthritis onset: a systematic literature review and meta-analysis

Ability of disease-modifying antirheumatic drugs to prevent or delay rheumatoid arthritis onset: a systematic literature review and meta-analysis | Rheumatology-Rhumatologie | Scoop.it
Background Recent advances in knowledge of the pathogenesis of rheumatoid arthritis (RA) has led to promoting very early intervention.

Objectives To assess the efficacy of therapeutic interventions in preventing or delaying RA onset with a systematic literature review (SLR) and meta-analysis (MA).

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Personalized medicine — a new reality in psoriatic arthritis?

Personalized medicine — a new reality in psoriatic arthritis? | Rheumatology-Rhumatologie | Scoop.it
Some patients with psoriatic arthritis are refractive to one biologic therapy but not to others, and a strategy for selecting the right therapy for each patient is needed. The findings of a new study highlight the potential benefit of stratifying patients by their immunophenotype to select the...

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In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones

In Rheumatoid Arthritis, Synovitis at Different Inflammatory Sites Is Dominated by Shared but Patient-Specific T Cell Clones | Rheumatology-Rhumatologie | Scoop.it
Genetic and immunological evidence clearly points to a role for T cells in the pathogenesis of rheumatoid arthritis (RA). Selective targeting of such disease-associated T cell clones might be highly effective while having few side effects. However, such selective targeting may only be feasible if the same T cell clones dominate the immune response at different sites of inflammation. We leveraged high-throughput technology to quantitatively assess whether different T cell clones dominate the inflammatory infiltrate at various sites of inflammation in this prototypic autoimmune disease. In 13 RA patients, we performed quantitative next-generation sequencing–based human TCRβ repertoire analysis in simultaneously obtained samples from inflamed synovial tissue (ST) from distinct locations within one joint, from multiple joints, and from synovial fluid (SF) and peripheral blood (PB). Identical TCRβ clones dominate inflammatory responses in ST samples taken from different locations within a single joint and when sampled in different joints. Although overall ST–SF overlap was comparable to higher ST–ST values, the overlap in dominant TCRβ clones in ST–SF comparisons was much lower than ST–ST and comparable to the low ST–PB overlap. In individual RA patients, a limited number of TCRβ clones dominate the immune response in the inflamed ST regardless of the location within a joint and which joint undergoes biopsy; in contrast, there is limited overlap of ST with SF or PB TCR repertoires. This limited breadth of the T cell response in ST of the individual RA patient indicates that development of immunotherapies that selectively modulate dominant T cell responses might be feasible.
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Big data boost for osteoarthritis genetics

The largest study to date on the genetics of hip and knee osteoarthritis (OA) has yielded new associations with genes encoding a cytokine, a kinase and a transcriptional repressor, as well as genetic correlations with other diseases. Can these clues help to unravel details of the pathogenesis of OA?
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Rescooped by Gilbert C FAURE from Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Immune response associated with inflammation and joint damage in rheumatoid arthritis | EurekAlert! Science News

Immune response associated with inflammation and joint damage in rheumatoid arthritis | EurekAlert! Science News | Rheumatology-Rhumatologie | Scoop.it
To diagnose rheumatoid arthritis, antibodies to the amino acid citrulline are commonly measured. A new study from Uppsala University shows that a broad mix of different antibodies in the joints is the dominant factor that can be associated with severe inflammation and joint damage.

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Molecular transport in articular cartilage — what have we learned from the past 50 years? | Nature Reviews Rheumatology

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Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction | Rheumatology-Rhumatologie | Scoop.it
Preclinical rheumatoid arthritis (RA) is characterized by the presence of RA-related autoantibodies in the serum in the absence of clinical symptoms. This Review discusses the relationships during this period between mucosal alterations and the initiation of local and systemic anti-citrullinated protein antibody production.
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Frontiers | The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling | Immunology

Frontiers | The Initiation, but Not the Persistence, of Experimental Spondyloarthritis Is Dependent on Interleukin-23 Signaling | Immunology | Rheumatology-Rhumatologie | Scoop.it
IL-17A is a central driver of spondyloarthritis, its production was originally proposed to be IL-23 dependent. Emerging preclinical and clinical evidence suggests, however, that IL-17A and IL-23 have a partially overlapping but distinct biology. We aimed to assess the extent to which IL-17A-driven pathology is IL-23 dependent in experimental spondyloarthritis. Experimental spondyloarthritis was induced in HLA-B27/Huβ2m transgenic rats, followed by prophylactic or therapeutic treatment with an anti-IL23R antibody or vehicle control. Spondylitis and arthritis were scored clinically and hind limb swelling was measured. Draining lymph node cytokine expression levels were analyzed directly ex vivo, and IL-17A protein was measured upon restimulation with PMA/ionomycin. Prophylactic treatment with anti-IL23R completely protected against the development of both spondylitis and arthritis, while vehicle treated controls did develop spondylitis and arthritis. In a therapeutic study, anti-IL23R treatment failed to reduce the incidence or decrease the severity of experimental spondyloarthritis. Mechanistically, expression of downstream effector cytokines, including IL-17A and IL-22, was significantly suppressed in anti-IL23R versus vehicle treated rats in the prophylactic experiments. Accordingly, the production of IL-17A upon restimulation was reduced. In contrast, there was no difference in IL-17A and IL-22 expression after therapeutic anti-IL23R treatment. Targeting the IL-23 axi
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Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis - ScienceDirect

Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis - ScienceDirect | Rheumatology-Rhumatologie | Scoop.it
T-cell resilience is critical to the immune pathogenesis of human autoimmune arthritis. Autophagy is essential for memory T cell generation and associ…
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S100 proteins in rheumatic diseases

S100 proteins in rheumatic diseases | Rheumatology-Rhumatologie | Scoop.it
S100 proteins have many intracellular functions, as well as being extracellular signalling molecules in inflammation. A deeper understanding of this family of proteins could lead the way to diagnostic and prognostic biomarkers and novel therapeutic strategies.
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Advances in stem cell therapy for cartilage regeneration in osteoarthritis: Expert Opinion on Biological Therapy: Vol 0, No ja

Advances in stem cell therapy for cartilage regeneration in osteoarthritis: Expert Opinion on Biological Therapy: Vol 0, No ja | Rheumatology-Rhumatologie | Scoop.it
SCs have proven their potential and safety for OA treatment. Nevertheless, there are still many questions to be resolved before their widespread used in clinical practice, such as the treatment mechanism, the best cell source, the most appropriate processing method, the most effective dose and delivery procedure, and their efficacy. In this sense, long-term follow-up and larger randomized controlled trials utilizing standardized and established outcome scores are mandatory to make objective conclusions.

Keywords: osteoarthritis, cell therapy, mesenchymal stem cells, cartilage regeneration, scaffolds/hydrogels, growth factors

Via Krishan Maggon
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Biologics and stem cell‐based therapies for rotator cuff repair - Bianco - - Annals of the New York Academy of Sciences - Wiley Online Library

Biologics and stem cell‐based therapies for rotator cuff repair - Bianco - - Annals of the New York Academy of Sciences - Wiley Online Library | Rheumatology-Rhumatologie | Scoop.it
The rotator cuff is composed of several distinct muscles and tendons that function in concert to coordinate shoulder motion. Injuries to these tendons frequently result in permanent dysfunction and persistent pain. Despite considerable advances in operation techniques, surgical repair alone still does not fully restore rotator cuff function. This review focuses on recent research in the use of biologics and stem cell‐based therapies to augment repair, highlighting promising avenues for future work and remaining challenges. While a number of animal models are used for rotator cuff studies, the anatomy of the rotator cuff varies dramatically between species. Since the rodent rotator cuff shares the most anatomical features with the human, this review will focus primarily on rodent models to enable consistent interpretation of outcome measures.

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IL-17 in the immunopathogenesis of spondyloarthritis

IL-17 in the immunopathogenesis of spondyloarthritis | Rheumatology-Rhumatologie | Scoop.it
Evidence from genetic, experimental and clinical studies has accumulated to indicate a role for the IL-17 pathway in the pathogenesis of spondyloarthritis. This Review discusses how IL-17A and IL-17F and their cellular sources contribute to the immunopathology of these diseases.
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Rheuminations by Adam Brown, MD on

Rheuminations by Adam Brown, MD on | Rheumatology-Rhumatologie | Scoop.it
Download past episodes or subscribe to future episodes of Rheuminations by Adam Brown, MD for free.
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The role of neutrophil extracellular traps in rheumatic diseases

The role of neutrophil extracellular traps in rheumatic diseases | Rheumatology-Rhumatologie | Scoop.it
A growing body of evidence indicates that neutrophils and neutrophil extracellular traps (NETs) are involved in the progression of rheumatic diseases. This Review focuses on the role of NETs in systemic lupus erythematosus, vasculitis, rheumatoid arthritis and gout.
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Can rheumatoid arthritis ever cease to exist: a review of various therapeutic modalities to maintain drug-free remission?

Can rheumatoid arthritis ever cease to exist: a review of various therapeutic modalities to maintain drug-free remission? | Rheumatology-Rhumatologie | Scoop.it
Therapies for rheumatoid arthritis (RA) were mostly aimed at reducing the pain, stiffness and further progression of joint destruction. However, with the advent of biologic agents that act against specific inflammatory cytokines contributing to RA pathogenesis ...

Via Krishan Maggon
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One year in review 2018: pathogenesis of rheumatoid arthritis. - PubMed - NCBI

One year in review 2018: pathogenesis of rheumatoid arthritis. - PubMed - NCBI | Rheumatology-Rhumatologie | Scoop.it
Clin Exp Rheumatol. 2018 Mar-Apr;36(2):175-184. Epub 2018 Apr 18. Review
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Auto-antibody Detection for Rheumatoid Arthritis Patients

Auto-antibody Detection for Rheumatoid Arthritis Patients | Rheumatology-Rhumatologie | Scoop.it
No case of rheumatoid arthritis (RA), an autoimmune disease, is the same.Now, researchers want RA diagnostic approaches to match its pathological diversit...

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Inflammatory mechanisms in tendinopathy – towards translation

Inflammatory mechanisms in tendinopathy – towards translation | Rheumatology-Rhumatologie | Scoop.it
Review Article
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