Rett syndrome and breathing difficulties
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The Rett Syndrome Research Trust Announces Roadmap to Cure Devastating Neurological Disorder that Afflicts 350,000 Girls and Women - Press Release Rocket

Human clinical trials of gene therapy on the horizon. Trumbull, CT (PRWEB) March 22, 2017 The Rett Syndrome Research Trust (RSRT) announced today a historic plan to cure Rett Syndrome, a devastating neurological disorder that afflicts 350,000 individuals worldwide. Rett Syndrome is caused by alterations in a single gene, MECP2, located on the X chromosome, …
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Serotonin 5-HT1A receptor biased agonist NLX-101 (F15599) elicits distinctive brain activation patterns: a pharmacoMRI study

Serotonin 5-HT1A receptor biased agonist NLX-101 (F15599) elicits distinctive brain activation patterns: a pharmacoMRI study | Rett syndrome and breathing difficulties | Scoop.it
Serotonin 1A (5-HT1A) receptors are involved in several physiological and pathological processes and constitute therefore an important therapeutic target.
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What do breathing problems look like in a Rett Syndrome girl

Read more about what it's like to struggle to breathe at www.magnoliashope.com Share this video: http://on.fb.me/1jLm3YS GoFundMe:

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24 June 2015 - Rett Syndrome Research Trust awards a new research grant to Neurolixis

24 June 2015 - Rett Syndrome Research Trust awards a new research grant to Neurolixis | Rett syndrome and breathing difficulties | Scoop.it

Neurolixis has been awarded a new research grant from the Rett Syndrome Research Trust (RSRT) to advance development of NLX-101, a clinical-phase candidate for treatment of Rett syndrome. NLX-101 has previously been awarded Orphan Drug designation for this indication in both the USA and in the European Union.

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21 April 2015 - Neurolixis CEO to present at World Orphan Drug Congress USA

21 April 2015 - Neurolixis CEO to present at World Orphan Drug Congress USA | Rett syndrome and breathing difficulties | Scoop.it
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Identification of a Serotonin Neuron Subtype That Regulates Breathing Dynamics

Identification of a Serotonin Neuron Subtype That Regulates Breathing Dynamics | Rett syndrome and breathing difficulties | Scoop.it
Adrian Newman-Tancredi's insight:

The life-sustaining respiratory CO2 chemoreflex is regulated by a specialized subtype of serotonergic neuron - the Egr2-Pet1 subtype.

http://www.cell.com/cell-reports/abstract/S2211-1247%2814%2900993-0

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Rett Syndrome: Why Girls?

Rett Syndrome: Why Girls? | Rett syndrome and breathing difficulties | Scoop.it
by Monica Coenraads.
“ Anyone who knows anything about Rett Syndrome knows that the disorder is primarily seen in girls. The disorder is caused by disruption of the MECP2 gene located on the X...
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Table summarizing strategies to treat Rett Syndrome - Rett Syndrome Research Trust

Ongoing research efforts to treat and cure Rett Syndrome.

Via Tommy Lawson
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Rousing silenced X chromosome may treat Rett syndrome - SFARI News

Rousing silenced X chromosome may treat Rett syndrome - SFARI News | Rett syndrome and breathing difficulties | Scoop.it

Drugs that activate the silent copy of the X chromosome in women may be able to undo the damage from mutations in genes located there. The study offers hope for treating Rett syndrome and other disorders linked to the X chromosome.

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The Ice Bucket Challenge for Rett Syndrome

In this video I decided to start something that will hopefully raise awareness for Rett Syndrome. My baby cousin has it which prompted me to do this after I saw how the ALS Ice Bucket Challenge...
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Rett syndrome research – What's happening

Rett syndrome research – What's happening | Rett syndrome and breathing difficulties | Scoop.it
Dr Julian Paton's, University of Bristol, a preclinical breathing study into NLX-101 from Neurolixis, which is being part funded by Cure Rett through Rettsyndrome.org. Dr Paton's study tackles an often overlooked area of Rett ...
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Rett Syndrome and Breathing » Grace for Rett

Rett Syndrome and Breathing » Grace for Rett | Rett syndrome and breathing difficulties | Scoop.it
“Just breathe, Baby!” I must say it to Grace every day. And when I do, I think 'why am I saying this? If she could, she would!' Breathing problems are one of the mysteries of Rett Syndrome.
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Effective drugs for Parkinson's reduce symptoms of Rett syndrome in mice

A combination of effective drugs for Parkinson's disease in mice that are used as a model of human Rett syndrome reduces some of the symptoms associated with this disease.
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MeCP2 mutations: progress towards understanding and treating Rett syndrome

MeCP2 mutations: progress towards understanding and treating Rett syndrome | Rett syndrome and breathing difficulties | Scoop.it
Rett syndrome is a profound neurological disorder caused by mutations in the MECP2 gene, but preclinical research has indicated that it is potentially treatable. Progress towards this goal depends on the development of increasingly relevant model systems and on our improving knowledge of MeCP2 function in the brain.
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Rett Syndrome Research Trust Awards $9 Million to Accelerate Translation of Lab Discoveries to the Clinic

Today the Rett Syndrome Research Trust (RSRT) announced research awards totaling nearly $9 million in 2015. This is the most research ever awarded in a given year by any Rett Syndrome organization.
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In mice, experimental drug treatment for Rett syndrome suggests the disorder is reversible

In mice, experimental drug treatment for Rett syndrome suggests the disorder is reversible | Rett syndrome and breathing difficulties | Scoop.it
A team at Cold Spring Harbor Laboratory (CSHL) has developed a strikingly new approach for treating Rett syndrome, a devastating autism spectrum disorder (ASD) that affects 1 in 10,000 people in the US, mostly girls.
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New studies contradict earlier findings on Rett syndrome

New studies contradict earlier findings on Rett syndrome | Rett syndrome and breathing difficulties | Scoop.it

Bone marrow transplant does not rescue mouse models of Rett syndrome, a severe neurological disease, a new study shows. The findings contradict seemingly promising presults previously published by another laboratory.

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Rett Syndrome Research Trust Awards $5.8 Million to Advance the Development of Treatments and Cures for Rett Syndrome and MECP2 Disorders

Rett Syndrome Research Trust Awards $5.8 Million to Advance the Development of Treatments and Cures for Rett Syndrome and MECP2 Disorders | Rett syndrome and breathing difficulties | Scoop.it
Trumbull, CT (PRWEB) February 03, 2015 -- Today the Rett Syndrome Research Trust (RSRT) announced research investments of $5.8 million awarded in 2014. RSRT’s sole and urgent goal is to abolish Rett Syndrome and related disorders.
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Transgenic monkey missing Rett syndrome gene prompts primate research debate at SfN

Transgenic monkey missing Rett syndrome gene prompts primate research debate at SfN | Rett syndrome and breathing difficulties | Scoop.it
A marmoset monkey model of Rett syndrome is revealed in SfN. Monkey missing Rett gene prompts primate research debate http://t.co/7KR0VWPOqa
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Rett Syndrome Foundation - research porfolio overview with Steve Kaminsky, CSO

Steve Kaminsky, International Rett Syndrome Foundation, Chief Science Officer. As CSO, Dr. Kaminsky oversees Rettsyndrome.org’s research portfolio.


Via Tommy Lawson
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Serotonin neurones have anti‐convulsant effects and reduce seizure‐induced mortality

Serotonin neurones have anti‐convulsant effects and reduce seizure‐induced mortality | Rett syndrome and breathing difficulties | Scoop.it

Serotonin: new evidence serotonin controls seizure threshold and reduces death from respiratory arrest. http://t.co/WIVrBpLwhx mouse study

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Rett Syndrome MeCP2 gene dysfunction redefined

Rett Syndrome MeCP2 gene dysfunction redefined | Rett syndrome and breathing difficulties | Scoop.it

Researchers have discovered that the protein product of the gene MECP2, which is mutated in about 95% of Rett syndrome is a global activator of neuronal gene expression. Mutations in the protein can cause decreased gene transcription, reduced protein synthesis, and severe defects in the AKT/mTOR signaling pathway.

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Rettsyndrome.Org awards $1.5M to advance translational research programs

Rettsyndrome.Org awards $1.5M to advance translational research programs | Rett syndrome and breathing difficulties | Scoop.it

Rettsyndrome.Org awards $1.5M to advance translational research, programs

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Brainstem mechanisms responsible for autonomic dysfunction in Rett syndrome: therapeutic perspectives for 5-HT1A agonists

Rett syndrome is a neurological disorder caused by loss of function of methyl-CpG-binding protein 2 (MeCP2). Reduced function of this ubiquitous transcriptional regulator has a devastating effect o...
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Respiratory Disturbances in Rett Syndrome

Abstract. Rett syndrome is characterized by loss of motor and social functions, development of stereotypic hand movements, seizures, and breathing disturbances. This study evaluates the presence of overnight respiratory disturbances.
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