Quorum sensing
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Topics related to bacteria and eukaryotes communitcation
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How scientists are fighting infection-causing biofilms

Smooth surfaces often provide nooks and crannies for bacteria to hold onto and create a colony. New research with nanoparticles is revealing the secrets of surfaces that prevent bacterial attachment.
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[1810.08887] Modeling Oral Multispecies Biofilm Recovery After Antibacterial Treatment

Download: PDF only (license) Current browse context: q-bio.QM < prev  |  next > new | recent | 1810 Change to browse by: math math.CA q-bio q-bio.PE References & Citations NASA ADS Quantitative Biology > Quantitative Methods Modeling Oral Multispecies Biofilm Recovery After Antibacterial Treatment Xiaobo Jing, Xiangya Huang, Markus Haapasalo, Ya Shen, Qi Wang (Submitted on 21 Oct 2018) Recovery of multispecies oral biofilms is investigated following treatment by chlorhexidine gluconate (CHX), iodine-potassium iodide (IPI) and Sodium hypochlorite (NaOCl) both experimentally and theoretically. Experimentally, biofilms taken from two donors were exposed to the three antibacterial solutions (irrigants) for 10 minutes, respectively. We observe that (a) live bacterial cell ratios decline for a week after the exposure and the trend reverses beyond a week; after fifteen weeks, live bacterial cell ratios in biofilms fully return to their pretreatment levels; (b) NaOCl is shown as the strongest antibacterial agent for the oral biofilms; (c) multispecies oral biofilms from different donors showed no difference in their susceptibility to all the bacterial solutions. Guided by the experiment, a mathematical model for biofilm dynamics is developed, accounting for multiple bacterial phenotypes, quorum sensing, and growth factor proteins, to describe the nonlinear time evolutionary behavior of the biofilms. The model captures time evolutionary dynamics of biofilms before and after antibacterial treatment very well. It reveals the crucial role played by quorum sensing molecules and growth factors in biofilm recovery and verifies that the source of biofilms has a minimal to their recovery. The model is also applied to describe the state of biofilms of various ages treated by CHX, IPI and NaOCl, taken from different donors. Good agreement with experimental data predicted by the model is obtained as well, confirming its applicability to modeling biofilm dynamics in general. Subjects: Quantitative Methods (q-bio.QM); Classical Analysis and ODEs (math.CA); Populations and Evolution (q-bio.PE) Cite as: arXiv:1810.08887 [q-bio.QM]   (or arXiv:1810.08887v1 [q-bio.QM] for this version) Submission history From: Xiaobo Jing [view email] [v1] Sun, 21 Oct 2018 03:19:29 UTC (1,341 KB) Which authors of this paper are endorsers? | Disable MathJax (What is MathJax?)
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Disrupting communication in infectious bacteria

Disrupting communication in infectious bacteria | Quorum sensing | Scoop.it
Chemists report that they have inhibited the biosynthesis of a bacterial signal and, as a result, blocked the infectious properties of Pseudomonas aeruginosa, the most common germ found in health care facilities.
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Evaluation of Biofilm Formation and Frequency of Multidrug-resistant and Extended Drug-resistant Strain in Pseudomonas aeruginosa Isolated from Bur... - PubMed - NCBI

Evaluation of Biofilm Formation and Frequency of Multidrug-resistant and Extended Drug-resistant Strain in Pseudomonas aeruginosa Isolated from Bur... - PubMed - NCBI | Quorum sensing | Scoop.it

Adv Biomed Res. 2018 Apr 24;7:61. doi: 10.4103/abr.abr_37_17. eCollection 2018.

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Biofilm-Inspired Fabrication of Complex Nanostructures [Video]

Biofilm-Inspired Fabrication of Complex Nanostructures [Video] | Quorum sensing | Scoop.it

Inspired by biofilm formation, a strategy for templated self-assembly of nano-objects is developed for the fabrication of complex nanostructures.

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Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance

Staphylococcus aureus interaction with Pseudomonas aeruginosa biofilm enhances tobramycin resistance | Quorum sensing | Scoop.it
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Bacterial biofilm-based catheter-associated urinary tract infections: Causative pathogens and antibiotic resistance

Bacterial biofilm-based catheter-associated urinary tract infections: Causative pathogens and antibiotic resistance | Quorum sensing | Scoop.it
Internal Medicine Article: Bacterial biofilm-based catheter-associated urinary tract infections: Causative pathogens and antibiotic resistance
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Gonorrhea: Possible new treatment uses peptide that interferes with respiratory enzyme - Outbreak News Today

Gonorrhea: Possible new treatment uses peptide that interferes with respiratory enzyme - Outbreak News Today | Quorum sensing | Scoop.it
Researchers have identified a possible new treatment for gonorrhea, using a peptide that thwarts the infection-causing bacterium by interfering with an enzyme the microbe needs to respirate. The findings are especially important since Neisseria gonorrhoeae is considered a “superbug” due to its resistance to all classes of antibiotics available for treating infections. Gonorrhea, a sexually …
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Researchers show laser-induced graphene kills bacteria, resists biofouling

Researchers show laser-induced graphene kills bacteria, resists biofouling | Quorum sensing | Scoop.it
Scientists at Rice University and Ben-Gurion University of the Negev (BGU) have discovered that laser-induced graphene (LIG) is a highly effective anti-fouling material and, when electrified, bacteria zapper.
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A Protein Found in Ticks Can Help Kill MRSA Infections

A Protein Found in Ticks Can Help Kill MRSA Infections | Quorum sensing | Scoop.it
As researchers from Yale searched our environment for compounds to aid in the battle against drug-resistant bacteria, they got an unlikely assist from ticks. Ticks are best known for being the nasty bloodsuckers that spread dangerous infections like Lyme disease, the Powassan virus, and babesiosis. For the most part, their range across the US is spreading, and so are the infections they carry. In surprising news, a study published in the journal Antimicrobial Agents and Chemotherapy describes how scientists took a protein from the Ixodes scapularis tick and used it to battle one of our most
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Nanotechnology Now - Press Release: Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling

Nanotechnology Now - Press Release: Zap! Graphene is bad news for bacteria: Rice, Ben-Gurion universities show laser-induced graphene kills bacteria, resists biofouling | Quorum sensing | Scoop.it
Scientists at Rice University and Ben-Gurion University of the Negev (BGU) have discovered that laser-induced graphene (LIG) is a highly effective anti-fouling material and, when electrified, bacteria zapper.<BR><BR><iframe width="560" height="315" src="https://www.youtube.com/embed/_dKZYCUE04A"; frameborder="0" allowfullscreen></iframe>
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In this real-time video, Pseudomonas aeruginosa bacteria tagged with green fluorescent protein, which appear as bright dots, are drawn to an anode of laser-induced graphene, where they die. The anode at the top, which is separated from a cathode by a 100-micron channel, carries a small voltage that boosts its antibacterial properties. (Credit: Arnusch Lab/Ben-Gurion University of the Negev)
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Searching for new strategies against biofilm infections: Colistin-AMP combinations against Pseudomonas aeruginosa and Staphylococcus aureus single- and double-species biofilms

Searching for new strategies against biofilm infections: Colistin-AMP combinations against Pseudomonas aeruginosa and Staphylococcus aureus single- and double-species biofilms | Quorum sensing | Scoop.it
Antimicrobial research is being pressured to look for more effective therapeutics for the ever-growing antibiotic-resistant infections, and antimicrobial peptides (AMP) and antimicrobial combinations are promising solutions. This work evaluates colistin-AMP combinations against two major pathogens, Pseudomonas aeruginosa and Staphylococcus aureus, encompassing non- and resistant strains. Colistin (CST) combined with the AMP temporin A (TEMP-A), citropin 1.1 (CIT-1.1) and tachyplesin I linear analogue (TP-I-L) was tested against planktonic, single- and double-species biofilm cultures. Overall synergy for planktonic P. aeruginosa and synergy/additiveness for planktonic S. aureus were observed. Biofilm growth prevention was achieved with synergy and additiveness. Pre-established 24 h-old biofilms were harder to eradicate, especially for S. aureus and double-species biofilms; still, some synergy and addictiveness was observed for higher concentrations, including for the biofilms of resistant strains. Different treatment times and growth media did not greatly influence AMP activity. CST revealed low toxicity compared with the other AMP but its combinations were toxic for high concentrations. Overall, combinations reduced effective AMP concentrations, mainly in prevention scenarios. Improvement of effectiveness and toxicity of therapeutic strategies will be further investigated.
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Better than nature: artificial biofilm increases energy production in microbial fuel cells

Better than nature: artificial biofilm increases energy production in microbial fuel cells | Quorum sensing | Scoop.it
Microbial fuel cells exploit the metabolism of bacteria in order to generate electricity. A new type of biofilm developed in Bayreuth could soon make this relatively young technology considerably more effective, more stable
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Antibiotic Resistant Bacteria Move Over – Bacillus Subtilis to the Rescue! –

Antibiotic Resistant Bacteria Move Over – Bacillus Subtilis to the Rescue! – | Quorum sensing | Scoop.it
Antibiotic resistant bacteria is on the rise and that puts lives in danger. Antibiotic resistant bacteria move over – Bacillus subtilis to the rescue!
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Rapid diagnostic assay for detection of cellulose in urine as biomarker for biofilm-related urinary tract infections

Rapid diagnostic assay for detection of cellulose in urine as biomarker for biofilm-related urinary tract infections | Quorum sensing | Scoop.it
A rapid test for the presence of bacterial cellulose in urine allows urinary tract infections due to bacteria in the biofilm state to be distinguished from less problematic ‘planktonic’ infections caused by free-living bacteria.
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Microorganisms | Free Full-Text | Role of SCFAs for Fimbrillin-Dependent Biofilm Formation of Actinomyces oris

Microorganisms | Free Full-Text | Role of SCFAs for Fimbrillin-Dependent Biofilm Formation of Actinomyces oris | Quorum sensing | Scoop.it
Actinomyces oris expresses type 1 and 2 fimbriae on the cell surface. Type 2 fimbriae mediate co-aggregation and biofilm formation and are composed of the shaft fimbrillin FimA and the tip fimbrillin FimB.
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Biofilm-Inspired Fabrication of Complex Nanostructures [Video]

Biofilm-Inspired Fabrication of Complex Nanostructures [Video] | Quorum sensing | Scoop.it

Inspired by biofilm formation, a strategy for templated self-assembly of nano-objects is developed for the fabrication of complex nanostructures.

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Making intricate images with bacterial communities

Making intricate images with bacterial communities | Quorum sensing | Scoop.it

Working with light and genetically engineered bacteria, researchers are able to shape the growth of bacterial communities. From polka dots to stripes to circuits, they can render intricate designs overnight.

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Microscopy visualisation confirms multi-species biofilms are ubiquitous in diabetic foot ulcers

International Wound Journal
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Bacteria harness the lotus effect to protect themselves: Biofilms: Researchers find the causes of water-repelling properties

Bacteria harness the lotus effect to protect themselves: Biofilms: Researchers find the causes of water-repelling properties | Quorum sensing | Scoop.it
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is often very difficult, in part because they are extremely water-repellent. Scientists have now been able to show how such biofilms adapt their surface texture to repel water -- similar to leaves.
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Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli

Biofilm microenvironment induces a widespread adaptive amino-acid fermentation pathway conferring strong fitness advantage in Escherichia coli | Quorum sensing | Scoop.it
Author summary Whereas Escherichia coli does not naturally produce the 1-propanol unless subjected to extensive genetic modifications, we show that this important industrial commodity is produced in hypoxic conditions inside biofilms. 1-propanol production corresponds to a native threonine fermentation pathway previously undocumented in E. coli and other Enterobacteriaceae. This widespread adaptive response contributes to maintain cellular redox balance and bacterial fitness in biofilms and other amino acid-rich hypoxic environments. This study therefore shows that mining complex lifestyles such as biofilm microenvironments provides new insight into the extent of bacterial metabolic potential and adaptive bacterial physiological responses.
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Biofilm discovery suggests new way to prevent dangerous infections | Knowridge Science Report

Biofilm discovery suggests new way to prevent dangerous infections | Knowridge Science Report | Quorum sensing | Scoop.it
Microbial biofilms–dense, sticky mats of bacteria that are hard to treat and can lead to dangerous infections–often form in medical equipment, such as flexible plastic tubing used in catheters or in tubes used to help patients breathe. By some estimates, more than 1 million people contract infections from medical devices in U.S. hospitals each year, …
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Experimental, quantum chemical and molecular dynamic simulations studies on the corrosion inhibition of mild steel by some carbazole derivatives

Experimental, quantum chemical and molecular dynamic simulations studies on the corrosion inhibition of mild steel by some carbazole derivatives | Quorum sensing | Scoop.it
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On Shape

On Shape | Quorum sensing | Scoop.it
by Manuel Sánchez | If there is something that draws attention to the study of eukaryotes it is the enormous diversity of their morphology, from the largest sequoias to the smallest radiolaria. Prokaryotes, on the other hand, seem rather simple and boring. If you open page 109 of the 7th edition of Murray, Rosenthal, and Phaller's "Medical Microbiology" you will find...
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A promising strategy to increase activity in antimicrobial peptides

A promising strategy to increase activity in antimicrobial peptides | Quorum sensing | Scoop.it
In an article published recently in Plos One, researchers from INRS-Institut Armand-Frappier Research Centre reported a strategy that could lead to the discovery of new cationic antimicrobial peptides (CAMPs) with greatl
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