Proteomics and other sciency stuff
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A Matter of Time: Faster Percolator Analysis via Efficient SVM Learning for Large-Scale Proteomics - Journal of Proteome Research (ACS Publications)

A Matter of Time: Faster Percolator Analysis via Efficient SVM Learning for Large-Scale Proteomics - Journal of Proteome Research (ACS Publications) | Proteomics and other sciency stuff | Scoop.it
A Matter of Time: Faster Percolator Analysis via Efficient SVM Learning for Large-Scale Proteomics
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Selection of collision energies in proteomics mass spectrometry experiments for best peptide identification: study of Mascot score energy dependence reveals double optimum - Journal of Proteome Res...

Selection of collision energies in proteomics mass spectrometry experiments for best peptide identification: study of Mascot score energy dependence reveals double optimum - Journal of Proteome Res... | Proteomics and other sciency stuff | Scoop.it
Selection of collision energies in proteomics mass spectrometry experiments for best peptide identification: study of Mascot score energy dependence reveals double optimum
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Systematic evaluation of immobilized trypsin based fast protein digestion for deep and high‐throughput bottom‐up proteomics - Shen - - PROTEOMICS - Wiley Online Library

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Routinely quantifying single cell proteomes: A new age in quantitative biology and medicine [PeerJ Preprints]

Many pressing medical challenges -- such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers -- have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to transcend these limitations by developing powerful methods to routinely quantify thousands of proteins and proteoforms across many thousands of single cells. We outline specific technological developments and ideas that can increase the sensitivity and throughput of single cell MS by orders of magnitude and usher in this new age. These advances will transform medicine and ultimately contribute to understanding biological systems on an entirely new level.
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Deve lopment an d va li dation of a rapi d, se lective, an d sensitive LC–MS/MS metho d for simu ltaneous determination of d- an d l-amino aci ds in human serum: app lication to the stu dy of hepat...

Deve lopment an d va li dation of a rapi d, se lective, an d sensitive LC–MS/MS metho d for simu ltaneous determination of d- an d l-amino aci ds in human serum: app lication to the stu dy of hepat... | Proteomics and other sciency stuff | Scoop.it
A validated liquid chromatography–tandem mass spectrometry method was developed for the simultaneous determination of d- and l-amino acids in human serum. Under the optimum conditions, except fo
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An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations

An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations | Proteomics and other sciency stuff | Scoop.it
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Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow

Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow | Proteomics and other sciency stuff | Scoop.it
Proteogenomics enable the discovery of novel peptides (from unannotated genomic protein-coding loci) and single amino acid variant peptides (derived from single-nucleotide polymorphisms and mutations). Increasing the reliability of these identification
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News in Proteomics Research: In depth analysis of the effect of phosphorylation and pH(!?!?) on ubiquitin!

News in Proteomics Research: In depth analysis of the effect of phosphorylation and pH(!?!?) on ubiquitin! | Proteomics and other sciency stuff | Scoop.it
You know what I was just thinking? The ubiquitin process in mammalian cells just wasn't anywhere near complex enough.... ...yo
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Discrimination of Isomers of Released N- and O-Glycans Using Diagnostic Product Ions in Negative Ion PGC-LC-ESI-MS/MS

Discrimination of Isomers of Released N- and O-Glycans Using Diagnostic Product Ions in Negative Ion PGC-LC-ESI-MS/MS | Proteomics and other sciency stuff | Scoop.it
Profiling cellular protein glycosylation is challenging due to the presence of highly similar glycan structures that play diverse roles in cellular physiology. As the anomericity and th
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Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag)

Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag) | Proteomics and other sciency stuff | Scoop.it
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Combining high resolution and exact calibration to boost statistical power: A well-calibrated score function for high-resolution MS2 data

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Functional and Early Folding Residues are separated in proteins to increase evolvability and robustness

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics

Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics | Proteomics and other sciency stuff | Scoop.it
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Multi-Dimensional Scaling based grouping of known complexes and intelligent protein complex detection - ScienceDirect

Multi-Dimensional Scaling based grouping of known complexes and intelligent protein complex detection - ScienceDirect | Proteomics and other sciency stuff | Scoop.it
Protein–Protein Interactions (PPI) play a vital role in cellular processes and are formed because of thousands of interactions among proteins. Advance…
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News in Proteomics Research: A pull-down top-down KRAS isoform assay!!

News in Proteomics Research: A pull-down top-down KRAS isoform assay!! | Proteomics and other sciency stuff | Scoop.it
KRAS is a little protein that is a big deal. As one of the most commonly mutated genes in cancer -- and one of the very worst -- load
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Reference Peptide Database for Proteome Quantification Based on Experimental Mass Spectrum Response Curves | Bioinformatics | Oxford Academic

Reference Peptide Database for Proteome Quantification Based on Experimental Mass Spectrum Response Curves | Bioinformatics | Oxford Academic | Proteomics and other sciency stuff | Scoop.it
AbstractMotivation. Mass spectrometry (MS) based quantification of proteins/peptides has become a powerful tool in biological research with high sensitivity an
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Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis | Proteomics and other sciency stuff | Scoop.it
Tracking both protein synthesis and degradation across thousands of proteins yields
insights into functional regulation by protein degradation.
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Semi-supervised quality control method for proteome analyses based on tandem mass spectrometry - ScienceDirect

Semi-supervised quality control method for proteome analyses based on tandem mass spectrometry - ScienceDirect | Proteomics and other sciency stuff | Scoop.it
With the increasing volume of bottom-up proteome analyses using liquid chromatography/mass spectrometry (LC–MS), a rapid and easy for interpretation a…
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Soft Picosecond Infrared Laser Extraction of Highly Charged Proteins and Peptides from Bulk Liquid Water for Mass Spectrometry - Analytical Chemistry (ACS Publications)

Soft Picosecond Infrared Laser Extraction of Highly Charged Proteins and Peptides from Bulk Liquid Water for Mass Spectrometry - Analytical Chemistry (ACS Publications) | Proteomics and other sciency stuff | Scoop.it
Soft Picosecond Infrared Laser Extraction of Highly Charged Proteins and Peptides from Bulk Liquid Water for Mass Spectrometry
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Recent mass spectrometry-based techniques and considerations for disulfide bond characterization in proteins

Recent mass spectrometry-based techniques and considerations for disulfide bond characterization in proteins | Proteomics and other sciency stuff | Scoop.it
Disulfide bonds are important structural moieties of proteins: they ensure proper folding, provide stability, and ensure proper function. With the increasing use of proteins fo
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Orthogonal fingerprinting for accurate and fast single-molecule mechanical profiling of proteins

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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News in Proteomics Research: Proteomics of gushing wine!

News in Proteomics Research: Proteomics of gushing wine! | Proteomics and other sciency stuff | Scoop.it
There are times when carbonated wine like Champagne is supposed to look like the picture above.  Example: However, if you haven'
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Enhanced Global Post-translational Modification Discovery with MetaMorpheus - Journal of Proteome Research (ACS Publications)

Enhanced Global Post-translational Modification Discovery with MetaMorpheus - Journal of Proteome Research (ACS Publications) | Proteomics and other sciency stuff | Scoop.it
Enhanced Global Post-translational Modification Discovery with MetaMorpheus
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News in Proteomics Research: PALEOPROTEOMICS Technology Review!

News in Proteomics Research: PALEOPROTEOMICS Technology Review! | Proteomics and other sciency stuff | Scoop.it
On a scale from 1 to "THERE IS A MOTHER FLIPPIN' T-REX ON THE COVER OF JPR AND YOU DON'T KNOW WHY FOR MORE THAN ONE DAY", how busy hav
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