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Home for sale: Vacaville property includes palatial home … and former anti ... - Modesto Bee

Home for sale: Vacaville property includes palatial home … and former anti ...
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Jack's Arcade

This was a dumb little video I made while my flight was delayed haha Please like it and thumbs up! - https://twitter.com/JackDail https://vine.co/u/937564661296017408 http://instagram.com/jackdail...
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US threatened #Yahoo with $250,000 daily fine over #NSA data refusal #FF #Snowden #Wikileaks

US threatened #Yahoo with $250,000 daily fine over #NSA data refusal #FF #Snowden #Wikileaks | Others | Scoop.it
Company releases 1,500 documents from failed suit against NSA over user data requests and cooperation with Prism compliance The US government threatened to fine Yahoo $250,000 a day if it refused to hand over user data to the National Security...
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#Nobel prize winner for #War #Obama declares war on #Syria #USimperialism

#Nobel prize winner for #War #Obama declares war on #Syria #USimperialism | Others | Scoop.it
Invoking the same ominous language as his predecessor, Barack Obama used a prime time presidential address on Wednesday to announce the beginning of a war on Syria.
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Rescooped by Adam Jacob from PARP Inhibitors Cancer Review
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Merck Serono pulls out of expensive Phase III lung Cancer Vaccine Gamble: Tecemotide (Stimuvax, Oncothyreon)


Via Krishan Maggon
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Krishan Maggon 's curator insight, September 12, 2014 5:45 PM

Poor results in Phase II trials NSCLC Japan indicate that the vaccine has little chance of success to compete vs PDI/PDL1 inhibitors like pembrolizumab and nivolumab. 

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#Kentucky man paints #KKK wants you to burn' on neighbor's fence #racism

#Kentucky man paints #KKK wants you to burn' on neighbor's fence #racism | Others | Scoop.it
New York Daily News
Kentucky man paints 'KKK wants you to burn' on neighbor's fence, pours ...
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Rescooped by Adam Jacob from Industrial Heritage
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UK: Discovering Cheshire’s Industrial Archaeology, Part 2

UK: Discovering Cheshire’s Industrial Archaeology, Part 2 | Others | Scoop.it

“As part of the Association for Industrial Archaeology’s annual conference in Chester, from the 5th to the 10th September 2014, there will be a one day seminar on the archaeology of the textile fini...”


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Attorney General Debate Segment 1 - WCVB Boston

Attorney General Debate Segment 1 - WCVB Boston | Others | Scoop.it
Attorney General Debate Segment 1
WCVB Boston
GOOD MORNING, EVERYONE. A SPECIAL "ON THE RECORD " THIS MORNING. THE CLOSEST RACE IN MASSACHUSETTS. TWO DEMOCRATS VYING TO BE THE STATE'S TOP ATTORNEY. THANK YOU FOR JOINING US.

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Rescooped by Adam Jacob from Heart and Vascular Health
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Accreditation for Cardiovascular Excellence; Lawrence General Hospital - first in New England

Accreditation for Cardiovascular Excellence; Lawrence General Hospital - first in New England | Others | Scoop.it

Lawrence General Hospital cardiac catheterization laboratory today achieved Accreditation for Cardiovascular Excellence for catheterization and PCI (angioplasty and stenting).  The first in New England.

• ACE accreditation is a professional review of an organization’s structure, internal processes, patient safety practices, and clinical outcomes to determine if it meets the standards established by experts in cardiac and endovascular care.
• ACE is sponsored by The Society for Cardiovascular Angiography and Interventions and American College of Cardiology, the two leading professional cardiovascular organizations, jointly representing over 40,000 practitioners.
• The extensive consultative and educational Accreditation recognizes committment to providing high quality care for patients. With ACE certification patients and providers in the community served can be certian that  the catheterizatuion laboratory is meeting or exceeding the standards set by experts in cardiac and endovascular care.

Lawrence Genral is committed to achieving the highest standards.

ACE accreditation/CQI also

provides a standard of care for patients comparing one facility to anothercertifies to insurers that beneficiaries are getting the best possible care provides independent, unbiased, outcome-based evidence to patients & families that they are receiving the highest quality carevalidates LGH's position, voice, and influence in government policy-making circlesreduces costs by supporting a more effective and efficient operation based on uniform standardsminimizes complications, which in turn benefits payors, patients, and society by reducing costs.


Via Seth Bilazarian, MD
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Seth Bilazarian, MD's curator insight, March 28, 2013 12:48 PM

Congratulations to the administration, physicians, nurses, techs and staff at Lawrence General Hospital for achieving this first in the region accreditation for the cardiac catheterization laboratory. The larger impact is that this recognizes the excellent quality of care patients recieve for treatment of cardiac conditions and coroanary artery disease.

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Authorized Free Applebyte coins Contest&Givea to win 10 000+ ABY + Also CEX GHS

Authorized Free Applebyte coins Contest&Givea to win 10 000+ ABY + Also CEX GHS

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For Oil and Gas Companies, Rigging Seems to Involve Wages, Too - Truth-Out

For Oil and Gas Companies, Rigging Seems to Involve Wages, Too - Truth-Out | Others | Scoop.it
For Oil and Gas Companies, Rigging Seems to Involve Wages, Too Truth-Out For instance, on one gas rig alone, the operator might hire one company to construct the well pad, another to drill the well, a third company to provide hydraulic fracking...
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Oncogenic KRAS signalling in pancreatic cancer

Oncogenic KRAS signalling in pancreatic cancer | Others | Scoop.it

Pancreatic ductal adenocarcinoma (PDAC) is almost universally fatal. The annual number of deaths equals the number of newly diagnosed cases, despite maximal treatment. The overall 5-year survival rate of <5% has remained stubbornly unchanged over the last 30 years, despite tremendous efforts in preclinical and clinical science. There is unquestionably an urgent need to further improve our understanding of pancreatic cancer biology, treatment response and relapse, and to identify novel therapeutic targets. Rigorous research in the field has uncovered genetic aberrations that occur during PDAC development and progression. In most cases, PDAC is initiated by oncogenic mutant KRAS, which has been shown to drive pancreatic neoplasia. However, all attempts to target KRAS directly have failed in the clinic and KRAS is widely assumed to be undruggable. This has led to intense efforts to identify druggable critical downstream targets and nodes orchestrated by mutationally activated KRAS. This includes context-specific KRAS effector pathways, synthetic lethal interaction partners and KRAS-driven metabolic changes. Here, we review recent advances in oncogenic KRAS signalling and discuss how these might benefit PDAC treatment in the future.


Via Krishan Maggon
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Krishan Maggon 's curator insight, September 12, 2014 7:13 AM

open access

 

Minireview
British Journal of Cancer (2014) 111, 817–822. doi:10.1038/bjc.2014.215 www.bjcancer.com

Published online 22 April 2014

Oncogenic KRAS signalling in pancreatic cancer

S Eser1,2, A Schnieke3, G Schneider1 and D Saur1,2

1Department of Internal Medicine II, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, 81675 München, Germany2German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany3Livestock Biotechnology, Technische Universität München, Liesel-Beckmann Str. 1., 85354 Freising, Germany

Correspondence: Professor D Saur, E-mail: Dieter.Saur@lrz.tum.de

Received 28 November 2013; Revised 19 March 2014; Accepted 26 March 2014
Advance online publication 22 April 2014

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Strong Solar Storm Set to Arrive Won't Fry Electronics | Patrick Thibodeau | CIO.com

Strong Solar Storm Set to Arrive Won't Fry Electronics | Patrick Thibodeau | CIO.com | Others | Scoop.it

Back-to-back solar flares, including one that received the highest classification of "X-Class," are striking the earth. U.S. scientists say electronics shouldn't be hurt, but there could be some GPS issues.

 

The larger of the two coronal mass ejections (CME) will hit sometime between late Friday morning and mid-day. The first CME arrived Thursday night.

 

These storms may cause radio communications problems and GPS signal degradation as well as lead to some voltage irregularities in the power grids in the northern latitudes of the U.S.

 

But the problems "are expected to be manageable and not cause any major disruptions to power transmission," said Thomas Berger, director of the U.S. Space Weather Prediction Center.

 

Electric grid operators have been notified, as well as the Federal Emergency Management Agency "just in case," said Berger, at a press briefing Thursday.

 

The caution displayed here is due to the rarity of two geomagnetic storms arriving so close to one another. On the geomagnetic storm scale of 1-5, the CMEs are expected to hit at either a G2, or moderate force, to G3, a strong geomagnetic storm.

 

Scientists aren't sure what may happen if these storms interact in a way that amplifies their strength. Berger said they cannot rule out a storm perhaps as high as a G4, or severe, particularly in regions where the interactions with the earth's magnetic field are strongest.

 

Click headline to read more--


Via Chuck Sherwood, Senior Associate, TeleDimensions, Inc
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Southwest Hangs Up Its Low-Cost Jersey

Southwest Hangs Up Its Low-Cost Jersey | Others | Scoop.it

As the onetime upstart has grown larger, so have expenses...the true low-cost airline leaders are not Southwest but the ultrabudget Spirit Airlines (SAVE) and Allegiant Travel (ALGT), carriers that squeeze more seats onto their planes by not letting seats recline.


Via Karl Wabst
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Karl Wabst's curator insight, September 12, 2014 4:15 PM

Southwest is no longer the low-fare carrier. The competitive market changed around them.

 

The question now is who are they? What will be their new strategy to differentiate themselves from the other major carriers?

 

Look for more changes than just the paint job.

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LISTEN: #moron #Koch executive warns minimum wage hike would lead US toward #fascism

LISTEN: #moron #Koch executive warns minimum wage hike would lead US toward #fascism | Others | Scoop.it

 

LISTEN: Koch executive warns minimum wage hike would lead US toward fascism http://t.co/6pyMasSC9W
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Rescooped by Adam Jacob from Industrial Heritage
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USA: Repurposing Old Rail Stations in the Rust Belt

USA: Repurposing Old Rail Stations in the Rust Belt | Others | Scoop.it

Many rust belt cities have seen their rail stations sitting empty for years. A look into the latest movement for adaptive reuse of these iconic buildings.


Via David Worth
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Latest General Workers Vacancies - Phuzemthonjeni - Jobs Indeed

Latest General Workers Vacancies - Phuzemthonjeni - Jobs Indeed | Others | Scoop.it

Warehouse Assistants (Checkers/Dispatch Clerks/General Workers)
Large Packhouse requires Checkers, packers and dispatch clerks as well as general workers . All training will be provided. Must be helpful, thorough, and dedicated.Clear criminal record required, SA ID/Work Permit as well as good,traceable track record. Mon - Fri with shift work offered and overtime. Salary R 7000- R9000 depending on experience and level of skill. 
Please follow the link to apply: http://jobsindeed.jimdo.com/general-workers/


Via Themba Dlamini
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Themba Dlamini's curator insight, August 22, 2014 11:28 AM

Latest General Workers Vacancies - Phuzemthonjeni - Jobs Indeed

Rescooped by Adam Jacob from #ALS AWARENESS #LouGehrigsDisease #PARKINSONS
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Joost heads to US for ALS medical treatment at Massachusetts General Hospital

Joost heads to US for ALS medical treatment  at Massachusetts General Hospital | Others | Scoop.it
Former Springbok captain Joost Van der Westhuizen on Sunday announced that he is heading to the United States for medical treatment after a diagnosis of a form of motor neuron disease.

Via TEAM Mike Lopez Memorial Foundation |Find us on Twitter:@TEAMCUREALS
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Mining Pools & GryfenCoin | Cryptocurrencies: B...

Mining Pools & GryfenCoin | Cryptocurrencies: B... | Others | Scoop.it
Mining Pools & GryfenCoin: http://t.co/d2af36puhT | Cryptocurrencies: Bitcoin, Litecoin, DarkCoin, Blackcoin, Potcoin and Cryptocurrency Altcoins in general: market trends, crypto investment advices, promotions, giveaways & announcements (RT @devnullius:...

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Weaseling about surveillance, Australian Attorney General attains ...

Weaseling about surveillance, Australian Attorney General attains ... | Others | Scoop.it
Indeed the A-G, George Brandis, is rumoured not to own a computer or mobile phone, which might explain why he seems to think there's a significant difference between tracking what web sites Australians visit and just ...
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