Noise, Stochasticity and Evolvability | Origin of Life: Emergence, Self-organization and Evolution |

Kuwahara and Soyer report about stochastic fluctuations in gene regulation that can lead to increased evolvability of biological systems by pushing "system parameters toward a nonlinear regime where phenotypic diversity is increased and small changes in genotype cause large changes in expression level".

These findings strongly suggest that stochasticity and noise are used by biosystems to increase plasticity and access new phenotypes.



Hiroyuki Kuwahara & Orkun S Soyer. Bistability in feedback circuits as a byproduct of evolution of evolvability. Molecular Systems Biology 8:564