An optogenetic approach in epilepsy | Neuroscience_technics |

[Review] Highlights:

  • Optogenetic tools allow selective activation/silencing of specific neuronal populations.
  • Inhibitory opsins have been shown to efficiently reduce epileptiform activity in brain slices.
  • New strategies for controlling seizures could be explored using optogenetics.
  • Technically challenging optimisation of optogenetic approaches.
  • Some uncertainty in predicting outcomes of optogenetic interventions on excitability of complex neuronal networks. (...) - by Kokaia M et al., NeuropharmacologyVolume 69, June 2013, Pages 89–95