NETWORKS
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BIOLOGICAL NETWORKS
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Structure - Structural Data in Synthetic Biology Approaches for Studying General Design Principles of Cellular Signaling Networks

 

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Christina Kiel, Luis Serrano

"In recent years, high-throughput discovery of macromolecular protein structures and complexes has played a major role in advancing a more systems-oriented view of protein interaction and signaling networks. The design of biological systems often employs structural information or structure-based protein design to successfully implement synthetic signaling circuits or for rewiring signaling flows. Here, we summarize the latest advances in using structural information for studying protein interaction and signaling networks, and in synthetic biology approaches. We then provide a perspective of how combining structural biology with engineered cell signaling modules—using additional information from quantitative biochemistry and proteomics, gene evolution, and mathematical modeling—can provide insight into signaling modules and the general design principles of cell signaling. Ultimately, this will improve our understanding of cell- and tissue-type-specific signal transduction. Integrating the quantitative effects of disease mutations into these systems may provide a basis for elucidating the molecular mechanisms of diseases."

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Via Gerd Moe-Behrens
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Child Anxiety Scale Free

You don't need to suffer helplessly after you are going via a panic attack. Right here we'll give you the very best anxiety support and panic disorder aid.
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Upregulation of Sirt1 in carbon-tetrachloride–induced acute liver injury, Drug and Chemical Toxicology, Informa Healthcare

Upregulation of Sirt1 in carbon-tetrachloride–induced acute liver injury, Drug and Chemical Toxicology, Informa Healthcare | NETWORKS | Scoop.it
Upregulation of Sirt1 in carbon-tetrachloride–induced acute liver injury: Drug and Chemical To...
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Interactomic and Pharmacological Insights on Human Sirt-1 in Frontiers in Experimental Pharmacology and Drug Discovery

Interactomic and Pharmacological Insights on Human Sirt-1 in  Frontiers in Experimental Pharmacology and Drug Discovery | NETWORKS | Scoop.it

Interactomic analysis showed for the first time about the  vast the number of physiological partners of this hub protein. Sirt-1 is an interesting case because we are just beginning to understand some of the mechanisms that lead to multi-specificity in the binding of hub proteins. In particular, a huge number of articles have been published on the clinical, biological and, functional aspects of human sirtuins but we know only general details about their structures and molecular mechanisms which govern the functional behavior of these proteins.

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TEDxDanubia 2011 - Csermely Peter - The Tao of Talent

Péter Csermely is a biochemist and professor at Semmelweis University. He is the chairman of LINK-group, an interdisciplinary group formed by researchers and...
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Core and Metro Networks |

Core and Metro Networks | | NETWORKS | Scoop.it
In this book, the authors provide an overview of the status, challenges, architectures, and technological solutions for core and metropolitan networks. Furthermore, the book describes the current state of core and metropolitan ...
   
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Sirtuins in cognitive ageing and Alzhei - PubMed Mobile

Sirtuins in cognitive ageing and Alzheimer's http://t.co/t8EQxCws #ageingresearch...
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Protein Fights Obesity, Diabetes - Laboratory Equipment

Protein Fights Obesity, Diabetes - Laboratory Equipment | NETWORKS | Scoop.it
domain-BProtein Fights Obesity, DiabetesLaboratory EquipmentGuarente first discovered the effects of SIRT1 and other sirtuin proteins while studying yeast in the 1990s.
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Virtual interactomics of proteins from biochemi... [Mol Biol Int. 2012] - PubMed - NCBI

PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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Frontiers | “Networks” is different | Frontiers in Bioinformatics and Computational Biology

Frontiers | “Networks” is different | Frontiers in Bioinformatics and Computational Biology | NETWORKS | Scoop.it
Will the new scientific discipline of "network science" help unravel the complexities of biology and medicine?
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Assorted links — Marginal Revolution

Assorted links — Marginal Revolution | NETWORKS | Scoop.it
1. How to sell cosmetics to men. 2. Paper in prison. 3. Is lab-grown meat actually on the horizon? 4. What kind of taxes are favored by public opinion? 5. Mark Bittman should be writing this.
   
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The Value of the Cytokinome Profile | InTechOpen

The Value of the Cytokinome Profile | InTechOpen | NETWORKS | Scoop.it

The Value of the Cytokinome Profile, Published on: 2011-12-16.

Cytokines form an informative network, for some ways very similar to the Internet, that capillary connects, as knots to the network, cellular systems also different. The study of this network is important for understanding the evolution of the pathogenesis of many chronic inflammatory diseases.

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CytokineDB and CytReD@CROM | Costantini | EMBnet.journal

CytokineDB and CytReD@CROM

The cytokines family is composed by many proteins that need to bind to specific receptors on the cell surface to perform their biological function. This binding can stimulate both the expression of receptors for cytokines and the production of other cytokines that in turn act on other target cells

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