Network Medicine
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Network Medicine
Exploring the structure, dynamics and function of networks in biology and medicine
Curated by Shawn Gomez
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Network Biology » Biocomicals

Network Biology » Biocomicals | Network Medicine | Scoop.it
Send your captions! Winner will get a FREE Biocomicals Contest t-shirt! Submission will be open until November 29, 2012. Follow Biocomicals. RSS · Facebook · Twitter. Latest cartoon ideas by the readers.
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PLOS Biology: Sequencing the Connectome

PLOS Biology: Sequencing the Connectome | Network Medicine | Scoop.it

Abstract: Connectivity determines the function of neural circuits. Historically, circuit mapping has usually been viewed as a problem of microscopy, but no current method can achieve high-throughput mapping of entire circuits with single neuron precision. Here we describe a novel approach to determining connectivity. We propose BOINC (“barcoding of individual neuronal connections”), a method for converting the problem of connectivity into a form that can be read out by high-throughput DNA sequencing. The appeal of using sequencing is that its scale—sequencing billions of nucleotides per day is now routine—is a natural match to the complexity of neural circuits. An inexpensive high-throughput technique for establishing circuit connectivity at single neuron resolution could transform neuroscience research.

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PLOS Computational Biology: Regulatory Network Structure as a Dominant Determinant of Transcription Factor Evolutionary Rate

PLOS Computational Biology: Regulatory Network Structure as a Dominant Determinant of Transcription Factor Evolutionary Rate | Network Medicine | Scoop.it
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HIV-1 transmission graph

HIV-1 transmission graph | Network Medicine | Scoop.it
A graph representing the transmission of HIV among patients from Europe. Vertices represent patients and are coloured by country of origin. Edges indicate transmission between connected patients.

Via Kenzibit
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Science News: When Networks Network

Science News: When Networks Network | Network Medicine | Scoop.it

Once studied solo, systems display surprising behavior when they interact.

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Open Network Biology

Open Network Biology | Network Medicine | Scoop.it

A new BMC journal focused on network biology: "Open Network Biology publishes articles relating to predictive, network-based models of living systems linked to..." http://t.co/J1nvVdQJ...

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PLOS Computational Biology: Functional Modules, Structural Topology, and Optimal Activity in Metabolic Networks

PLOS Computational Biology: Functional Modules, Structural Topology, and Optimal Activity in Metabolic Networks | Network Medicine | Scoop.it

"Author Summary: Biological networks are an inherent concept in systems biology that is useful in elucidating how biological entities—as metabolites or proteins—work together in supporting specific phenotypes in microorganisms. Notably, topological analyses carried out over these networks have shown that modular organization is a ubiquitous property at different levels of biological organization, in such a way that modular organization may serve as an organizing principle governing the metabolic activity in microorganisms. With the aim of elucidating the relationship among functional modules, network topology, and optimal metabolic activity, here we present an integrative study that combines computational modeling and metabolome data for evaluation of the metabolic activity of the soil bacterium Rhizobium etli during symbiotic nitrogen fixation with Phaseolus vulgaris. As a result, we supply experimental and computational evidence supporting the concept that the optimal metabolic activity during this biological process is guided by modular structures in the metabolic network of R. etli. Even more fundamentally, we suggest that these biochemical modules interact among each other to ensure an optimal phenotype during nitrogen fixation. Finally, through the in silico analysis on the genome scale metabolic reconstruction for R.etli, we give some examples that suggest that these modular structures supporting nitrogen fixation are robust to external physiological conditions."

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A network of molecules, building each other at the dawn of life | Not Exactly Rocket Science | Discover Magazine

A network of molecules, building each other at the dawn of life | Not Exactly Rocket Science | Discover Magazine | Network Medicine | Scoop.it

Replicating networks of RNA.

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Discovery Medicine: Network Medicine Approaches to the Genetics of Complex Diseases

Discovery Medicine: Network Medicine Approaches to the Genetics of Complex Diseases | Network Medicine | Scoop.it
Complex diseases are caused by perturbations of biological networks. Genetic analysis approaches focused on individual genetic determinants are unlikely to characterize the network architecture of complex diseases comprehensively.
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