Juanlimycins A and B, Ansamycin Macrodilactams from Streptomyces sp. | Nat Product Chemistry | Scoop.it

Ansamycins are a family of macrolactams characterized by an aromatic chromophore with an aliphatic chain (ansa chain) connected back to a nonadjacent position through an amide bond. This family has shown a high degree of druggability exemplified by rifamycins, maytansinoids, and geldanamycins. In this study, the isolation of two novel ansamycin macrodilactams with unprecedented features, juanlimycins A (1) and B (2), from Streptomyces sp. LC6 were reported. The structures of 1 and 2 were assigned on the basis of analysis of NMR spectroscopic data and X-ray single crystal diffraction.


Juanli Zhang†, Zhengyi Qian‡, Xingkang Wu†, Yanjiao Ding†, Jianfang Li†§, Chunhua Lu†, and Yuemao Shen
Org. Lett., Article ASAPDOI: 10.1021/ol501072tPublication Date (Web): May 5, 2014
Via NatProdChem