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Pamlico BioPharma Human Monoclonal Antibodies

Pamlico BioPharma Human Monoclonal Antibodies | nanobiotechnology |

Pamlico Biopharma, Inc. was founded around human monoclonal antibody therapeutics and technologies from the OMRF and from Emory University. PAMLICO focuses on human monoclonal antibody therapeutics for human pathogens, cancer and autoimmune diseases. The lead project will address pneumonia caused by S pneumoniae. Pneumococcal pneumonia remains a major cause of morbidity and mortality worldwide. The magnitude of the clinical challenge is likely to increase as multiple strains of the bacteria have developed resistance to multiple antibiotics. PAMLICO’s lead project is a monoclonal antibody therapy for severe (PSI -V) community-acquired pneumonococcal pneumonia, which has a 20-35% mortality rate that has remained constant for 2 decades. The therapeutic goal is to reduce mortality by 20%, which the company anticipates demonstrating in a superiority study compared to standard care alone.

Via Krishan Maggon
Rescooped by Rachael Wyld Stacey from Social Foraging!

Liquid transport facilitated by channels in Bacillus subtilis biofilms

Many bacteria on earth exist in surface-attached communities known as biofilms. These films are responsible for manifold problems, including hospital-acquired infections and biofouling, but they can also be beneficial. Biofilm growth depends on the transport of nutrients and waste, for which diffusion is thought to be the main source of transport. However, diffusion is ineffective for transport over large distances and thus should limit growth. Nevertheless, biofilms can grow to be very large. Here we report the presence of a remarkable network of well-defined channels that form in wild-type Bacillus subtilis biofilms and provide a system for enhanced transport. We observe that these channels have high permeability to liquid flow and facilitate the transport of liquid through the biofilm. In addition, we find that spatial variations in evaporative flux from the surface of these biofilms provide a driving force for the flow of liquid in the channels. These channels offer a remarkably simple system for liquid transport, and their discovery provides insight into the physiology and growth of biofilms.


Via Ashish Umre
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Scooped by Rachael Wyld Stacey!

Biofilm: A New (Gross) Thing to Worry About

Slime can be great, but when it's the wrong kind of slime (you know, the kind that can kill you?), it gets added to the list of things Hank wishes he didn't ...
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Rescooped by Rachael Wyld Stacey from FOOD? HEALTH? DISEASE? NATURAL CURES???!

Morgellons Morphology - Pictures of an Unknown Fungal-like GMO Parasite

Morgellons Morphology - Pictures of an Unknown Fungal-like GMO Parasite | nanobiotechnology |
morgellons morphology-pictures, GMO aspect morgellons, Morgellons Research - Marc Neumann, morgellons worldwide-Delusional-Parasitosis, morgellons skin symptoms, morgellons lyme disease pictures

Via Troy Mccomas (troy48)
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Rescooped by Rachael Wyld Stacey from Amazing Science!

Nanosatellites are smartphone-sized spacecraft that can perform simple, yet very valuable space missions

Nanosatellites are smartphone-sized spacecraft that can perform simple, yet very valuable space missions | nanobiotechnology |
The next generation of micro rockets could be built around a magnetic fluid that appears to defy gravity.


Nanosatellites borrow many of their components from terrestrial gadgets: miniaturized cameras, wireless radios and GPS receivers that have been perfected for hand-held devices are also perfect for spacecraft. However, according to Michigan Technological University's L. Brad King, there is at least one technology need that is unique to space: "Even the best smartphones don't have miniaturized rocket engines, so we need to develop them from scratch."


Miniature rockets aren't needed to launch a nanosatellite from Earth. The small vehicles can hitchhike with a regular rocket that is going that way anyway. But because they are hitchhikers, these nanosats don't always get dropped off in their preferred location. Once in space, a nanosatellite might need some type of propulsion to move it from its drop-off point into its desired orbit. This is where the micro rocket engine comes in.


For the last few years, researchers around the world have been trying to build such rockets using microscopic hollow needles to electrically spray thin jets of fluid, which push the spacecraft in the opposite direction. The fluid propellant is a special chemical known as an ionic liquid. A single thruster needle is finer than a human hair, less than one millimeter long and produces a thrust force equivalent to the weight of a few grains of sand. A few hundred of these needles fit in a postage-stamp-size package and produce enough thrust to maneuver a nanosatellite.


These new electrospray thrusters face some design challenges, however. "Because they are so small and intricate, they are expensive to make, and the needles are fragile," says King, the Ron and Elaine Starr Professor of Mechanical Engineering-Engineering Mechanics. "They are easily destroyed either by a careless bump or an electrical arc when they're running."


To get around the problem, King and his team have developed an elegant strategy: eliminate the expensive and tedious microfabrication required to make the needles by letting Mother Nature take care of the assembly. "We're working with a unique type of liquid called a ferrofluid that naturally forms a stationary pattern of sharp tips in the liquid surface," he says. "Each tip in this self-assembling structure can spray a jet of fluid just like a micro-needle, so we don't actually have to make any needles."


Ferrofluids have been around since the 1960s. They are made of tiny magnetic particles suspended in a solvent that moves when magnetic force is applied. King illustrates with a tiny container holding a ferrofluid made of kerosene and iron dust. The fluid lies flat until he puts a magnet beneath it. Then suddenly, the liquid forms a regular series of peaks reminiscent of a mountain range or Bart Simpson's haircut. These peaks remain perfectly stable despite vigorous shaking and even turning the container upside down. It is, nonetheless, completely liquid, as a finger-tip touch proves undeniably. When the magnet is removed, the liquid relaxes to a perfectly flat surface.


King's team was trying to make an ionic liquid that behaved like a ferrofluid when they learned about a research team at the University of Sydney that was already making these substances. The Sydney team was using magnetic nanoparticles made by the life-sciences company Sirtex, which are used to treat liver cancer. "They sent us a sample, and we've used it to develop a thruster," King said. "Now we have a nice collaboration going. It's amazing that the same technology used to treat cancer can also function as a micro rocket for spacecraft."

Via Dr. Stefan Gruenwald
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Nanotechnology and Ocular Drug Delivery: Part I

Nanotechnology and Ocular Drug Delivery: Part I | nanobiotechnology |
Author: Tilda Barliya PhD Ocular drug delivery is a very challenging field for pharmaceutical scientists.  The unique structure of the eye restricts the entry of drug molecules at the required site...

Via Luís Bastos, Pedro Nadal Polo
Luís Bastos's curator insight, February 25, 2013 10:08 AM

Ophthalmic drug delivery, more than any other route of administration, may benefit to a full extent from the characteristics of nano-sized drug particles.