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cannabinoid osteosarcoma - PubMed - NCBI

cannabinoid osteosarcoma - PubMed - NCBI | ricerca | Scoop.it
PubMed comprises more than 27 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma?

What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma? | ricerca | Scoop.it
Despite the availability of multimodal and aggressive therapies, currently patients with skeletal sarcomas, including osteosarcoma and chondrosarcoma, often have a poor prognosis. In recent decades, advances in sequencing technology have revealed the presence of RNAs without coding potential known as non-coding RNAs (ncRNAs), which provides evidence that protein-coding genes account for only a small percentage of the entire genome. This has suggested the influence of ncRNAs during development, apoptosis and cell proliferation. The discovery of microRNAs (miRNAs) in 1993 underscored the importance of these molecules in pathological diseases such as cancer. Increasing interest in this field has allowed researchers to study the role of miRNAs in cancer progression. Regarding skeletal sarcomas, the research surrounding which miRNAs are involved in the tumourigenesis of osteosarcoma and chondrosarcoma has rapidly gained traction, including the identification of which miRNAs act as tumour suppressors and which act as oncogenes. In this review, we will summarize what is new regarding the roles of miRNAs in chondrosarcoma as well as the latest discoveries of identified miRNAs in osteosarcoma.
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A Proteomic Study on a Human Osteosarcoma Cell Line Saos-2 Treated with Diallyl Trisulfide - Saving Sophie

A Proteomic Study on a Human Osteosarcoma Cell Line Saos-2 Treated with Diallyl Trisulfide - Saving Sophie | ricerca | Scoop.it
ABSTRACT:  Garlic is generally used as a therapeutic reagent against various diseases, and numerous studies have indicated that garlic and its derivatives can reduce th
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Schoolgirl, 12, discovers her GROWING PAINS were cancer

Schoolgirl, 12, discovers her GROWING PAINS were cancer | ricerca | Scoop.it
Ashleigh Massey, from Chessington, struggled with the discomfort in her right leg when it first began in September. But after going to hospital a month later, she was found to have osteosarcoma.
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Co-Expression of XIAP and CIAP1 Play Synergistic Effect on Patient’s Prognosis in Head and Neck Cancer

Co-Expression of XIAP and CIAP1 Play Synergistic Effect on Patient’s Prognosis in Head and Neck Cancer | ricerca | Scoop.it
Purpose: To explore the relationship between XIAP and CIAP1 co-expression and the prognosis in HNSCC.
Experimental design: 69 patients were recruited in our study, expre..
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Marracash, hip hop non è per ragazzini - ANSA.it

Marracash, hip hop non è per ragazzini - ANSA.it | ricerca | Scoop.it
ANSA.it Marracash, hip hop non è per ragazzini ANSA.it Marracash, hip hop non è per ragazzini (ANSA) - MILANO, 26 SET - Il rap non è musica per ragazzini: parola di Marracash, che è uno degli artisti più in vista della scena urban, ma pensa che...

Via La Droga Poetica
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Involvement of small G protein RhoB in the regulation of proliferation, adhesion and migration by dexamethasone in osteoblastic cells

Involvement of small G protein RhoB in the regulation of proliferation, adhesion and migration by dexamethasone in osteoblastic cells | ricerca | Scoop.it
Long-term exposure to therapeutic doses of glucocorticoids (GCs) results in bone remodeling, which frequently causes osteoporosis and fracture healing retardation because of the abnormality of osteoblastic proliferation and differentiation. The mechanisms of GCs’ effect on osteoblasts are largely unknown. In this present study, we found that dexamethasone (Dex) could induce the expression of the small G protein, RhoB, in mRNA and protein levels in the osteoblast-derived osteosarcoma cell lines MG-63. The up-regulation of RhoB mRNA by Dex mainly occurs at posttranscriptional level by increasing its mRNA stability through PI-3K/Akt and p38 mitogen-activated protein kinase signaling pathways. Over-expression of RhoB in MG-63 cells magnified while down-regulation of RhoB level by RNA interference impaired Dex-induced growth inhibition but not differentiation. What’s more, over-expression of RhoB mimicked the effect of Dex on cell adhesion and migration. And interfering RhoB expression partially suppressed Dex-induced pro-adhesion and anti-migration in MG-63 cells. In conclusion, these results indicate that RhoB plays an important role in the pathological effect of Dex on osteoblastic growth and migration, which is a part of the mechanisms of GCs’ adverse effect on bone remodeling.
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What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma?

What Is New in the miRNA World Regarding Osteosarcoma and Chondrosarcoma? | ricerca | Scoop.it
Despite the availability of multimodal and aggressive therapies, currently patients with skeletal sarcomas, including osteosarcoma and chondrosarcoma, often have a poor prognosis. In recent decades, advances in sequencing technology have revealed the presence of RNAs without coding potential known as non-coding RNAs (ncRNAs), which provides evidence that protein-coding genes account for only a small percentage of the entire genome. This has suggested the influence of ncRNAs during development, apoptosis and cell proliferation. The discovery of microRNAs (miRNAs) in 1993 underscored the importance of these molecules in pathological diseases such as cancer. Increasing interest in this field has allowed researchers to study the role of miRNAs in cancer progression. Regarding skeletal sarcomas, the research surrounding which miRNAs are involved in the tumourigenesis of osteosarcoma and chondrosarcoma has rapidly gained traction, including the identification of which miRNAs act as tumour suppressors and which act as oncogenes. In this review, we will summarize what is new regarding the roles of miRNAs in chondrosarcoma as well as the latest discoveries of identified miRNAs in osteosarcoma.
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Rescooped by Andrea Giordani Senso Zetaerre from Osteoporosis New drugs Review
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Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression. - PubMed - NCBI

Blocking tumor-educated MSC paracrine activity halts osteosarcoma progression. - PubMed - NCBI | ricerca | Scoop.it
Clin Cancer Res. 2017 Jan 4. pii: clincanres.2726.2016. doi: 10.1158/1078-0432.CCR-16-2726. [Epub ahead of print]

Abstract PURPOSE: Human osteosarcoma is a genetically heterogeneous bone malignancy with poor prognosis despite the employment of aggressive chemotherapy regimens. Because druggable driver mutations have not been established, dissecting the interactions between osteosarcoma cells and supporting stroma may provide insights into novel therapeutic targets. EXPERIMENTAL DESIGN: By using a bioluminescent orthotopic xenograft mouse model of osteosarcoma we evaluated the effect of tumor extracellular vesicle (EV)-educated mesenchymal stem cells (TEMSCs) on osteosarcoma progression. Characterization and functional studies were designed to assess the mechanisms underlying MSC education. Independent series of tissue specimens were analyzed to corroborate the preclinical findings, and the composition of patient serum EVs was analyzed after isolation with size-exclusion chromatography. RESULTS: We show that EVs secreted by highly malignant osteosarcoma cells selectively incorporate a membrane-associated form of TGFB, which induces pro-inflammatory IL-6 production by MSCs. TEMSCs promote tumor growth, accompanied with intratumor STAT3 activation and lung metastasis formation, which was not observed with control MSCs. Importantly, intravenous administration of the anti-IL-6 receptor antibody tocilizumab abrogated the tumor-promoting effects of TEMSCs. RNA-seq analysis of human osteosarcoma tissues revealed a distinct TGFB-induced pro-metastatic gene signature. Tissue microarray immunostaining indicated active STAT3 signaling in human osteosarcoma, consistent with the observations in TEMSC-treated mice. Finally, we isolated pure populations of EVs from serum and demonstrated that circulating levels of EV-associated TGFB are increased in osteosarcoma patients. CONCLUSION: Collectively, our findings suggest that TEMSCs promote osteosarcoma progression and provide the basis for testing IL-6 and TGFB blocking agents as new therapeutic strategies for osteosarcoma patients.

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Krishan Maggon 's curator insight, January 6, 2017 12:30 PM
Serena Rubina Baglio, Tonny Lagerweij, Maria Pérez Lanzón, Dung Xuan Ho, Nicolas Léveillé, Sonia A Melo, Anne-Marie Cleton-Jansen, Ekaterina S Jordanova, Laura Roncuzzi, Michelina Greco, Monique A. J. van Eijndhoven, Giulia Grisendi, Massimo Dominici, Roberta Bonafede, Sinead Lougheed, Tanja D de Gruijl, Nicoletta Zini, Silvia Cervo, Agostino Steffan, Vincenzo Canzonieri, Aare Martson, Katre Maasalu, Sulev Koks, Thomas Wurdinger, Nicola Baldini and Dirk M Pegtel 

Clinical Cancer Research

DOI: 10.1158/1078-0432.CCR-16-2726 Published 4 January 2017
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Your smartphone can fight cancer

Your smartphone can fight cancer | ricerca | Scoop.it
IBM Press Room - Medical researchers and IBM are asking for the public's help in finding prospective treatments for childhood cancers.
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CANCER TREATMENT SYSTEM

The Magnetic Nanoparticle Hyperthermia System is designed as a non invasive, multi aim point system that can focus, scan and rotate to treat small or larg
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CAMBIANO LE REGOLE DEL GIOCO AL LIDO’ : GUEST DJ SHABLO

CAMBIANO LE REGOLE DEL GIOCO AL LIDO’ : GUEST DJ SHABLO | ricerca | Scoop.it

Cambiano le regole del gioco! Si salta al “top”. Al Piano superiore TOP FLOOR HOUSE, dj & live concept. In Arena Hip Hop Zone. Due prodotti di grande livello, completamente opposti, due sale di una bellezza unica, ma completamente distinte. La nuovissima sala al primo piano, magnificamente arredata, colpisce la particolare consolle al centro, completamente circondata da comodissimi divani, si gode di un’atmosfera dal calore unico. Per accedere si consiglia la prenotazione del tavolo, acquisendo il diritto del percorso privilegiato, fino a raggiungere il “TOP FLOOR HOUSE”. La serata parte alle ore 21,00 con la cena di livello: una degustazione completa, a scelta fra terra oppure mare ed il Fantastico con una proposta di alta cucina alla carta. Intorno alle ore 24,00 inizia la seconda parte della serata.

In Arena la serata inizia alle ore 21,00 con una proposta della cucina Lidò: un ricco buffet ove poter assaporare molte ricette sfiziose, che uniscono alla cucina tradizionale, creatività e ricercatezza, in attesa dell’evento hip hop di questa settimana RAP IN DA CLUB con SHABLO & RISE BEATBOX. DJ SHABLO, nasce a Buenos Aires, in Argentina. Si trasferisce a Perugia, dove ha un primo approccio con l’hip hop. Si cementa nel rap, ma trova la sua vocazione nella figura del dj producer. Nel 1999 si trasferisce a Bologna, città in cui trova una situazione rosea in fatto di musica. Si unisce così alla PMC Porzione Massiccia Crew e ne diventa il produttore e dj. Si occupa così dei dischi “5 Dan” e “Demolizione 2” che gli aprono le porte del futuro e gli fanno guadagnare il rispetto della scena.Negli anni a seguire le sue produzioni saranno presenti in quasi tutti i più importanti dischi di hip hop italiano pubblicati nella penisola, collaborando con artisti come Kaos, Club Dogo, Marracash, Esa, Tormento, Turi, Ensi e molti altri. Nel 2004 partecipa al mixtape “PMC VS Club Dogo The Official Mixtape”. Nel 2005 cura il progetto “My Sentence”, unica traccia di 14 minuti ove si unisce rap italiano, francese, inglese ed arabo. Dal 2006 risiede ad Amsterdam e nel 2007 debutta come solista con l’album “The Second Feeling”. A suo fianco Rise Beatbox per il progetto “Rap in da Club” questa settimana al Lidò di Montecatini. Info e prenotazoni 0572 71958

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