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I’m 84 years old what I got to lose cell you know we wrote a longer informed consent in the journal Nature and we followed him trip few years and his PSA started aids it went down to seven it went down to six went down into the fines and after two years it's stabilized at six that man is now 89 years old she stilling my practice he still is fine he still on testosterone in prostate cancer is never really been an issue for him that is phenomenal wow you know before we in the show doctor a bye want to make sure that we talk to you about the types treatment that might be available because there’s so many different options and not every man really can I use the injections are wants to use the injections what are some of the options that that men might have for testosterone replacement therapy well .