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Scooped by Fernando Á. Busca
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Viaje al centro del cerebro

Viaje al centro del cerebro | Mi contenido | Scoop.it
Europa y Estados Unidos apuestan sus cartas a dos grandes proyectos de investigación dedicados a este órgano
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Rescooped by Fernando Á. Busca from Breast Cancer News
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More than 20% of African American Women Carry Inherited Mutations in at Least One Breast Cancer Susceptibility Gene

More than 20% of African American Women Carry Inherited Mutations in at Least One Breast Cancer Susceptibility Gene | Mi contenido | Scoop.it

"A genomic profiling study of African American women with breast cancer found that about one in five carries an inherited abnormality in at least 1 of 18 genes associated with breast cancer susceptibility. Such mutations were more prevalent among women with aggressive triple-negative breast cancer, early onset disease, and a family history of breast and ovarian cancer. The findings, presented at the 2013 ASCO Annual Meeting (Abstract CRA1501), suggest that broader genetic screening with next-generation sequencing may be beneficial for these women and their family members."


Via Curated by A4BC.ORG
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Curated by A4BC.ORG's curator insight, June 10, 2013 2:37 PM

To see the abstract go to: http://meetinglibrary.asco.org/content/116465-132


"Key Points in this article:

  • A genomic profiling study of African American women with breast cancer found that about one in five carries an inherited abnormality in at least 1 of 18 genes associated with breast cancer susceptibility.
  • Compared to other ethnic groups, African American women have increased rates of early onset and aggressive triple-negative breast cancer, as well as poorer survival once diagnosed with breast cancer.
  • Next-generation sequencing assays, like BROCA, which allow assessment of multiple genes, would be useful in assessing African American women, who have a great diversity of inherited mutations."
Ruth Ferguson's curator insight, June 20, 2013 11:42 AM

will this lead to more black women wrestling with the decision Angella recently faced?