Membrane vesicle trafficking
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Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection

Virulence of invasive Salmonella Typhimurium ST313 in animal models of infection | Membrane vesicle trafficking | Scoop.it
Author summary Salmonella Typhimurium sequence type (ST) 19 causes self-limiting gastroenteritis throughout the world. In recent years, a new ST of Salmonella Typhimurium, ST313, has been circulating in sub-Saharan Africa and causes fever in infants and immunocompromised individuals in the absence of gastroenteritis. The differences in pathogenesis between Salmonella Typhimurium ST313 and ST19 is not clearly understood in animal models. In our current study, we examined possible differences between ST19 and ST313 strains in different animal models. We found that ST313 strains could replicate in the blood of mice to higher levels than ST19 strains. Furthermore, when rhesus macaques were orally infected with Salmonella Typhimurium ST19 or ST313, we observed increased diarrhea, inflammation and higher bacterial burden in ST19-infected monkeys compared to ST313-infected monkeys. Our data supports the clinical evidence which suggests that Salmonella Typhimurium ST313 do not cause gastroenteritis and instead are more invasive than ST19 strains.
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Salmonella serotypes are varied and some cause serious disease @ http://icmr.nic.in/ijmr/2007/december/1211.pdf
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ScienceDirect

Publication date: February 2017
Source:Trends in Biotechnology, Volume 35, Issue 2
Author(s): Christian Rüter, M. Alexander Schmidt
Bacterial pathogens have developed intriguing virulence mechanisms, including several sophisticated nanomachines, for injecting effector proteins to manipulate host immune signaling pathways for their own benefit. Therefore, bacterial genomes harbor a wealth of information about how to manipulate the defense systems of the host. Current understanding addresses virulence mechanisms mostly as targets for antimicrobials. We propose a change of paradigm by exploiting bacterial effectors not as targets but as tools for the directed manipulation of host signaling – for the benefit of the host. Recently, effector proteins have been identified that autonomously translocate into host cells, representing a novel class of cell-penetrating peptides (CPPs) or effectors (CPEs). Moreover, autonomous cell penetration overcomes a major hurdle in pharmacology by transducing specific therapeutic agents to intracellular targets.
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Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections. - PubMed - NCBI

Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections. - PubMed - NCBI | Membrane vesicle trafficking | Scoop.it
Mucosal Immunol. 2017 Jan 4. doi: 10.1038/mi.2016.113. [Epub ahead of print]
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Poultry Nutritional Health V Foodborne Pathogens

Poultry Nutritional Health V Foodborne Pathogens | Membrane vesicle trafficking | Scoop.it
Global nutritional health company Diamond V brings pre-harvest food safety research and expertise to the EuroTier international agricultural trade show in Hanover, Germany during 15-18 November.
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How salmonella survives the macrophage's acid attack

How salmonella survives the macrophage's acid attack | Membrane vesicle trafficking | Scoop.it
Macrophages destroy bacteria by engulfing them in intracellular compartments, which they then acidify to kill or neutralize the bacteria.
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3D Visualization of bacterial type III secretion machines in situ | Department of Chemistry

Bacterial type III secretion system (T3SS) is widely used by many bacterial pathogens to assemble flagella for locomotion or injectisomes for translocation of virulence factors into eukaryotic host cells.
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Type III SS injectisomal structures have been implicated in biogenesis of outer membrane vesicles from Salmonella pathogens while invading host tissue @ http://www.labome.org/research/Membrane-vesicle-trafficking-in-prokaryotes-molecular-biomechanics-of-biogenesis-of-outer-membrane-v.html
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Competition Among gut Bacteria Reduces Pathogens

Competition Among gut Bacteria Reduces Pathogens | Membrane vesicle trafficking | Scoop.it
Commensal bacteria, the normal flora in the digestive tract, have a multitude of functions and are critical to health. One of those functions is keeping ha
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In addition to Type6SS, commensal bacteria can also lyse invading pathogenic bacteria by translocating lytic enzymes via outer membrane vesicles at the host-pathogen interface @ https://en.wikipedia.org/wiki/Host-pathogen_interface
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Sugar Coating the Envelope: Glycoconjugates for Microbe–Host Crosstalk

Publication date: Available online 30 June 2016
Source:Trends in Microbiology
Author(s): Hanne L.P. Tytgat, Willem M. de Vos
Tremendous progress has been made on mapping the mainly bacterial members of the human intestinal microbiota.
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Glycosylation may act as barcode for bacterial interaction with host cells at the host-pathogen interface @ https://en.wikipedia.org/wiki/Host-pathogen_interface
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Plant Natural Products Targeting Bacterial Virulence Factors - Chemical Reviews (ACS Publications)

Plant Natural Products Targeting Bacterial Virulence Factors - Chemical Reviews (ACS Publications) | Membrane vesicle trafficking | Scoop.it
Chemical ReviewsDOI: 10.1021/acs.chemrev.6b00184
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Plants defend themselves from not only bacterial attack, but also repel insect attack @ https://www.researchgate.net/publication/230822379_Opinion_Neem-seed_oil_as_termite_repellent
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A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

Author Summary Pseudomonas aeruginosa is a gram-negative, opportunistic pathogen that accounts for about 10% of all hospital-acquired infections in the US and primarily infects immunocompromised hosts, including patients with chronic...
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Observation of sRNAs in outer membrane vesicles adds new dimension to discovery of vesicular exoctyosis in bacteria and its role in pathogenesis, invasion infection and disease production @ https://www.researchgate.net/publication/230793568_Discovery_of_vesicular_exocytosis_in_prokaryotes_and_its_role_in_Salmonella_invasion?ev=prf_pub
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Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how uptake of human lipids enhances bacterial virulence

Metabolic labelling of cholesteryl glucosides in Helicobacter pylori reveals how uptake of human lipids enhances bacterial virulence | Membrane vesicle trafficking | Scoop.it
Chem. Sci., 2016, Accepted Manuscript DOI: 10.1039/C6SC00889E, Edge Article Open Access This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.Chun-Hung Lin, Hau-Ming Jan, Yi-Chi Chen, Yu-Yin Shih, Yu-Chen Huang,...
Rakesh Yashroy's insight:
This work corroborates linkage among cholesterol rafts, membrane lipids, outer membrane vesicles of gram negative pathogens and virulence at the host-pathogen interface @ https://en.wikipedia.org/wiki/Host-pathogen_interface
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Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation

Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation | Membrane vesicle trafficking | Scoop.it
Publication date: Available online 5 May 2016
Source:Cell
Author(s): Sivapriya Kailasan Vanaja, Ashley J. Russo, Bharat Behl, Ishita Banerjee, Maya Yankova, Sachin D. Deshmukh, Vijay A.K.
Rakesh Yashroy's insight:
Outer membrane vesicles of gram negative bacteria, not only carry LPS, but also many other highly interactive signaling molecules from pathogen to host cells @ https://en.wikipedia.org/wiki/Host-pathogen_interface
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Legionella pneumophila -Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages

Legionella pneumophila -Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages | Membrane vesicle trafficking | Scoop.it
Author Summary Of all intracellular pathogens, Legionella pneumophila show the highest genetic adaptation to the host. They are important human pathogens causing mainly pneumonia, but are also highly successful pathogens of water amoeba.
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Microbe-Microbe and Host-Microbe Interactions Drive Microbiome Dysbiosis and Inflammatory Processes - Amy D Proal - Discovery Medicine

Microbe-Microbe and Host-Microbe Interactions Drive Microbiome Dysbiosis and Inflammatory Processes - Amy D Proal - Discovery Medicine | Membrane vesicle trafficking | Scoop.it
An extensive microbiome comprised of bacteria, viruses, bacteriophages, and fungi is now understood to persist in nearly every human body site, including tissue and blood. The genomes of these microbes continually interact with the human genome in order to regulate .
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Scientifically, we are more microbe than humans https://in.pinterest.com/pin/218495019401607518/
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Cell-Penetrating Bacterial Effector Proteins: Better Tools than Targets

Publication date: February 2017
Source:Trends in Biotechnology, Volume 35, Issue 2
Author(s): Christian Rüter, M. Alexander Schmidt
Bacterial pathogens have developed intriguing virulence mechanisms, including several sophisticated nanomachines, for injecting effector proteins to manipulate host immune signaling pathways for their own benefit. Therefore, bacterial genomes harbor a wealth of information about how to manipulate the defense systems of the host. Current understanding addresses virulence mechanisms mostly as targets for antimicrobials. We propose a change of paradigm by exploiting bacterial effectors not as targets but as tools for the directed manipulation of host signaling – for the benefit of the host. Recently, effector proteins have been identified that autonomously translocate into host cells, representing a novel class of cell-penetrating peptides (CPPs) or effectors (CPEs). Moreover, autonomous cell penetration overcomes a major hurdle in pharmacology by transducing specific therapeutic agents to intracellular targets.
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Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients

Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients | Membrane vesicle trafficking | Scoop.it
Article
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LPS secreted via bacterial outer membrane vesicles (OMVs) causes increase in LDL and oxidized LDL sticks to arterial endothelial cells causing cellular immunity to deposit monocytes, macrphages and neutrophils to enter the region so to form plaque on the arterial wall, resulting in heart disease. OMVs can released from gram negative bacteria infecting the body @ https://en.wikipedia.org/wiki/Membrane_vesicle_trafficking
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A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles

A Novel Mechanism of Host-Pathogen Interaction through sRNA in Bacterial Outer Membrane Vesicles | Membrane vesicle trafficking | Scoop.it
Author Summary Pseudomonas aeruginosa is a gram-negative, opportunistic pathogen that accounts for about 10% of all hospital-acquired infections in the US and primarily infects immunocompromised hosts, including patients with chronic...
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Bacterial vesicles are becoming the center attraction in host-pathogen interactions @ http://medlibrary.org/medwiki/Membrane_vesicle_trafficking
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Bacterial membrane vesicles can cause preterm birth

Bacterial membrane vesicles can cause preterm birth | Membrane vesicle trafficking | Scoop.it
A study published on Sept. 1 in PLOS Pathogens reports that GBS produces membrane-bound vesicles containing bacterial factors that can attack the host tissue.
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Life with Bacterial Secretion Systems

Mysterious organelles that span the bacterial envelope have grabbed my heart throughout my life.
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Dr Kubori's contribution on structural aspects of type 3 SS of Salmonella is outstanding. Kudos! Surprisingly, our lab found striking semblance of these syringe like structures with the biogenesis of outer membrane vesicles of Salmonella while infecting animal host ileum in vivo @ http://www.labome.org/research/Membrane-vesicle-trafficking-in-prokaryotes-molecular-biomechanics-of-biogenesis-of-outer-membrane-v.html
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What to know about About Salmonella during an Outbreak | Food Poison Journal

What to know about About Salmonella during an Outbreak | Food Poison Journal | Membrane vesicle trafficking | Scoop.it
WHAT IS SALMONELLA? It has long been said that, in 1885, pioneering American veterinary scientist, Daniel E. Salmon, discovered the first strain of Salmonella. Actually, Theobald Smith, research-assistant to Dr.
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Conquering Neutrophils

Antibacterial Arsenal Deployed by Neutrophils and Disarming by GAS Neutrophils are the most predominant and first innate immune cells arriving at the site of bacterial inoculation, where they exert diverse antimicrobial activities to prevent...
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Not only live pathogens, even pathogen-free toxic extract of Salmonella organisms injected in ileum, draws flux of neutrophils to the treated ileal villi, perhaps to detoxify enterotoxins @ http://s3.amazonaws.com/academia.edu.documents/33985759/IJAS_1994_vol_64_pp_103-107.pdf?AWSAccessKeyId=AKIAJ56TQJRTWSMTNPEA&Expires=1469894281&Signature=OH3TBPuGc7Th1P7T6KTYT7cbZE0%3D&response-content-disposition=inline%3B%20filename%3DYashRoy_R_C_1994_Light_and_electron_micr.pdf
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Pseudomonas syringae type III effector HopAF1 suppresses plant immunity by targeting methionine recycling to block ethylene induction

[PNAS] HopAF1 targets plant methionine recycling pathway [Plant Biology]: HopAF1 is a type III effector prote... https://t.co/Ml7QYrlnwF
Rakesh Yashroy's insight:
Most of the bacterial virulence factors/proteins are now suspected to be translocated via outer membrane vesicles released by bacterium at host-pathogen interface https://en.wikipedia.org/wiki/Host-pathogen_interface
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Switched-on Salmonella: Fluid Forces Guide Disease Traits of Multidrug-Resistant Bacteria

Switched-on Salmonella: Fluid Forces Guide Disease Traits of Multidrug-Resistant Bacteria | Membrane vesicle trafficking | Scoop.it
Once inside the human body, infectious microbes like Salmonella face a fluid situation. They live in a watery world, surrounded by liquid continually flowing over and abrading their cell surfaces--a property known as fluid shear.
Rakesh Yashroy's insight:
Salmonella is a highly versatile pathogen. In intestine, it secretes nanovesicles to poison the host cells and infect @ http://icmr.nic.in/ijmr/2007/december/1211.pdf
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Bacterial Outer Membrane Vesicles Induce Plant Immune Responses — Molecular Plant-Microbe Interactions | Plant pathogens and pests

Bacterial Outer Membrane Vesicles Induce Plant Immune Responses — Molecular Plant-Microbe Interactions | Plant pathogens and pests | Membrane vesicle trafficking | Scoop.it
Gram-negative bacteria continuously pinch off portions of their outer membrane, releasing membrane vesicles.
Rakesh Yashroy's insight:
Host-bacteria interface is a highly active area of inter-species and inter-kingdom war-fare and peace parleys @ https://en.wikipedia.org/wiki/Host-pathogen_interface
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Bacteria use traffic-cop-like mechanism to infect gut - Scienmag

Bacteria use traffic-cop-like mechanism to infect gut - Scienmag | Membrane vesicle trafficking | Scoop.it
Credit: Shelly Hanks, WSU Photo Services
A study has found that a syringe-like device used to invade intestinal cells also acts as a traffic cop -- directing bacteria where to go and thereby enabli..
Rakesh Yashroy's insight:
Type III secretion syringes of gram negative bacteria, are intriguing structures as they also appear to be involved with targeted secretion of virulence proteins via outer membrane vesicles as well @ http://www.labome.org/research/Membrane-vesicle-trafficking-in-prokaryotes-molecular-biomechanics-of-biogenesis-of-outer-membrane-v.html
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