Fatigue is a common and often debilitating symptom for people with advanced cancer. A recent clinical trial found that the steroid dexamethasone reduced fatigue in cancer patients who took it for 14 days. Other related symptoms, such as pain and loss of appetite, also improved, as did overall quality of life. However, in a recent survey, only one-quarter to one-third of cancer physicians said that they regularly use steroids to manage cancer-related fatigue. Because steroids can have serious side effects with long-term use, they may be most useful for patients with limited life expectancies or whose fatigue can be expected to resolve after short-term treatment.