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‘Stealth disease’ written off as old age may be behind thousands of cancers and joint problems, study shows

‘Stealth disease’ written off as old age may be behind thousands of cancers and joint problems, study shows | MRC research in the news | Scoop.it

A “stealth disease” which causes iron to build up to toxic levels may be responsible for thousands of cancers and disabling joint problems written off as part of ageing, a British study has found.

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Professor Melzer’s team studied 2,890 patients enrolled the UK Biobank scheme who carry mutations in the HFE C282Y gene that causes the condition.
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Beyond ‘superbabies’: how Crispr is revolutionising medicine

Beyond ‘superbabies’: how Crispr is revolutionising medicine | MRC research in the news | Scoop.it

The tail-end of last year brought news that a Chinese scientist had apparently created the world’s first genome-edited babies. It left fellow scientists, and the rest of the world, horrified that such a momentous leap had occurred in secret, with its potential for unintended consequences.

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“Many scientists consider genome editing to have great potential for dealing with inherited genetic disorders,” says Professor Robin Lovell-Badge, a developmental biologist and geneticist at the Francis Crick Institute in London. The Francis Crick Institute receives its core funding from the MRC, Cancer Research UK and Wellcome.
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Blow to low carb diet as landmark study finds high fibre cuts heart disease risk | Life and style | The Guardian

Blow to low carb diet as landmark study finds high fibre cuts heart disease risk | Life and style | The Guardian | MRC research in the news | Scoop.it

Eating more fibre, found in wholegrain cereals, pasta and bread as well as nuts and pulses, will cut people’s chances of heart disease and early death, according to a landmark review commissioned by the World Health Organization.

MRC press's insight:
Prof Nita Forouhi of Cambridge University’s MRC Epidemiology Unit said the findings “do imply that, though increasingly popular in the community at large, any dietary regimes that recommend very low-carbohydrate diets should consider the opportunity cost of missing out on fibre from whole grains”.
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Huge trove of British biodata is unlocking secrets of depression, sexual orientation, and more

Huge trove of British biodata is unlocking secrets of depression, sexual orientation, and more | MRC research in the news | Scoop.it

In early 2017, epidemiologist Rory Collins at the University of Oxford in the United Kingdom and his team faced a test of their principles. They run the UK Biobank (UKB), a huge research project probing the health and genetics of 500,000 British people. They were planning their most sought-after data release yet: genetic profiles for all half-million participants.

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The UK Biobank is part-funded by the MRC.
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New techniques are making it easier for scientists to monitor the immune system’s immediate response to pathogens. This information will help researchers to develop better vaccines, which are needed urgently to fight a worldwide resurgence of infectious diseases.
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Human infection studies are enjoying rapid growth in the UK, propelled by a £2.6m grant programme led by the Medical Research Council.
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New Year Honours 2019 – list in full: everyone being recognised this year

New Year Honours 2019 – list in full: everyone being recognised this year | MRC research in the news | Scoop.it
The famous faces named in this year's list are just a small sample of a total of 1,148 recipients – so here they all are in one mammoth list.
MRC press's insight:
The following people, with ties to the MRC, are among those listed in the New Year Honours 2019: Donald Brydon, MRC Chairman; Jane Margaret Armitage, (Professor of Clinical Trials and Epidemiology, MRC Population Health Research Unit); Professor Jonathan Robert Seckl and Professor David Richard (Herbie) Newell (respectively, current and former chairmen of the Developmental Pathway Funding Scheme panel); Professor David Klenerman; Professor John Frederick William Birney.
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Willie Russell obituary | Scotland | The Times

Willie Russell obituary | Scotland | The Times | MRC research in the news | Scoop.it

Willie Russell was a leading figure in virology, in particular his work investigating the structure of herpes viruses, adenoviruses and the association of paramyxoviruses with chronic diseases such as multiple sclerosis.

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He worked for two years in the research laboratories of J&P Coats in Paisley before changing from chemistry to virology and joining the Medical Research Council’s experimental virus research unit in Glasgow.
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Women with slim hips are more at risk of diabetes and heart attacks | Daily

Women with slim hips are more at risk of diabetes and heart attacks | Daily | MRC research in the news | Scoop.it

Women with slim hips could be at risk of diabetes and heart attacks, researchers have shown.

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Lead author Dr Luca Lotta, of the Medical Research Council Epidemiology Unit in Cambridge said: ‘It may seem counter-intuitive to think that some people with less fat around their hips are at higher risk of diabetes or heart disease.
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Clues to cause of Chronic Fatigue Syndrome found in immune system - Daily Mail

Clues to cause of Chronic Fatigue Syndrome found in immune system - Daily Mail | MRC research in the news | Scoop.it
Researchers at King´s College London say it is the "first step" in identifying those who could be at risk of contracting the condition.
MRC press's insight:
Dr Neha Issar-Brown, of the MRC which funded the research, said: “CFS/ME is a serious condition and its underpinning biology is poorly understood. Encouragingly, this work sheds light on potential mechanisms of immune dysregulation underlying early stages of chronic fatigue syndrome. The MRC strongly encourages more research to better understand this condition in order to address an area of unmet clinical need.”
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Human antibody discovery could save lives from fungal killer - Medical Xpress

Human antibody discovery could save lives from fungal killer - Medical Xpress | MRC research in the news | Scoop.it
A new way to diagnose, treat and protect against stealth fungal infections that claim more than 1.5 million lives per year worldwide has been moved a step closer, according to research published in Nature Communications.
MRC press's insight:
The new technique, within the MRC Centre for Medical Mycology at the University of Aberdeen and funded by the MRC and Wellcome, is the first to successfully use antibodies that are cloned from patients who have recovered from an infection caused by the fungus Candida
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University of Cambridge scientists in brown fat breakthrough - Cambridge Independent 

University of Cambridge scientists in brown fat breakthrough - Cambridge Independent  | MRC research in the news | Scoop.it
Breakthrough from scientists at the Wellcome Trust-MRC Institute of Metabolic Science
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The research was funded by the MRC, British Heart Foundation, European Research Council, WHRI-Academy and Wellcome.
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Scientists grow 'mini-placentas' for future trials | Daily Mail

Scientists grow 'mini-placentas' for future trials | Daily Mail | MRC research in the news | Scoop.it
The 'organoids' were developed at Cambridge University as a tool for unravelling some of the mysteries of early pregnancy.
MRC press's insight:
The Francis Crick Institute receives its core funding from the MRC, Cancer Research UK and Wellcome
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Sir Aaron Klug obituary | Science | The Guardian

Sir Aaron Klug obituary | Science | The Guardian | MRC research in the news | Scoop.it
Chemist and biophysicist who won the Nobel prize for developing crystallographic electron microscopy
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Sir Aaron Klug was the Director of the MRC Laboratory of Molecular Biology from 1986 to 1996.
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Drug used to treat stroke may also prevent Alzheimer's | Daily

Drug used to treat stroke may also prevent Alzheimer's | Daily | MRC research in the news | Scoop.it

An experimental drug used to treat stroke may also prevent Alzheimer's, research suggests.

MRC press's insight:
Professor Tara Spires-Jones, of the UK Dementia Research Institute, added: 'Dr Zlokovic and his team published a very encouraging paper showing that a drug called 3K3A-APC prevents Alzheimer's-like symptoms in a mouse model of disease.
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£150 DNA test could tell if you have the genes for a long life - Daily Telegraph 

£150 DNA test could tell if you have the genes for a long life - Daily Telegraph  | MRC research in the news | Scoop.it
A new DNA test could predict whether a person has the genes for a long life.
MRC press's insight:
The research, published in the journal eLife, was funded by the MRC and the AXA Research Fund.
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Recurrent Miscarriages May Be Caused By A Hugely Overlooked Factor, Says New Study - IFL Science

Recurrent Miscarriages May Be Caused By A Hugely Overlooked Factor, Says New Study - IFL Science | MRC research in the news | Scoop.it

"A new study argues that males' sperm quality might play a role in recurrent miscarriage, challenging the old assumption that the issue fundamentally lies in the female's health."

MRC press's insight:
The work was supported by the MRC, Biotechnology and Biological Sciences Research Council, and the National Institute for Health Research Imperial Biomedical Research Centre.
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It’s a fact: blonds have more . . . complex genetics | News | The Sunday Times

It’s a fact: blonds have more . . . complex genetics | News | The Sunday Times | MRC research in the news | Scoop.it

Blonds are more complex than anyone realised. Scientists have unravelled the mystery of hair colour, finding that blond hair needs 200 genes to create it, compared with 60 for brown locks and a handful for most redheads.

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“Blond hair is associated with over 200 genetic variants,” said the researchers, led by the Medical Research Council’s Human Genetics Unit at the University of Edinburgh.
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New Year diet? Here are health tips from a leading obesity scientist

New Year diet? Here are health tips from a leading obesity scientist | MRC research in the news | Scoop.it
Choosing the right diet for your body and lifestyle is important – but there are universal tips we can all benefit from, says Dr Giles Yeo
MRC press's insight:
Do we have a problem with our food environment that we need to fix? Are obesity and other diet-related illnesses killing us? Of course. I am not blind to these problems; my day job at Cambridge University’s MRC Metabolic Diseases Unit is about studying obesity after all. 
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Cancer breakthrough: Scientists say immune system transplants mean 'future is incredibly bright'

Cancer breakthrough: Scientists say immune system transplants mean 'future is incredibly bright' | MRC research in the news | Scoop.it

Scientists have discovered a breakthrough treatment to fight cancer, as they claim the disease will no longer be deadly for future generations.

MRC press's insight:
Researchers at the Francis Crick Institute in London believe it is possible to strengthen the body's defences by transplanting immune cells from strangers. The Francis Crick Institute receives its core funding from the MRC, Cancer Research UK and Wellcome.
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When the King of Sweden presents Greg Winter with a Nobel chemistry prize for his antibody discoveries on Monday, he will be the 16th laureate from the UK Medical Research Council’s Laboratory of Molecular Biology in Cambridge.
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During the past 60 years no other lab in the world has been more successful than the LMB in proportion to its size at picking up the greatest award in science.
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Removing sweets from checkouts could help tackle obesity - The Guardian

Removing sweets from checkouts could help tackle obesity - The Guardian | MRC research in the news | Scoop.it
Positioning of snacks near supermarket tills increases their sales, research shows
MRC press's insight:
The study was led by the Centre for Diet and Activity Research at the University of Cambridge.
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Dr Jan Löwe on the next frontier for MRC Laboratory of Molecular Biology in Cambridge - Cambridge Independent 

Dr Jan Löwe on the next frontier for MRC Laboratory of Molecular Biology in Cambridge - Cambridge Independent  | MRC research in the news | Scoop.it
The director of the world-renowned lab explains what it is like to lead Cambridge's 'Nobel Prize factory'
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Dr Löwe was joint head of the laboratory’s structural studies division, and became deputy director before taking over in April from the retiring Prof Sir Hugh Pelham in April.
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Scientists unravel complexities of what gives people red hair- i news 

Scientists unravel complexities of what gives people red hair- i news  | MRC research in the news | Scoop.it
It was previously thought that red hair was controlled by just one gene called MC1R, but academics at the University of Edinburgh have now confirmed that the process is far more complex.
MRC press's insight:
The paper, published in the journal Nature Communications, was funded by the MRC and the Biotechnology and Biological Sciences Research Council (BBSRC).
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Snoring is more dangerous to WOMEN and increases their risk of heart attack and stroke more than men | Daily Mail

Snoring is more dangerous to WOMEN and increases their risk of heart attack and stroke more than men | Daily Mail | MRC research in the news | Scoop.it
Although unclear why this occurs, scans analysed by Munich University Hospital reveal women with the sleep disturbance have thicker heart walls than men, which means the organ has to work harder.
MRC press's insight:
The UK Biobank is part-funded by the MRC.
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Machine learning spots viral reservoirs - Laboratory News

Machine learning spots viral reservoirs - Laboratory News | MRC research in the news | Scoop.it
A machine learning algorithm has been developed at The University of Glasgow that can predict viral reservoirs in the animal kingdom. Viruses circulate in animal and insect communities long before spreading to humans and causing severe disease. However, finding these natural virus hosts – which could help prevent the spread to humans – currently pose
MRC press's insight:
Dr Daniel Streicker, the senior author of the study from the MRC-University of Glasgow Centre for Virus Research, said: “Genome sequences are just about the first piece of information available when viruses emerge, but until now they have mostly been used to identify viruses and study their spread."
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