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Why Don't More People Want to Donate Their Organs?

Why Don't More People Want to Donate Their Organs? | Medical Research | Scoop.it
Around 21 Americans die each day waiting for transplants. What's behind the reluctance to posthumously save a life?
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Myths and facts about hiring employees with disabilities - The Business Journals

Myths and facts about hiring employees with disabilities - The Business Journals | Medical Research | Scoop.it
Here are some myths and facts about disabled employees to keep in mind for your next hiring decision.
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Here Are the Best Cities for Successful Aging

Here Are the Best Cities for Successful Aging | Medical Research | Scoop.it
The new Milken Institute rankings of Best Cities for Successful Aging feature many places in the Midwest and college towns, but very few in the Sunbelt.
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How To Live The Way You Want As You Age

How To Live The Way You Want As You Age | Medical Research | Scoop.it
To live the way you want, try to imagine what the hurdles will be and plan ahead.
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Can Big Data Improve Medical Diagnoses?

Can Big Data Improve Medical Diagnoses? | Medical Research | Scoop.it
A new startup called Enlitic is building software that analyzes x-rays, lab results, physicians' notes, and other data to improve medical diagnoses.
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A friendly introduction can transform a patient's experience

A friendly introduction can transform a patient's experience | Medical Research | Scoop.it
The #hellomynameis social media campaign, set up by a doctor, Kate Granger, being treated for cancer, encourages healthcare staff to take a few seconds to humanise the experience of being in hospital (From clinical trials to standard office...
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Alzheimer's Association Seeks Cure; Needs Clinical Trial Patients - KIVI-TV

Alzheimer's Association Seeks Cure; Needs Clinical Trial Patients - KIVI-TV | Medical Research | Scoop.it
Alzheimer's Association Seeks Cure; Needs Clinical Trial Patients
KIVI-TV
"If they had all the money in the world, what would be the next biggest hurdle to curing Alzheimer's disease, and in all cases ...
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From target discovery to clinical trials with armed antibody products

From target discovery to clinical trials with armed antibody products | Medical Research | Scoop.it

Highlights

 

Chemotherapeutics do not accumulate at the neoplastic mass, causing toxicity to normal organs.

Targeted drugs coupling potent payloads to ligands for tumor-specific antigens may improve therapeutic index.

We developed chemical proteomic strategies based on perfusion of rodents with biotin

We applied these techniques to the discovery of novel targets in human specimens

These methodologies led to development of novel antibody-based biologics, now in advanced clinical trials


Via Krishan Maggon
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Krishan Maggon 's curator insight, August 12, 2014 12:01 PM

Graphic Abstract

 

Journal of Proteomics

Volume 107, 31 July 2014, Pages 50–55

Special Issue: "20 years of Proteomics" in memory of Vitaliano Pallini

 

DOI: 10.1016/j.jprot.2014.02.034

 

Review From target discovery to clinical trials with armed antibody products ☆Giuliano Eliaa, Tim Fugmanna, Dario Nerib, , 

 

 

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Way to block immune rejection after transplant surgery

Way to block immune rejection after transplant surgery | Medical Research | Scoop.it
A water-based gel, ‘hydrogel,’ has shown promising results in animal trials
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Better Clinical Trial Designs Could Lower Development Costs And Yield More New Drugs

Better Clinical Trial Designs Could Lower Development Costs And Yield More New Drugs | Medical Research | Scoop.it
In order to reduce the diversity gap between men and women and among various subpopulations represented in clinical trials, and to moderate the costs of these studies, we need to innovate in trial design and the statistical analysis of results. In other words, we need to think outside the box. That will require cooperation among Congress, FDA, the pharmaceutical industry and academics, an awfully big pill to swallow.
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Euthanizing the Unhappy: The Urgent Need for Love

Euthanizing the Unhappy: The Urgent Need for Love | Medical Research | Scoop.it
The case of a Belgian woman who committed physician-assisted suicide after a sex-change operation reveals that we must not only look more closely at the causes
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FDA: No starch solutions for critically ill, cardiopulmonary bypass patients : Cardiology News

FDA: No starch solutions for critically ill, cardiopulmonary bypass patients : Cardiology News | Medical Research | Scoop.it
The Food and Drug Administration is warning that hydroxyethyl starch solutions should no longer be used in the treatment of critically ill adult patients –including patients with sepsis and those admitted to an intensive care unit – after completing an analysis of data indicating that treatment with these solutions increases the risk of death and renal injury in these groups.
In a statement, the agency also recommended that the use of hydroxyethyl starch (HES) solutions, used as plasma volume e
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Overweight Men Face Higher Risk of Aggressive Prostate Cancer PCa

Overweight Men Face Higher Risk of Aggressive Prostate Cancer PCa | Medical Research | Scoop.it
Obese men are at a greater risk of developing more advanced forms of prostate cancer PCa.
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Henry Cisneros Wants to Design Cities for All Ages

Henry Cisneros Wants to Design Cities for All Ages | Medical Research | Scoop.it
Communities need to adapt to a growing older population, former HUD secretary argues.
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Options plentiful for aging in place locally

Options plentiful for aging in place locally | Medical Research | Scoop.it
ECHO Cottages Ltd.
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Stroke Rounds: MI, Stroke Tied to Long-Term Decline

Stroke Rounds: MI, Stroke Tied to Long-Term Decline | Medical Research | Scoop.it
Post-stroke decline is often steady and long term.
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New Geriatric Assessment Tools Enhance Care of Older Adults with Cancer

New Geriatric Assessment Tools Enhance Care of Older Adults with Cancer | Medical Research | Scoop.it
Amid a coming storm of demographic trends signaling a sharp increase in the number of older people diagnosed with cancer in the United States, researchers are developing new geriatric assessment tools to help oncology specialists better manage this patient population.
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US speeds up human clinical trials for promising Ebola vaccine - Los Angeles Times

US speeds up human clinical trials for promising Ebola vaccine - Los Angeles Times | Medical Research | Scoop.it
Guardian Liberty Voice US speeds up human clinical trials for promising Ebola vaccine Los Angeles Times Phase 1 of the clinical trials, which were previously not expected to begin until the end of September, will start early next month in response...
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Trials by fire: Tough to recruit patients for pancreatic cancer studies - San Francisco Business Times

Trials by fire: Tough to recruit patients for pancreatic cancer studies - San Francisco Business Times | Medical Research | Scoop.it
Roughly a quarter of pancreatic cancer patients qualify for a clinical trial; even fewer actually actually enroll. The Pancreatic Cancer Action Network is trying to change that.
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The Voice of the Patient in Clinical Trials: Hearing It, Understanding It.

The Voice of the Patient in Clinical Trials: Hearing It, Understanding It. | Medical Research | Scoop.it
Sponsors, regulators and even patients themselves are placing an increasing emphasis on patient-direct data in clinical trials.
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Gender disparities uncovered in desire to receive living donor kidney transplants

Gender disparities uncovered in desire to receive living donor kidney transplants | Medical Research | Scoop.it
Among black kidney failure patients undergoing dialysis, women are much less likely than men to want to receive kidney transplants from living donors, despite more offers from family and friends. The findings, which are from a study appearing in an upcoming issue of the Clinical Journal of the American ...
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Stimuli-responsive drug delivery system prevents transplant rejection

Stimuli-responsive drug delivery system prevents transplant rejection | Medical Research | Scoop.it
A global collaboration including researchers from Brigham and Women's Hospital; Institute for Stem Cell Biology and Regenerative Medicine in Bangalore, India; and University Hospital of Bern, Switzerland, have developed a way to deliver immunosupressant drugs locally and when prompted, with the use of a biomaterial that self-assembles into a hydrogel (jello-like) material. The novel system is able to deliver targeted, controlled release of medication where and when it is needed.
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