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Rescooped by Barbara Krutchkoff from Cell Therapy & Regenerative Medicine
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Genetically engineered T-cells for cancer cell therapy

Genetically engineered T-cells for cancer cell therapy | Medical Industry | Scoop.it

Developments in genetic engineering make it possible to 're-programme' the human immune system so that T cells - white blood cells that normally fight viruses - recognize and kill cancer cells. This approach, which directly harnesses the potency of the immune system, holds the prospect of a powerful new weapon in the fight against cancer.


Via Ella Buzhor
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Ella Buzhor's curator insight, November 16, 2013 5:54 AM

T cells are re-programmed by synthetic genes, which encode a 'chimeric antigen receptor', a chemical hook that makes those T cells to target the cancerous cells. This therapy shows a great promise for blood cancers treatment, and expected to be expanded for the treatment of infectious diseases and GvHD as well.  

Carlos Garcia Pando's curator insight, November 17, 2013 7:42 AM

Wonderful indeed. They refer to this as "Chimeric antigen"

This means teching the system to fight in a different war, with better weapons, agains an old insidious enemy.

Rescooped by Barbara Krutchkoff from Cell Therapy & Regenerative Medicine
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CryoShot®- off-the-shelf cell therapy for osteoarthritis-clinical trial

CryoShot®-  off-the-shelf cell therapy for osteoarthritis-clinical trial | Medical Industry | Scoop.it

Regenerative medicine company Regeneus' (ASX: RGS) will use Japan’s new laws to fast-track the clinical trial and potential approval of its new human “off-the-shelf” CryoShot® cell therapy to treat osteoarthritis.


Via Ella Buzhor
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Ella Buzhor's curator insight, November 25, 2013 4:21 AM

CryoShot® is allogeneic human adipose-derived mesenchymal stem cells for treatment of osteoarthritis and other musculoskeletal conditions. It is on a way to accelerated cell therapy approval process in Japan.

Rescooped by Barbara Krutchkoff from Cell Therapy & Regenerative Medicine
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Stem cells for Parkinson's getting ready for clinic

Stem cells for Parkinson's getting ready for clinic | Medical Industry | Scoop.it
Stem cells for Parkinson's getting ready for clinic
U-T San Diego
For eight Parkinson's patients seeking treatment with a new form of stem cell therapy, 2014 promises to be a milestone.

Via Ella Buzhor
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Ella Buzhor's curator insight, December 9, 2013 9:47 AM

Parkinson's patients- derived iPSCs differentiated into dopaminergic neurons will be assessed in the clinical trial, providing a milestone and a great promise for Parkinson's disease treatment.

Rescooped by Barbara Krutchkoff from Digital Health
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42% of docs fear mHealth will lessen their power over patients [study]

42% of docs fear mHealth will lessen their power over patients [study] | Medical Industry | Scoop.it

Patient empowerment might be going a step too far for nearly half of physicians surveyed in a PWC report about mHealth. Patients remain highly interested in the use of mHealth on a smartphone or tablet to monitor their health, motivate changes, communicate with providers, and collect personal data.  Nearly 60% said in the next three years, mHealth will change how they seek information on health issues, and around half believe that providers will get on board, changing the way health information is communicated.  Patients look forward to the increased convenience and availability that mHealth will bring the, and 48% think that mobile medicine will improve the quality of their care.


Via Marc Phippen
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Rescooped by Barbara Krutchkoff from Cell Therapy & Regenerative Medicine
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Stem Cells Build "Biobridges" to Aid Brain Repair

Stem Cells Build "Biobridges" to Aid Brain Repair | Medical Industry | Scoop.it
University of South Florida (USF) scientists have suggested a new strategy for stem cell-mediated brain repair following trauma. In several preclinical experiments, the USF group found that transpl...

Via Ella Buzhor
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Ella Buzhor's curator insight, November 8, 2013 5:12 AM

SB623, Notch1-transfected mesenchymal stem cells, have been shown to restore function to damaged neurons associated with stroke, traumatic brain injury, retinal diseases, and Parkinson's disease. SB623 cells function by promoting the body's natural regenerative process. 

 SB632 transplantation in rat models demonstarated better motor and neurological functions and reduced brain tissue damage. SB623 is in early clinical testing for stroke.

Rescooped by Barbara Krutchkoff from Cell Therapy & Regenerative Medicine
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Stem Cell Biology in Normal Life and Diseases

Stem Cell Biology in Normal Life and Diseases | Medical Industry | Scoop.it

Stem cells have a prominent role in normal life and also in pathogenesis of disorders. Today, these cells are clinically applicable in hematopoietic stem cell transplantation but expansion of their application in many more disorders needs more work. For safe and effective application of these cells, we need better knowledge of their biology, their interaction with other cells (especially supporting niche cells), growth, maturation and also immigration of stem cells through body in normal and abnormal conditions. Also for clinical application we need to understand better, their separation methods and safe manipulation. This book is written to clarify some aspects of stem cell biology, their characteristics, assessment of damage to cells during ex vivo manipulation and also their role in a model of cancers (chronic myeloid leukemia).


Via Ella Buzhor
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Ella Buzhor's curator insight, December 18, 2013 4:26 PM

Open access book.

Carlos Garcia Pando's comment, December 19, 2013 2:01 PM
great resource
David O'Connell's comment, December 19, 2013 6:14 PM
The praise goes to Ella.
Rescooped by Barbara Krutchkoff from Stem Cells & Tissue Engineering
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Poster : Molecular mechanisms of stem-cell identity and fate (2006)

Poster : Molecular mechanisms of stem-cell identity and fate (2006) | Medical Industry | Scoop.it

Via Jacob Blumenthal
Barbara Krutchkoff's insight:

Nice poster.

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Rescooped by Barbara Krutchkoff from Stem Cells & Tissue Engineering
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Mini-pancreas grown from stem cells has implications for future insulin delivery

Mini-pancreas grown from stem cells has implications for future insulin delivery | Medical Industry | Scoop.it

Via Jacob Blumenthal
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Jacob Blumenthal's curator insight, October 16, 2013 2:02 AM

In a paper, published in Development journal, researchers from the  Danish Stem Cell Centre have shown that they can culture mouse pancreatic cells into expanded, branched structures in a 3D culture.

By manipulating the medium composition they  generated either hollow spheres, which are mainly composed of pancreatic progenitors, or complex organoids that spontaneously undergo pancreatic morphogenesis and differentiation.

Manipulation and improvement of  culture and expansion techniques 

 could lead to a more efficient and  developed method of creating insulin-releasing beta cells, which will eventually be used for cell therapy of diabetes.

http://dev.biologists.org/content/140/21/4452.full

 

To learn about pancreatic development:

http://discovery.lifemapsc.com/in-vivo-development/pancreas

 

To learn about stem cells differentiation protocols:

http://discovery.lifemapsc.com/stem-cell-differentiation/protocols

 

 

Carlos Garcia Pando's curator insight, October 16, 2013 2:04 PM

Another wonder result from tissue engineering!