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Digital strategy: The four fights companies need to win | #esante #hcsmeufr

From www.mckinsey.com

Successful companies need clarity about the demands of digital technologies, strong leadership, agility and bold investments.
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PhRMA: List of 2018 Medicines in Development                 48 for melanoma, 69 skin cancer and 300 for Skin Disease    #esante #hcsmeufr

From www.phrma.org

More than 300 medicines to treat skin diseases are in development
by biopharmaceutical research companies to help more than 100 million Americans affected by a broad range of skin conditions.

 

48 new drugs in development for melanoma and metastatic refractory melanoma.

69 drugs in development for skin cancer and over 300 for skin diseases

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Pharmacie du futur et médicaments sur mesure  #esante #hcsmeufr

From lesclesdedemain.lemonde.fr

L'innovation dans l'industrie pharmaceutique est transverse à tous les acteurs. Un écosystème qui, poussé par la vague du numérique, se traduit par une élaboration plus rapide des médicaments et une amélioration de la qualité de la prise en charge du patient dès l'officine. Les métiers évoluent, certains naissent, comme le Care Manager, chargé de suivre le patient à l'aide d'un programme de santé personnalisé.
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AI in healthcare: Can AI solve the health tech puzzle of new drug discovery?

From www.information-age.com

R&D is critical in the world of healthcare, but it is also tricky; progress is slow, and further progress is hampered by the way different researchers and drug developers work in silos, data is kept secret, locked away from the rest of the world. Can AI in healthcare come to the rescue?

Vas Narasimhan, CEO at Novartis, recently warned of a problem finding new data. In an interview with Bloomberg, he said that this lack of data has in part caused his initial enthusiasm for AI to turn more cautious.

This may yet prove to be the single biggest hurdle in applying AI in healthcare to help find cures to new diseases, extend life, and improve the quality of life.

Julien de Salaberry, CEO of Galen Growth Asia, a Singapore based organisation that is creating a $70 billion health tech ecosystem across Asia put it this way: “AI as a tool to aid research is still largely hype.”

He explains: “Its use is hampered largely because of the way data is held in silos and the interoperability of data is not there — everybody is hoarding data as if it was gold, and so the academic centres don’t speak to each other, the researchers don’t speak to each other, either.

“Everyone is building data, it’s growing faster than any other commodity on the planet, but no one is really sharing that data.”
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Novartis launches digital health innovation lab the Novartis Biome #esante #hcsmeufr #digitalhealth #pharma

From pharmaphorum.com

Novartis has launched a digital health innovation lab network named the Novartis Biome to accelerate its digital evolution.

The Swiss pharma company will also run a series of open innovation initiatives it says are designed to provide an ‘on-ramp’ for start-ups that wish to work with it.

The Novartis Biome, whose first digital health innovation lab is based in San Francisco, has been co-founded by its head Mohanad Fors, head of open innovation Shwen Gwee and head of innovation and strategy Robin Roberts.

Novartis Biome Robin RobertsRoberts (pictured) said: “The idea is to give the health tech ecosystem a boost and clear ‘on-ramp’ to work with Novartis.

“It’s clear to anyone who works in digital health that the vast majority of disruptive technologies are not going to come from big pharma companies. But we can engage and work with startups and innovators, and together make something bold, sustainable and scalable.”

The company hopes to fill what it sees as a gap in the current ecosystem, whereby “nascent technologies are not typically supported and shaped by the companies that can ultimately harness them”.

The Novartis Biome by proactively scouting for technology, seeking referrals and issuing challenges through an initiative called the HealthX World Series. The first of this series of global, open innovation challenges took place last month in San Francisco at TechCrunch Disrupt SF.
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#Pharma, Life Science Leaders Face Big Data Analytics Challenges #esante #hcsmeufr #digitalhealth

From healthitanalytics.com

Pharmaceutical and life science companies are staring down major challenges as value-based care alters the healthcare landscape, but those that are further along in their digital transformations are also more likely to embrace innovation and creative thinking about common business problems, according to a new survey by Deloitte and MIT.

Organizations that have more mature big data analytics and digital engagement skills are tend to have leaders that embrace change and staff members who are willing to get on board with new initiatives, positioning them well for exponential growth.

However, many organizations are failing to translate their recognition of the need for digital strategies into real-world adoption, leaving them at risk of falling behind their peers in a highly competitive environment.

“Biopharma leaders know that if they don't embrace digital transformation they will be surpassed by more agile competitors,” said Greg Reh, principal, Deloitte Consulting LLP, and US and global life sciences leader.

“But transformation can pose some cultural challenges that slow the pace of change. The good news is that their mindsets are shifting toward greater digital experimentation, collaboration, and innovation.”

The international survey of biopharma leaders revealed that more than 75 percent of companies are still in the early phases of digital development, with 25 percent placing themselves on the lowest rung of adoption and 55 percent stating that they are “developing their capabilities.”

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The First FDA-approved Digital Pill — What It Means for Pharma | FiercePharma #hcsmeufr #esante

From www.fiercepharma.com

The FDA recently approved a digital pill that tracks whether a patient has taken it. Learn how it works — and how it could transform patient-centered care.
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What The Hell Is Blockchain And What Does It Mean For Healthcare And Pharma? https://blog.healthxl.com/a-non-technical-guide-to-blockchain-in-healthcare/

From medicalfuturist.com

Don Tapscott, author of the book entitled Blockchain Revolution said in his superb, no-frills TED Talk that blockchain is the technology that is likely to have the greatest impact on the next few decades. No, it’s not social media. No, it’s not big data, not robotics, not even artificial intelligence. It’s the technology behind the cryptocurrency, Bitcoin.

Stop there for a moment. So, blockchain will have more transformative power on our lives than Facebook, Instagram and Donald Trump using Twitter for diplomacy? How? Why? When? Is that true or is it another bubble shaping up in front of our eyes?

When looking at how fast companies in various industries are adopting blockchain, the latter question is certainly worth considering. According to Transparency Market Research, the global blockchain technology market is expected to be worth $20 billion(!!) by the end of 2024 as compared to $315.9 million in 2015. The overall market is anticipated to exhibit a 58.7 percent annual growth between 2016 and 2024. Moving faster than Elon Musk’s red Tesla Roadster in space. And the drivers of this massive expansion are innovators, start-ups, bold companies in finance, retail and manufacturing, government – and healthcare.

Due to blockchain’s ties to cryptocurrencies, most people believe that the financial system will adopt the technology soonest, but healthcare’s speed of leveraging blockchain seems to actually surpass it. A new IBM Institute for Business Value blockchain study, Healthcare Rallies for Blockchain, surveyed 200 healthcare executives in 16 countries. They found that 16 percent aren’t just experimenting; they expect to have a commercial blockchain solution at scale in 2017. Moreover, according to IBM’s estimation, another 56 percent will follow the first adopters until 2020. That means within 2 years!

Thus, it is high time to have a look at how and why the technology behind Bitcoin, the cryptocurrency in a great part powering criminals trading on the darknet could become the cornerstone of future healthcare. More briefly, let’s see what the hell blockchain is!


Blockchain is the new word for trust online

On the Internet, nobody knows that you’re a dog. Although Peter Steiner’s cartoon drawn for The New Yorker in 1993 is mostly associated with the issue of anonymity on the Internet, it highlights deeper problems in relation to trust, credibility, security, and privacy. In the era of fake news and online scam, it does not come as a surprise to anyone that it is difficult to secure information, communication processes or trade online. And it is especially important in case of such sensitive information as money or healthcare data.

In case of money, trust and credibility have long been established by central intermediaries, such as banks, and other types of middlemen. You transfer money via your online bank account knowing its safe and secure because you trust the financial institution behind it. And in the case of online transactions, there has been another problem for which trustworthy intermediaries have meant the solution for years. The problem of duplications. When you send an e-mail with an attached cat photo, the image will automatically be copied. So, how do you make sure that doesn’t happen with your money? That the well-earned dollars that you spend on books will actually disappear from your bank account and appear on Amazon’s. In the case of digital assets like money, stocks or intellectual property, not to speak about electronic health records, authentication and accountability are key elements.

Still, middlemen such as banks are too slow. And too expensive. While an e-mail arrives in seconds in another person’s mailbox, an international transfer could take several days, even weeks. And it is not even that secure, as it could be hacked more easily due to the banks’ centralized nature. As a response to all these issues, Satoshi Nakamoto, a mysterious Japanese programmer or a group, worked out the world’s first digital currency, Bitcoin and its underlying, supporting system, the blockchain. Since then, several types and modified versions of the technology appeared. As The Economist explained, blockchain enables an economy where trust is established not by central intermediaries but through consensus and complex computer code. It lets people who have no particular confidence in each other collaborate without having to go through a neutral central authority. Simply put, it is a machine for creating trust.


Blockchain is like a scarf knitted by your grandmother

The concept and the operation of the technology are rather difficult, but it is perhaps easier to imagine with a nicely-put metaphor by The New Yorker’s Nathan Heller. In his article about Estonia as a digital republic, he said that a blockchain is like the digital version of a scarf knitted by your grandmother. She uses one ball of yarn, and the result is continuous. Each stitch depends on the one just before it. It’s impossible to remove part of the fabric, or to substitute a swatch, without leaving some trace: a few telling knots, or a change in the knit.

When The Medical Futurist asked Ivo Lohmus from Guardtime, an Estonian company developing K.S.I. blockchain technology, he said it to imagine as a shared book of records, or in more technical terms, a distributed database, that’s designed in such a smart way that whatever is added to this database, that’s immutable. As if it’s carved into stone. Any change becomes immediately evident. Another aspect of the system is that there is no central authority to decide what’s right or wrong. The participants need to come to a consensus, to articulate some shared view of the world.

There are several methods for making a decision about a new entry based on the particular consensus, Medium’s Collin Thompson explains the proof of work process used by Bitcoin as the following: when a digital transaction is carried out, it is grouped together in a cryptographically protected block with other transactions that have occurred in the last 10 minutes and sent out to the entire network. Miners (members in the network with high levels of computing power) then compete to validate the transactions by solving complex coded problems. The first miner to solve the problems and validate the block receives a reward. The validated block of transactions is then timestamped and added to a chain in a chronological order.

New blocks of validated transactions are linked to older blocks, making a chain or blocks that show every transaction made in the history of that blockchain. The entire chain is continually updated so that every database in the network is the same, giving each member the ability to prove who owns what at any given time.


The benefits of blockchain

The technology has numerous benefits for online transactions, especially in the field of digital assets, such as health data. Blockchain’s time-sensitive nature allows any data to move around in that particular format only once in the network. The blocks are impossible to change; only new entries can be added to the network. This is critical in case of health data. Just imagine what might happen if someone could change a patient’s blood type in the health record system without anyone noticing it.

Moreover, Ivo Lohmus said that many times, as in the case of the K.S.I blockchain which is used for the Estonian medical records system, the blockchain does not directly deal with the data. Through the cryptographic process, a unique identifier of the data, a hash, is created, which functions similarly to the biological fingerprint. While you can identify anyone based on his or her fingerprint, you cannot “reconstruct” the whole person. And finally, as the blockchain is based on the consensus of network participants, access to data can be linked to permission.

Beyond ensuring authentication and credibility, blockchain also brings unprecedented security benefits. Hacking attacks that commonly impact large, centralized intermediaries like banks would be virtually impossible to pull off on the blockchain. For example — if someone wanted to hack into a particular block in a blockchain, a hacker would not only need to hack into that specific block, but all of the proceeding blocks going back the entire history of that blockchain. And they would need to do it on every ledger in the network, which could be millions, simultaneously.


Blockchain in healthcare – Long instead of big data

Blockchain has immense potential in healthcare. According to the IBM Institute for Business Value blockchain study, new adopters of the technology expect the greatest blockchain benefits across time, cost, and risk in three areas: clinical trial records, regulatory compliance, and medical/health records.

It is capable of transforming the entire system of medical records, just as Estonia already did. In March 2017, the Baltic country’s eHealth Authority has signed a deal with Guardtime to secure the health records of over a million Estonians. Patientory, a start-up helping hospitals to secure their patient data while enabling patients to follow the fate of their own data, has urged the British government “to get behind a blockchain-enabled national IT health system” at the time of the NHS ransomware attack. If there were political will and comprehensive financial support, other countries could also Estonia’s as well as Dubai’s lead. The latter has also started to test blockchain technology for securing its electronic medical records.

Due to its time-sensitive nature, blockchains shift the lens from disparate bits of information held by a single owner, to the lifetime history of an asset. Instead of big data, capturing long-term data becomes more easily possible. And that’s exactly why it is the perfect solution when we need to document a patient’s health record, to set up reliable vaccine registries or to secure the movement of drugs through the supply chain.


Blockchain in pharma

The issue of counterfeit medicines, as the dark side of networked markets and globalization, has become increasingly pressing, both in terms of the economic cost of this global black market and the risk to human lifethat comes from taking counterfeit drugs. In many developing countries in Asia, Africa, and South America, counterfeit drugs comprise between 10 percent and 30 percent of the total medicines on sale.

Cindy Greatrex, Vice President of The National Alliance of Research Associates Programs remarked that for combatting fake pharmaceuticals a solution needs to be employed that stops the counterfeits from contaminating the supply chain. The best solution is to track pharmaceuticals so that digital systems linked to medication moving in the physical world are established. This is important because when you have a unique digital reference to a drug and a physical copy of that drug, it is much harder to erase or duplicate one without the other.

Blockchain offers security through transparency. It might work as follows: barcode-tagged drugs could be scanned and entered into secure digital blocks whenever they change hands. This ongoing real-time record could be viewed anytime by authorized parties and even patients at the far end of the supply chain. This would make it much more difficult for criminal networks to sell their counterfeit drugs on the market.

However, the advantages of blockchain for pharma does not stop there. Drug developers running clinical trials might be able to share clinical data and medical samples more securely. And while blockchain underpins the digital currencies demanded in ransomware attacks, the technology could also play a role in securing sensitive industry data from malicious attack.


It’s clear that blockchain will have a massive impact on dealing with healthcare data. It’s also worth looking at news about blockchain differently than those related to Bitcoin. The blockchain is a technology, Bitcoin is a product of it. As it is going to be more and more widespread in the future, we’ll keep on writing about the many ways blockchain can support healthcare and pharma.

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Pierre Fabre Pharmaceuticals Joins Embleema Health Blockchain Consortium to Pilot Blockchain to Optimize Patient Engagement | Business Wire #hcsmeufr #esante

From www.businesswire.com

Pierre Fabre Pharmaceuticals joins Embleema Health Blockchain Consortium to Pilot Blockchain to Optimize Patient Engagement.
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Otsuka and Proteus sign 5-year, $88M digital pill partnership | FierceBiotech #hcsmeufr #esante

From www.fiercebiotech.com

Otsuka and Proteus Digital Health have re-upped their global smart-tablet partnership for another five years, aiming to develop a new generation of ingestible sensors.
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The Top CROs in the United States - Contract Research Organization #esante #hcsmeufr #digitalhealth

From explorebiotech.com

Contract Research Organization (CRO) provides all kinds of outsourced research services. Their offerings cover the entire gamut of R&D, starting from drug discovery to clinical trials and further.
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How big data can revolutionize pharmaceutical R&D | McKinsey

From www.mckinsey.com

Pharmaceutical R&D suffers from declining success rates and a stagnant pipeline. Big data and the analytics that go with it could be a key element of the cure.
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Are the Right Drugs Getting Faster FDA Approval? | #esante #hcsmeufr #digitalhealth

From www.pharmexec.com

Leela Barham continues her series of features exploring expedited FDA approvals with a look at the therapy areas and the overlap with orphan drug designations.
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Janssen & Nouveal s'associent pour la télésurveillance en hématologie #esante #hcsmeufr

From nouveal.com

Janssen et Nouveal s’associent pour accompagner les services d’hématologie en déployant une solution de télésurveillance de l'hémopathie maligne.
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« L’industrie pharmaceutique assume seule l’effort » d’innovation dans le médicament #esante #hcsmeufr 

From mobile.lemonde.fr

Jean-David Zeitoun, médecin, conteste dans une tribune au « Monde » les arguments de certains de ses collègues qui mettent en avant les profits trop élevés de l’industrie du médicament aux dépens de l’accès aux soins.
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Les défis du nouveau président du médicament, Philippe Tcheng #esante #hcsmeufr 

From www.latribune.fr

Philippe Tcheng vient d'accéder à la présidence du Leem. Pur produit Sanofi et grand connaisseur des négociations avec les pouvoirs publics, l'homme devrait s'inscrire dans la continuité de la politique du syndicat professionnel du médicament.
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In-Depth: How digital sensors could change the face of pharma #esante #hcsmeufr #digitalhealth

From www.mobihealthnews.com

Correction: An earlier version of this article was unclear about differences between Abilify MyCite and the Proteus Digital Medicine Platform. 
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Sandoz launches second digital health competition - PharmaTimes #esante #hcsmeufr #digitalhealth

From www.pharmatimes.com

Novartis’ generics arm Sandoz has launched the second Healthcare Access Challenge (HACk), which is looking to support digital solutions to local healthcare access challenges. - News - PharmaTimes
Florian Morandeau's curator insight, October 5, 2:00 AM

Digital innovation could provide cost-effective and practical solutions with the power to transform access to healthcare.

Médicaments : qui fixe les prix récolte la pénurie #esante #hcsmeufr

From www.contrepoints.org

Incroyable : la France connaîtrait des pénuries de médicaments !
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The State Of Customer Experience In European Pharma, 2017: Physician Interactions #esante #hcsmeufr #digitalhealth

From dt-associates.com

Fueled by digital innovation, industry forces are reshaping pharma’s customer base. As payers and providers move to value-based care and patients demand more control and choice, pharmaceutical firms need a new approach to meeting their needs. While rethinking the business using a customer experience (CX) mindset will give pharma companies the direction they need, only three companies received a Customer Experience Quotient (CXQ™) that shows they’ve mastered this approach. The others need to step up their CX transformation effort by expanding the role of design in their organization.
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