Macular Degeneration
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PERIPHERAL RETINAL DRUSEN-LIKE DEPOSITS IN GUCY2C CONGENITAL SECRETORY DIARRHEA SYNDROME.

PERIPHERAL RETINAL DRUSEN-LIKE DEPOSITS IN GUCY2C CONGENITAL SECRETORY DIARRHEA SYNDROME. | Macular Degeneration | Scoop.it
To report the presence of drusen in infancy, in a patient with Type 1 retinopathy of prematurity and a rare congenital sodium diarrhea secondary to a sporadic G...
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Inexpensive eye imaging method may help monitor Alzheimer’s progression

Inexpensive eye imaging method may help monitor Alzheimer’s progression | Macular Degeneration | Scoop.it
A new study from Queen’s University Belfast researchers found the eye may be a critical indicator for Alzheimer’s disease (AD) along with a host of other neurodegenerative diseases.
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Macular Degeneration Facts, News, FAQ and Treatments

Macular Degeneration Facts, News, FAQ and Treatments | Macular Degeneration | Scoop.it
Macular degeneration may not mean blindness; learn what you need to know about wet and dry AMD, symptoms and signs, treatment and prevention.
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Origins of ghost drusen: a follow-up analysis | OAPOC

Origins of ghost drusen: a follow-up analysis | OAPOC | Macular Degeneration | Scoop.it
Abstract Purpose Ghost drusen (GD) are pyramidal or dome-shaped retinal pigment epithelium elevations observed in some geographic atrophy (GA) areas in the context of age-related macular degeneration (AMD).
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Study to Evaluate Sub-retinal Transplantation of Retinal Pigmented Epithelial Cells in Patients With Dry AMD - Full Text View - ClinicalTrials.gov

Study to Evaluate Sub-retinal Transplantation of Retinal Pigmented Epithelial Cells in Patients With Dry AMD (PORTRAY) This study has been withdrawn prior to enrollment. (Changes to the study design and the cell line) Sponsor: Astellas Institute for Regenerative Medicine Information provided by...
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Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration

Association of C-Reactive Protein Genetic Polymorphisms With Late Age-Related Macular Degeneration | Macular Degeneration | Scoop.it
This pooled analysis assesses whether CRP single-nucleotide polymorphisms that influence circulating C-reactive protein concentrations are associated with late
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Antioxidant vitamin and mineral supplements to slow down the progression of age-related macular degeneration (AMD) | Cochrane

Antioxidant vitamin and mineral supplements to slow down the progression of age-related macular degeneration (AMD) | Cochrane | Macular Degeneration | Scoop.it
What is the aim of this review? The aim of this Cochrane Review was to find out whether taking antioxidant vitamin and mineral supplements slows down the progression of AMD and prevents visual loss. Cochrane researchers collected and analysed all relevant studies to answer this question and found...
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Geographic atrophy phenotype identification by cluster analysis

Geographic atrophy phenotype identification by cluster analysis | Macular Degeneration | Scoop.it
Ophthalmology Article: Geographic atrophy phenotype identification by cluster analysis
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Gene therapy for age-related macular degeneration. - PubMed - NCBI

Gene therapy for age-related macular degeneration. - PubMed - NCBI | Macular Degeneration | Scoop.it
Expert Opin Biol Ther. 2017 Jul 20:1-10. doi: 10.1080/14712598.2017.1356817. [Epub ahead of print]
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Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane. - PubMed - NCBI

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3046-3054. doi: 10.1167/iovs.17-21720.
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Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells

Lutein Attenuates Both Apoptosis and Autophagy upon Cobalt (II) Chloride-Induced Hypoxia in Rat Műller Cells | Macular Degeneration | Scoop.it
Retinal ischemia/reperfusion injury is a common feature of various retinal diseases such as glaucoma and diabetic retinopathy. Lutein, a potent anti-oxidant, is used to improve visual function in patients with age-related macular degeneration (AMD). Lutein attenuates apoptosis, oxidative stress and inflammation in animal models of acute retinal ischemia/hypoxia. Here, we further show that lutein improved Műller cell viability and enhanced cell survival upon hypoxia-induced cell death through regulation of intrinsic apoptotic pathway. Moreover, autophagy was activated upon treatment of cobalt (II) chloride, indicating that hypoxic injury not only triggered apoptosis but also autophagy in our in vitro model. Most importantly, we report for the first time that lutein treatment suppressed autophagosome formation after hypoxic insult and lutein administration could inhibit autophagic event after activation of autophagy by a pharmacological approach (rapamycin). Taken together, lutein may have a beneficial role in enhancing glial cell survival after hypoxic injury through regulating both apoptosis and autophagy.
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Pluripotent stem cells: A therapeutic source for age-related macular degeneration. - PubMed - NCBI

Indian J Ophthalmol. 2017 Mar;65(3):177-183. doi: 10.4103/ijo.IJO_1026_15. Review
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AMD and inherited retinal diseases ― recording - 2016 NEI/FDA Endpoints Workshops

A  A Home > Conferences & Courses > Endpoints Workshop > AMD and inherited retinal diseases > AMD and inherited retinal diseases ― recording 2016 NEI/FDA Endpoints Workshops NOV 09, 2016 BETHESDA, MARYLAND AMD and inherited retinal diseases ― recording       The Workshop was held live and via...
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Why the eye could be the window to brain degeneration such as Alzheimer's disease

Why the eye could be the window to brain degeneration such as Alzheimer's disease | Macular Degeneration | Scoop.it
Researchers from Queen's University Belfast have shown for the first time that the eye could be a surrogate for brain degeneration like Alzheimer's disease (AD).
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Natural History of Geographic Atrophy in Untreated Eyes with Nonexudative Age-Related Macular Degeneration

Natural History of Geographic Atrophy in Untreated Eyes with Nonexudative Age-Related Macular Degeneration | Macular Degeneration | Scoop.it
Systematic review and meta-analysis of the natural history of geographic atrophy (GA).
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Risk of age-related macular degeneration in patients with prostate cancer: a nationwide, population-based cohort study.

Risk of age-related macular degeneration in patients with prostate cancer: a nationwide, population-based cohort study. | Macular Degeneration | Scoop.it
Prostate cancer (PC) can be related to increased systemic oxidative stress and dihydrotestosterone level, which are also reported to be involved in th
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Extracellular matrix nitration alters growth factor release and activates bioactive complement in human retinal pigment epithelial cells. - PubMed - NCBI

PLoS One. 2017 May 15;12(5):e0177763. doi: 10.1371/journal.pone.0177763. eCollection 2017.
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Antioxidant vitamin and mineral supplements to prevent the development of age-related macular degeneration (AMD) | Cochrane

Antioxidant vitamin and mineral supplements to prevent the development of age-related macular degeneration (AMD) | Cochrane | Macular Degeneration | Scoop.it
What is the aim of this review? The aim of this Cochrane Review was to find out whether taking antioxidant vitamin and mineral supplements prevents the development of AMD. Cochrane researchers collected and analysed all relevant studies to answer this question and found five studies.
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Origins of ghost drusen: a follow-up analysis | OAPOC

Origins of ghost drusen: a follow-up analysis | OAPOC | Macular Degeneration | Scoop.it
Origins of ghost drusen: a follow-up analysis Ophthalmol @ point care 2017; 1(1): e51 - e55 Article Type: RESEARCH @ POINT OF CARE DOI:10.5301/oapoc.0000011 Authors Caroline Bottin, Olivia Zambrowski, Giuseppe Querques, Salomon Yves Cohen, Mayer Srour, Oudy Semoun, Eric H.
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Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration. - PubMed - NCBI

Optical Coherence Tomography Features Preceding the Onset of Advanced Age-Related Macular Degeneration. - PubMed - NCBI | Macular Degeneration | Scoop.it
Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3519-3529. doi: 10.1167/iovs.17-21696.
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Environmental Health Perspectives – Pesticide Use and Age-Related Macular Degeneration in the Agricultural Health Study

Introduction Age-related macular degeneration (AMD) is a degenerative condition of the central portion of the retina, the macula (Velez-Montoya et al. 2014). AMD is the leading cause of blindness in older individuals in developed countries, affecting >8 million U.S. residents. The early stage of the disease is often asymptomatic, but late AMD, either geographic atrophy […]
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The Status of Maculopathy in Diabetes and Prediabetes Patients in a Population-Based Study Detected by Optical Coherence Tomography: The 2011 Health Examination Survey in Beijing

The Status of Maculopathy in Diabetes and Prediabetes Patients in a Population-Based Study Detected by Optical Coherence Tomography: The 2011 Health Examination Survey in Beijing | Macular Degeneration | Scoop.it
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles as well as review articles covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject-specific sections.
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The formation of a functional retinal pigment epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry

The formation of a functional retinal pigment epithelium occurs on porous polytetrafluoroethylene substrates independently of the surface chemistry | Macular Degeneration | Scoop.it
Subretinal transplantation of functioning retinal pigment epithelial (RPE) cells may have the potential to preserve or restore vision in patients affected by blinding diseases such as age-related macu
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Anatomy and physiology of ageing 6: the eyes and ears

Anatomy and physiology of ageing 6: the eyes and ears | Macular Degeneration | Scoop.it
Normal age-related changes to the eyes and ears mean older people gradually see, hear and balance less well. Regular testing to detect common sight and hearing pathologies is essential
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Study Finds 25% of Patients with AMD Remain Undiagnosed After Dilated Eye Exam

Study Finds 25% of Patients with AMD Remain Undiagnosed After Dilated Eye Exam | Macular Degeneration | Scoop.it
Of those undiagnosed, 30% had large drusen at the time.
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