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Rescooped by YK Ma from Complex Insight - Understanding our world
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Genomics: ENCODE explained : Nature : Nature Publishing Group

Genomics: ENCODE explained : Nature : Nature Publishing Group | Life Code | Scoop.it
The Encyclopedia of DNA Elements (ENCODE) project dishes up a hearty banquet of data that illuminate the roles of the functional elements of the human genome.

Via Gerd Moe-Behrens, Phillip Trotter
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Rescooped by YK Ma from Complex Insight - Understanding our world
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Cell - A Whole-Cell Computational Model Predicts Phenotype from Genotype

Cell - A Whole-Cell Computational Model Predicts Phenotype from Genotype | Life Code | Scoop.it

More on the Stanford teams success on creating a whole cell computational model predicting phenotype from genotype. Understanding how complex phenotypes arise from individual molecules and their interactions is a primary challenge in biology that computational approaches are poised to tackle. The Stanford team's publication describes a cell computational model of the life cycle of the human pathogen Mycoplasma genitalium that includes all of its molecular components and their interactions.  Using an integrative approach to modeling that combines diverse mathematics enabled the simultaneous inclusion of fundamentally different cellular processes and experimental measurements.  The whole-cell model accounts for all annotated gene functions and was validated against a broad range of data. The model provides insights into many previously unobserved cellular behaviors, including in vivo rates of protein-DNA association and an inverse relationship between the durations of DNA replication initiation and replication. In addition, experimental analysis directed by model predictions identified previously undetected kinetic parameters and biological functions. The team conclude that comprehensive whole-cell models can be used to facilitate biological discovery.


Via Phillip Trotter
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