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Rescooped by Alejandra garcia 11 from QUIMICA
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Quimica2santillana


Via HCASALLAS
Alejandra garcia 11's insight:

Quimica

 

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HCASALLAS's curator insight, February 18, 2014 10:15 PM

Este es uno de los textos guia para el desarrollo de la química orgánica

Rescooped by Alejandra garcia 11 from QUIMICA
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libro de quimica

para el aprendizaje de quimica, conceptos basicos

Via HCASALLAS
Alejandra garcia 11's insight:

Exelente libro :)

 

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HCASALLAS's curator insight, September 29, 2013 10:53 PM

Texto guía y de apoyo para comprensión de conceptos

Rescooped by Alejandra garcia 11 from Viruses, Immunology & Bioinformatics from Virology.uvic.ca
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HIV: Antibodies advance the search for a cure

Efforts to make a prophylactic HIV vaccine have identified monoclonal antibodies that potently suppress viral replication. Studies in monkeys show that these reagents effectively treat HIV infection.

 

A major breakthrough from the HIV-vaccine research community in recent years was the isolation and characterization of novel antibodies from HIV-infected people that have the remarkable ability to efficiently neutralize most circulating HIV strains1, 2. The antibodies' mechanism of action involves the recognition and blockade of evolutionarily conserved, functionally crucial structures of the HIV viral envelope. These unusual antibodies have reinvigorated the effort to develop an antibody-based prophylactic HIV vaccine by defining effective human antibody responses to the virus and providing a 'map' for reverse engineering of vaccines that recapitulate these responses. Because these antibodies develop infrequently, emerge only after many years of HIV infection and are characterized by a high degree of mutation1, 2, this task is not likely to be quickly accomplished. But that does not necessarily mean that the clinical benefit of these antibodies is relegated to the distant future. On the contrary, two reports published on Nature's website today, by Barouch et al.3 and Shingai et al.4, demonstrate that combinations of such antibodies drastically reduce virus levels in chronically infected rhesus macaques, bolstering the hope that such therapies might be effective in humans.


Via Torben Barsballe
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Gitaga Jeremiah's curator insight, November 7, 2013 11:21 PM
Studying the molecular binding of a couple of those antibodies will be key to understanding the involved mechanism and develop models that will enable us come up with a more specific cure. Using software such as Molecular Operating Environment (MOE) can give us a better insight into this.