Just a PHAGE
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Rescooped by Karen Soucie from Aquatic Viruses
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Diversity of Virophages in Metagenomic Data Sets

Diversity of Virophages in Metagenomic Data Sets | Just a PHAGE | Scoop.it

Virophages, e.g., Sputnik, Mavirus, and Organic Lake virophage (OLV), are unusual parasites of giant double-stranded DNA (dsDNA) viruses, yet little is known about their diversity. Here, we describe the global distribution, abundance, and genetic diversity of virophages based on analyzing and mapping comprehensive metagenomic databases. The results reveal a distinct abundance and worldwide distribution of virophages, involving almost all geographical zones and a variety of unique environments. These environments ranged from deep ocean to inland, iced to hydrothermal lakes, and human gut- to animal-associated habitats.

 

Image from ViralZone, http://viralzone.expasy.org/all_by_species/670.html


Via Ed Rybicki
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Ed Rybicki's curator insight, March 26, 2013 4:33 AM

So, as one might expect, "virophages" (or big satellite viruses) are everywhere...we shall be looking for them in our Oceanic Viromics study soon!

Karen Soucie's comment, June 25, 2013 10:29 PM
I believe I traced my ancestors to a bump on a log in a hole in the bottom of the sea. ;) Great scoop! If you come across Chi phage send her over!
Ed Rybicki's comment, June 28, 2013 5:37 AM
We all come from the sea...B-) And sure: we will be sharing data.
Rescooped by Karen Soucie from Viruses, Immunology & Bioinformatics from Virology.uvic.ca
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What is needed for phage therapy to become a reality in Western medicine?

What is needed for phage therapy to become a reality in Western medicine? | Just a PHAGE | Scoop.it

The current status of phage therapy approaches is reviewed and possible hurdles to a practical medical application of bacteriophages in Western countries are identified as discussed at a recent EMBO meeting on “Viruses of Microbes” in Brussels. In view of the growing antibiotic resistance crisis, a coordinated effort by the public health sector is needed to evaluate the potential of phage therapy as an adjunct to antibiotics.

 T4 coliphage picture by Russell Kightley Media


Via Ed Rybicki, Chris Upton + helpers
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Ed Rybicki's curator insight, May 29, 2013 10:45 AM

 

 I missed this first time around - but it is one of the most-downloaded papers from Virology, so probably well worth a read.Or getting into the field...?
Rescooped by Karen Soucie from Natural Products Chemistry Breaking News
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Inducers of Hypoxic Response: Marine Sesquiterpene Quinones Activate HIF-1

Inducers of Hypoxic Response: Marine Sesquiterpene Quinones Activate HIF-1 | Just a PHAGE | Scoop.it

The hypoxia-inducible factor-1 (HIF-1) transcription factor regulates cellular oxygen homeostasis. Agents that activate HIF-1 and downstream HIF targets represent potential drug leads for the prevention and/or treatment of ischemic disorders. In a search for small-molecule HIF-1 activators, 1936 marine invertebrate and algal extract samples (U.S. National Cancer Institute’s Open Repository) were evaluated for HIF-1 activation activity in a cell-based reporter assay. Bioassay-guided fractionation of two active extracts of the sponge Dactylospongia elegans afforded four new sesquiterpene quinones (2–5), one new sesquiterpene phenol (6), the known Golgi disruptor ilimaquinone (1), and three previously reported ilimaquinone analogues (7–9). While antiproliferative activity was observed at higher concentrations, the sesquiterpene quinones (1–3) possessing a 2-hydroxy-5-methoxy-1,4-benzoquinone moiety activated HIF-1 and increased the expression of HIF-1 target gene vascular endothelial growth factor (VEGF) in T47D cells.

 

Lin Du†, Yu-Dong Zhou*†, and Dale G. Nagle

J. Nat. Prod., Article ASAP

DOI: 10.1021/np400320r

Publication Date (Web): June 3, 2013


Via NatProdChem
Karen Soucie's insight:

Golgi disruptor ilimaquinone

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Scooped by Karen Soucie
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New immune system discovered

New immune system discovered | Just a PHAGE | Scoop.it
(Medical Xpress)—A research team, led by Jeremy Barr, a biology post-doctoral fellow, unveils a new immune system that protects humans and animals from infection.
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