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Heated chemotherapy may be viable treatment for ovarian cancer - CBS News

Heated chemotherapy may be viable treatment for ovarian cancer - CBS News | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Heated chemotherapy may be viable treatment for ovarian cancer
CBS News
Doctors say a promising treatment that delivers heated chemotherapy to ovarian cancer patients may be a better way to treat the disease.
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Innovative Israeli Cancer Treatment To Be Tested in Japan - Al-Monitor

Innovative Israeli Cancer Treatment To Be Tested in Japan - Al-Monitor | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
The Japan Daily Press
Innovative Israeli Cancer Treatment To Be Tested in Japan
Al-Monitor
Israeli company IceCure Medical Inc., which is active in the market of medical instrumentation for women's health care, announced today [Sept.
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Breast cancer research highlights gaps - Medical Xpress

Breast cancer research highlights gaps - Medical Xpress | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
The Guardian Breast cancer research highlights gaps Medical Xpress The Gap Analysis 2013 is the most comprehensive review of breast cancer research to have ever taken place and provides us with what we need to know and what we need to do to...
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Few Oncologists Monitor Lab Quality - Clinical Oncology News

Few Oncologists Monitor Lab Quality - Clinical Oncology News | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Few Oncologists Monitor Lab Quality Clinical Oncology News “With the ever-increasing role of biomarkers in cancer care, oncologists' awareness of biomarker testing performance and participation in decision making related to biomarkers are becoming...
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Biomarkers Market Worth $25.79 Billion by 2016 – New Report by MarketsandMarkets

(PRWEB) September 21, 2013 The report “Biomarkers Market (Discovery Technologies, Applications & Indications) – Global Trends, Opportunities & Forecasts (2011 – 2020)”, as the name suggests, analyzes and studies the major market drivers,...
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A New Diagnostic Test for Endometrial Cancer?: Cytology Anal... : International Journal of Gynecological Cancer

A New Diagnostic Test for Endometrial Cancer?: Cytology Anal... : International Journal of Gynecological Cancer | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Objective: During saline-infused sonohysterography (SIS), the distension fluid is typically discarded. If cytology analysis could identify those patients with endometrial cancer, many women would be spared from further procedures.
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FDA: Roche drug works in early-stage breast cancer

FDA: Roche drug works in early-stage breast cancer | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
WASHINGTON (AP) — The Food and Drug Administration has issued a positive review of a breast cancer drug from Roche that could soon become the first (FDA recommends accelerating approval of Roche breast cancer drug, could become 1st drug to treat disease...
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Merck, AstraZeneca reach deal on cancer treatment - NorthJersey.com

Merck, AstraZeneca reach deal on cancer treatment - NorthJersey.com | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
NorthJersey.com
Merck, AstraZeneca reach deal on cancer treatment
NorthJersey.com
WHITEHOUSE STATION, N.J. - AstraZeneca PLC will take over clinical development of a potential ovarian cancer treatment from Merck & Co.
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Oncodesign, Banook Central Imaging To Develop Cancer Biomarkers - News-Medical.net

Oncodesign, Banook Central Imaging To Develop Cancer Biomarkers - News-Medical.net | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Oncodesign, Banook Central Imaging To Develop Cancer Biomarkers News-Medical.net Oncodesign is teaming up with Banook Central Imaging, which specializes in the centralized reading of medical images, with the goal of expanding the use of new...
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Personalized Treatment For Ovarian Cancer Has Positive Results - CBS Local

Personalized Treatment For Ovarian Cancer Has Positive Results - CBS Local | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Personalized Treatment For Ovarian Cancer Has Positive Results
CBS Local
“I had bloating, I had gas, I had bowel problems, didn't have much of an appetite,” she said. Then, she noticed extreme fatigue.
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Cabozantinib-S-Malate in Treating Patients With Recurrent or Metastatic Endometrial Cancer

This phase II trial studies how well giving cabozantinib-s-malate works in treating patients with recurrent or metastatic endometrial cancer...
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Long-term use of calcium-channel blockers may raise breast cancer risk - Healio

Long-term use of calcium-channel blockers may raise breast cancer risk - Healio | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Long-term use of calcium-channel blockers may raise breast cancer risk Healio Use of calcium-channel blockers for 10 years or more was associated with higher risk for ductal breast cancer and lobular breast cancer, according to findings from a...
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Endometrial Polyps in Women Affected by Levothyroxine-Treated ...

Endometrial Polyps in Women Affected by Levothyroxine-Treated ... | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
1Department of Women's and Children's Health, University of Padua, 35128 Padua, Italy 2Department of Medical Diagnostic and Special Therapy, University of Padua, 35128 Padua, Italy 3Ospedale San Bassiano, OB/GYN Unit, 36061 ...
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Biomarkers Market worth $40.8 Billion by 2018 | ASDReports

Biomarkers Market worth $40.8 Billion by 2018 | ASDReports | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
The new Biomarkers Market Research, analyzes and studies the major market drivers, restraints, and opportunities in North America, Europe, Asia-Pacifi (Biomarkers Market worth $40.8 Billion by 2018: The new Biomarkers Market Research, analyzes and...
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'Critical gaps' in breast cancer research - Medical Xpress

'Critical gaps' in breast cancer research - Medical Xpress | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Four States Homepage
'Critical gaps' in breast cancer research
Medical Xpress
'Critical gaps' in breast cancer research.
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Critical gaps discovered in breast cancer research - Science Daily (press release)

Critical gaps discovered in breast cancer research - Science Daily (press release) | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Critical gaps discovered in breast cancer research
Science Daily (press release)
Sep. 30, 2013 — Critical gaps have been identified in breast cancer research.
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Approval of breast cancer treatment triggers $5M payment to Immunogen - Boston Business Journal (blog)

Approval of breast cancer treatment triggers $5M payment to Immunogen - Boston Business Journal (blog) | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Examiner.com
Approval of breast cancer treatment triggers $5M payment to Immunogen
Boston Business Journal (blog)
The approval follows ImmunoGen's first approval from the U.S.
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Unusual combination therapy shows promise for preventing prostate cancer ... - Medical Xpress

Unusual combination therapy shows promise for preventing prostate cancer ... - Medical Xpress | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Unusual combination therapy shows promise for preventing prostate cancer ...
Medical Xpress
The National Cancer Institute-funded research will be published in the Oct. 1 issue of the journal Cancer Research.
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Three-gene biomarker can help determine treatment option for early prostate cancer

Three-gene biomarker can help determine treatment option for early prostate cancer | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
The level of expression of three genes associated with aging can be used to predict whether seemingly low-risk prostate cancer will remain slow-growing, according to researchers at the Herbert Irving Comprehensive Cancer Center at Columbia...
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Biomarker Predicts Long-Term Risk of Breast Cancer Recurrence - Science Daily (press release)

Biomarker Predicts Long-Term Risk of Breast Cancer Recurrence - Science Daily (press release) | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
DigitalJournal.com
Biomarker Predicts Long-Term Risk of Breast Cancer Recurrence
Science Daily (press release)
Sep.
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Correlation of molecular alterations with efficacy of everolimus in hormone-receptor–positive, HER2-negative advanced breast cancer: Results from BOLERO-2

Correlation of molecular alterations with efficacy of everolimus in hormone-receptor–positive, HER2-negative advanced breast cancer: Results from BOLERO-2 | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Abstract: 

 

Background: Everolimus (EVE) plus exemestane (EXE) more than doubled progression-free survival (PFS) while maintaining quality of life vs EXE alone in postmenopausal women with hormone receptor–positive (HR+), HER2-negative (HER2–) advanced breast cancer (BOLERO-2 phase III; NCT00863655). PFS benefit was seen in all clinically defined subgroups. We evaluated genetic variations of a broad panel of cancer-related genes and explored their correlations with EVE benefit. Methods: Exon sequence and gene copy number variations were analyzed in 182 cancer-related genes by next-generation sequencing (NGS). Correlations with PFS were evaluated using univariate and multivariate Cox models. Results: NGS data (>250x coverage) were successfully generated from archival tumor specimens from 227 patients (NGS population, 157 in EVE + EXE arm and 70 in EXE arm) whose baseline characteristics and clinical outcome were comparable to the trial population (PFS HR = 0.40 and 0.45, respectively). The treatment benefit of EVE + EXE over EXE was maintained in the subgroups defined by each of the 9 genes with a mutation rate >10% (e.g., PIK3CA, FGFR1, CCND1) or when less frequently mutated genes (e.g., PTEN, AKT1) were included in their respective pathways. Patients with 0 or 1 genetic alteration in PI3K or FGFR pathways or CCND1 had a greater treatment effect from EVE (HR = 0.27, 95% CI 0.18-0.41, adjusted by covariates, in 76% of the NGS population), indicating the value of these pathways for predicting sensitivity to EVE in this setting.


Via Curated by A4BC.ORG
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Curated by A4BC.ORG's curator insight, September 9, 2013 6:47 PM

Conclusions: This is the first global registration trial in which efficacy-predictive biomarkers were explored by correlating broad genetic variations with clinical efficacy. The preliminary results suggest that a large subgroup of patients (76%), defined by minimal genetic variations in the PI3K or FGFR pathways or CCND1, derives the most benefit from EVE therapy (HR = 0.27 vs 0.40 for the full NGS population). These exploratory results and their implication in understanding the interplay of multiple pathways in tumor cells and testing new hypotheses for targeted combination therapies in HR+/HER2– BC will be further investigated.


From #BCS13

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ASCO: Few Women Accurately ID Their Breast Cancer Risk - Monthly Prescribing Reference

ASCO: Few Women Accurately ID Their Breast Cancer Risk - Monthly Prescribing Reference | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
The Guardian ASCO: Few Women Accurately ID Their Breast Cancer Risk Monthly Prescribing Reference (HealthDay News) – Most women overestimate or underestimate their risk of breast cancer, with fewer than one in 10 accurately estimating their risk,...
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New ovarian cancer gene found in mice

New ovarian cancer gene found in mice | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Mouse study finds if a DNA repair gene Helq is faulty, it raises the risk for ovarian cancer and other tumors, and suggests this may also be the case in humans.
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9th Annual Biomarkers Congress 2014, Manchester | 25–26 Feb 2014

250 delegates representing leading biotech companies, global pharma organisations and internationally renowned academic institutions 55...
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Scientists find new gene linked to ovarian cancer - Cancer Research UK - Cancer Research and Relief Foundation

Scientists find new gene linked to ovarian cancer - Cancer Research UK - Cancer Research and Relief Foundation | Invivis Pharmaceuticals : Innovative drugs to improve cancer treatments | Scoop.it
Scientists find new gene linked to ovarian cancer - Cancer Research UK » Cancer Research and Relief Foundation | Working to Save Lives (Scientists find new gene linked to ovarian cancer – Cancer Research UK: Tweet Scientists find new gene...
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