gut CD4 T cells can switch to CD8 cytotoxic. Nat Immunol 20 january 2013 | Immunology for University Students |

CD4+ and CD8+ T cells are considered distinct functional lymphocyte subsets. Cheroutre and Mucida and their colleagues show that mature gut-associated CD4+ T cells lose ThPOK expression and reactivate CD8 cytolytic effector programs.