Immunology, vaccine & infectious diseases
12.4K views | +2 today
Follow
Immunology, vaccine & infectious diseases
Your new post is loading...
Your new post is loading...
Scooped by Denis Hudrisier
Scoop.it!

Dr. Luis B. Barreiro - Genetic and epigenetic determinants of inter-individual variation in immune response to bacterial infections | IPBS

Dr. Luis B. Barreiro - Genetic and epigenetic determinants of inter-individual variation in immune response to bacterial infections | IPBS | Immunology, vaccine & infectious diseases | Scoop.it
Denis Hudrisier's insight:
Top notch seminar at IPBS coming soon!
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe

Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe | Immunology, vaccine & infectious diseases | Scoop.it
Tuberculosis (TB) is the leading infectious killer worldwide. The prevalence of drug- and multidrug-resistant Mycobacterium tuberculosis necessitates more rapid and specific diagnostics. Kamariza et al . designed a color-changing dye based on trehalose, a sugar that makes up the outer membrane of M. tuberculosis . The dye stained live bacteria within minutes, emitting fluorescence upon incorporation into the hydrophobic mycobacterial membrane. Heat-inactivated bacteria did not fluoresce, and drug-treated bacteria emitted reduced fluorescence. Fluorescence intensity was similar between trehalose analog– and Auramine O–stained human sputum samples from patients with TB. This trehalose-based dye does not require sample washing and emits minimal background fluorescence, which could make it particularly useful for the rapid detection of metabolically active M. tuberculosis in resource-limited environments.
Denis Hudrisier's insight:
Carolyn Bertozzi strikes again and offers now a metabolic probe to identiify and stain mycobacteria: it is metabolized then incorporated into the mycocmembrane where the hydrophobic environment confers on it a strong fluorescence intensity
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Les facteurs qui affectent le plus notre système immunitaire - L'actu de l'

Les facteurs qui affectent le plus notre système immunitaire - L'actu de l' | Immunology, vaccine & infectious diseases | Scoop.it
Les facteurs qui affectent le plus notre système immunitaire. Retrouvez toute l'actualité et les projets de l'Institut Pasteur sur son site.
Denis Hudrisier's insight:
Age, sex, genetics: those parameters that critically affect our immune system
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

How Can Systems Biology Test Principles and Tools Using Immune Cells as a Model?

How Can Systems Biology Test Principles and Tools Using Immune Cells as a Model? | Immunology, vaccine & infectious diseases | Scoop.it
The field of systems immunology has grown extensively over the last few years, spurred
by the generation of large datasets, new analytical tools, and modeling approaches.
In this piece and its counterpart in Trends in Immunology [http://www.cell.com/trends/immunology/fulltext/S1471-4906(18)30013-9],
eight authors discuss what immunologists can learn from systems biology and, conversely,
how systems biologists can use immune cells as a model and outline the many directions
this interdisciplinary field can expand in.
Denis Hudrisier's insight:
Nine scientists give their view on the potential of System Immunology
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets

Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets | Immunology, vaccine & infectious diseases | Scoop.it
Naive CD4+ T cells differentiate into specific effector subsets—Th1, Th2, Th17, and T follicular helper (Tfh)—that provide immunity against pathogen infection. The signaling pathways involved in generating these effector cells are partially known. However, the effects of mutations underlying human primary immunodeficiencies on these processes, and how they compromise specific immune responses, remain unresolved. By studying individuals with mutations in key signaling pathways, we identified nonredundant pathways regulating human CD4+ T cell differentiation in vitro. IL12Rβ1/TYK2 and IFN-γR/STAT1 function in a feed-forward loop to induce Th1 cells, whereas IL-21/IL-21R/STAT3 signaling is required for Th17, Tfh, and IL-10–secreting cells. IL12Rβ1/TYK2 and NEMO are also required for Th17 induction. Strikingly, gain-of-function STAT1 mutations recapitulated the impact of dominant-negative STAT3 mutations on Tfh and Th17 cells, revealing a putative inhibitory effect of hypermorphic STAT1 over STAT3. These findings provide mechanistic insight into the requirements for human T cell effector function, and explain clinical manifestations of these immunodeficient conditions. Furthermore, they identify molecules that could be targeted to modulate CD4+ T cell effector function in the settings of infection, vaccination, or immune dysregulation.
Denis Hudrisier's insight:
Understanding CD4 T cell differentiation through thr prism of primary immunodeficiencies
more...
Gilbert C FAURE's curator insight, February 28, 4:50 AM
signaling pathways coming of interest in T cells functions
Scooped by Denis Hudrisier
Scoop.it!

New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity

New Tuberculosis Vaccine Strategies: Taking Aim at Un-Natural Immunity | Immunology, vaccine & infectious diseases | Scoop.it
Despite some major progress made in developing tuberculosis (TB) vaccine strategies,
with a dozen novel vaccines currently in the clinical pipeline, the world is still
missing an effective TB vaccine. This questions whether any major breakthroughs can
be achieved without making a drastic departure from the current strategy, which creates
a state of ‘near-natural immunity’, imitating the natural immunity developed after
Mycobacterium tuberculosis (Mtb) infection. Here, we argue instead that mounting evidence
suggests an effective strategy ought to induce a state of all-around ‘un-natural’
immunity comprising trained innate immunity (TII), tissue-resident memory T cells
(TRM), and anti-Mtb surface antibodies in the lung.
Denis Hudrisier's insight:
A review on anti-tuberculosis vaccine
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity

Rapid activation of tumor-associated macrophages boosts preexisting tumor immunity | Immunology, vaccine & infectious diseases | Scoop.it
![Figure][1]



Depletion of immunosuppressive tumor-associated macrophages (TAMs) or reprogramming toward a proinflammatory activation state represent different strategies to therapeutically target this abundant myeloid population. In this study, we report that inhibition of colony-stimulating factor-1 receptor (CSF-1R) signaling sensitizes TAMs to profound and rapid reprogramming in the presence of a CD40 agonist before their depletion. Despite the short-lived nature of macrophage hyperactivation, combined CSF-1R+CD40 stimulation of macrophages is sufficient to create a proinflammatory tumor milieu that reinvigorates an effective T cell response in transplanted tumors that are either responsive or insensitive to immune checkpoint blockade. The central role of macrophages in regulating preexisting immunity is substantiated by depletion experiments, transcriptome analysis of ex vivo sorted TAMs, and gene expression profiling of whole tumor lysates at an early treatment time point. This approach enabled the identification of specific combination-induced changes among the pleiotropic activation spectrum of the CD40 agonist. In patients, CD40 expression on human TAMs was detected in mesothelioma and colorectal adenocarcinoma.

[1]: pending:yes
Denis Hudrisier's insight:
Converting tumor-associated mecrophages (detrimental) inot favourable ones through antibody treatment
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Causal effects of the microbiota on immune-mediated diseases

Causal effects of the microbiota on immune-mediated diseases | Immunology, vaccine & infectious diseases | Scoop.it
The mammalian immune system has evolved in the presence of a complex community of indigenous microorganisms that constitutively colonize all barrier surfaces. This intimate relationship has resulted in the development of a vast array of reciprocal interactions between the microbiota and the host immune system, particularly in the intestine, where the density and diversity of indigenous microbes are greatest. Alterations in the gut microbiota have been correlated with almost every known immunological disease, but in most cases, it remains unclear whether these changes are a cause or effect of the disease or merely a reflection of epidemiological differences between groups. Here, we review recent efforts to demonstrate a causal role for the microbiota in health and disease, outline experimental advances that have made these studies possible, and highlight how changes in microbial composition may influence immune system function.
Denis Hudrisier's insight:
How does microbiota influence our immune system?
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair

Microbiota induce a form of adaptive immunity that couples antimicrobial function
with tissue repair.
Denis Hudrisier's insight:
Combined anti-microbial and tissue protective response elicited by microbiota through T cells restricted to non-classical MHC class I molecules
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis - ScienceDirect

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis - ScienceDirect | Immunology, vaccine & infectious diseases | Scoop.it
Denis Hudrisier's insight:
A stimulating and beautiful work on how BCG acts on innate immunity to afford protection against tuberculosis
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Intrinsic Immunity Shapes Viral Resistance of Stem Cells

Intrinsic expression of interferon-stimulated genes makes stem cells resistant to
infections, preserving their pool throughout the organism’s lifespan.
Denis Hudrisier's insight:
Stem cells: protected from viral infections through constitute expression ot interferons
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Kiss-and-tell way to track cell contacts

Kiss-and-tell way to track cell contacts | Immunology, vaccine & infectious diseases | Scoop.it
Transient cellular contacts are essential for the generation of an immune response, but these are difficult to measure in vivo. A labelling technique now offers a way to record such interactions between cells.
Denis Hudrisier's insight:
Very nice technique to detect transient cellular contacts between immune cells. This looks like a reproduction of the trogocytosis process, which occurs in vivo!
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

JEM | The Journal of Experimental Medicine

JEM | The Journal of Experimental Medicine | Immunology, vaccine & infectious diseases | Scoop.it
Denis Hudrisier's insight:
JEM advertises its best papers for 2017
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Pasteur

Visite de l'exposition consacrée à Pasteur au Palais de la Découverte (Paris, mars 2018)
Denis Hudrisier's insight:
Une petite visite de l'expo Pasteur au Palais de la Découverte à Paris pour ceux qui ne peuvent pas y aller
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism | Immunology, vaccine & infectious diseases | Scoop.it
T cells are a central component of defenses against pathogens and tumors. Their effector
functions are sustained by specific metabolic changes that occur upon activation,
and these have been the focus of renewed interest. Energy production inevitably generates
unwanted products, namely reactive oxygen species (ROS), which have long been known
to trigger cell death. However, there is now evidence that ROS also act as intracellular
signaling molecules both in steady-state and upon antigen recognition.
Denis Hudrisier's insight:
ROS: not solely weapons  but also signalling molecules
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex

Reciprocal TCR-CD3 and CD4 Engagement of a Nucleating pMHCII Stabilizes a Functional Receptor Macrocomplex | Immunology, vaccine & infectious diseases | Scoop.it
Glassman, Parrish et al. use functional and biophysical assays to demonstrate that
CD4 stabilizes TCR-pMHCII interactions via membrane distal and proximal domains. The
data indicate that CD4 docks along a composite surface created by the TCR-CD3-pMHCII
axis to confer a uniform macrocomplex architecture upon a diverse TCR repertoire.
Denis Hudrisier's insight:
More insights into the TCR-MHC-CD4 interaction
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection

Fat Body Cells Are Motile and Actively Migrate to Wounds to Drive Repair and Prevent Infection | Immunology, vaccine & infectious diseases | Scoop.it
Adipocytes and their fly equivalent, fat body cells, have been considered immotile,
but Franz et al. now show the latter can actively migrate to wounds using a peristaltic-like
“swimming” motility. Once there, they multitask to clear wound cell debris, plug the
epithelial gap, and upregulate AMPs to prevent infection.
Denis Hudrisier's insight:
A contribution of adipocytes to antimicrobial function wound healing and tissue repair
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors

Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors | Immunology, vaccine & infectious diseases | Scoop.it
Resource
Denis Hudrisier's insight:
Le milieu interieur: featuring key parameters of our immune system at steady state through large genome and phenotypic analysis of immune cells
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes

Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes | Immunology, vaccine & infectious diseases | Scoop.it
The assembly of the NLRP3 inflammasome can promote the release of IL-1β/IL-18 and
initiate pyroptosis. Accordingly, the dysregulation of NLRP3 inflammasome activation
is involved in a variety of human diseases, including gout, diabetes, and Alzheimer’s
disease. NLRP3 can sense a variety of structurally unrelated pathogen-associated molecular
patterns (PAMPs) or danger-associated molecular patterns (DAMPs) to trigger inflammation,
but the unifying mechanism of NLRP3 activation is still poorly understood.
Denis Hudrisier's insight:
NLRP3 inflammasome: coupling pathogen or danger detection to  the production of mature pro-inflammatory cytokines
more...
ScientificAnimations's comment, February 20, 7:59 AM
Infectious Disease Deaths in US: What’s changed in 100 Years? - http://sco.lt/4wlk0H
Scooped by Denis Hudrisier
Scoop.it!

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism

Reactive Oxygen Species: Involvement in T Cell Signaling and Metabolism | Immunology, vaccine & infectious diseases | Scoop.it
T cells are a central component of defenses against pathogens and tumors. Their effector
functions are sustained by specific metabolic changes that occur upon activation,
and these have been the focus of renewed interest. Energy production inevitably generates
unwanted products, namely reactive oxygen species (ROS), which have long been known
to trigger cell death. However, there is now evidence that ROS also act as intracellular
signaling molecules both in steady-state and upon antigen recognition.
Denis Hudrisier's insight:
The multiple functions of reactive oxygen species
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Breaching Self-Tolerance to Alu Duplex RNA Underlies MDA5-Mediated Inflammation

Constitutive activation of the viral RNA sensor MDA5 in the auto-inflammatory disorder
Aicardi-Goutières syndrome (AGS) results from loss of tolerance to endogenous Alu
retroelement transcripts.
Denis Hudrisier's insight:
Aberrant recognition of Alu retroelements by the viral RNA sensor MDA5 implicated in auto-inflammatory disorders
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Une stratégie vaccinale contre les douleurs inflammatoires

Une stratégie vaccinale contre les douleurs inflammatoires | Immunology, vaccine & infectious diseases | Scoop.it
Des chercheurs Inserm viennent de montrer qu’il est possible de réduire des douleurs inflammatoires intestinales chez des souri
Denis Hudrisier's insight:
A new domain of application for vaccines?
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine

Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine | Immunology, vaccine & infectious diseases | Scoop.it
Article
Denis Hudrisier's insight:
The best candidate to replace BCG as an anti-tuberculosis vaccine?
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

Engineered Sialylation of Pathogenic Antibodies In Vivo Attenuates Autoimmune Disease

Endogenous pathogenic antibodies can be enzymatically converted into anti-inflammatory
mediators in inflamed tissues, revealing a new strategy to treat autoimmune diseases.
Denis Hudrisier's insight:
Manipulating antibody glycosylation to reduce inflammation
more...
No comment yet.
Scooped by Denis Hudrisier
Scoop.it!

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A

MAIT cell clonal expansion and TCR repertoire shaping in human volunteers challenged with Salmonella Paratyphi A | Immunology, vaccine & infectious diseases | Scoop.it
Article
Denis Hudrisier's insight:
MAIT cell expand, increase their affinity and contract upon bacterial infection: new targets for vaccine strategies?
more...
No comment yet.