Immunology
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Innate and Adaptive Immune Functions of Peyer’s Patch Monocyte-Derived Cells: Cell Reports

Innate and Adaptive Immune Functions of Peyer’s Patch Monocyte-Derived Cells: Cell Reports | Immunology | Scoop.it
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Rescooped by Piet Van de Steen from Immunology, vaccine & infectious diseases
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Toll-Like Receptor Activation in Immunity vs. Tolerance

Christophe M Filippi

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Frontiers | Vitamin D Actions on CD4+ T Cells in Autoimmune Disease | T Cell Biology

This review summarizes and integrates research on vitamin D and CD4+ T lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. Evidence for CD4+ T cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4+ T lymphocytes is summarized to support the thesis that calcitriol is sunlight’s main protective signal transducer in autoimmune disease risk. Animal modeling and human mechanistic data to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3+CD4+ Treg cell and CD4+ Tr1 cell functions, and a Th1-Tr1 switch. The proposed Th1-Tr1 switch appears to bridge two stable, self-reinforcing immune states, pro- and anti-inflammatory, each with a characteristic gene regulatory network. The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell-cell interactions, and soluble mediators and respond in a biologically appropriate manner. Finally, we highlight unanswered questions that potentially informative future research directions that may speed delivery of etiology-based strategies to reduce autoimmune disease.
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Rescooped by Piet Van de Steen from Allergy (and clinical immunology)
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Infant gut bacteria and food sensitization: Associations in the first year of life

Infant gut bacteria and food sensitization: Associations in the first year of life | Immunology | Scoop.it
New light has been shed on changes in intestinal bacteria of infants that can predict future development of food allergies or asthma.

Via Gilbert C FAURE
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Rescooped by Piet Van de Steen from History of Immunology
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A brief history of T cell help to B cells : Nature Reviews Immunology : Nature Publishing Group

A brief history of T cell help to B cells : Nature Reviews Immunology : Nature Publishing Group | Immunology | Scoop.it
A brief history of T cell help to B cells : Nature Reviews Immunology : Nature Publishing Group http://t.co/LPfNLIubWq #immunology

Via Gilbert C FAURE
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What Does Your Gut Microbiome Have To Do With Your Immune System?

What Does Your Gut Microbiome Have To Do With Your Immune System? | Immunology | Scoop.it
RT @TweetImmune: What Does Your Gut #Microbiome Have To Do With Your Immune System? http://t.co/bvKdovX7f1 #immunology

Via Denis Hudrisier
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Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum -- Mann et al. -- Gut

Compartment-specific immunity in the human gut: properties and functions of dendritic cells in the colon versus the ileum -- Mann et al. -- Gut | Immunology | Scoop.it
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The colon and the ileum contain denditric cells with distinct roles in mucosal immunity.

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Environment, not genes, plays starring role in human immune variation, study finds

Environment, not genes, plays starring role in human immune variation, study finds | Immunology | Scoop.it
Improving gene-sequencing technologies have focused immunologists’ attention on the role of genes in diseases. But it appears the environment is an even greater factor in the human immune response.
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Environment, Not Genes, Plays Starring Role in Human Immune Variation

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Rescooped by Piet Van de Steen from Immunology, vaccine & infectious diseases
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Scientists identify new and beneficial function of endogenous retroviruses in immune response

Scientists identify new and beneficial function of endogenous retroviruses in immune response | Immunology | Scoop.it
Retroviruses are best known for causing contagious scourges such as AIDS, or more sporadically, cancer.

Via Denis Hudrisier
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Simultaneous treatment for several food allergies passes safety hurdle, Stanford team shows

Simultaneous treatment for several food allergies passes safety hurdle, Stanford team shows | Immunology | Scoop.it
Living with one food allergy is a challenge; living with more than one can make ordinary activities such as eating at a restaurant feel downright
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Insulin‐like growth factor‐1 stimulates regulatory T cells and suppresses autoimmune disease

Insulin‐like growth factor‐1 stimulates regulatory T cells and suppresses autoimmune disease | Immunology | Scoop.it
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CD8αα+ Innate-Type Lymphocytes in the Intestinal Epithelium Mediate Mucosal Immunity: Immunity

CD8αα+ Innate-Type Lymphocytes in the Intestinal Epithelium Mediate Mucosal Immunity: Immunity | Immunology | Scoop.it
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Rescooped by Piet Van de Steen from Cancer Immunotherapy Review
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Immune-mediated mechanisms influencing the efficacy of anticancer therapies: Trends in Immunology

Immune-mediated mechanisms influencing the efficacy of anticancer therapies: Trends in Immunology | Immunology | Scoop.it

Highlights

 

•Anticancer therapies alter the composition, phenotype, and function of immune cells.•The immune system is a major regulator of the success of anticancer therapy.•Immunotherapy and immunomodulatory agents often synergize with conventional therapies.•Resistance mechanisms following immunotherapy and immunodulatory agents are not fully defined.•Targeting both cancer cells and immune cells may be the key to fight metastasis.

 

Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off-target effects within the host immune system. Cytotoxic treatment regimens elicit several changes in immune-related parameters including the composition, phenotype, and function of immune cells. Here we discuss the impact of innate and adaptive immune cells on the success of anticancer therapy. In this context we examine the opportunities to exploit host immune responses to boost tumor clearing, and highlight the challenges facing the treatment of advanced metastatic disease.


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Krishan Maggon 's curator insight, April 12, 2015 2:48 AM

Trends in Immunology

Volume 36, Issue 4, p198–216, April 2015Feature Review Immune-mediated mechanisms influencing the efficacy of anticancer therapiesSeth B. Coffelt, Karin E. de VisserDivision of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands DOI: http://dx.doi.org/10.1016/j.it.2015.02.006
Rescooped by Piet Van de Steen from Immunology and Biotherapies
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New sensor of bacterial DNA - Nature.com

Nature.com
New sensor of bacterial DNA
Nature.com
The transcription factor SOX2 is known for its role in the maintenance of embryonic and neural stem cells. Now, reporting in Nature Immunology, Xia et al.

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Gilbert C FAURE's curator insight, March 29, 2015 2:11 PM

The transcription factor SOX2 is known for its role in the maintenance of embryonic and neural stem cells. Now, reporting in Nature Immunology, Xia et al. show that SOX2 is also expressed by neutrophils, where it functions as a sensor of cytosolic bacterial DNA.

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Northeastern researchers find inhaling supplemental oxygen can awaken anti-tumor cells

Northeastern researchers find inhaling supplemental oxygen can awaken anti-tumor cells | Immunology | Scoop.it
Immunophysiology researcher Michail Sitkovsky and his colleagues have found that supplemental oxygenation could dramatically increase the survival rate of patients with cancer. The breakthrough fin...
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Inhaling supplemental oxygen can revive anti-tumor cells

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Rescooped by Piet Van de Steen from History of Immunology
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The early history of B cells : Nature Reviews Immunology : Nature Publishing Group

The early history of B cells : Nature Reviews Immunology : Nature Publishing Group | Immunology | Scoop.it
RT @ramos_casals: Good review
The early history of B cells : Nature Reviews Immunology : Nature Publishing Group http://t.co/nuQyy7ReGc

Via Gilbert C FAURE
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Breastfeeding, Other Factors Help Shape Immune System Early in Life Detroit, Michigan (MI) - Henry Ford Hospital

Breastfeeding, Other Factors Help Shape Immune System Early in Life Detroit, Michigan (MI) - Henry Ford Hospital | Immunology | Scoop.it
The latest news on Henry Ford Health System and the care providers who make it one of the nation's leading academic medical institutions.
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Rescooped by Piet Van de Steen from Immunology, vaccine & infectious diseases
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A Common Origin for Immunity and Digestion

Nichole A Broderick

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Access : FOXP3|[plus]| regulatory T cells and their functional regulation : Cellular & Molecular Immunology

Cellular and Molecular Immunology aims to report the dynamic progress being made in China and abroad in immunological research, and welcomes high-quality Research Articles, Reviews and Brief Reports across a broad range of topics including, but not limited to, clinical immunology, comparative immunology, immunobiology, immunogenetics, immunological techniques, immunopathology, immunopharmacology, infection immunology, neuroimmunology, transplantation immunology, tumor immunology, and veterinary immunology.
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Gilbert C FAURE's curator insight, March 25, 2015 3:42 AM
FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years. Here, we summarize these intriguing findings, and provide insight into their potential use or manipulation during Treg cell therapy for the treatment of autoimmune diseases, graft-versus-host disease (GVHD) and cancer.
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Oropharyngeal Colostrum Administration in Extremely Premature Infants: An RCT

Oropharyngeal Colostrum Administration in Extremely Premature Infants: An RCT | Immunology | Scoop.it
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Oropharyngeal colostrum may improve immune markers, reduce sepsis
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mTOR inhibition improves immune function in the elderly

mTOR inhibition improves immune function in the elderly
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mTOR inhibition may improve immune function in the elderly
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Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status : Nature Communications : Nature Publishing Group

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status : Nature Communications : Nature Publishing Group | Immunology | Scoop.it
Piet Van de Steen's insight:

First clues how our microbiota and immune system may influence obesity

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World Journal of Gastroenterology-Baishideng Publishing

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Many IBD patients don't get hepatitis B vaccine a US study finds
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King's College London - Newborns have stronger immunity than first thought

King's College London - Newborns have stronger immunity than first thought | Immunology | Scoop.it
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