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Continuous Chromatography for the Purification of Biomolecules

Continuous Chromatography for the Purification of Biomolecules | iBB | Scoop.it

Professor José Paulo Mota will be giving a talk at IST entitled "Continuous Chromatography for the Purification of Biomolecules" (see details in poster above).

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Expansion and Harvesting Of Human Induced Pluripotent Stem Cells on Dissolvable Microcarriers

Expansion and Harvesting Of Human Induced Pluripotent Stem Cells on Dissolvable Microcarriers | iBB | Scoop.it

Development of efficient bioprocesses for human induced pluripotent stem cells (hiPSC) is critical for their medical and biotechnological applications. Scalable expansion of hiPSC is often performed using polystyrene microcarriers, which have to be removed using a time-consuming separation step. At the Stem Cell Engineering Research Group, novel xeno-free dissolvable microcarriers were applied for the first time for the integrated expansion and harvesting of hiPSC. After expansion, microcarriers were dissolved inside the bioreactor, allowing the recovery of more than 90% of the cells, which represents a significantly higher cell yield when compared with microcarrier filtration (45%). These results represent a major improvement for the downstream processing of hiPSC. Find more on the paper on Biotechnology Journal.

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Following the Evolution Towards Fluconazole Resistance in C. glabrata

Following the Evolution Towards Fluconazole Resistance in C. glabrata | iBB | Scoop.it

The effectiveness of Candida glabrata as an emerging human pathogen relies on its ability to acquire azole drug resistance. In a paper just published in Antimicrobial Agents and Chemotherapy, the first time-course evaluation of the global gene expression changes that lead a drug susceptible C. glabrata clinical isolate to step-wise acquisition of resistance to azole drugs was conducted. This work, which results from the collaboration of six different teams under the coordination of Miguel C Teixeira from BSRG-iBB, highlights the multifactorial nature of azole resistance acquisition, including the Epa3 adhesin as a new player, while providing fascinating clues on the underlying evolutionary path. This knowledge is of crucial importance to design more effective antifungal therapy.

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Diogo Pinto Defends PhD Thesis in Bioengineering (MIT Portugal)

Diogo Pinto Defends PhD Thesis in Bioengineering (MIT Portugal) | iBB | Scoop.it

Diogo Pinto will be defending his PhD thesis in Bioengineering (MIT Portugal) at Instituto Superior Técnico, thursday the 15th November 2018 (10:30 H, room PA3). During the last years, and under the supervision of Cláudia Lobato Silva from SCERG-iBB and António Fiarresga from Hospital de Santa Marta, Diogo worked on the development of a mesenchymal stem/stromal cells product derived from the umbilical cord matrix with enhanced therapeutic features for myocardial regeneration. The title of his thesis is "Towards the Development of a Mesenchymal Stem/Stromal Cell Product with Enhanced Therapeutic Features for Myocardial Infarction”.

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The Various Roles of Fatty Acids

The Various Roles of Fatty Acids | iBB | Scoop.it

Lipids comprise a large group of chemically heterogeneous compounds that, in general, have in their structure fatty acids (FA). In a review paper published this week in the Special Issue of Molecules edited by both authors and entitled “The Multiple Roles of Fatty Acids”, Dr. Carla CCR de Carvalho (BERG-iBB) and Dr. Maria José Caramujo (CE3C, FCUL) discuss the various roles of FA in prokaryotes and eukaryotes and highlight the application of FA analysis to elucidate ecological mechanisms. The authors briefly describe FA synthesis; analyse the role of FA as modulators of cell membrane properties and FA ability to store and supply energy to cells; and inspect the role of polyunsaturated FA (PUFA) and the suitability of using FA as biomarkers of organisms.

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Diogo Silva Defends PhD Thesis in Bioengineering (Cell Therapies and Regenerative Medicine)

Diogo Silva Defends PhD Thesis in Bioengineering (Cell Therapies and Regenerative Medicine) | iBB | Scoop.it

Diogo Silva will be defending his PhD thesis in Bioengineering (Cell Therapies and Regenerative Medicine) at Instituto Superior Técnico, wednesday the 17th October 2018 (9:00 H, room 4.41). During the last years, and under the supervision of Joaquim Cabral from SCERG-iBB and Manuel Abecasis from IPO, Diogo developed new Chimeric Antigen Receptors (CARs) for various types of hematologic cancers and optimized existing CARs that are already in the clinic. The title of his thesis is "Engineering of T-Cells with Chimeric Antigen Receptors as a Therapy for Hematologic Cancers”.

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Fátima Pinto Defends PhD Thesis in Bioengineering

Fátima Pinto Defends PhD Thesis in Bioengineering | iBB | Scoop.it

Fátima Pinto will be defending her PhD thesis in Bioengineering at Instituto Superior Técnico, wednesday the 10th October 2018 (15:30 H, room PA3). During the last years, and under the supervision of Luís Fonseca and Dragana Barros from BERG-iBB, Fátima focused her attention on the development and characterization of biodegradable nanocarriers to be incorporated in pharmaceutical, nutraceutical or cosmeceutical formulations for the targeted release of bioactive substances. The title of her thesis is "Design and Characterization of Lipid Nanoparticles for an Effective Topical Administration of Active Compounds”.

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Regulation of Zygosaccharomyces bailii Early Response to Acetic Acid and Copper Stress

Regulation of Zygosaccharomyces bailii Early Response to Acetic Acid and Copper Stress | iBB | Scoop.it

The non-conventional food spoiling yeast species Zygosaccharomyces bailii is remarkably tolerant to acetic acid, a highly important microbial inhibitory compound in Food Industry and Biotechnology. The study recently published in Scientific Reports, coordinated by Isabel Sá-Correia and Margarida Palma and first authored by the BIOTECnico PhD student Miguel Antunes, investigates the genomic transcription changes occurring during the early response of Z. bailii to acetic acid or copper stresses and uncovers the regulatory network activated under the bifunctional transcriptional factor ZbHaa1 control. This study provides valuable insights regarding Z. bailii adaptation mechanisms to acetic acid or copper stresses, ZbHaa1-dependent regulatory network, and the evolution of transcription factors and regulatory networks in pre- whole genome duplication (WGD) and post-WGD yeast species.

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International Microorganism Day: Interactive Exhibition, Quiz, Short talks and Craft Beer at IST

International Microorganism Day: Interactive Exhibition, Quiz, Short talks and Craft Beer at IST | iBB | Scoop.it

The Portuguese Society of Microbiology (SPM) in collaboration with researchers from BSRG-iBB, celebrated the 2nd edition of the International Microorganism Day (IMD 2018) at Instituto Superior Técnico (IST). An interactive exhibition in the IST main building featured several national institutions  (Faculty of Sciences/cE3c, Faculty of Veterinary Medicine, IST-iBB of Universidade de Lisboa, The Institute for Hygiene and Tropical Medicine, Instituto de Tecnologia Química e Biológica, University of Évora/Hercules, University of Coimbra, and University of Minho/CBMA. In an entertaining and dynamic quiz organized by young researchers from iBB and graduate students from “Núcleos de Engenharia Biológica (NEB) e Engenharia Biomédica (NEBM) do IST”, the visitors could then test what they had learnt about microorganisms. At the end of an enriching day full of presentations and hands-on experiences, a tasty and refreshing craft beer locally produced by “Clube de Cervejeiros do IST” and the commercial "Cerveja D'Ourique" was waiting for thirsty (adult) visitors.

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"The Admirable World of Microbes": A Training Course for Secondary School Teachers

"The Admirable World of Microbes": A Training Course for Secondary School Teachers | iBB | Scoop.it

A training course for secondary school teachers entiled "The admirable world of Microbes: small in size, great in action" was carried out at Instituto Superior Técnico (IST) on the 17 and 22 september within the frame of the commemorations of the International Microorganism Day 2018. The course was accredited by the Training Center of the Ordem dos Biólogos (OB) and aimed at updating and reinforcing theoretical knowledge and practical skills in the area of Microbiology and Biotechnology. The 12-hour training included theoretical (4 hours), computational (2 hours) and laboratory (4 hours) modules as well as a roundtable discussion (2 hours). The course was organized and taught by Arsénio Fialho, Cristina Viegas and Leonilde Moreira from the Bioengineering Department of IST and BSRG-iBB. It was attended by 22 teachers from schools all over the country. The initiative was supported by the Portuguese Society of Microbiology (SPM), OB and IST.

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ESBES 2018: Lisbon at the Forefront of Biochemical Engineering

ESBES 2018: Lisbon at the Forefront of Biochemical Engineering | iBB | Scoop.it

The 12th European Symposium on Biochemical Engineering Sciences was held in Lisbon from 9 to 12 of September of 2018 at the Calouste Gulbenkian Foundation. This year, the European Society of Biochemical Engineering Sciences (ESBES) organized the event with the collaboration of iBB/IST, SPBT and Dechema. Raquel Aires-Barros, the event chair, and Ana Azevedo, co-chair, mobilized a team of 15 PhD and MSc students from IST to receive 324 participants (75% non-portuguese). As a complement to scientific lectures, the event featured workshops on Modelling, Monitoring, Measurement and Control (M3C), Scientific Writing and Bioengineering Education. The last topic was extensively discussed during the Symposium as a possible emergent section of ESBES to address and promote an active cooperation between European academia and industry. Click on the title for more information on ESBES 2018.

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Inês Pinto Wins ESBES 2018 Award

Inês Pinto Wins ESBES 2018 Award | iBB | Scoop.it

Inês Pinto from BERG-iBB just won the ESBES Award at the ESBES 2018 conference held in Lisbon (8-12 September 2018) for her work “Optimizing the performance of chromatographic separations using integrated microfluidic devices: adsorption/elution kinetic studies and multiplexed analysis”. The work is part of Inês' PhD project on Biotechnology and is co-authored by Raquel Aires Barros, Viginia Chu, João Pedro Conde and Ana Azevedo. Diogo Pinto from SCERG was one of the runnerups of the competition. The ESBES Award is granted biannually by the European Society of Biochemical Engineering Sciences and aims at recognizing outstanding PhD thesis or scientific publications by students or early carrier researchers in the field of biochemical engineering.

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Engineering Human MSC with VEGF-encoding Minicircles for Angiogenic Gene Therapy

Engineering Human MSC with VEGF-encoding Minicircles for Angiogenic Gene Therapy | iBB | Scoop.it

Peripheral artery disease (PAD) is a debilitating condition characterized by the blockage of arteries, which leads to limb amputation in more severe cases. Researchers from SCERG- and BERG-iBB propose the use of human bone marrow (BM) MSC transiently transfected with minicircles encoding for VEGF as an ex vivo gene therapy strategy to enhance angiogenesis in PAD patients. The data shows that VEGF overexpression improved the angiogenic potential of MSC in vitro, as confirmed by endothelial cell tube formation and cell migration assays.These results suggest that minicircle-mediated VEGF gene delivery, combined with the unique properties of human MSC, could represent a promising ex vivo gene therapy approach to improve angiogenesis in the context of PAD. The work was published in Human Gene Therapy.

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Raquel Cunha Defends PhD Thesis in Bioengineering (MIT Portugal)

Raquel Cunha Defends PhD Thesis in Bioengineering (MIT Portugal) | iBB | Scoop.it

Raquel Medina dos Santos Cunha will be defending her PhD thesis in Bioengineering (MIT Portugal) at Instituto Superior Técnico, tuesday the 20th November 2018 (10:30 H, room PA3). During the last years, and under the supervision of Cláudia Lobato Silva from SCERG-iBB, Jeffrey Karp from Harvard Medical School and António Fiarresga from Hospital de Santa Marta, Raquel worked on the development of platforms for the production and characterisation of clinical grade stem cell-based therapies with enhanced regenerative potential. The title of her thesis is "Towards the development of potency assays and 3D inflammation models to evaluate the regenerative potential of Mesenchymal Stem/Stromal Cell (MSC) and MSC-derived products”.

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Seminar on Biorefineries (Fuel Oriented or Product Oriented) by Anton Friedl

Seminar on Biorefineries (Fuel Oriented or Product Oriented) by Anton Friedl | iBB | Scoop.it

Anton Friedl will be giving a talk entitled "Biorefineries - Fuel oriented or Product oriented", Thursday the 8th november at 16:45 h (room GA3, Alameda campus). In his talk, Anton will focus on the following topics: i) general requirements for the development of sustainable processes based on renewable biomas, ii) substrate and products from biorefineries and iii) ecological and economical evaluation of biorefinery concepts. Anton Friedl is a full professor at the Vienna University of Technology, Institute of Chemical Engineering, where he is the Head of the Research Division on Bio resources and Plant Science.

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Teresa Silva Defends PhD Thesis in Bioengineering (Cell Therapies and Regenerative Medicine)

Teresa Silva Defends PhD Thesis in Bioengineering (Cell Therapies and Regenerative Medicine) | iBB | Scoop.it

Teresa Silva will be defending his PhD thesis in Bioengineering (MIT Portugal) at Instituto Superior Técnico, wednesday the 26th October 2018 (15:00 H, room PA3). During the last years, and under the supervision of Carmo Fonseca from IMM and Tiago Fernandes and Evguenia Bekman from SCERG-iBB, Teresa worked on the development of new models to study neurodegenerative diseases such as ataxias that are caused by dysfunction of the cerebellum. The title of her thesis is "Novel bioengineering strategies for modeling cerebellar ataxias”.

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The ABC Transporters Pdr18 and Snq2 Derive from a Recent Gene Duplication Event

The ABC Transporters Pdr18 and Snq2 Derive from a Recent Gene Duplication Event | iBB | Scoop.it

Several membrane transporters from the ATP-binding cassette (ABC) superfamily present in yeast genomes are implicated in multidrug/multixenobiotic resistance (MDR/MXR). This is the case of Pdr18, that confers tolerance to ethanol and acetic acid and several other toxicants in yeast and has a biological role attributed in ergosterol transport at the plasma membrane. A recently iBB-BSRG paper published in Frontiers in Genetics, Evolutionary and Genomic Microbiology section, reconstructs the evolutionary history of the encoding gene PDR18 and the paralogue gene SNQ2. This publication results from the PhD thesis in Biotechnology and Biosciences of Cláudia P. Godinho advised by Prof. Isabel Sá-Correia with collaboration of Paulo J. Dias and Elise Ponçot. By combining phylogenetic gene neighborhood analysis for 117 yeast genomes belonging to 29 species across the Saccharomycetaceae family, the gene duplication event was traced to the last common ancestor of the Saccharomyces genus yeasts. The fact that Snq2 and Pdr18 confer resistance to different sets of chemical compounds with little overlapping is consistent with the subfunctionalization and neofunctionalization of these gene copies. Remarkably, PDR18 is only found in Saccharomyces genus genomes. 

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Rúben Soares Defends PhD Thesis in Biotechnology and Biosciences

Rúben Soares Defends PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Rúben Soares will be defending his PhD thesis in Biotechnology and Biosciences at Instituto Superior Técnico, monday the 15th October 2018 (10:00 H, room PA3). During the last years, and under the supervision of Profs. João Pedro Conde from INESC-MN and Raquel Barros from BERG-iBB, Rúben worked on the development of several miniaturized modules (analyte preparation, immunodetection, optical transduction and portable eçlectronics) of a portable point-of-need mycotoxin screening chip. The title of his thesis is "Development of integrated microfluidic mycotoxin screening chip for point-of-need food safety applications”.

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Miriam Sousa Defends PhD Thesis in Biotechnology and Biosciences

Miriam Sousa Defends PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Miriam Sousa will be defending her PhD thesis in Biotechnology and Biosciences at Instituto Superior Técnico, wednesday the 19th October 2018 (14:00 H, room PA3). During the last years, and under the supervision of Frederico Ferreira from SCERG-iBB, Miriam developed nanofiber scaffolds for the cultivation of neural stem cells. The title of her thesis is "Ex-Vivo Culture of Neural Stem Cells in Nanofiber Scaffolds: Cellular Organization and Dynamic Systems”.

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Bioreactors for Stem Cell Expansion and Differentiation

Bioreactors for Stem Cell Expansion and Differentiation | iBB | Scoop.it

The book "Bioreactors for Stem Cell Expansion and Differentiation", edited by Joaquim Cabral and Cláudia Lobato Silva from SCERG-iBB has just been released by CRC Press. In the book, an international team of investigators presents thought-provoking reviews of bioreactors for stem cell expansion and differentiation and provides cutting-edge information on different bioreactor systems. The authors offer novel insights into bioreactor-based culture systems specific for tissue engineering, including sophisticated and cost-effective manufacturing strategies geared to overcome technological shortcomings that currently preclude advances towards product commercialization.

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Rapid Formation of Mineralized Bone Tissue Based on Stem Cell-mediated Osteogenesis

Rapid Formation of Mineralized Bone Tissue Based on Stem Cell-mediated Osteogenesis | iBB | Scoop.it

Bone regeneration, following fracture, relies on autologous and allogenic bone grafts. However, majority of fracture population consists of older individuals with poor quality bone associated with loss and/or modification of matrix proteins critical for bone formation and mineralization. Allografts sufer from same limitations and carry the risk of delayed healing, infection, immune rejection and eventual fracture. Researchers from SCERG-iBB, working in collaboration with colleagues from the Rensselaer Polytechnic Institute in the US, have applied a synergistic biomimetic strategy to develop matrices that rapidly form bone tissue. Collagen matrices, enhanced with osteocalcin and/or osteopontin, increased the rate and quantity of synthesized bone matrix by increasing mesenchymal stem/stromal (MSC) cell proliferation, accelerating osteogenic diferentiation and enhancing angiogenesis The work was published in Scientific Reports.

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Inês Pinto Defends PhD Thesis in Biotechnology and Biosciences

Inês Pinto Defends PhD Thesis in Biotechnology and Biosciences | iBB | Scoop.it

Inês Pinto will be defending her PhD thesis in Biotechnology and Biosciences at Instituto Superior Técnico, monday the 24th September 2018 (9:30 H, room PA3). During the last years, and under the supervision of Profs. Ana Azevedo and Raquel Barros from BERG-iBB, and João Pedro Conde from INESC-MN, Inês developed a microfluidic platform for the rapid screening of the chromatographic purification of monoclonal antibodies. The title of her thesis is "Screening of multimodal ligands for the capture and polishing of antibody streams: A microfluidic approach for rapid optimization of chromatographic operating conditions”.

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Microbial Infections and Cancer Therapy

Microbial Infections and Cancer Therapy | iBB | Scoop.it

The book "Microbial Infections and Cancer Therapy", co-edited by Arsénio Fialho from BSRG-iBB in collaboration with Ananda Chakrabarty (University of Illinois) has just been released by Pan Stanford Publishing. The book deals with the emerging concept that certain pathogenic bacteria and viruses, when infecting people with cancer, actively fight tumors, allowing their regression. It features 12 chapters written by pioneers in microbial, biotech, and cancer research and covers the emerging roles of various microorganisms and their products in cancer therapy. The book highlights the benefits of using conventional cancer treatments (such as chemo- and radiotherapies) with microbial-based therapies.

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Networking Meeting "From Protein Dynamics to Membrane Biophysics"

Networking Meeting "From Protein Dynamics to Membrane Biophysics" | iBB | Scoop.it

The Lisbon Biophysics Networking Meeting "From Protein Dynamics to Membrane Biophysics", which brings together the Portuguese Biophysical community working in the field of Protein Structural Biology and Membrane Biophysics, will be held at Instituto Superior Técnico, Lisbon, October 12th 2018. The event is designed to promote scientific networking among distinct groups in the two research areas and to encourage future productive collaborations in the lipid-protein interaction field. The registration and abstract submission are free of charge for all attendees. Click on title to learn more.

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Eduardo Brás Presents Research on Point-of-care Devices for Plant Health at Eurosensors 2018

Eduardo Brás Presents Research on Point-of-care Devices for Plant Health at Eurosensors 2018 | iBB | Scoop.it

Eduardo Brás from BERG-iBB delivered an oral presentation at the 32nd edition of Eurosensors in Graz, Austria, concerning his work on the development of a Point-of-Care device for early plant health assessment. The system developed consists of a microfluidic chip containing sample preparation and detection modules, coupled with integrated photodetectors for real time optical transduction. The work is part of Eduardo´s PhD project on Biotechnology, which is supervised by João Pedro Conde from INESC-MN and Pedro Fernandes from BERG-iBB in collaboration with Margarida Fortes from (BioISI). 

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