Hormones, Cytokines and Immunity
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Hormones, Cytokines and Immunity
Cross-talk between different hormones, neuromediators and cytokines
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Norepinephrine through β2-adrenoceptor activation down-regulates pro-inflammatory pathogenic Th17 cells in a rodent model of rheumatoid arthritis

Norepinephrine through β2-adrenoceptor activation down-regulates pro-inflammatory pathogenic Th17 cells in a rodent model of rheumatoid arthritis | Hormones, Cytokines and Immunity | Scoop.it
First evidence that norepinephrine (noradrenaline) through stimulation of β2-adrenoceptors down-regulates the highly pathogenic Th17 cells in animal model of rheumatoid arthritis.
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The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia

The Chemokines CX3CL1 and IL-8 May Be Implicated in the Pathogenesis of Fibromyalgia | Hormones, Cytokines and Immunity | Scoop.it
New study reporting the presence of high levels of the chemokines CX3CL1 and IL-8 in fibromyalgia (FM) patients.
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Macrophages Are the Ultimate Multitaskers

Macrophages Are the Ultimate Multitaskers | Hormones, Cytokines and Immunity | Scoop.it
For more than a century, macrophages—which means “big eaters” in Greek—were considered relatively simple cells whose sole job was to engulf bacteria, other microbes, and cellular debris. Averaging around 20 μm across in humans, they are among the largest cells in the body, which helps them to physically surround and digest their microscopic meals. “You can think of them as the vacuum cleaners of the body,” Babak Razani, a physician and researcher at Washington University School of Medicine in St. Louis, writes in an email.

But over the last 10 years, research has demonstrated that this is only part of the picture. In terms of immune defense, investigators now understand that macrophages mount a three-stage response to infection.

Via Ray and Terry's
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Short and long sleep, and sleep disturbances associated with increased risk of dementia and lung cancer

Short and long sleep, and sleep disturbances associated with increased risk of dementia and lung cancer | Hormones, Cytokines and Immunity | Scoop.it
Difficulties in initiating or maintaining sleep at middle-age are associated with an increased risk of dementia, according to a new study from the University of Eastern Finland. The 20-year follow-up study was conducted amon
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Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans

Experimental Study Shows Link between Cerebrospinal Fluid IL-6 and Depressive Symptoms in Humans | Hormones, Cytokines and Immunity | Scoop.it
A study in Molecular Psychiatry links depression and inflammation to an increase in cerebrospinal IL-6 concentrations.
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Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination

Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination | Hormones, Cytokines and Immunity | Scoop.it
Narcolepsy is a sleep disorder characterised by loss of hypothalamic hypocretin (orexin)
neurons. The prevalence of narcolepsy is about 30 per 100 000 people, and typical
age at onset is 12–16 years. Narcolepsy is strongly associated with the HLA-DQB1*06:02
genotype, and has been thought of as an immune-mediated disease. Other risk genes,
such as T-cell-receptor α chain and purinergic receptor subtype 2Y11, are also implicated.
Interest in narcolepsy has increased since the epidemiological observations that H1N1
infection and vaccination are potential triggering factors, and an increase in the
incidence of narcolepsy after the pandemic AS03 adjuvanted H1N1 vaccination in 2010
from Sweden and Finland supports the immune-mediated pathogenesis.

Via Krishan Maggon , Gilbert C FAURE
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Activation of the Brain-Splenic Nerve Axis in Hypertension: The Cholinergic-Sympathetic-Immune System Connection

Activation of the Brain-Splenic Nerve Axis in Hypertension: The Cholinergic-Sympathetic-Immune System Connection | Hormones, Cytokines and Immunity | Scoop.it
A recent Nature Communications study indicates that hypertension is linked to T cell activation and an egression of T-cells from the spleen, and that this process is dependent on a vagus-splenic nerve connection. Hypertension is a major risk factor for coronary heart diseases and stroke. Despite various therapeutic approaches 10-15% of the general hypertensive population …
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The Therapeutic Potential of Secukinumab in Rheumatic Diseases

The Therapeutic Potential of Secukinumab in Rheumatic Diseases | Hormones, Cytokines and Immunity | Scoop.it
A review by Marije Koenders in Drug Design, Development and Therapy outlines some major features and characteristics of the new biological Secukinumab, which blocks the actions of interleukin 17A (IL-17), and explores its development, therapeutic potential and use in several rheumatic diseases. IL-17 provides protection against extracellular bacterial and fungal infections. However, IL-17 and Th17 …
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Study: Unvaccinated Children Healthier Than Vaccinated Kids – Doctors Agree

Study: Unvaccinated Children Healthier Than Vaccinated Kids – Doctors Agree | Hormones, Cytokines and Immunity | Scoop.it
A new peer-reviewed study comparing health outcomes of vaccinated and unvaccinated children, provisionally published in a journal of public health and assigned
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Vaccine Critic Kennedy Claims Trump Tapped Him to Chair Panel on Vaccination Safety

Vaccine Critic Kennedy Claims Trump Tapped Him to Chair Panel on Vaccination Safety | Hormones, Cytokines and Immunity | Scoop.it

"Like the president-elect, Robert Kennedy, Jr., has pushed arguments of a link to autism"


"“President-elect Trump has some doubts about the current vaccine policies and he has questions about it,” Kennedy told reporters after the meeting. “His opinion doesn’t matter but the science does matter and we ought to be reading the science and we ought to be debating the science. And that everybody ought to be able to be assured that the vaccines that we have—he’s very pro-vaccine, as am I—but they’re as safe as they possibly can be.” "


Via iPamba
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12 Natural Antibiotics That Our Ancestors Used Instead of Pills - Healthy Food and Remedies

12 Natural Antibiotics That Our Ancestors Used Instead of Pills - Healthy Food and Remedies | Hormones, Cytokines and Immunity | Scoop.it
Over the last several decades, over-use of antibiotics has reached an all-time high. The result has been drug-resistant bacteria and “superbugs” that evolve faster than scientists can figure out how to fight them.
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HPV Vaccine Linked to Nervous System Disorder and Autoimmunity

HPV Vaccine Linked to Nervous System Disorder and Autoimmunity | Hormones, Cytokines and Immunity | Scoop.it
Greenmedinfo.com - Natural Health Resource - The world's most widely referenced, open access, natural medicine database, with 20,000+ study abstracts and growing daily
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Researchers uncover pneumonia causing bacteria as trigger for autoimmune disease GBS

Researchers uncover pneumonia causing bacteria as trigger for autoimmune disease GBS | Hormones, Cytokines and Immunity | Scoop.it
Guillain-Barré syndrome (GBS) is an acute life-threatening disease of the nervous system that leads to sensory disturbances and acute flaccid paralysis.
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First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells

First Evidence that Catecholamines Inhibit IL-27 Production by Antigen Presenting Cells | Hormones, Cytokines and Immunity | Scoop.it
First evidence that catecholamines such as norepinephrine and epinephrine suppress the production of interleukin-27 (IL-27) via the activation of β2-adrenoceptors and by mechanisms involving IL-10.
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The Future of Rheumatoid Arthritis: How Genes, Lifestyle and Environment Factor In | AbbVie

The Future of Rheumatoid Arthritis: How Genes, Lifestyle and Environment Factor In | AbbVie | Hormones, Cytokines and Immunity | Scoop.it
JULY 6, 2017 / MOVING SCIENCE FORWARD The Future of Rheumatoid Arthritis: How Genes, Lifestyle and Environment Factor In A clearer understanding of how and why RA develops could help researchers map a better path for treating it. DNA autoradiogram in front of glassware in a laboratory.

Via Krishan Maggon
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Magnesium has anti-inflammatory effects

Natural health news, wellness, wellbeing, articles, videos, campaigns and courses as well as a unique Remedy Finder to guide you in your choice of herbs, homeopathy, aromatherapy and more.
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Pro-Inflammatory Th17 Cells and Glucocorticoid Resistance: Implications for Chronic Inflammatory Diseases and Their Treatment

Pro-Inflammatory Th17 Cells and Glucocorticoid Resistance: Implications for Chronic Inflammatory Diseases and Their Treatment | Hormones, Cytokines and Immunity | Scoop.it
Overview about pathogenic pro-inflammatory Th17 Cells, their Glucocorticoid Resistance & subsets of Th17 cells with distinct GC sensitivity.
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New Evidence that Th17 Cells Contribute to Hashimoto’s Thyroiditis

New Evidence that Th17 Cells Contribute to Hashimoto’s Thyroiditis | Hormones, Cytokines and Immunity | Scoop.it
Comments by Alicia Juana Klecha and María Laura Arcos on the article 'Circulating Th17 cytokine levels are altered in Hashimoto's thyroiditis'
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Antibiotics through Effects on the Microbiota-Gut-Brain Axis and Inflammatory Monocytes May Reshape Brain Hippocampal Neurogenesis

Antibiotics through Effects on the Microbiota-Gut-Brain Axis and Inflammatory Monocytes May Reshape Brain Hippocampal Neurogenesis | Hormones, Cytokines and Immunity | Scoop.it
Inflammatory monocytes as the missing link between the antibiotics’ effects on gut microbiota, and the brain hippocampal neurogenesis.
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Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma

Rhinovirus Infections via ATP Release May Trigger IL-33 Production by Bronchial Smooth Muscle Cells: Implications for Asthma | Hormones, Cytokines and Immunity | Scoop.it
A recent Journal of Translational Medicine study indicates that interleukin (IL)-33 is produced by bronchial smooth muscle cells (BSMCs) upon rhinovirus (RV) infection and activation of TLR3, and that this response is associated and/or mediated by ATP released by viral-stimulated BSMCs. IL-33 is a cytokine constitutively expressed in epithelial barrier tissues, and was originally described …
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IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells. - PubMed - NCBI

IL-15 Activates the Jak3/STAT3 Signaling Pathway to Mediate Glucose Uptake in Skeletal Muscle Cells. - PubMed - NCBI | Hormones, Cytokines and Immunity | Scoop.it
Front Physiol. 2016 Dec 20;7:626. doi: 10.3389/fphys.2016.00626. eCollection 2016.
Via Société Francaise d'Immunologie
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An Integrated Workflow To Assess Technical and Biological Variability of Cell Population Frequencies in Human Peripheral Blood by Flow Cytometry

An Integrated Workflow To Assess Technical and Biological Variability of Cell Population Frequencies in Human Peripheral Blood by Flow Cytometry | Hormones, Cytokines and Immunity | Scoop.it
In the context of large-scale human system immunology studies, controlling for technical and biological variability is crucial to ensure that experimental data support research conclusions. In this study, we report on a universal workflow to evaluate both technical and biological variation in multiparameter flow cytometry, applied to the development of a 10-color panel to identify all major cell populations and T cell subsets in cryopreserved PBMC. Replicate runs from a control donation and comparison of different gating strategies assessed the technical variability associated with each cell population and permitted the calculation of a quality control score. Applying our panel to a large collection of PBMC samples, we found that most cell populations showed low intraindividual variability over time. In contrast, certain subpopulations such as CD56 T cells and Temra CD4 T cells were associated with high interindividual variability. Age but not gender had a significant effect on the frequency of several populations, with a drastic decrease in naive T cells observed in older donors. Ethnicity also influenced a significant proportion of immune cell population frequencies, emphasizing the need to account for these covariates in immune profiling studies. We also exemplify the usefulness of our workflow by identifying a novel cell-subset signature of latent tuberculosis infection. Thus, our study provides a universal workflow to establish and evaluate any flow cytometry panel in systems immunology studies.

Via Gilbert C FAURE
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Toothpaste significantly reduces dental plaque and inflammation throughout the body

Toothpaste significantly reduces dental plaque and inflammation throughout the body | Hormones, Cytokines and Immunity | Scoop.it
For decades, research has suggested a link between oral health and inflammatory diseases affecting the entire body -- in particular, heart attacks and strokes. Results from a randomized trial of a novel plaque identifying toothpaste, Plaque HD®, produced statistically significant reductions in dental plaque and inflammation throughout the body as measured by high sensitivity C-reactive protein (hs-CRP), a sensitive marker for future heart attacks and strokes.
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Role of Parvovirus B19 in Autoimmunity and Autoimmune Disease

Role of Parvovirus B19 in Autoimmunity and Autoimmune Disease | Hormones, Cytokines and Immunity | Scoop.it
Parvovirus B19 infection has been associated with the development of a variety of autoimmune diseases. This article reviews its epidemiology and possible mechanisms involved in disease pathogenesis.
Via Gilbert C FAURE
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Study: Aluminum Exposure During Puberty Disrupts Hormonal Development

Study: Aluminum Exposure During Puberty Disrupts Hormonal Development | Hormones, Cytokines and Immunity | Scoop.it
On September 28, 2016 the Daily Mail Online reported that scientists in Reading had discovered a possible link between antiperspirants and breast cancer. To my
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