HIV and TB
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HIV and TB
Interesting discoveries in the field
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Immunity - RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of the Activating Receptor NKp44

Online Now: RORγt+ Innate Lymphoid Cells Acquire a Proinflammatory Program upon Engagement of… http://t.co/KIH5wvKSYn

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Frontiers | For host factors weddings and a Koch’s bacillus funeral: actin, lipids, phagosome maturation and inflammasome activation. "

For host factors weddings and a Koch’s bacillus funeral: http://t.co/6bURIGe1Qh #Immunology #Microbiology #Frontiersin

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On guard: coronin proteins in innate and adaptive immunity : Nature Reviews Immunology : Nature Publishing Group

On guard: coronin proteins in innate and adaptive immunity : Nature Reviews Immunology : Nature Publishing Group | HIV and TB | Scoop.it
On guard: coronin proteins in innate and adaptive immunity
http://t.co/ZEdgsyCeUi

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Early HIV treatment led to “functional cure” in 14 patients, report researchers | BMJ

Early HIV treatment led to “functional cure” in 14 patients, report researchers | BMJ | HIV and TB | Scoop.it
NotesCite this as: BMJ 2013;346:f1759
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Frontiers | Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis.

Frontiers | Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis. | HIV and TB | Scoop.it
Intercellular transfer of cell surface proteins by trogocytosis is common and could affect T cell responses. Yet, the role of trogocytosis in T cell function is still elusive, and it is unknown...

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Frontiers | Emerging Trends in the Formation and Function of Tuberculosis Granulomas | Frontiers in Inflammation

Frontiers | Emerging Trends in the Formation and Function of Tuberculosis Granulomas | Frontiers in Inflammation | HIV and TB | Scoop.it
Frontiers | Emerging Trends in the Formation and Function of Tuberculosis Granulomas | Frontiers in Inflammation publishes articles on the most outstanding discoveries across the research spectrum of Frontiers | Emerging Trends in the Formation...

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Frontiers | Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs.

Frontiers | Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. | HIV and TB | Scoop.it
The onset of the adaptive immune response to Mycobacterium tuberculosis is delayed compared with that of other infections or immunization, and allows the bacterial population in the lungs to expand...

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Gilbert C FAURE's curator insight, September 24, 2014 10:00 AM

.....  markedly during the preimmune phase of infection. We used adoptive transfer of M. tuberculosis Ag85B-specific CD4(+) T cells to determine that the delayed adaptive response is caused by a delay in initial activation of CD4(+) T cells, which occurs earliest in the local lung-draining mediastinal lymph node. We also found that initial activation of Ag85B-specific T cells depends on production of antigen by bacteria in the lymph node, despite the presence of 100-fold more bacteria in the lungs. Although dendritic cells have been found to transport M. tuberculosis from the lungs to the local lymph node, airway administration of LPS did not accelerate transport of bacteria to the lymph node and did not accelerate activation of Ag85B-specific T cells. These results indicate that delayed initial activation of CD4(+) T cells in tuberculosis is caused by the presence of the bacteria in a compartment that cannot be mobilized from the lungs to the lymph node, where initial T cell activation occurs.

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Single-Cell Imaging of HIV-1 Provirus (SCIP)

Shepherd's insight:

Recent advances in fluorescence microscopy provided tools for the investigation and the analysis of the viral replication steps in the cellular context. In the HIV field, the current visualization systems successfully achieve the fluorescent labeling of the viral envelope and proteins, but not the genome. Here, we developed a system able to visualize the proviral DNA of HIV-1 through immunofluorescence detection ofrepair foci for DNA double-strand breaks specifically induced in the viral genome by the heterologous expression of the I-SceI endonuclease. The system for Single-Cell Imaging of HIV-1 Provirus, named SCIP, provides the possibility to individually track integrated-viral DNA within the nuclei of infected cells. In particular, SCIP allowed us to perform a topological analysis of integrated viral DNA revealing that HIV-1preferentially integrates in the chromatin localized at the periphery of the nuclei.

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