Fish oil (ω-3 Fatty Acid Supplements) for Secondary Prevention of Cardiovascular Disease: From “No Proof of Effectiveness” to “Proof of No Effectiveness” | Heart and Vascular Health | Scoop.it

The Figure shows the results of our analysis. The analysis of the 14 randomized placebo-controlled studies indicated futility, ie, proof of no effectiveness; interestingly enough, the final part of the curve was far beyond the boundary of futility. Our secondary analysis, which was based on 16 studies, gave essentially the same result (data not shown).

The results of our analysis can be seen as the proof of no effectiveness of ω-3 fatty acid supplements for secondary prevention of cardiovascular disease. Our evaluation is also a good example of the role that TSA can play to integrate the results of traditional meta-analyses.