Exocytosis
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Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction: Cell

Quantitative Temporal Viromics: An Approach to Investigate Host-Pathogen Interaction: Cell | Exocytosis | Scoop.it

A systematic quantitative analysis of temporal changes in host and viral proteins throughout the course of a productive infection could provide dynamic insights into virus-host interaction. We developed a proteomic technique called “quantitative temporal viromics” (QTV), which employs multiplexed tandem-mass-tag-based mass spectrometry. Human cytomegalovirus (HCMV) is not only an important pathogen but a paradigm of viral immune evasion. QTV detailed how HCMV orchestrates the expression of >8,000 cellular proteins, including 1,200 cell-surface proteins to manipulate signaling pathways and counterintrinsic, innate, and adaptive immune defenses. QTV predicted natural killer and T cell ligands, as well as 29 viral proteins present at the cell surface, potential therapeutic targets. Temporal profiles of >80% of HCMV canonical genes and 14 noncanonical HCMV open reading frames were defined. QTV is a powerful method that can yield important insights into viral infection and is applicable to any virus with a robust in vitro model.


Via burkesquires
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As such, host-pathogen signaling is fast becoming the field of immense interest @ https://en.wikipedia.org/wiki/Membrane_vesicle_trafficking

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Combating virulence of Gram-negative bacilli by OmpA inhibition

Combating virulence of Gram-negative bacilli by OmpA inhibition | Exocytosis | Scoop.it
Article
Rakesh Yashroy's insight:
Inhibiting OMP-A of gram negative pathogens with specific peptides is innovative for fighting gram negative bacterial infections in general. OmpA is also liberated from bacteria by such bacteria as outer membrane vesicles, which too cause pathogenicity @ https://www.sciencedirect.com/science/article/pii/B9780323461528000159
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Emergent properties of extracellular vesicles: a holistic approach to decode the complexity of intercellular communication networks - Molecular BioSystems (RSC Publishing)

Emergent properties of extracellular vesicles: a holistic approach to decode the complexity of intercellular communication networks - Molecular BioSystems (RSC Publishing) | Exocytosis | Scoop.it
Shedding of nano-sized bilayered extracellular vesicles and extracellular vesicle-mediated intercellular communication are evolutionarily conserved biological processes. Communication between cells and the environment is an essential process in living organisms and dysregulation of intercellular communicatio
Rakesh Yashroy's insight:
Membrane vesicle trafficking within or outside cells is opening a plethora of information on cell-cell communications @ https://pediaview.com/openpedia/Membrane_vesicle_trafficking
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Lateral Gene Transfer Between Humans and Microbes

Lateral Gene Transfer Between Humans and Microbes | Exocytosis | Scoop.it
This DNA-sharing process, known as horizontal or lateral gene transfer (LGT), is now understood to occur by the direct movement of DNA between two organisms. Almost all bacterial genomes show evidence of past LGT events, and the phenomenon is known to have profound effects on microbial biology, from spreading antibiotic resistance genes to creating new pathways for degrading chemicals. But LGT is not limited to bacteria. Scientists now recognize that microbes transfer DNA to the plants, fungi, and animals they infect or reside in, and conversely, human long interspersed elements (LINEs) have been found in bacterial genomes. Moreover, researchers have documented LGT from fungi to insects and from algae to sea slugs. There is reason to believe that any two major groups of organisms—including humans—can share their genetic codes.


Via Ed Rybicki
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Turning back time: Salk scientists reverse signs of aging 

Turning back time: Salk scientists reverse signs of aging  | Exocytosis | Scoop.it

New technique rejuvenated organs and helped animals live longer


Via Integrated DNA Technologies
Rakesh Yashroy's insight:
Getting rid of cellular toxins by exocytosis of metabolic waste can also be rejuvenating @ http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2000;volume=43;issue=1;spage=17;epage=22;aulast=Yashroy;type=0
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Audiobook: Outer Membrane Vesicles of Bacteria

Get your free audiobook or ebook: http://zaxo.space/sabk/35/en/B00A9YGWD6/book This book provides a detailed account of the physico-chemical properties an
Rakesh Yashroy's insight:
Outer membrane vesicles carry signals from gram negative microbes to host cells at the host pathogen interface @ https://en.wikipedia.org/wiki/Host-pathogen_interface
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Cardiac Extracellular Vesicles in Normal and Infarcted Heart. - PubMed - NCBI

Int J Mol Sci. 2016 Jan 5;17(1). pii: E63. doi: 10.3390/ijms17010063. Review
Rakesh Yashroy's insight:
Exocytosis of membrane vesicles are getting increasing importance in cell-cell signaling @ http://wikipedia.moesalih.com/Exocytosis
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Carbon 13 nmr studies of membrane lipid protein interactions upon protein heat denaturation

Carbon 13 nmr studies of membrane lipid protein interactions upon protein heat denaturation | Exocytosis | Scoop.it
Yashroy R.C., 1991: Carbon 13 nmr studies of membrane lipid protein interactions upon protein heat denaturation
Rakesh Yashroy's insight:
Membrane lipid protein interactions hold key to membrane physiology.
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Structure and function of vulture pecten

Structure and function of vulture pecten | Exocytosis | Scoop.it
Bawa, SR.; Yash Roy, RC., 1974: Structure and function of vulture pecten
Rakesh Yashroy's insight:
Bird eye has highly vascular specialized organ, pecten oculi, which exocytoses nutrients to high acuity avascular retina.
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Effect of dark and light adaptation on the retina and pecten of chicken

Effect of dark and light adaptation on the retina and pecten of chicken | Exocytosis | Scoop.it
Bawa S.R.; Yashroy R.C., 1972: Effect of dark and light adaptation on the retina and pecten of chicken
Rakesh Yashroy's insight:
Bird eye pecten oculi exocytoses nutrients from its bridge area into vitreous in order to nourish avascular retina in birds.
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Membrane lipid - The Free Online Dictionary and Encyclopedia (TFODE)

Rakesh Yashroy's insight:
Membrane lipids are behind flexibility, necessary for membrane phenomena like exocytosis and others.
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Exocytosis from gram negative bacteria for Salmonella invasion of chicken ileal epithelium

Exocytosis from gram negative bacteria for Salmonella invasion of chicken ileal epithelium | Exocytosis | Scoop.it
Yashroy, R. C., 1998: Exocytosis from gram negative bacteria for Salmonella invasion of chicken ileal epithelium
Rakesh Yashroy's insight:
New dimension of exocytosis.
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Liver damage by intra-ileal treatment with Salmonella 3,10r extract as studied by light and electron microscopy

Liver damage by intra-ileal treatment with Salmonella 3,10r extract as studied by light and electron microscopy | Exocytosis | Scoop.it
Yashroy, Rakesh C., 1994: Liver damage by intra-ileal treatment with Salmonella 3,10r extract as studied by light and electron microscopy
Rakesh Yashroy's insight:
Toxins exocytosed by salmonella in patients intestine may leak out into circulation to severely damage liver.
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Destabilisation of lamellar dispersion of thylakoid membrane lipids by sucrose

Destabilisation of lamellar dispersion of thylakoid membrane lipids by sucrose | Exocytosis | Scoop.it
Yashroy, Rakesh C., 1994: Destabilisation of lamellar dispersion of thylakoid membrane lipids by sucrose
Rakesh Yashroy's insight:
Unlike all other biological membranes, earth's most abundant membrane system of plant thylakoids are strangely deficient in phospholipids - their phase behavior is unique as they are predominated by galactolipids.
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Scientists discover genes are controlled by ‘nano footballs’ 

Scientists discover genes are controlled by ‘nano footballs’  | Exocytosis | Scoop.it

Research at the University of York has revealed that genes are controlled by ‘nano footballs’ – structures that look like footballs but 10 million times smaller than the average ball.


Via Integrated DNA Technologies
Rakesh Yashroy's insight:
Nano-ball signaling has a wide role in living beings in general https://wiki2.org/en/Membrane_vesicle_trafficking
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Virulence - Infogalactic: the planetary knowledge core

Virulence - Infogalactic: the planetary knowledge core | Exocytosis | Scoop.it
Virulence of bacteria and viruses https://t.co/fT85ZMmwti
Rakesh Yashroy's insight:
Virulence is a survival strategy in the living world.
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Bacterial outer membrane vesicles - Corsica

Bacterial outer membrane vesicles - Corsica | Exocytosis | Scoop.it
Gram negative bacteria - outer membrane vesicles https://t.co/gXIOZtyiD3
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Mechanism of infection of a human isolate Salmonella (3,10 : r :-) in chicken ileum: Ultrastructural study

Mechanism of infection of a human isolate Salmonella (3,10 : r :-) in chicken ileum: Ultrastructural study | Exocytosis | Scoop.it
Yashroy, Rakesh-Chander, 2007: Mechanism of infection of a human isolate Salmonella (3,10 : r :-) in chicken ileum: Ultrastructural study
Rakesh Yashroy's insight:
Human Salmonella invasion and infection modalities.
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Making bacteria an unwelcome guest | Resolve Magazine, Lehigh Engineering

Making bacteria an unwelcome guest | Resolve Magazine, Lehigh Engineering | Exocytosis | Scoop.it
Students of entrepreneurship grad program find success in many venues
Rakesh Yashroy's insight:
Gram negative bacterial outer membranes have generated lot of interest in host -pathogen interactions @ https://www.labome.org/research/Membrane-vesicle-trafficking-in-prokaryotes-molecular-biomechanics-of-biogenesis-of-outer-membrane-v.html
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Lateral Gene Transfer Between Humans and Microbes | The Scientist Magazine®

Lateral Gene Transfer Between Humans and Microbes | The Scientist Magazine® | Exocytosis | Scoop.it
Bacteria inhabit most tissues in the human body, and genes from some of these microbes have made their way to the human genome. Could this genetic transfer contribute to diseases such as cancer?
Rakesh Yashroy's insight:
Lateral gene transfer between bacteria and host cells is expected to happen via bacterial membrane vesicles carrying DNA segments to animal host cells at the host-pathogen interface @ https://en.wikipedia.org/wiki/Host-pathogen_interface
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Carbon 13 nmr studies of membrane lipid protein interactions upon protein heat denaturation

Carbon 13 nmr studies of membrane lipid protein interactions upon protein heat denaturation | Exocytosis | Scoop.it
Yashroy R.C., 1991: Carbon 13 nmr studies of membrane lipid protein interactions upon protein heat denaturation
Rakesh Yashroy's insight:
Lipids are the matrix for protein function in membrane phenomena.
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Belgian scientists discover missing link in septic shock

Belgian scientists discover missing link in septic shock | Exocytosis | Scoop.it
Belgian scientists discover missing link in septic shock https://t.co/LwwvRtjLy6
Rakesh Yashroy's insight:
Membrane vesicle trafficking either through eukaryote cell secretions as ECVs or prokaryote cell secretion as OMVs have immense importance in health and disease cell-cell communications @ https://en.wikipedia.org/wiki/Membrane_vesicle_trafficking
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Determination of membrane lipid phase transition temperature from carbon nmr intensities

Determination of membrane lipid phase transition temperature from carbon nmr intensities | Exocytosis | Scoop.it
Yashroy R.C., 1990: Determination of membrane lipid phase transition temperature from carbon nmr intensities
Rakesh Yashroy's insight:
Novel method to measure membrane phase transition temperature from NMR spectral intensities.
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Liver damage by intra-ileal treatment with Salmonella 3,10r extract as studied by light and electron microscopy

Liver damage by intra-ileal treatment with Salmonella 3,10r extract as studied by light and electron microscopy | Exocytosis | Scoop.it
Yashroy, Rakesh C., 1994: Liver damage by intra-ileal treatment with Salmonella 3,10r extract as studied by light and electron microscopy
Rakesh Yashroy's insight:
Toxins exocytosed by Salmonella in intestine can damage liver via circulation.
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Exocytosis from gram negative bacteria for Salmonella invasion of chicken ileal epithelium

Exocytosis from gram negative bacteria for Salmonella invasion of chicken ileal epithelium | Exocytosis | Scoop.it
Yashroy, R. C., 1998: Exocytosis from gram negative bacteria for Salmonella invasion of chicken ileal epithelium
Rakesh Yashroy's insight:
Linkage of bacterial invasion of host with bacterial outer membrane vesicles
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Light and electron microscope studies on the toxic effect of Salmonella 3, 10r cell-free extract on rabbit ileum

Light and electron microscope studies on the toxic effect of Salmonella 3, 10r cell-free extract on rabbit ileum | Exocytosis | Scoop.it
Yashroy, Rakesh C., 1994: Light and electron microscope studies on the toxic effect of Salmonella 3, 10r cell-free extract on rabbit ileum
Rakesh Yashroy's insight:
Sonicated cell-free Salmonella filtrate contains bacterial toxins secreted by the pathogens as outer membrane vesicles. How they stimulate cell mediated immunity in chicken ileum is studied by transmission electron microscopy.
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