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UAB researchers completely cure type 1 diabetes in dogs with a single session of gene therapy

UAB researchers completely cure type 1 diabetes in dogs  with a single session of gene therapy | education | Scoop.it

Researchers at the Universitat Autónoma de Barcelona have succeeded in completely curing type 1 diabetes in dogs with a single session of gene therapy. This is the first time that the disease has been cured in large animals, a fundamental step towards applying the therapy in humans. The study, based on introducing a "glucose sensor" into muscle, has been published in Diabetes, the most prestigious journal in this field. 

Researchers from the Universitat Autònoma de Barcelona (UAB), led by Fátima Bosch, have shown for the first time that it is possible to cure diabetes in large animals with a single session of gene therapy. As published this week in Diabetes, the principal journal for research on the disease, after a single gene therapy session, the dogs recover their health and no longer show symptoms of the disease. In some cases, monitoring continued for over four years, with no recurrence of symptoms.
 
The therapy is minimally invasive. It consists of a single session of various injections in the animal's rear legs using simple needles that are commonly used in cosmetic treatments. These injections introduce gene therapy vectors, with a dual objective: to express the insulin gene, on the one hand, and that of glucokinase, on the other. Glucokinase is an enzyme that regulates the uptake of glucose from the blood. When both genes act simultaneously they function as a "glucose sensor", which automatically regulates the uptake of glucose from the blood, thus reducing diabetic hyperglycemia (the excess of blood sugar associated with the disease).
 
As Fátima Bosch, the head researcher, points out, "this study is the first to demonstrate a long-term cure for diabetes in a large animal model using gene therapy.”
 
This same research group had already tested this type of therapy on mice, but the excellent results obtained for the first time with large animals lays the foundations for the clinical translation of this gene therapy approach to veterinary medicine and eventually to diabetic patients.
 
The study was led by the head of the UAB's Centre for Animal Biotechnology and Gene Therapy (CBATEG) Fàtima Bosch, and involved the Department of Biochemistry and Molecular Biology of the UAB, the Department of Medicine and Animal Surgery of the UAB, the Faculty of Veterinary Science of the UAB, the Department of Animal Health and Anatomy of the UAB, the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), the Children’s Hospital of Philadelphia (USA) and the Howard Hughes Medical Institute of Philadelphia (USA).
 
The study provides ample data showing the safety of gene therapy mediated by adeno-associated vectors (AAV) in diabetic dogs. The therapy has proved to be safe and efficacious: it is based on the transfer of two genes to the muscle of adult animals using a new generation of very safe vectors known as adeno-associated vectors. These vectors, derived from non-pathogenic viruses, are widely used in gene therapy and have been successful in treating several diseases.
 
In fact, the first gene therapy medicine ever approved by the European Medicines Agency, named Glybera®, makes use of adeno-associated vectors to treat a metabolic disease caused by a deficiency of lipoprotein lipase and the resulting accumulation of triglycerides in the blood.


Via Dr. Stefan Gruenwald
Destiny Muniz's insight:

They inject numerious things into the hine legs this introduces the gene therapy vectors, with a dual objective Glucokinase and insuline. 
They say that the goal of this study is demonstrate a long term cure for diabetes in large animals using this type of method. This has been tested on mice before and now these are very good results from this test.

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Angelica D. Ignacio's curator insight, December 6, 2013 11:03 AM

it is the first time autonma de barcelona have cured type 1 diabetes. They cured it in dogs with a single session of gene therapy. It is the first time it has been cured in a large animal. It is a fundamental step to humans. After the gene session the dogs recover there health and show no more symptoms of type 1 diabetes. They tested in mice aready it was the same. 

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The Dangers of Meat Glue and Processed Meat

Meat, aside from being a scam, is a potentially dangerous substance and is another reason why you should avoid eating processed meat.


Via New Life Chiropractic
Destiny Muniz's insight:

This article talks about what meat glue is made of, what products its used on, and how harmful it can be. It also tells you other thing in meat you should watch out for and which would be best to eat.

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Rescooped by Destiny Muniz from iGeneration - 21st Century Education (Pedagogy & Digital Innovation)
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Animal Dissection? There’s an App for That | MindShift

Animal Dissection? There’s an App for That | MindShift | education | Scoop.it
Animal dissection is one of the most controversial topics in science education. Scientists, teachers, animal rights activists, and parents and students all hav

Via Tom D'Amico (@TDOttawa)
Destiny Muniz's insight:

Since there is much convtroversy over dissection Punfly created an application. The app takes them step by step through the disection give them a 3D image of the organs. And gives explanations of the from and its habitat. This is avilibale on the ipad, and this is also good becasue some schools are struggling with keeping up with good lab equiptment. For creating this app Punfly has been nominated for many educaitonal awards. But does it really give the kids hands on learning doing it through a screen?

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Olivia Haltom's curator insight, December 6, 2013 9:45 AM

i think its good to have a virtual app for this because then we arent killing as many animals.

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Crop Flop: 7 Million Prevented Planting

Crop Flop: 7 Million Prevented Planting | education | Scoop.it

As of Aug. 1, the Farm Service Agency (FSA) disclosed that 7.71 million acres were reported as prevented planting for the 2013 crop season. That’s a sharp rise from 2012’s 1.24 million acres.

Chatter in the countryside started back in the spring about farmers choosing to take prevented planting on large numbers of acres.


The North Star State is followed by Iowa with 613,257 reported prevented planting acres. USDA figures Iowa has 13.5 million acres of corn in the ground. Illinois, Mississippi, Missouri, North Dakota and Wisconsin all have 200,000 plus prevented planting acres. For soybeans, North Dakota is the clear leader in prevented planting acres, with 418,046. Minnesota is second is with 203,760 prevented planting acres.For corn, Minnesota kicks off the list in prevented planting acres, with 616,671. In USDA’s August Crop Production report, Minnesota is shown to have planted 8.2 million acres of corn.

Prevent plant acres have already bid into the market, explains Art Barnaby, Kansas State University ag economist. Yield will be the driving force now. "I don’t think we’ll make trend yield this year," he says, noting that an early freeze could also reduce harvested acres.

USDA will begin to incorporate the FSA data into its October Crop Production report.

For more information and to download the full report, visit the Farm Service Agency’s website at www.fsa.usda.gov.

 

Destiny Muniz's insight:

This article is talking about how farmers planted less crops this year and how it might effect the market. Its not really that they planted less just they arent using as much land. And that an early freeze this year might reduct harvsted acres. 

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