Diabetes & Metabolism
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Journal of Diabetes & Metabolism Introduction

Journal of Diabetes & Metabolism Introduction | Diabetes & Metabolism | Scoop.it
Journal of Diabetes & Metabolism is a high quality scientific journal with an international readership. It is focused on cutting edge research in the prevention, pharmacological treatment, management, and education of diabetes and related disorders.
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Editor in Chief | Journal of Diabetes & Metabolism

Editor in Chief | Journal of Diabetes & Metabolism | Diabetes & Metabolism | Scoop.it

Editors-in-Chief
Charles W. Heilig, MD
Professor
Department of Medicine
University of Florida
USA

 

 

 

Rao M. Uppu, PhD
Professor
Southern University and A & M College
USA
Tel. 225-77-3630
Fax 225-771-5350

 

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Type2 Diabetes: New Research Could Benefit Young Obese People

Type2 Diabetes: New Research Could Benefit Young Obese People | Diabetes & Metabolism | Scoop.it

The very common form of diabetes that is Type 2 Diabetes occurs due to the deficiency of insulin in body and insulin resistance. Over the past many decades, the rates of diabetes have hiked markedly. Type 2 diabetes occurs mostly in adults but nowadays youths are also developing this disease. Greater changes in lifestyle of young people including limited physical activity, poor diet, stress and obesity increases the risk of Type 2 diabetes in them. A lot of research is going on to find the treatment of diabetes. Researchers have found out new mechanisms in muscle cells that relate insulin resistance and decreased response to exercise in young obese people having Type 2 diabetes. This study demonstrated the role of genes responsible for the development of diabetes in young obese people. Scientists studied the development and advancement of Type 2 diabetes in young people and found that due to the abnormal function of many essential mitochondrial genes and proteins in obese young people, they are developing Type 2 diabetes. Since mitochondria is the energy reservoir of cell, such genetic abnormalities lead to insulin resistance and an extremely less response to physical exercise. In middle aged and older people aerobic exercise is recommended to prevent and treat Type 2 diabetes. A more precise knowledge of the cellular mechanisms of this disease will aid in developing targeted treatments for Type 2 diabetes in young people. These new findings on muscle mitochondrial function also contributed to the development of new treatment strategies for Type 2 diabetes in youth.

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Epidemiology of flu virus and type 1 diabetes

Flu virus causes moderate to severe illness in all age groups. The virus infects humans and other animals. Scientists reported that the flu virus may cause diabetes, which give us a way to prevent some forms of the disease.

Type 1 Diabetes (T1D) is a heterogeneous disorder accounted by destruction of pancreatic beta cells by our own immune system, crowning in loss of insulin secretion. Epidemiologic studies data indicating that during the last decades the incidence of T1D has increased significantly 2-5% annually. There is a significant environmental trigger impacting the development of the disease. Viruses like H1N1 influenza are one of the environmental factors associated with the development of T1D in susceptible individuals.

Since the 1970s, researchers have assuming that viruses may provide this trigger, as type 1 diabetes often sets in suddenly after an infection.

Enteroviruses and rotaviruses were both involved in causing infections and confuse the immune system enough to make it attack the pancreas. Ilaria Capua said, a few per cent of type 1 diabetes is caused by only flu, we can vaccinate and prevent flu in people who are genetically adapted. There are 65,000 new cases of type 1 diabetes worldwide annually, and that figure is growing by 3-5% every year.

The connection between diabetes and flu casts to growing evidence that many diseases acknowledged as non-infectious are actually caused by infection and spreading.

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Journal of Diabetes & Metabolism

Journal of Diabetes & Metabolism is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of Diabetes & the related complications from the molecular to the population level. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals. It publishes original research papers, reviews, case reports, and short communications and allows users to read, copy, distribute, and make derivative works for non-commercial purposes. Journal of Diabetes & Metabolism- Open Access leads to wider dissemination of information and increased efficiency in science

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OMICS Group

OMICS Group | Diabetes & Metabolism | Scoop.it

To Collaborate Scientific Professionals around the World


World Congress on Endocrinology
Dates of the Conference August 26-28, 2013
Venue of the Conference Las Vegas, USA
Theme Revealing a New World from Cells to Glands

 

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Potential Therapeutic for Treatment of Type 2 Diabetes

Potential Therapeutic for Treatment of Type 2 Diabetes | Diabetes & Metabolism | Scoop.it

A transmembrane glycoprotein which is highly expressed in adipocytes and found in tissues for glucose and lipid metabolism is known as Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1); which at the level of the alpha subunit interacts with the insulin receptor.Lessened insulin-mediated activation of tyrosine phosphorylation in beta-subunit of the insulin receptor, and downstream insulin signaling activation is result of this interaction. Single nucleotide polymorphism of the ENPP1 is linked with type 2 diabetes in humans.

Results of animal experiments elucidate that the suppression of ENPP1 expression helps in improving insulin sensitivity which further supports the hypothesis that inhibition of ENPP1 can be a potential therapeutic for treatment of type 2 diabetes but it still remained controversial in case humans due to effect of ENPP1 on complications of insulin resistance. In humans inhibitor effect of ENPP1 on insulin signaling has been found effected by the presence of 121Q gene variant, obesity, lipid disorder(Significant) or type 2 diabetes and gender. Also factors such as different ethnic origin and environment were also responsible for the failure to elucidate the linkage between ENPP1 and insulin resistance. The study also reveals that improvement on glucose homeostasis has been observed in ENPP1 K121Q variant with weight reduction, which suggests that people of the category can be benefitted more change in life style by lightening metabolic challenge which is found to be induced by positive caloric balance.

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