Among the more than 25 million Americans who have diabetes is Jay Cutler, the Bears quarterback who was diagnosed with type 1 diabetes when he was with the Denver Broncos. Learning of the disease helped...
JDRF, the leading global organization funding type 1 diabetes (T1D) research, announced today the formation of a new external Research Advisory Committee (RAC) comprised of individuals internationally renowned for their expertise in research as well as the care and treatment of those with T1D.
Ellen H Ullman, MSW's insight:
"to bring the greatest good for the largest number of people in the shortest amount of time." - The majority of the people worldwide with t1 diabetes will not benefit from the artificial pancreas - they need a biological cure.
Device shields beta cells from immune system attack | Researchers at MIT’s David H. Koch Institute for Integrative Cancer Research, in collaboration with scientists at the Harvard Stem Cell Institute and several other institutions, have developed an implantable device that in mice shielded insulin-producing beta cells from immune system attack for six months — a substantial proportion of life span.
A newly-developed micro-pancreas can prevent transplanted islet cells from failing, potentially overcoming one of the biggest problems with islet cell transplantation for people with type 1 diabetes. The platform, known as the engineered micro-pancreas (EMP), is developed by Israeli biotech company Betalin Therapeutics. It solves several of the difficulties associated with islet cell transplantation. Researchers know how to transplant islet cells to people with type 1 diabetes, and they know how to make those cells work. What they don't know is how to stop those cells from failing. Half of islet cell transplant patients are back on insulin injections with a year; 90 per cent within five years.
Introduction: Currently type 1 diabetes mellitus (T1DM) is treated with insulin and a high carbohydrate diet. In the literature, however, there are studies indicating that low carbohydrate diets may be beneficial in reducing hypoglycemic episodes as well as the need for insulin. Previously we reported a case of a 19-year-old T1DM patient who was successfully treated with a modified version of the ketogenic diet we refer to as the Paleolithic ketogenic diet. Case Report: Here we provide a case study of a 9-year-old child with T1DM who initially was on an insulin regime with high carbohydrate diet then was put on the Paleolithic ketogenic diet. Following dietary shift glucose levels normalized and he was able to discontinue insulin. No hypoglycemic episodes occurred on the diet and several other benefits were achieved including improved physical fitness, reduction of upper respiratory tract infections and eczema. Currently he is on the diet for 19 months. Conclusion: Adopting the Paleolithic ketogenic diet ensured normoglycemia without the use of external insulin. The diet was sustainable on the long-term. Neither complications nor side-effects emerged on the diet.
Ellen H Ullman, MSW's insight:
SHARING WITH AN ABUNDANCE OF CAUTION. THERE IS NOTHING HEALTHFUL ABOUT THIS DIET IN A 9 YEAR OLD GROWING CHILD IMO.
Using a growth factor produced naturally by the human body – and used in spinal-fusion surgeries – scientists from the Diabetes Research Institute (DRI) at the University of Miami Miller School of Medicine have coaxed “leftover” cells from the...
Ellen H Ullman, MSW's insight:
Rodent studies. Next step "animal studies". Let's hope HUMANS will someday benefit from this research.
Jane K. Dickinson is a nurse and Certified Diabetes Educator, who has been living with type 1 diabetes for 40 years. In 1993 Jane gave her first talk on the ...
In the first U.S. safety trial of a new form of immunotherapy for type 1 diabetes (T1D), led by UC San Francisco scientists and physicians, patients experienced no serious adverse reactions after receiving infusions of as many as 2.6 billion cells that had been specially selected to protect the body's ability to produce insulin.
A way to deliver insulin in a capsule that can be taken orally has been developed with the hope that it can replace injections for people with diabetes.
A new technique to produce cells with insulin-secretion capabilities has been developed, according to research presented today at the 54th Annual European Society for Paediatric Endocrinology Meeting. The technique could be further developed to be used in the transplantation for patients with type 1 diabetes.
Nemaura Medical stealthily listed on the Nasdaq OTC market late last year. That followed a corporate restructuring in late 2013. All this is in the name of developing a novel continuous glucose monitoring system that includes a disposable patch, a watch and a smartphone app--that the company has dubbed SugarBeat.
Investigators at Montreal's Lady Davis Institute at the Jewish General Hospital and McGill University Health Centre have announced the start of a landmark clinical study aimed at restoring normal insulin secretion in people with longstanding type 1 diabetes. The treatment combines INGAP Peptide (ExsulinTM), which stimulates growth of the insulin secreting islets, and ustekinumab (SteleraTM), a drug approved for the treatment of psoriasis.
Dr. David Klonoff is spearheading an effort to eliminate dangerous security holes in insulin pumps, which could help secure other medical devices as well.
Call it the scientist’s version of happy hour: A new, four-drug cocktail has shown a novel ability to reverse established Type 1 diabetes in some mice, University of Florida Health researchers have found.
Randomized cross-over design (11 days bionic pancreas, 11 days usual care)Subjects work or study on one of four campusesMGH, UNC Chapel Hill, Stanford, UMass Medical Center10 subjects per site (40 total)Normal daily routine, no restrictions on diet or exerciseRemote monitoring of alarms in BP, call subject if not response to alarms
Ellen H Ullman, MSW's insight:
Thank you Joshua Levy for sharing this via Twitter
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