Dementia Caregivers
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Click every day to fund vital Alzheimer's research.

Click every day to fund vital Alzheimer's research. | Dementia Caregivers | Scoop.it
Your click is FREE and funds research through the University of Michigan. Together, we can forward desperately needed research about Alzheimer's disease.
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Helping the Person with End Stage Alzheimer's dementia to Eat - Alzheimers Support

Helping the Person with End Stage Alzheimer's dementia to Eat - Alzheimers Support | Dementia Caregivers | Scoop.it
Helping the person with end stage Alzheimer's includes learning to eat and swallow.

Via Sandy Spencer
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Sandy Spencer's curator insight, December 13, 2014 9:16 AM

With all the goodies this holiday season, be sure to help your loved one with all the delightful tastes of the season!.

http://www.free-alzheimers-support.com

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Watch heart-melting moment Alzheimer's patient recognises her daughter and says 'I love you'

The video shows American Kelly Gunnerson and her mother talking in a hospital bed before the 87-year-old correctly remembers her daughter's name... This is t...
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AARP's Ten Tips for Caregivers During the Holidays - The Ridgefield Press

AARP's Ten Tips for Caregivers During the Holidays - The Ridgefield Press | Dementia Caregivers | Scoop.it
During the busy holiday season, family caregivers – more than 486,000 of them right here in Connecticut – already feel overwhelmed with daily responsibilities.
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Israeli scientist: Stronger immune system could cure Alzheimer’s

Israeli scientist: Stronger immune system could cure Alzheimer’s | Dementia Caregivers | Scoop.it
The Weizmann Institute’s Prof. Michal Schwartz has been developing ways to use the immune system to treat devastating injuries.
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Speakset: Skype for Seniors | Stylus | Innovation Research & Advisory

Speakset: Skype for Seniors | Stylus | Innovation Research & Advisory | Dementia Caregivers | Scoop.it
Speakset is a new video-calling service designed especially for seniors. The system reduces the risk of social isolation, as well as enabling health workers to carry out remote consultations for patients with impaired mobility.
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At SMU's Meadows Museum, Connections reaches dementia patients, launches ... - Dallas Morning News

At SMU's Meadows Museum, Connections reaches dementia patients, launches ... - Dallas Morning News | Dementia Caregivers | Scoop.it
Established in 2011, the program serves people in early stages of dementia and their caregivers. It’s not just for people with Alzheimer’s.
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Moving Elderly Parents Into Your Home

Moving Elderly Parents Into Your Home | Dementia Caregivers | Scoop.it
If you decide to move a parent or other relative in with you, you won't be alone: 1 of 4 caregivers lives with the elderly or disabled relative he or she cares for.
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Letter: Groups help families dealing with dementia - Buffalo News

Letter: Groups help families dealing with dementia - Buffalo News | Dementia Caregivers | Scoop.it
“I’m losing my mind” was an expression my mother was fond of using when I was growing up, especially when my brother cranked up the volume while listening to his Led Zeppelin albums. But my mother never did lose her mind.
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Alzheimer's treatment shows promise in study

Alzheimer's treatment shows promise in study | Dementia Caregivers | Scoop.it
This isn't a cure but it is a promising step in the process.
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Running Can Cut Risk Of Alzheimer’s Disease, Study Shows

Running Can Cut Risk Of Alzheimer’s Disease, Study Shows | Dementia Caregivers | Scoop.it
Running, eating fruit and taking cholesterol-management drugs can help prevent death by Alzheimer’s.
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Drugs used for impotence could treat vascular dementia? - Medical Xpress

Drugs used for impotence could treat vascular dementia? - Medical Xpress | Dementia Caregivers | Scoop.it
Scientists are to explore whether drugs usually used to treat erectile problems by expanding blood vessels could become the next major way to tackle the dementia epidemic.
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How I'm preparing to get Alzheimer's

How I'm preparing to get Alzheimer's | Dementia Caregivers | Scoop.it
When faced with a parent suffering from Alzheimer's, most of us respond with denial ("It won't happen to me") or extreme efforts at prevention. But global health expert and TED Fellow Alanna Shaikh sees it differently.
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2015 Alzheimer's disease facts and figures

Abstract

This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care and the overall effect on caregivers and society. It also examines the challenges encountered by health care providers when disclosing an AD diagnosis to patients and caregivers. An estimated 5.3 million Americans have AD; 5.1 million are age ≥65 years, and approximately 200,000 are age <65 years and have younger onset AD. By mid-century, the number of people living with AD in the United States is projected to grow by nearly 10 million, fueled in large part by the aging baby boom generation. Today, someone in the country develops AD every 67 seconds. By 2050, one new case of AD is expected to develop every 33 seconds, resulting in nearly 1 million new cases per year, and the estimated prevalence is expected to range from 11 million to 16 million. In 2013, official death certificates recorded 84,767 deaths from AD, making AD the sixth leading cause of death in the United States and the fifth leading cause of death in Americans age ≥65 years. Between 2000 and 2013, deaths resulting from heart disease, stroke and prostate cancer decreased 14%, 23% and 11%, respectively, whereas deaths from AD increased 71%. The actual number of deaths to which AD contributes (or deaths with AD) is likely much larger than the number of deaths from AD recorded on death certificates. In 2015, an estimated 700,000 Americans age ≥65 years will die with AD, and many of them will die from complications caused by AD. In 2014, more than 15 million family members and other unpaid caregivers provided an estimated 17.9 billion hours of care to people with AD and other dementias, a contribution valued at more than $217 billion. Average per-person Medicare payments for services to beneficiaries age ≥65 years with AD and other dementias are more than two and a half times as great as payments for all beneficiaries without these conditions, and Medicaid payments are 19 times as great. Total payments in 2015 for health care, long-term care and hospice services for people age ≥65 years with dementia are expected to be $226 billion. Among people with a diagnosis of AD or another dementia, fewer than half report having been told of the diagnosis by their health care provider. Though the benefits of a prompt, clear and accurate disclosure of an AD diagnosis are recognized by the medical profession, improvements to the disclosure process are needed. These improvements may require stronger support systems for health care providers and their patients.


Via Krishan Maggon
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Krishan Maggon 's curator insight, March 29, 2015 12:40 PM

In 2014, there were 5.3 million Ad

patients in the US and number will double in 2 decades.

 

AD costs

 

Medicare       #226 billion

 

Caretaker/family    $217 billion

 

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Review: Still Alice: Julianne Moore Reveals Alzheimer's From the Inside - TIME

Review: Still Alice: Julianne Moore Reveals Alzheimer's From the Inside - TIME | Dementia Caregivers | Scoop.it
One of America's great actresses turns this story of tragic forgetfulness into a heroic struggle, and a master class in the delicacy and power of performance
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Seth Rogen on his 'family love story' and the ravages of Alzheimer's - Today.com

Seth Rogen on his 'family love story' and the ravages of Alzheimer's - Today.com | Dementia Caregivers | Scoop.it
Alzheimer’s is one of the few things comedian Seth Rogen doesn't joke about. "The Interview" star is opening up about his family's "long,...
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Examining the work of young caregivers

Montreal filmmaker Chris Wynn talks about his documentary, Much Too Young, a film about young caregivers whose lives have been turned upside down trying to deal with parents with early onset...
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America's Senior Citizens Rank Dead Last Among Developed Nations in This ... - Motley Fool

America's Senior Citizens Rank Dead Last Among Developed Nations in This ... - Motley Fool | Dementia Caregivers | Scoop.it
America may be an economic superpower and rank at the top of a number of lists, but when it comes to taking care of its senior citizens America is far from the best! - Sean Williams - Health Care
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Elderly Scarborough man found dead in snow-covered stairwell

Elderly Scarborough man found dead in snow-covered stairwell | Dementia Caregivers | Scoop.it
An elderly Scarborough man who went missing in a heavy snowstorm Thursday has been found dead.
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Psoriasis Drug Being Eyed as Treatment for Alzheimer's Disease; Patients ... - Franchise Herald

Psoriasis Drug Being Eyed as Treatment for Alzheimer's Disease; Patients ... - Franchise Herald | Dementia Caregivers | Scoop.it
Acknowledging the huge threat posed by Alzheimer’s disease especially for the elderly, a new research by German scientists suggests that an approved psoriasis drug can help cure the most common form of dementia.
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What Not to Do to People with Alzheimer’s Disease

What Not to Do to People with Alzheimer’s Disease | Dementia Caregivers | Scoop.it
(About.com) Do you know someone who has Alzheimer's? If you don't, it might only be a matter of time before you do. The Alzheimer's Association estimates that approximately 5.4 million Americans ha...
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Running 15 Miles a Week Could Slash Alzheimers Risk - Daily Beast

Running 15 Miles a Week Could Slash Alzheimers Risk - Daily Beast | Dementia Caregivers | Scoop.it
A new study from the Journal of Alzheimer’s Disease might offer the best reason yet to lace up your shoes and grind out some serious miles.
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Carers for the elderly experience stress and their careers suffer - Phys.Org

Carers for the elderly experience stress and their careers suffer - Phys.Org | Dementia Caregivers | Scoop.it
An ageing population means that increasing numbers of people – predominantly women – need to spend time caring for elderly relatives.
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Repurposed experimental cancer drug restores brain function in mouse models of Alzheimer’s disease

Repurposed experimental cancer drug restores brain function in mouse models of Alzheimer’s disease | Dementia Caregivers | Scoop.it
NIH-supported research enables clinical trial to explore treatment for most common form of dementia
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Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways

Abstract

Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or clearance of the neurotoxic amyloid β-peptide (Aβ). Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of Aβ produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD). Similarly, the more prevalent late-onset forms of AD are associated with both coding and non-coding variants in genes such as SORL1, PICALM and ABCA7 that affect the production and clearance of Aβ. This review summarises some of the recent molecular and structural work on the role of these genes and the proteins coded by them in the biology of Aβ. We also briefly outline how the emerging knowledge about the pathways involved in Aβ generation and clearance can be potentially targeted therapeutically. This article is part of Special Issue entitled "Neuronal Protein".


Via Krishan Maggon
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Krishan Maggon 's curator insight, April 2, 2015 9:24 AM

doi:10.1016/j.mcn.2015.02.016Get rights and contentOpen Access funded by Wellcome TrustUnder a Creative Commons license Highlights

 

Rare, medium and common variants in at least 20 genes are associated with AD.

Multiple genes affect processing of APP and production of Aβ peptide.

Others relate to immunity, inflammation, vesicular trafficking, and lipid metabolism.

These genes reflect steps in a complex metabolic/signalling cascade.

Nodal points in these pathways may represent potential therapeutic targets.

 

 

Fig. 3. 

3-D rendition of the 17 Å structure of the human presenilin complex under native conditions demonstrating the presence of a soluble head domain containing the ectodomain of nicastrin and a membrane-bound body containing the transmembrane domains of the other presenilin complex component proteins (PS1/PS2, PEN-2, APH1 and nicastrin).