Cytokines et Chimiokines
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Cytokines et Chimiokines
Actualités sur les cytokines et les chimiokines. Club de la SFI
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Club Cytokines et Chimiokines

Cette page a été ouverte par la secrétaire de la SFI à laquelle il faut rendre hommage, du fait de cet esprit d'innovation et de veille, dès 2011.

Du fait de la charge de travail, la page a été reprise et maintenue par GC FAURE de 2013 à 2018. 

Hélas en l'absence d'intérêt individuel et collectif au sein de la SFI pour la veille scientifique et compte tenu de l'évolution des conditions de fonctionnement de l'outil Scoop.it, ce sujet ne sera désormais plus actualisé.

Pour toute information concernant les cytokines en 
Immunologie fondamentale, 
Scoop.it Immunology 
Immunité muqueuse, 

Immunothérapies, 
Allergie et Immunologie clinique, 

Vous trouverez dans les liens ci-dessus une veille scientifique et technique d'informations relevantes dont nous assurons la curation.

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pour plus d'informations sur les Clubs de la SFI

http://www.sfi-immunologie.com.fr/pages/?page=613&idl=21


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Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation

Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation | Cytokines et Chimiokines | Scoop.it
Multiple sclerosis (MS) is a neuroinflammatory disorder, and current therapies focus on altering immune activity to reduce symptoms. Vogelaar and colleagues tested the ability of intrathecally applied IL-4, a cytokine typically associated with T helper type 2 responses, to treat established disease in several experimental autoimmune encephalomyelitis (EAE) models. IL-4 treatment led to reduced clinical scores, improved locomotor activity, and diminished axon damage. Somewhat surprisingly, the beneficial effects of IL-4 did not depend on T cell modulation in the chronic disease phase. The receptor for IL-4 was observed in postmortem brain histology of several MS patients, and they demonstrated that IL-4 could act directly on neurons in vitro. They also showed benefits of intranasal IL-4 administration in one of the EAE models, which could be a promising avenue to pursue in the clinic.
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Frontiers | Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation | Immunology

Frontiers | Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation | Immunology | Cytokines et Chimiokines | Scoop.it
IL-23 is a member of the IL-12 family of cytokines that, as the other members of this family, is secreted by monocytes, macrophages and dendritic cells (DC) upon recognition of bacterial, viral and fungal components. IL-23 is critical during immunity against acute infections and it is also involved in the development of autoimmune diseases. Although immunoregulatory effects of IL-23 on mouse NK cells have been described, the effect of IL-23 on human NK cells remains ill-defined. In this study, we observed that monocytes stimulated with LPS secreted IL-23 and that blockade of this cytokine during monocyte and NK cell co-culture led to a diminished production of IFN-gamma by NK cells. Accordingly, rIL-23 induced NK cell activation and stimulated IFN-gamma production by CD56bright NK cells. This effect involved MEK1/MEK2, JNK, PI3K, mTOR and NF-kappaB, but not STAT-1, STAT-3 nor p38 MAPK pathways. Moreover, while NK cell-mediated cytotoxicity remained unaltered, antibody-dependent cellular cytotoxicity (ADCC) was enhanced after IL-23 stimulation. In addition, IL-23 displayed a synergistic effect with IL-18 for IFN-gamma production by both CD56bright and CD56dim NK cells, and this effect was due to a priming effect of IL-23 for IL-18 responsiveness. Furthermore, NK cells pre-stimulated with IL-18 promoted an increase in CD86 expression and IL-12 secretion by DC treated with LPS, and IL-23 potentiated these effects. Moreover, IL-23-driven enhancement of NK cell “helper” function was dependent on NK cell-derived IFN-gamma. Therefore, our results suggest that IL-23 may trigger NK cell-mediated “helper” effects on adaptive immunity, shaping T cell responses during different pathological situations through the regulation of DC maturation.
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Benefits of immune protection versus immunopathology costs: A synthesis from cytokine KO models. - PubMed - NCBI

Benefits of immune protection versus immunopathology costs: A synthesis from cytokine KO models. - PubMed - NCBI | Cytokines et Chimiokines | Scoop.it
Infect Genet Evol. 2017 Oct;54:491-495. doi: 10.1016/j.meegid.2017.08.014. Epub 2017 Aug 15.
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Award trilogy for rheumatology education resource provider

Award trilogy for rheumatology education resource provider | Cytokines et Chimiokines | Scoop.it
Cytokine signalling education forum and resource for rheumatologists, the Cytokine …
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Structural principles of tumor necrosis factor superfamily signaling

Structural principles of tumor necrosis factor superfamily signaling | Cytokines et Chimiokines | Scoop.it
Tumor necrosis factor (TNF) superfamily pathways regulate cell proliferation, cell death, and morphogenesis. TNF superfamily receptors mediate various cancers and immune-mediated diseases. Understanding of the mechanisms of TNF superfamily signaling and the structure and geometry of ligands, receptors, and their interactions is essential to designing effective agonist and antagonist drugs. In this review, consisting of four figures, one table, and 96 references, we discuss our current understanding of TNF ligand-receptor conformations and how this informs signaling and the design of current and prospective therapeutics.

Via Gilbert C FAURE
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Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions: R&D Systems

Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions: R&D Systems | Cytokines et Chimiokines | Scoop.it
View our poster on Common gamma-Chain Family Cytokines Play a Pivotal Role in Regulating Immune System Functions.
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2017 Top 10 Innovations

2017 Top 10 Innovations | Cytokines et Chimiokines | Scoop.it
From single-cell analysis to whole-genome sequencing, this year’s best new products shine on many levels.
Société Francaise d'Immunologie's insight:
isolight
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Inflammasomes, the eye and anti-inflammasome therapy

Inflammasomes, the eye and anti-inflammasome therapy | Cytokines et Chimiokines | Scoop.it
Review
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Infections from seven clinical trials of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriasis

Infections from seven clinical trials of ixekizumab, an anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriasis | Cytokines et Chimiokines | Scoop.it
Summary

Background
Infections are associated with biological therapies in psoriasis.


Objectives
To summarize the incidence of infections in patients with moderate-to-severe psoriasis treated with ixekizumab, an anti-interleukin-17A monoclonal antibody.


Methods
Infections are summarized from an integrated database of seven controlled and uncontrolled ixekizumab psoriasis trials. Data are presented from placebo-controlled induction
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Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis

Macrophage-Specific Expression of IL-37 in Hyperlipidemic Mice Attenuates Atherosclerosis | Cytokines et Chimiokines | Scoop.it
Atherosclerosis, the progressive buildup of plaque within arterial blood vessels, can lead to fatal downstream events, such as heart attack or stroke. A key event contributing to the development of atherosclerosis is the infiltration of monocytes and its associated inflammation, as well as the formation of lipid-laden macrophage foam cells within the vessel wall. IL-37 is recognized as an important anti-inflammatory cytokine expressed especially by immune cells. This study was undertaken to elucidate the role of macrophage-expressed IL-37 in reducing the production and effects of proinflammatory cytokines, preventing foam cell formation, and reducing the development of atherosclerosis. Expression of human IL-37 was achieved with a macrophage-specific overexpression system, using the CD68 promoter in mouse primary bone marrow–derived macrophages via retroviral transduction. Macrophage IL-37 expression in vitro resulted in decreased mRNA (e.g., IL-1B, IL-6, and IL-12) and secreted protein production (e.g., IL-6, M-CSF, and ICAM-1) of key inflammatory mediators. IL-37 expression also inhibited macrophage proliferation, apoptosis, and transmigration, as well as reduced lipid uptake, compared with controls in vitro. The in vivo effects of macrophage-expressed IL-37 were investigated through bone marrow transplantation of transduced hematopoietic stem cells into irradiated atherosclerosis-prone Ldlr−/− mice. After 10 wk on a high-fat/high-cholesterol diet, mice with IL-37–expressing macrophages showed reduced disease pathogenesis, which was demonstrated by significantly less arterial plaque development and systemic inflammation compared with control mice. The athero-protective effect of macrophage-expressed IL-37 has implications for development of future therapies to treat atherosclerosis, as well as other chronic inflammatory diseases.
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Inflammation: Cytokines alter inflammatory responses via chromatin changes : Nature Reviews Rheumatology : Nature Research

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IL‐27: a double agent in the IL‐6 family - Jones - - Clinical & Experimental Immunology - Wiley Online Library

Clinical & Experimental Immunology, Ahead of Print.
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Dupilumab: A review of its use in the treatment of atopic dermatitis

Dupilumab: A review of its use in the treatment of atopic dermatitis | Cytokines et Chimiokines | Scoop.it
Atopic dermatitis (AD) is a chronic, pruritic immune-mediated inflammatory dermatosis
characterized by a T helper 2 (Th2) immune response phenotype and may be associated
with systemic inflammation. Dupilumab is an interleukin 4 (IL-4) receptor α-antagonist
that inhibits IL-4 and IL-13 signaling through blockade of the shared IL-4α subunit.
Blockade of IL-4/13 is effective in reducing Th2 response. Dupilumab has recently
been approved in the United States and Europe for the treatment of adult patients
with moderate-to-severe AD.
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IL-36 cytokines in autoimmunity and inflammatory disease. - PubMed - NCBI

IL-36 cytokines in autoimmunity and inflammatory disease. - PubMed - NCBI | Cytokines et Chimiokines | Scoop.it
Oncotarget. 2017 Dec 1;9(2):2895-2901. doi: 10.18632/oncotarget.22814. eCollection 2018 Jan 5. Review
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Interleukin-10 stiffens the heart

Interleukin-10 stiffens the heart | Cytokines et Chimiokines | Scoop.it
Cardiac-resident macrophages are a diverse population of cells that have a critical role in the pathogenesis of heart failure. A new understanding of communication between macrophages and cardiac fibroblasts could lead to novel therapeutic strategies for heart failure with preserved ejection function.
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Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity

The mechanisms by which IL-10 facilitates the establishment of chronic infections
are not fully understood. Smith et al. demonstrate that during chronic infections,
IL-10 upregulates N-glycan branching on CD8+ T cell surface glycoproteins, which reduces
signal transduction downstream of the T cell receptor and decreases CD8+ T cell antigen
sensitivity and capacity to control pathogen burden.
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Functional expression of CCL8 and its interaction with chemokine receptor CCR3

Functional expression of CCL8 and its interaction with chemokine receptor CCR3 | Cytokines et Chimiokines | Scoop.it
Chemokines and their cognate receptors play important role in the control of leukocyte chemotaxis, HIV entry and other inflammatory diseases. Developing an effcient method to investigate the functional expression of chemokines and its interactions with specific receptors will be helpful to asses the structural and functional characteristics as well as the design of new approach to therapeutic intervention. By making systematic optimization study of expression conditions, soluble and functional production of chemokine C-C motif ligand 8 (CCL8) in Escherichia coli (E. coli) has been achieved with approx. 1.5 mg protein/l culture. Quartz crystal microbalance (QCM) analysis exhibited that the purified CCL8 could bind with C-C chemokine receptor type 3 (CCR3) with dissociation equilibrium constant (K
D) as 1.2 × 10−7 M in vitro. Obvious internalization of CCR3 in vivo could be detected in 1 h when exposed to 100 nM of CCL8. Compared with chemokine C-C motif ligand 11 (CCL11) and chemokine C-C motif ligand 24 (CCL24), a weaker chemotactic effect of CCR3 expressing cells was observed when induced by CCL8 with same concentration. This study delivers a simple and applicable way to produce functional chemokines in E. coli. The results clearly confirms that CCL8 can interact with chemokine receptor CCR3, therefore, it is promising area to develop drugs for the treatment of related diseases.
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Screening of genes involved in epithelial-mesenchymal transition and differential expression of complement-related genes induced by PAX2 in renal t... - PubMed - NCBI

Screening of genes involved in epithelial-mesenchymal transition and differential expression of complement-related genes induced by PAX2 in renal t... - PubMed - NCBI | Cytokines et Chimiokines | Scoop.it
Nephrology (Carlton). 2017 Dec 27. doi: 10.1111/nep.13216. [Epub ahead of print]
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Frontiers | IL17eScan: A Tool for the Identification of Peptides Inducing IL-17 Response | Immunology

Frontiers | IL17eScan: A Tool for the Identification of Peptides Inducing IL-17 Response | Immunology | Cytokines et Chimiokines | Scoop.it
IL-17 cytokines are proinflammatory cytokines and are crucial in host defense against various microbes. Induction of these cytokines by microbial antigens has been investigated in the case of ischemic brain injury, gingivitis, candidiasis, autoimmune myocarditis, etc. In this study, we have investigated the ability of amino acid sequence of antigens to induce IL-17 response using machine learning approaches. A total of 338 IL-17 inducing and 984 IL-17 non-inducing peptides were retrieved from IEDB database. 80% of the data was randomly selected as training dataset and rest 20% as validation dataset. To predict the IL-17 inducing ability of peptides/protein antigens, different sequence-based machine learning models were developed. The performance of support vector machine (SVM), and Random Forest (RF) were compared with different parameters to predict IL-17 inducing epitopes. The dipeptide composition-based SVM-model displayed an accuracy of 82.4% with MCC = 0.62 at polynomial (t=1) kernel on 10-fold cross validation, and outperformed RF. Amino acid residues Leu, Ser, Arg, Asn and Phe, and dipeptides LL, SL, LK, IL, LI, NL, LR, FK, SF and LE are abundant in IL-17 inducing epitopes. The present tool helps in the identification of IL-17 inducing epitopes using machine learning approaches. The induction of IL-17 plays an important role in several inflammatory diseases and identification of such epitopes would be of great help to the immunologists. It is freely available at http://metagenomics.iiserb.ac.in/IL17eScan/ and http://metabiosys.iiserb.ac.in/IL17eScan/
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The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages | Cytokines et Chimiokines | Scoop.it
Inflammasomes elicit pyroptosis or cell hyperactivation, with the latter defined as
living cells that release IL-1. Evavold et al report that the pore-forming protein
gasdermin D regulates IL-1 release from hyperactive macrophages. Cell- and liposome-based
assays revealed that gasdermin D pores permit IL-1 passage across intact lipid bilayers.
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Paper: T Cell Engagement without Cytokine Storm: A Novel Bcma x CD3 Antibody Killing Myeloma Cells with Minimal Cytokine Secretion

Paper: T Cell Engagement without Cytokine Storm: A Novel Bcma x CD3 Antibody Killing Myeloma Cells with Minimal Cytokine Secretion | Cytokines et Chimiokines | Scoop.it
Introduction Multiple myeloma (MM) is a plasma cell malignancy with an annual incidence of ~25,000. Improvements in standard of care have extended median survival to greater than 5 years; however, disease refractory to bortezomib and lenalidomide is still associated with a median life expectancy...
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TNF Antagonists: Killing Two “Birds” with one Biologic “Stone”

TNF Antagonists: Killing Two “Birds” with one Biologic “Stone” | Cytokines et Chimiokines | Scoop.it
Forty years have passed since it was first recognized that patients with autoimmune rheumatic disease have an increased risk of fatal and non‐fatal cardiovascular (CV) events (1) Although initia
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Watching immune proteins and therapeutics diffuse through lymph nodes

Watching immune proteins and therapeutics diffuse through lymph nodes | Cytokines et Chimiokines | Scoop.it
ACS Meeting Coverage
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