Comparative Oncology
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Medical Trials Using Dogs Show Promise for Brain Cancer

Glioblastoma is the deadliest brain cancer in people. It's the cancer that claimed the lives of Senators John McCain and Ted Kennedy. Now an experimental drug being tested on dogs could hold promise for people.
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Why do we give our pets death with dignity but not ourselves?

Why do we give our pets death with dignity but not ourselves? | Comparative Oncology | Scoop.it
My years as an emergency veterinarian have shown me the relief that assisted death can bring.
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SAP BrandVoice: Big Data Gets Opioids Off The Street, More People Into Effective Treatment

SAP BrandVoice: Big Data Gets Opioids Off The Street, More People Into Effective Treatment | Comparative Oncology | Scoop.it
At SAPPHIRE NOW, SAP partner Esri shared how big data can help communities win the battle against opioid addiction.
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Advancing the Use of Real-World Evidence with a Noteworthy Industry Collaborative Pilot Project

Advancing the Use of Real-World Evidence with a Noteworthy Industry Collaborative Pilot Project | Comparative Oncology | Scoop.it
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Cancer researchers study elephants, who rarely get the disease - The

Cancer researchers study elephants, who rarely get the disease - The | Comparative Oncology | Scoop.it
Scientists explore interspecies variations, hoping to find better ways of treating or preventing the disease in humans.
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New Computational Strategy Designed for More Personalized Cancer Treatment « News from The Johns Hopkins University

New Computational Strategy Designed for More Personalized Cancer Treatment « News from The Johns Hopkins University | Comparative Oncology | Scoop.it
Johns Hopkins University
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WeatherTech's founder lost three dogs to cancer. He says his new pet bowls are safe enough for a human. - Chicago Tribune

WeatherTech's founder lost three dogs to cancer. He says his new pet bowls are safe enough for a human. - Chicago Tribune | Comparative Oncology | Scoop.it
WeatherTech's David MacNeil, who built a booming floor mat manufacturing business in Bolingbrook, is launching ergonomic dog and cat bowls
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Puppy’s stenosis case opens option to treatment

Puppy’s stenosis case opens option to treatment | Comparative Oncology | Scoop.it
Fresh hope for dogs suffering pulmonic stenosis that cannot be corrected using a traditional approach after new procedure success.
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Practice Culture Impacts Practice Success

Practice Culture Impacts Practice Success | Comparative Oncology | Scoop.it
The bottom-line benefits of a healthier practice culture include lower turnover, higher productivity, better personal well-being and improved practice reputation.
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Crowdsourcing: Fueling Veterinary Research - NAVC SPARK! Your Veterinary News, Your Veterinary Life

Crowdsourcing: Fueling Veterinary Research - NAVC SPARK! Your Veterinary News, Your Veterinary Life | Comparative Oncology | Scoop.it
A new startup is bringing practicing veterinarians into pharmaceutical research...and helping sick pets at the same time.
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Suppressing resistance to cancer therapy

Capitalising on competition between cells, and on cooperation between disciplines.
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New $6.4M grant to test a preventive cancer vaccine in a dog clinical trial | The Biodesign Institute | ASU

The Open Philanthropy Project awarded a multi-year grant of $6,421,402 to Stephen Albert Johnston at Arizona State University to support the largest interventional canine clinical trial ever conducted. The trial will assess the effectiveness of a unique vaccine in preventing any type of cancer in dogs.
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Researchers make breakthrough in feline infectious peritonitis trial

Researchers make breakthrough in feline infectious peritonitis trial | Comparative Oncology | Scoop.it
The study, funded by Morris Animal Foundation, saw patients go into remission after antiviral treatment.
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Lymphoma in Horses: Treatments and Outcomes –

Lymphoma in Horses: Treatments and Outcomes – | Comparative Oncology | Scoop.it
Recent research suggests that chemotherapy can help horses with lymphoma achieve remission and extend their lifespans for several months or years.
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Elephants rarely get cancer. Here's why this matters to humans

Elephants rarely get cancer. Here's why this matters to humans | Comparative Oncology | Scoop.it
You'd think elephants would be getting cancer left and right, but they have evolved resistance. They're being studied for clues about how to treat cancer in humans.
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Liquid Biopsy: Promises and Problems

Liquid Biopsy: Promises and Problems | Comparative Oncology | Scoop.it
Liquid biopsy, which is often performed using a simple blood draw, can tell scientists about cancer DNA in the blood. What promises does it hold?
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How 3,000 very good golden retrievers could help all dogs live longer - The

How 3,000 very good golden retrievers could help all dogs live longer - The | Comparative Oncology | Scoop.it
An ambitious study is tracking thousands of these popular pooches for their entire lives, and it could lead to breakthroughs in canine cancer prevention.
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Roche - Roche’s TECENTRIQ in combination with chemotherapy helped people with previously-untreated extensive-stage small cell lung cancer live significantly longer compared to chemotherapy

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Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma

Exploiting Drug Addiction Mechanisms to Select against MAPKi-Resistant Melanoma | Comparative Oncology | Scoop.it
Melanoma resistant to MAPK inhibitors (MAPKi) displays loss of fitness upon experimental MAPKi withdrawal and, clinically, may be resensitized to MAPKi therapy after a drug holiday. Here, we uncovered and therapeutically exploited the mechanisms of MAPKi addiction in MAPKi-resistant BRAFMUT or NRAS MUT melanoma. MAPKi-addiction phenotypes evident upon drug withdrawal spanned transient cell-cycle slowdown to cell-death responses, the latter of which required a robust phosphorylated ERK (pERK) rebound. Generally, drug withdrawal–induced pERK rebound upregulated p38–FRA1–JUNB–CDKN1A and downregulated proliferation, but only a robust pERK rebound resulted in DNA damage and parthanatos-related cell death. Importantly, pharmacologically impairing DNA damage repair during MAPKi withdrawal augmented MAPKi addiction across the board by converting a cell-cycle deceleration to a caspase-dependent cell-death response or by furthering parthanatos-related cell death. Specifically in MEKi-resistant NRASMUT or atypical BRAF MUT melanoma, treatment with a type I RAF inhibitor intensified pERK rebound elicited by MEKi withdrawal, thereby promoting a cell death–predominant MAPKi-addiction phenotype. Thus, MAPKi discontinuation upon disease progression should be coupled with specific strategies that augment MAPKi addiction.

Significance: Discontinuing targeted therapy may select against drug-resistant tumor clones, but drug-addiction mechanisms are ill-defined. Using melanoma resistant to but withdrawn from MAPKi, we defined a synthetic lethality between supraphysiologic levels of pERK and DNA damage. Actively promoting this synthetic lethality could rationalize sequential/rotational regimens that address evolving vulnerabilities. Cancer Discov; 8(1); 74–93. ©2017 AACR.

See related commentary by Stern, [p. 20][1] .

This article is highlighted in the In This Issue feature, [p. 1][2]

[1]: /lookup/volpage/8/20?iss=1
[2]: /lookup/volpage/8/1?iss=1
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It’s a Dog’s World, Especially in the Lab. Where Are the Cats? - The New York Times

It’s a Dog’s World, Especially in the Lab. Where Are the Cats? - The New York Times | Comparative Oncology | Scoop.it
An inquiry into why research on the nature of dogs gets so much attention raises the question of whether there are actually more studies of dogs.
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New ethics committee aims to help veterinarians navigate complex care situations

New ethics committee aims to help veterinarians navigate complex care situations | Comparative Oncology | Scoop.it
Clinicians and researchers have developed a first-of-its-kind veterinary medical ethics committee to aid care providers in navigating complex care situations.
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Cancer ‘vaccine’ eliminates tumors in mice

Cancer ‘vaccine’ eliminates tumors in mice | Comparative Oncology | Scoop.it
Activating T cells in tumors eliminated even distant metastases in mice, Stanford researchers found. Lymphoma patients are being recruited to test the technique in a clinical trial.
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ASU awarded $6.4M grant to test preventive cancer vaccine for dogs

ASU awarded $6.4M grant to test preventive cancer vaccine for dogs | Comparative Oncology | Scoop.it
The Open Philanthropy Project has awarded a multi-year, $6.4 million grant to Stephen Albert Johnston at Arizona State University to support the largest interventional canine clinical trial ever conducted. The trial will assess the effectiveness of a unique vaccine in preventing any type of cancer in dogs.
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SolveBio Awarded $1.5 Million from the National Institutes of Health to Expand Genomic Applications in Precision Medicine

SolveBio Awarded $1.5 Million from the National Institutes of Health to Expand Genomic Applications in Precision Medicine | Comparative Oncology | Scoop.it
SolveBio Awarded $1.5 Million from the National Institutes of Health to Expand Genomic Applications in Precision Medicine
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The NIH is in danger of losing its edge in creating biomedical innovations

The NIH is in danger of losing its edge in creating biomedical innovations | Comparative Oncology | Scoop.it
To safeguard biomedical innovation, the U.S. needs more federal funding for basic research and better allocation of those funds by the NIH.
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