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The Connections Between Us: Learning to Leverage the Power of a Network Approach

The Connections Between Us: Learning to Leverage the Power of a Network Approach | Building Networks | Scoop.it
This is the second article in our series about the role of networks in the non-profit sector. The series is published as a collaboration between The
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Recent article I wrote as part of a series on the Network Approach with Ontario Nonprofit Network. Key principles and examples are shared. 

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Predicting perturbation patterns from the topology of biological networks

High-throughput technologies, offering unprecedented wealth of quantitative data underlying the makeup of living systems, are changing biology. Notably, the systematic mapping of the relationships between biochemical entities has fueled the rapid development of network biology, offering a suitable framework to describe disease phenotypes and predict potential drug targets. Yet, our ability to develop accurate dynamical models remains limited, due in part to the limited knowledge of the kinetic parameters underlying these interactions. Here, we explore the degree to which we can make reasonably accurate predictions in the absence of the kinetic parameters. We find that simple dynamically agnostic models are sufficient to recover the strength and sign of the biochemical perturbation patterns observed in 87 biological models for which the underlying kinetics is known. Surprisingly, a simple distance-based model achieves 65% accuracy. We show that this predictive power is robust to topological and kinetic parameters perturbations, and we identify key network properties that can increase up to 80% the recovery rate of the true perturbation patterns. We validate our approach using experimental data on the chemotactic pathway in bacteria, finding that a network model of perturbation spreading predicts with ~80% accuracy the directionality of gene expression and phenotype changes in knock-out and overproduction experiments. These findings show that the steady advances in mapping out the topology of biochemical interaction networks opens avenues for accurate perturbation spread modeling, with direct implications for medicine and drug development.
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Network Leadership – Build, Manage, and Evaluate Effective Networks | PARTNER Tool

Network Leadership – Build, Manage, and Evaluate Effective Networks | PARTNER Tool | Building Networks | Scoop.it

Via june holley
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Rescooped by Liz Rykert from Movements
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Creating Culture: Promising Practices of Successful Movement Networks

The Management Assistance Group launched a multiyear program to explore how movement networks can best achieve successful cross-issue collaboration.

Via Patricia Thompson
Liz Rykert's insight:

Building trust is "the most fundamental, irreducible task for movement network leaders and members." Couldn't agree more.

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Patricia Thompson's curator insight, March 11, 2014 12:35 AM

Building trust is "the most fundamental, irreducible task for movement network leaders and members." Couldn't agree more.

Liz Rykert's curator insight, January 24, 10:56 PM

Building trust is "the most fundamental, irreducible task for movement network leaders and members." Couldn't agree more.

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The elegant law that governs us all

The elegant law that governs us all | Building Networks | Scoop.it

 

A dog owner weighs twice as much as her German shepherd. Does she eat twice as much? Does a big city need twice as many gas stations as one that is half its size? Our first instinct is to say yes. But, alas, we are wrong. On a per-gram basis, a human requires about 25% less food than her dog, and the larger city needs only 85% more gas stations. As Geoffrey West explains in Scale, the reason behind these intriguing phenomena is a universal law known as allometry—the finding that as organisms, cities, and com­panies grow, many of their characteristics scale nonlinearly.

 

The elegant law that governs us all

Albert-László Barabási
Scale. Geoffrey West. Penguin Press, 2017. 490 pp.

Science  14 Jul 2017:
Vol. 357, Issue 6347, pp. 138
DOI: 10.1126/science.aan4040


Via Complexity Digest
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Sensitive Dependence of Optimal Network Dynamics on Network Structure

Sensitive Dependence of Optimal Network Dynamics on Network Structure | Building Networks | Scoop.it
The relationship between the structure and dynamics of a network is key to understanding the behavior of complex systems. A new analysis shows how network optimization, whether designed or evolved, can lead to collective dynamics that depend sensitively on the structure of the network.

 

Sensitive Dependence of Optimal Network Dynamics on Network Structure

Takashi Nishikawa, Jie Sun, and Adilson E. Motter
Phys. Rev. X 7, 041044


Via Complexity Digest
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Rescooped by Liz Rykert from networks and network weaving
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In social networks, group boundaries promote the spread of ideas, study finds

In social networks, group boundaries promote the spread of ideas, study finds | Building Networks | Scoop.it
Social networks affect every aspect of our lives, from the jobs we get and the technologies we adopt to the partners we choose and the healthiness of our lifestyles. But where do they come from?

Via june holley
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Rescooped by Liz Rykert from Self-organizing, Systems and Complexity
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12 Empowering Ways to Engage in Civic Affairs

12 Empowering Ways to Engage in Civic Affairs | Building Networks | Scoop.it
It's evident that there's a growing desire among people, especially here in the U.S., to get involved in civic affairs. While online organizing can be an effective means of bringing about change, there's something powerful about showing up in person to talk with public officials and connect with others who are fighting for the same causes. We've pulled together a list of 12 ways to boost civic engagement. The list includes several suggestions from Lawrence Grodeska, founder of CivicMakers, a San Francisco-based social enterprise that offers collaborative civic tech tools, consulting, and other services for public agencies and nonprofits. 
 

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How to Welcome and Engage People in Community Spaces

How to Welcome and Engage People in Community Spaces | Building Networks | Scoop.it
Why do some community spaces thrive while others struggle or fail? A lot of it comes down to how people are welcomed. Last April, I joined a group of activists and academics in Madrid, Spain, to build software that helps communities self-organize. This group was part of the P2Pvalue project, a three-year research initiative that looked into what makes peer production sustainable.

Via june holley
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Transformation Governance is Taking Off | Networking Action

Transformation Governance is Taking Off | Networking Action | Building Networks | Scoop.it

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Public Engagement for Resilience

Public Engagement for Resilience | Building Networks | Scoop.it
A team of us at IISC are partnered with an engineering firm to work on a climate change resiliency planning initiative in a vulnerable neighborhood in New York City. Our role is to lead the creatio…
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Building intentional networks that drive impact (part 1)

Building intentional networks that drive impact (part 1) | Building Networks | Scoop.it
These days everyone is familiar with some type of network – whether that's their professional network on LinkedIn, their social network on Facebook, or the informal web of relationships within your local community. But there's a distinct difference between a network as a structure of relationships and a network as a
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CO-Bologna runs towards new cooperative forms of governance of the commons: a focus on Bolognina site. | LabGov

CO-Bologna runs towards new cooperative forms of governance of the commons: a focus on Bolognina site. | LabGov | Building Networks | Scoop.it

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Better Together: Why Networks Are the Future of Learning

Better Together: Why Networks Are the Future of Learning | Building Networks | Scoop.it
The demands of the work have outstripped the toolset. Creating powerful learning is hard work and there’s no reason for teacher teams to work alone.

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Rescooped by Liz Rykert from Digital Delights
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learning to create the future of work

learning to create the future of work | Building Networks | Scoop.it

Via Ana Cristina Pratas
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nukem777's curator insight, February 22, 7:40 AM
lifelong learning is the key to just about everything!
Andreas Christodoulou's curator insight, February 24, 3:33 AM
Always be learning with passion.

Let me know in the comments if we are on the same page.
Rescooped by Liz Rykert from Network Leadership
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Network Leadership – Build, Manage, and Evaluate Effective Networks | PARTNER Tool

Network Leadership – Build, Manage, and Evaluate Effective Networks | PARTNER Tool | Building Networks | Scoop.it

Via june holley
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Rescooped by Liz Rykert from Movements
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Creating Culture: Promising Practices of Successful Movement Networks

The Management Assistance Group launched a multiyear program to explore how movement networks can best achieve successful cross-issue collaboration.

Via Patricia Thompson
Liz Rykert's insight:

Building trust is "the most fundamental, irreducible task for movement network leaders and members." Couldn't agree more.

more...
Patricia Thompson's curator insight, March 11, 2014 12:35 AM

Building trust is "the most fundamental, irreducible task for movement network leaders and members." Couldn't agree more.

Liz Rykert's curator insight, January 24, 10:56 PM

Building trust is "the most fundamental, irreducible task for movement network leaders and members." Couldn't agree more.

Scooped by Liz Rykert
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LLC Webinar | Network Structures: Innovative Governance and Decision-Making with June Holley | Leadership Learning Community

LLC Webinar | Network Structures: Innovative Governance and Decision-Making with June Holley | Leadership Learning Community | Building Networks | Scoop.it
 Many networks organize governance and operations with structures that mirror those of organizations:  governing boards, committees, and operations staff.
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Network Principles in Action = A Visual Gift!

Network Principles in Action = A Visual Gift! | Building Networks | Scoop.it
I mentioned in a previous post how much I love Twitter, for a variety of reasons, including how it helps me to see networks at work and can help create a variety of great network effects. Well I ha…
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Rescooped by Liz Rykert from Economic & Social Networks - Networked Economy
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Cities Developing Worker Coops: Efforts in Ten Cities

This new report from the Imagined Economy Project assesses municipally led cooperative development approaches used in ten cities across the United States. Highlighting The Democracy Collaborative’s

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Rescooped by Liz Rykert from Self-organizing, Systems and Complexity
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A How-to Book for Wielding Civic Power

A How-to Book for Wielding Civic Power | Building Networks | Scoop.it

Lots of simple but powerful examples and strategies. "They should be codifying all the steps they took, even if they sound simple. From “make a spreadsheet” to “think about people who are in nodes of networks” to “create a good visual meme to spread on social media.”


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Network Mapping: Leveraging Your Influence

Network Mapping: Leveraging Your Influence | Building Networks | Scoop.it
This month’s Change the World offers a Network Mapping Guide that uses commonly-accepted mapping strategies to understand your network. The resulting map, however, allows you to look more deeply into the patterns of interaction and decision making that shape the patterns of your network. It opens insights that can increase your ability to leverage adaptive capacity in your highly interconnected and interdependent world. This Network Mapping Guide helps you look beyond the surface to see and understand the conditions that shape the patterns in your world.

Via june holley
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Give cities a seat at the top table

Give cities a seat at the top table | Building Networks | Scoop.it
Building more strategic links between urban innovation and global governance will help to tackle today's grand challenges, argues Michele Acuto.
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The New Laws of Explosive Networks | Quanta Magazine

The New Laws of Explosive Networks |  Quanta Magazine | Building Networks | Scoop.it
Researchers are uncovering the hidden laws that reveal how the Internet grows, how viruses spread, and how financial bubbles burst.

Via june holley
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