Cancer - Advances, Knowledge, Integrative & Holistic Treatments
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Metabolic Burning of Body Fat Linked to Cachexia in Cancer Patients

Metabolic Burning of Body Fat Linked to Cachexia in Cancer Patients | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it

Conversion of white fat to brown is associated with muscle atrophy and weight loss in cancer patients.

Graham Player Ph.D.'s insight:

Cachexia is a wasting disorder of fat and muscle tissue that results in severe weight loss, loss of appetite, altered taste, and weakness, as seen in people suffering from some chronic disease states such as cancer, HIV and others.  About 50% of cancer patients suffer from cachexia, which impairs their quality of life, limits their cancer therapy and decreases their survival.

Cancer cachexia may not be able to be reversed by normal nutritional support and can lead to progressive functional impairment. It is the result of an interaction between the tumor, the person’s metabolism and the involvement of pro-inflammatory cytokines, which are protein molecules that signal cells to produce an inflammatory reaction.

Now a study published in Cell Metabolism has found a link that implicates the browning of white fat to cancer cachexia. One of the study authors, Erwin Wagner, comments that  “the transformation of white fat into brown fat, currently one of the most researched subjects because of its potential effects on obesity and diabetes, has very severe consequences” when it comes to cancer.

The researchers, led by Michele Petruzzelli of the Spanish National Cancer Research Center, found that the browning of white fat was linked to higher expression of uncoupling protein 1 (UCP1), which increased lipid metabolism and promoted energy expenditure in mice.

You may wonder what brown fat is. So here is a brief introduction for you. We have two types of fat in our body – white fat and brown fat.

In healthy, non-overweight people, white fat represents up to 20% of body weight in men and 25% in women. White fat is the main form of fat in the body that we are familiar with. It is where excess calories are stored which can later be used as energy when needed, and it also acts as a thermal insulator, helping to maintain our body temperature. It also produces the hormone leptin (the "satiety hormone") which regulates the storage of fat in the body. Leptin also plays a role in other physiological processes. White fat cells have receptors for insulin, growth hormones, norepinephrine, and glucocorticoids.

Brown fat fulfils a different purpose, and is made up of several small fat droplets, together with a large number of iron-containing mitochondria which are the cell’s heat-burning engine. Brown fat's main function is to generate body heat. Fatter people have less brown fat than thinner people. It gets its color due to its high iron content and its many tiny blood vessels to support a higher oxygen consumption. It is mainly found in the upper part of the back, and the front and back of the neck. The purpose of brown fat is to burn calories (rather than store calories) in order to generate heat.

Brown fat is believed to be more like muscle than like white fat. When activated, brown fat burns white fat, and may be able to burn several hundred calories per day. So the browning of white fat in people with cancer could indeed lead to cachexia.

Here is an article published by the American Physiological Society on the subject of the Mechanisms of Cancer Cachexia for anybody interested - http://physrev.physiology.org/content/89/2/381

As cachexia often begins long before it is obvious on physical exam, it is important to address this complication in people with cancer as soon as possible after a diagnosis.

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Why Medicine Won’t Allow Cancer to Be Cured : Body, Mind, Soul & Spirit – UPDATED DAILY! | BodyMindSoulSpirit.com

Why Medicine Won’t Allow Cancer to Be Cured : Body, Mind, Soul & Spirit – UPDATED DAILY! | BodyMindSoulSpirit.com | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
by Dr. Mercola Imagine a commercial plane crashed and there were some fatalities involved. You can be sure that would make the headline of every major newspaper. Well, we have the equivalent of 8-1…
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Can you vaccinate yourself against cancer?

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Studies touting the benefits of cancer vaccines are emerging, but do those studies really show hope or just hype?
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Prostate cancer now third deadliest cancer in UK

Prostate cancer now third deadliest cancer in UK | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Prostate cancer now accounts for more deaths than breast cancer in the United Kingdom. Lung cancer and bowel cancer remain the top two deadliest cancers.
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Over 100 Cannabis Cancer Studies Prove That Marijuana Is Medicine

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Over cannabis cancer studies have demonstrated that marijuana can cure a variety of tumours and cancers. Plus, it doesn't have harmful side-effects.
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Are artificial sports pitches causing cancer?

Are artificial sports pitches causing cancer? | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
@IanRGould some references here https://t.co/LWHYCrTFBi lots of cases of non Hodgkins lymphoma.
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70 cancer patients prescribed wrong chemo dosage at Sydney hospital

70 cancer patients prescribed wrong chemo dosage at Sydney hospital | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Up to 70 cancer patients at Sydney's St Vincent's Hospital have been given markedly lower doses of a chemotherapy drug for up to three years, an ABC 7.30 ...
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Toothpaste chemical may increase risk of cancer, warn scientists

Toothpaste chemical may increase risk of cancer, warn scientists | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Triclosan, an antibacterial chemical found in liquid hand soap, Dermalogica
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New test spots most deadly forms of breast cancer BEFORE they spread

New test spots most deadly forms of breast cancer BEFORE they spread | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Scientists at the Institute of Cancer Research in London have developed a new test that was able to determine those women at the highest risk of dying from their disease.
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Cancer 'vaccine' that remembers disease and fights it years later is developed by scientists

Cancer 'vaccine' that remembers disease and fights it years later is developed by scientists | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Researchers in immunotherapy trials engineer cells so they boost body’s
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Shattering cancer with resonant frequencies: Anthony Holland at TEDxSkidmoreCollege

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How BANANAS could help cure skin cancer

How BANANAS could help cure skin cancer | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Scientists in Switzerland discovered the enzyme tyrosinase is a reliable marker for melanoma growth, with greater quantities in human skin indicating a greater risk of developing skin cancer.
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Nursery teacher given weeks to live claims she beat cancer by JUICING

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Natasha Grindley, 37, from Liverpool, was diagnosed with stomach cancer in July 2014. She claims she has lived for 18 months longer than predicted due to swapping junk food for healthy juices.
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Quit the EU to SAVE our NHS: Top cancer doctor says migrants are bleeding it dry

Quit the EU to SAVE our NHS: Top cancer doctor says migrants are bleeding it dry | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
BRITAIN should leave the EU in order to save an NHS which is being overrun by migrants, according to a top cancer specialist.
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How THC Kills Cancer Cells : Body, Mind, Soul & Spirit – UPDATED DAILY! | BodyMindSoulSpirit.com

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According to a molecular scientist, THC has a wide therapeutic potential for cancer.
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How Ann Fonfa healed stage 4 breast cancer

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Ann Fonfa is a 25-year holistic survivor of stage 4 breast cancer and founder of the Annie Appleseed Project, a non-profit that provides information and education on complementary and alternative medicine (CAM) and natural therapies for cancer.
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How I Healed My Mother’s Skin Cancer At Home –

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For the last 3 years, my mother had been suffering with a type of ski
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Cancer risk: Study suggests link to consumption of ultra-processed foods

Cancer risk: Study suggests link to consumption of ultra-processed foods | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
European study of what are called ultra-processed foods – basically, stuff made in factories with ingredients not usually found in home kitchens – has found they may be linked to cancer.
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How running could help beat cancer: Exercise shrinks tumours by 50%

How running could help beat cancer: Exercise shrinks tumours by 50% | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Researchers from the University of Copenhagen believe adrenaline helps move cancer killing immune cells towards lung, liver, or skin tumours.
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Odoreader accurately detects prostate cancer from urine

Odoreader accurately detects prostate cancer from urine | Cancer - Advances, Knowledge, Integrative & Holistic Treatments | Scoop.it
Current tests for prostate cancer are far from ideal, sometimes resulting in unnecessary biopsies, and even failing to detect some cancers. Now, a team of researchers has turned to a machine it calls the Odoreader, designed to analyze urine samples to provide a non-invasive prostate cancer test.
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New 10-minute test for cancer developed by scientists

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Scientists are developing a 10-minute cancer test which can be taken at home
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94% Of Terminally Ill Cancer Patients Symptom-Free With New Therapy

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A new cancer therapy has produced unprecedented success rates in early studies.
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Finally! The FDA Admits That Nearly Over 70% of U.S. Chickens Contain Cancer-Causing Arsenic

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Nanoparticle therapy that uses LDL and fish oil kills liver cancer cells

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An experimental nanoparticle therapy that combines low-density lipoproteins (LDL) and fish oil preferentially kills primary liver cancer cells without harming healthy cells, UT Southwestern Medical Center researchers report.
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Revealed... the 10 'red flag' cancer symptoms YOU need to know

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Have scientists found a way to stop breast cancer cells spreading?

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