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Rescooped by Bernadette Sneed from Cystic Fibrosis News
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Management Of Cystic Fibrosis | Easy Pediatrics

Management Of Cystic Fibrosis | Easy Pediatrics | BreathMatters | Scoop.it
Cystic fibrosis is an inherited disorder that causes thick, sticky mucus to build up in the lungs, digestive tract, and other areas of the body. It is one of the most common chronic lung diseases in children and young adults.

Via Ritesh Patel
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Rescooped by Bernadette Sneed from FOOD? HEALTH? DISEASE? NATURAL CURES???
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How chronic obstructive pulmonary disease develops

Chronic obstructive pulmonary disease (COPD) describes a number of long-term lung conditions that cause breathing difficulties. Find out more about COPD here...

Via Troy Mccomas (troy48)
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Rescooped by Bernadette Sneed from Pharma Biotech Industry Review (Krishan Maggon)
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MannKind Announces FDA approval of AFREZZA® a novel,rapid acting inhaled insulin

MannKind Announces FDA approval of AFREZZA® a novel,rapid acting inhaled insulin | BreathMatters | Scoop.it

MannKind Corporation (Nasdaq:MNKD) today announced that the U.S. Food & Drug Administration (FDA) has approved AFREZZA® (insulin human) Inhalation Powder to improve glycemic control in adult patients with diabetes mellitus.

"Approval of AFREZZA is an important milestone for MannKind, as today's FDA action validates the years of clinical research and commitment that powered the development of this unique therapy," said Alfred Mann, Chief Executive Officer, MannKind Corporation. "We are excited for patients, as we believe that AFREZZA's distinct profile and non-injectable administration will address many of their unmet needs for mealtime insulin therapy, and has the potential to change the way that diabetes is treated. We thank the more than 6,500 adult patients and healthy volunteers who participated in the AFREZZA clinical program."

Currently, diabetes mellitus affects 29.1 million people in the United States, according to the Centers for Disease Control and Prevention. Diabetes mellitus is characterized by the body's inability to regulate levels of blood glucose properly. Insulin, a hormone produced by the pancreas, normally regulates the body's glucose levels, but in people with diabetes mellitus insufficient levels of insulin are produced or the body fails to respond adequately to the insulin it produces. In patients with diabetes, current injected insulins are absorbed into the bloodstream slower than the body's own insulin would be released if the pancreas was healthy.

AFREZZA® (uh-FREZZ-uh) is a novel, rapid-acting inhaled insulin therapy indicated to improve glycemic control in adult patients with diabetes mellitus. The product consists of AFREZZA Inhalation Powder delivered using a small, discreet and easy-to-use inhaler. Administered at the start of a meal, AFREZZA dissolves rapidly upon inhalation to the deep lung and delivers insulin quickly to the bloodstream. Peak insulin levels are achieved within 12 to 15 minutes of administration, and decline to baseline by approximately 180 minutes.

"The FDA approval of AFREZZA provides healthcare professionals with an important new safe and effective treatment option for patients with diabetes," said Janet McGill, M.D., Professor of Medicine at Washington University School of Medicine. "We have seen in clinical studies that the combination of rapid action, injection-free delivery and ease of use makes AFREZZA a welcome alternative for many patients who require insulin."  

LIMITATIONS OF USE: AFREZZA must be used in combination with a long-acting insulin in patients with type 1 diabetes mellitus. AFREZZA is not recommended for the treatment of diabetic ketoacidosis and is not recommended for patients who smoke. 

Full US Prescribing Information, including BOXED WARNING, Medication Guide and Instructions for Use will soon be available at www.afrezza.com. Prior to the label being posted online, a copy of the label may be requested from the MannKind Media contacts listed at the end of this document.

AFREZZA has been approved with a Risk Evaluation and Mitigation Strategy (REMS) required by the FDA to ensure that the benefits of AFREZZA outweigh the potential risk of acute bronchospasm in patients with chronic lung disease. 

Important Safety Information about AFREZZA (insulin human Inhalation Powder)

The following information is taken from the highlights section of the US Prescribing Information. Please see full Prescribing Information including boxed warning.

BOXED WARNING: RISK OF ACUTE BRONCHOSPASM IN PATIENTS WITH CHRONIC LUNG DISEASE

Acute bronchospasm has been observed in patients with asthma and COPD using AFREZZA.   AFREZZA is contraindicated in patients with chronic lung disease such as asthma or COPD. Before initiating AFREZZA, perform a detailed medical history, physical examination and spirometry (FEV1) to identify potential lung disease in all patients. 

CONTRAINDICATIONS

AFREZZA is contraindicated during episodes of hypoglycemia, in patients with chronic lung disease such as asthma or chronic obstructive pulmonary disease (COPD), or in patients with a hypersensitivity to regular human insulin or any of the AFREZZA excipients.

WARNINGS AND PRECAUTIONS

Acute Bronchospasm: Acute bronchospasm has been observed in patients with asthma and COPD. Before initiating, perform spirometry (FEV1) in all patients. Do not use in patients with chronic lung disease.

Change in Insulin Regimen: Carry out under close medical supervision and increase frequency of blood glucose monitoring.

Hypoglycemia: May be life-threatening. Increase frequency of glucose monitoring with changes to; insulin dosage, co-administered glucose lowering medications, meal pattern, physical activity; and in patients with renal or hepatic impairment and hypoglycemia unawareness.

Decline in Pulmonary Function: Assess pulmonary function (e.g., spirometry) before initiating, after 6 months of therapy, and annually, even in the absence of pulmonary symptoms.

Lung Cancer: AFREZZA should not be used in patients with active lung cancer. In patients with a history of lung cancer or at risk for lung cancer, the benefit of AFREZZA use should outweigh this potential risk.

 

Diabetic Ketoacidosis: More patients using AFREZZA experienced diabetic ketoacidosis in clinical trials. In patients at risk for DKA, monitor and change to alternate route of insulin delivery, if indicated.

Hypersensitivity Reactions: May be life-threatening. Discontinue AFREZZA, monitor and treat if indicated.

Hypokalemia: May be life-threatening. Monitor Potassium levels in patients at risk of hypokalemia and treat if indicated.

Fluid Retention and Heart Failure with Concomitant Use of Thiazolidinediones (TZDs): Observe for signs and symptoms of heart failure; consider dosage reduction or discontinuation if heart failure occurs. 


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Rescooped by Bernadette Sneed from News Daily About Celebrities
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Quit Smoking says Leonard Nimoy to his Fans - I4U News

Quit Smoking says Leonard Nimoy to his Fans - I4U News | BreathMatters | Scoop.it

Quit smoking was the message an 82 year old Leonard Nimoy had for his fans. The very popular thespian played the role of the pointy-eared Mr. Spock on Star Trek. He has chronic lung disease now thanks to years of smoking.
Read more at http://www.i4u.com/2014/02/63113/quit-smoking-says-leonard-nimoy-his-fans#bec7DwlBTAt2a34t.99


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Rescooped by Bernadette Sneed from Drugs, Society, Human Rights & Justice
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CDC Fact Sheet: Health Effects of Cigarette Smoking - Smoking & Tobacco Use

CDC Fact Sheet: Health Effects of Cigarette Smoking - Smoking & Tobacco Use | BreathMatters | Scoop.it
The adverse health effects from cigarette smoking account for more than 440,000 deaths, or nearly one of every five deaths, each year in the United States.2,3,4More deaths are caused each year by tobacco use than by human immunodeficiency virus (HIV), illegal drug use, alcohol use, motor vehicle injuries, suicides, and murders combined.3,5If nobody smoked, one of every three cancer deaths in the United States would not happen.2Smoking causes an estimated 90% of all lung cancer deaths in men1,2 and 80% of all lung cancer deaths in women.1An estimated 90% of all deaths from chronic obstructive lung disease are caused by smoking.1,2

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Julian Buchanan's curator insight, October 21, 2013 4:30 PM

So I wonder why it took 40yrs for the damming scientific evidence to emerge of this highly commercialised, heavily promoted and culturally embedded drug?
While during that same time the massive investment in scientific research has been made to attempt to prove cannabis is very dangerous.
There is no doubt whatsoever - that tobacco is much more dangerous than cannabis.

Rescooped by Bernadette Sneed from Pulmonary Fibrosis News
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What Causes Idiopathic Pulmonary Fibrosis (IPF)?

What Causes Idiopathic Pulmonary Fibrosis (IPF)? | BreathMatters | Scoop.it

In most cases, however, the cause of lung scarring isn’t known. These cases are called idiopathic pulmonary fibrosis (IPF). With IPF, doctors think that something inside or outside of the lungs attacks them again and again over time.

 

These attacks injure the lungs and scar the tissue inside and between the air sacs. This makes it harder for oxygen to pass through the air sac walls into the bloodstream.


Via Bill Vick
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Bill Vick's curator insight, July 20, 2014 7:36 AM

The most common signs and symptoms are:

Shortness of breath. This usually is the main symptom of IPF. At first, you may be short of breath only during exercise. Over time, you'll likely feel breathless even at rest.A dry, hacking cough that doesn't get better. Over time, you may have repeated bouts of coughing that you can't control.

Other signs and symptoms that you may develop over time include:

Rapid, shallow breathingGradual, unintended weight lossFatigue (tiredness) or malaise (a general feeling of being unwell)Aching muscles and jointsClubbing, which is the widening and rounding of the tips of the fingers or toes
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Dust exposure penalty for company director - AirQualityNews

Dust exposure penalty for company director - AirQualityNews | BreathMatters | Scoop.it
AirQualityNews Dust exposure penalty for company director AirQualityNews If inhaled it can cause occupational asthma, chronic obstructive pulmonary disease (COPD), silicosis or even lung cancer, so it is vital that adequate measures are in place to...
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FDA Approves New Treatment for People With COPD - WebMD

FDA Approves New Treatment for People With COPD - WebMD | BreathMatters | Scoop.it
Headlines & Global News FDA Approves New Treatment for People With COPD WebMD 1, 2014 (HealthDay News) -- Patients with the progressive, deadly respiratory ailment known as chronic obstructive pulmonary disease (COPD) have a new weapon to battle...
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Clearing confusion on adult vaccination - The Macomb Daily

Clearing confusion on adult vaccination
The Macomb Daily
August is National Immunization Awareness Month.
Bernadette Sneed's insight:

come out in October and get your vaccine at our October meeting

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Rescooped by Bernadette Sneed from clinicallabnews
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One step closer to a breath test for lung cancer

One step closer to a breath test for lung cancer | BreathMatters | Scoop.it
A test of organic compounds in exhaled breath can not only distinguish patients with lung cancer from patients with chronic obstructive pulmonary disease (COPD), but can also define the stage of any cancer present, new research shows.

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Rescooped by Bernadette Sneed from A Tale of Two Medicines
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From common colds to deadly lung diseases, one protein plays key role.

From common colds to deadly lung diseases, one protein plays key role. | BreathMatters | Scoop.it

An international team of researchers has zeroed in on a protein that plays a key role in many lung-related ailments, from seasonal coughing and hacking to more serious diseases such as MRSA infections and cystic fibrosis.

 

The finding advances knowledge about this range of illnesses and may point the way to eventually being able to prevent infections such as MRSA.

 

The key protein is called MUC5B. It’s one of two sugar-rich proteins, with similar molecular structure, that are found in the mucus that normally and helpfully coats airway surfaces in the nose and lung. The other is MUC5AC.

 

“We knew these two proteins are associated with diseases in which the body produces too much mucus, such as cystic fibrosis, asthma, pulmonary fibrosis and COPD,” said researcher Chris Evans, PhD, an associate professor in the University of Colorado School of Medicine. “We also knew that many patients with asthma or COPD have as much as 95 percent less MUC5B in their lungs than healthy individuals, so we wanted to see if one of these is the bad player in chronic lung diseases.”


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Christian Yamashiba Kasongo's curator insight, January 30, 2014 3:20 PM

From common colds to deadly lung diseases, one protein plays key role.

Rescooped by Bernadette Sneed from Discover Sigalon Valley - Where the Tags are the Topics
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Stem cells repair lung damage after flu infection | Biotechnology

Stem cells repair lung damage after flu infection | Biotechnology | BreathMatters | Scoop.it

Guided by insights into how mice recover after H1N1 flu, researchers at Harvard Medical School and Brigham and Women's Hospital, together with researchers at A*STAR of Singapore, have cloned three distinct stem cells from the human airways and demonstrated that one of these cells can form into the lung's alveoli air sac tissue. What's more, the researchers showed that these same lung stem cells are rapidly deployed in a dynamic process of lung regeneration to combat damage from infection or chronic disease.


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Rescooped by Bernadette Sneed from FOOD? HEALTH? DISEASE? NATURAL CURES???
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Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease | BreathMatters | Scoop.it
Natural remedies offer safe treatment for COPD (Chronic Obstructive Pulmonary Disease), a lung ailment that narrows airways, making it difficult to breathe.

Via Troy Mccomas (troy48)
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Rescooped by Bernadette Sneed from How to use inhaler
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Introduction Metered Dose Inhaler

Introduction Metered Dose Inhaler | BreathMatters | Scoop.it
For respiratory diseases the most prevalent inhaler is a MDI. It can control inflammation of lungs with the help of corticosteroids or relax the smooth muscles of the lung airways with long-acting bronchodilators.

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Rescooped by Bernadette Sneed from Pulmonary Fibrosis News
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Idiopathic Pulmonary Fibrosis: Hope, At Last

Idiopathic Pulmonary Fibrosis: Hope, At Last | BreathMatters | Scoop.it
There have been stunning “firsts” in research on idiopathic pulmonary fibrosis (IPF), a mysterious disease that stiffens and stills the lungs, killing half its victims in three years.

Via Bill Vick
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Rescooped by Bernadette Sneed from Silver Spring Allergy Clinic
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Bronchodilators - Allergy Clinic

Bronchodilators - Allergy Clinic | BreathMatters | Scoop.it
Bronchodilators are substances that alleviate the symptoms of asthma and lung diseases like Chronic Obstructive Pulmonary Disease (COPD) and Bronchiectasis.

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Asthma and COPD

COPD stands for chronic obstructive pulmonary disease. This is chronic asthma. Chronic means it progresses slowly while obstructive means that it causes narr...
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Breath Matters | Lung Disease Support Group of Virginia

Breath Matters | Lung Disease Support Group of Virginia | BreathMatters | Scoop.it
Breath Matters sponsored by the CJW Medical Center - Lung disease support group of Virginia
Bernadette Sneed's insight:
Support for our community whose lives are impacted by chronic lung disease. http://breathmatters.com/      ;
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