bioproduction
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Everything you always wanted to know about Antibody Humanisation

Everything you always wanted to know about Antibody Humanisation | bioproduction | Scoop.it
We have discussed with Olivier Léger about antibody humanisation. He is an expert in antibody engineering with over 25 years experience in the field.
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GTP adds trained Biosafety Officer to expert team

GTP adds trained Biosafety Officer to expert team | bioproduction | Scoop.it
The production of recombinant proteins and antibodies requires specific biological and chemical agents and entails biological risks. As we know how much biosafety matters to our staff and clients, we’ve decided to train a Biological Safety Officer (BSO). Our BSO assists GTP’s technical leaders, assesses potential risks and is key to the implementation and continued application of a full-fledged biosafety policy.
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Novasep invests €17 M in “mAbulous”, its dedicated cGMP monoclonal antibody (mAb) production facility

Novasep invests €17 M in “mAbulous”, its dedicated cGMP monoclonal antibody (mAb) production facility | bioproduction | Scoop.it
The facility will address increasing demand for small-volume mAb CDMO services
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Chromatography toolbox: Think membranes! - GTP Technology

Chromatography toolbox: Think membranes! - GTP Technology | bioproduction | Scoop.it
Here we discuss the reasons why a membrane chromatography step might be beneficial in your protein purification process.
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Evolution Global | The Future of BioManufacturing

Since its inception in the 1980s-1990s, the field of biologics has developed from being a relative rarity in the human pharmaceutical market to one that, by the beginning of the next decade, will more than likely equal new molecular entities (NMEs) in terms of generating revenue for the pharmaceutical industry.
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Choosing the right QC development process and subcontractor for your project - GTP Technology

Choosing the right QC development process and subcontractor for your project - GTP Technology | bioproduction | Scoop.it
In this third article of our series on QC, we are sharing our thoughts on the best way for biotech companies to address QC development for characterisation of their biotherapeutic candidate at preclinical and clinical stages.
GTP Technology's insight:
Our advice to biotechs for analytical methods development for their recombinant proteins and monoclonal antibodies therapeutics
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Novasep opens €11M new antibody-drug conjugate (ADC) bioconjugation unit

Novasep opens €11M new antibody-drug conjugate (ADC) bioconjugation unit | bioproduction | Scoop.it
ADCs, used in innovative treatments against cancer, will be produced in Le Mans, France to serve international markets
GTP Technology's insight:
Our parner Novasep just launched its new antibody-drug conjugate bioconjugation unit in Le Mans, France
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Infographic: A History of Approved Therapeutic Antibodies

Infographic: A History of Approved Therapeutic Antibodies | bioproduction | Scoop.it
there are currently 49 therapeutic antibodies with market approval from the EMA and thousands more in clinical trials. Here is a timeline of those approved so far!
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GTP Technology et Novasep s’associent pour offrir des services de CDMO pour la production des anticorps et protéines thérapeutiques

GTP Technology et Novasep s’associent pour offrir des services de CDMO pour la production des anticorps et protéines thérapeutiques | bioproduction | Scoop.it
Buzz4Bio : infos, communication et événementiel pour la Pharma et la Biotech
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And why not Pichia pastoris? - GTP Technology

And why not Pichia pastoris? - GTP Technology | bioproduction | Scoop.it

Despite a few flaws, P. pastoris has key advantages that make it one of the systems of choice for the production of certain types of protein.

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Top 10 Best-selling Biologicals of 2015

Top 10 Best-selling Biologicals of 2015 | bioproduction | Scoop.it
Here, we take a look at the biggest blockbuster biologicals, who produces them, what diseases they treat, and the effects of market trends like the rising tide of biosimilars, a ‘generic’ copy sold by other companies once the therapy goes off-patent.
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Novartis invests €100m to boost mAb production 70% at French biologics site

Novartis invests €100m to boost mAb production 70% at French biologics site | bioproduction | Scoop.it
Novartis has recruited Jacobs to undertake a €100m expansion at a French biomanufacturing facility which will add a second purification line and several cell culture bioreactors.
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Lonza Launches Sentinel APART™ Server-Based Platform Designed to Help Improve the Quality and Safety of Therapeutic Antibodies

Lonza Launches Sentinel APART™ Server-Based Platform Designed to Help Improve the Quality and Safety of Therapeutic Antibodies | bioproduction | Scoop.it
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Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development | npj Vaccines

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Which platform & partner to select for my CHO cell line development?

Which platform & partner to select for my CHO cell line development? | bioproduction | Scoop.it
Here, we provide a picture of the recent advances in mammalian cell line development and discuss the criteria a biotech company should consider when starting its cell line development process.
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How about developing a new CHO bioproduction platform based on lentiviral vectors? - GTP Technology

How about developing a new CHO bioproduction platform based on lentiviral vectors? - GTP Technology | bioproduction | Scoop.it
Here we discuss about the feasibility to develop a CHO cell line based on retroviral vectors for therapeutic protein projects.
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Human Antibody Discovery: Of Mice And Phage | LifeSciVC

Human Antibody Discovery: Of Mice And Phage | LifeSciVC | bioproduction | Scoop.it
Humanization techniques help convert mouse-derived antibodies into less immunogenic constructs, largely by limiting the murine sequences to just the CDRs (the binding loops) in the variable domains. It’s well established that humanized mAbs have lower immunogenicity than chimeric or murine formats. Fully human mAbs, where the entire sequence derives from human genetic repertoire, were developed originally via transgenic mice or phage display, and are believed by many to be the “preferred” mAb format.
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Using continuous chromatography to improve process performance and debottleneck bioproduction capacity - GTP Technology

Using continuous chromatography to improve process performance and debottleneck bioproduction capacity - GTP Technology | bioproduction | Scoop.it
In this article, Vincent Monchois, Director of Strategic Projects at  Novasep, our CMO partner, explains why integration of continuous chromatography could help the biopharma industry overcome the challenge of increasing capacities and decreasing manufacturing costs.
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What methods to use for glycan characterisation of your antibody and protein products during process development? - GTP Technology

What methods to use for glycan characterisation of your antibody and protein products during process development? - GTP Technology | bioproduction | Scoop.it
In this second article of our series on QC development for biotherapeutics, our partner PROTEODYNAMICS, an expert company in glycan analysis and protein characterisation, gives a review of the relevant methods to characterise the glycosylation of your biotherapeutic candidates.
GTP Technology's insight:
Our partner Proteodynamics has kindly accepted to share its expertise on glycosylation analysis of therapeutic proteins and antibodies on our blog.
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How to handle challenges in the analysis of host cell proteins for biologics development - GTP Technology

How to handle challenges in the analysis of host cell proteins for biologics development - GTP Technology | bioproduction | Scoop.it
We are starting a series of articles addressing the question of QC development for biotherapeutic projects and have asked IDBiotech, which specialises in ELISA development, to explain why the quantification of HCPs is a key point to consider in CMC strategy.
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Are biosimilars coming of age?

Are biosimilars coming of age? | bioproduction | Scoop.it
Dr Brian Wendelburg discusses how successful biosimilar mAbs have been on the issue of pricing for parts of the world where they are not easily affordable
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We have tested the MEP HyperCel™ Chromatography Sorbent from Pall as a capture step for a polyclonal antibody - GTP Technology

We have tested the MEP HyperCel™ Chromatography Sorbent from Pall as a capture step for a polyclonal antibody - GTP Technology | bioproduction | Scoop.it

Lately, we drew our focus to the characteristics of the MEP HyperCel™ sorbent developed by Pall. The most significant advantages of this mixed-mode sorbent are its unique separation mechanism and its high selectivity, which makes it suitable for direct immunoglobulin capture. Because it allows for protein binding in no salt or low salt conditions, it is also an appealing potential alternative to the HIC step. In order to verify the benefits of using this mechanism, we tested it as part of the development of a purification process for a polyclonal antibody, as the cost of using a protein A capture step was prohibitive in this project.

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Could Artificial Enzymes be the Future of Synthetic Chemistry?

Could Artificial Enzymes be the Future of Synthetic Chemistry? | bioproduction | Scoop.it
As synthetic organic chemistry struggles to reinvent itself, the field is shifting its focus to emulating and engineering enzymes. A team of researchers in Basel has developed an artificial metalloenzyme with unique functionality that can be activated in a cell.
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EMA says biologics developers need to be extra vigilant

EMA says biologics developers need to be extra vigilant | bioproduction | Scoop.it
Biologics developers need to be more vigilant about immunogenicity and manufacturing changes than small molecule drug manufacturers according to the EMA.
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Servier invests in a bioproduction programme in France

Servier invests in a bioproduction programme in France | bioproduction | Scoop.it
Servier has announced the launch of a bioproduction programme at its site in Gidy. First research batches in 2019 and first clinical batches in 2020.
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