Biochemistry
7.2K views | +0 today
Follow
Biochemistry
Your new post is loading...
Your new post is loading...
Scooped by Duncan Cole
Scoop.it!

Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework | Biochemistry | Scoop.it
Click on the article title to read more.
Duncan Cole's insight:
Important paper that clarifies the definitions used in biomarker research, and puts this into the context of drug discovery and development. Well worth reading.
more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Thyroid function testing - Overview - Best Practice - English

Thyroid function testing - Overview - Best Practice - English | Biochemistry | Scoop.it
Duncan Cole's insight:
Excellent overview of thyroid function tests, covering the physiology of thyroid hormone production, the tests themselves, and also the patterns you may see when testing patients, with the causes listed and further investigations you may need to request.
more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Thyroid Function Tests - British Thyroid Foundation

Thyroid Function Tests - British Thyroid Foundation | Biochemistry | Scoop.it
The British Thyroid Foundation is a UK charity dedicated to supporting people with thyroid disorders and helping their families and people around them to understand the condition.
Duncan Cole's insight:
Patient information on thyroid function tests, but actually quite detailed and therefore a good starting point for medical students. The rest of the website is also well worth a look, as it has lots of information on thyroid disorders, including some of the complications (e.g. osteoporosis) associated with hyper- and hypo-thyroidism.
more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Biomarker panel: details | UK Biobank

Improving the Health of Future Generations
Duncan Cole's insight:
Take a look at how the UK biobank is using biomarkers in its researchers. You'll find quite a lot of information on this website, which emphasises how useful biomarkers can be in large population studies.
more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Overview of Metabolism - Anabolism and Catabolism

What is the purpose of metabolism? Learn about the two major divisions in metabolism: anabolism (building up) and catabolism (breaking down).
Duncan Cole's insight:

If you are new to metabolism, or find it daunting and/or somewhat scary, this is a good place to start.  The broad concepts are outlined well and the explanations are good, with the meanings of key terms explained and not assumed. 

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Cellular Respiration 1 - Overview

Cellular Respiration 1 - Overview | Biochemistry | Scoop.it
Duncan Cole's insight:

This is the first in series of video tutorials in this excellent series from Handwritten Tutorials - the others can be all accessed from this webpage.  Each video has an accompanying completed diagram in pdf format which you can download.  Other tutorials in the series can be found on this scoop.it page, but all you really need is this link.

 

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

▶ Molarity, Molality, Osmolarity, Osmolality, and Tonicity - What's the difference? - YouTube

See how each of these terms tells us something different about a solution. Rishi is a pediatric infectious disease physician and works at Khan Academy. More ...
Duncan Cole's insight:

Nice, easy to follow explanation of what the different terms mean.  To clarify on tonicity - this is used to describe one solution with respect to another, and not really to describe two solutions.

more...
Duncan Cole's curator insight, November 17, 2014 11:46 AM

Nice, easy to follow explanation of what the different terms mean.  To clarify on tonicity - this is used to describe one solution with respect to another, and not really to describe two solutions.

Scooped by Duncan Cole
Scoop.it!

ATP & Respiration: Crash Course Biology #7 - YouTube

In which Hank does some push ups for science and describes the "economy" of cellular respiration and the various processes whereby our bodies create energy i...
Duncan Cole's insight:

Quirky and fun introduction to how a molecule of glucose is turned into ATP.  It covers glycolysis, the Krebs cycle, and the electron transport chain.  I would suggest you view this with the relevant pathway diagrams and frequent pauses so you can follow what is going on.  Handwritten tutorials (see other posts) provide an additional level of detail once you have grasped the material contained here.

more...
No comment yet.
Scooped by Cardiff University School of Medicine C4ME
Scoop.it!

Nutrient Metabolism, Human | Learn Science at Scitable

Nutrient Metabolism, Human | Learn Science at Scitable | Biochemistry | Scoop.it
The human body is a changing environment in which each cell has to continually adapt. For example, energy needs vary widely from one physiological situation to another within a cell type, as well as among different tissues.
Cardiff University School of Medicine C4ME's insight:

Helpful resource for integrating knowledge of multiple metabolic pathways.

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Exercise Physiology: musculoskeletal system

Exercise Physiology: musculoskeletal system | Biochemistry | Scoop.it
Exercise Physiology. Exercise represents one the highest levels of extreme stresses to which the body can be exposed.
Duncan Cole's insight:

This is a good description of the events that occur in the muscle during exercise, and will help provide context for those learning metabolism.  It has discussions on recovery and oxygen debt, fuel use during exercise, and does describe some of the interactions between metabolic pathways at different intensities of exercise.  There is also a description of the events involved in muscle contraction, and other pages discuss exercise-realted changes in other organ systems.

more...
Lisa Rhiannon Jeffers's curator insight, October 13, 2013 3:50 PM

Very good at explaining muscle contraction and where the ATP required for this process is from in a clear way. If you want the process written in bullet points for you this is a good document.

Suggested by Cardiff University School of Medicine C4ME
Scoop.it!

How Exercise Changes Fat and Muscle Cells

How Exercise Changes Fat and Muscle Cells | Biochemistry | Scoop.it
Several striking new studies provide some clarity by showing that exercise seems able to drastically alter how genes operate, perhaps altering the risk for problems like obesity and diabetes.
Duncan Cole's insight:

Interesting article reviewing research on how DNA methylation patterns are influenced by exercise.  Adaptations to exercise are not just related to alterations in the flux through metabolic pathways - they also involve epigenetic alterations that regulate expression of genes involved in these pathways.    

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Metabolism - ChemWiki

Metabolism - ChemWiki | Biochemistry | Scoop.it
Duncan Cole's insight:

Some good brief articles are available here on various metabolism topics from UC Davis in the USA.  I have spotted one or two mistakes, although these are not too serious, so be careful and check anything you are not sure about.

 

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

UNC student lives with rare illness

Despite living with a rare genetic illness that keeps his muscles from storing glycogen, UNC student Andrew Ashley maintains his passion for soccer.
Duncan Cole's insight:

An insight into living with McArdle disease, and the problems encountered when exercising.

 

more...
No comment yet.
Rescooped by Duncan Cole from Clinical biochemistry
Scoop.it!

How to interpret thyroid function tests

Duncan Cole's insight:
Excellent overview of TFT interpretation, covering anomalous TFT results as well as the most common patterns. Not much detail on individual diseases, but then this is not the focus of the article.
more...
Duncan Cole's curator insight, September 12, 2017 5:10 AM
Excellent overview of TFT interpretation, covering anomalous TFT results as well as the most common patterns. Not much detail on individual diseases, but then this is not the focus of the article.
Scooped by Duncan Cole
Scoop.it!

Thyroid Diseases

Thyroid Diseases | Biochemistry | Scoop.it
Overview of Thyroid Diseases, including Hyperthyroidism, Hypothyroidism, Thyroid Cancer, Solitary Thyroid Nodules, Thyroiditis, Goiters.
Duncan Cole's insight:
Useful summary of thyroid disease from labtestsonline, a peer reviewed resource aimed primarily at patients, but also a good non-technical introduction for medical students. It has links to the specific tests as well, which students need to be familiar with.
more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Thyroid Hormone Production

Thyroid Hormone Production | Biochemistry | Scoop.it
Duncan Cole's insight:
Really good, straightforward, description of how thyroid hormones are produced by the thyroid glands. Well worth a look as an introduction to the process.
more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

What are Biomarkers?

What are Biomarkers? | Biochemistry | Scoop.it
This article provides working definitions and a conceptual framework to understand the roles of biomarkers in clinical research.The definitions of the terms discussed in this article—medical signs, symptoms, biomarkers, surrogate endpoints, clinica
Duncan Cole's insight:
Useful, concise overview of biomarkers and their use in clinical research. This is particularly clear on the various definitions of terms, and how biomarkers relate to underlying pathophysiological processes.
more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Normal Acid-Base Regulation (Understanding ABGs - Lecture 2)

A lecture on the physiology of normal acid-base regulation, including a discussion of the bicarbonate buffering system, the Henderson-Hasselbalch equation, a...
Duncan Cole's insight:

Well explained, easy to follow lecture on acid-base physiology.  This is ideal for year 1 medical students, and for all those who need to brush up on the underlying principles of acid-base homeostasis.  It is a little long for an online video, but it is worth the effort.

more...
Anne Marie Cunningham's curator insight, November 7, 2014 12:38 PM

From Dr Cole : Well explained, easy to follow lecture on acid-base physiology.  This is ideal for year 1 medical students, and for all those who need to brush up on the underlying principles of acid-base homeostasis.  It is a little long for an online video, but it is worth the effort

Scooped by Duncan Cole
Scoop.it!

▶ Tonicity - comparing 2 solutions - YouTube

Find out how tonicity is determined by ions that don't move across membranes and how it affects the movement of water. Rishi is a pediatric infectious diseas...
Duncan Cole's insight:

Covers the core concepts of tonicity and fluid shifts very well - you really need to know this in order to understand fluid and electrolyte homeostasis.  To relate this to human biochemistry more specifically, urea crosses cell membrane and so is equivalent to "solute a" and sodium does not (without help from membrane pumps) and so is equivalent to "solute b".

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Codon-Amino Acid Abbreviations

Duncan Cole's insight:

A full list of codons, the full name of the amino acid coded for, and both the 3 letter and 1 letter amino acid abbreviations can be found here.  A useful resource!

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

pH (Acid) Homeostasis: Part 1

Part 1 of a short two part video outlining the homeostatic methods the body uses to maintain balance of hydrogen ion, hydroxyl ion, and pH. Causes, effects a...
Duncan Cole's insight:

A good, short, introduction to acid-base homeostasis, which covers buffers in the body, effects of pH dysregulation, and discusses some of the causes.  I would recommend other resources for discussion of causes of acidosis and alkalosis, but for an overview of basic principles this is worth a look.

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Interaction among Skeletal Muscle Metabolic Energy Systems during Intense Exercise

Interaction among Skeletal Muscle Metabolic Energy Systems during Intense Exercise | Biochemistry | Scoop.it
Journal of Nutrition and Metabolism is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of nutrition and metabolism.
Duncan Cole's insight:

For those who want a little bit more detail...  this is a recent review focussing on the interaction of various energy systems during exercise.  It contains excellent figures and explains it all well, but only have a look beyond the abstract if you are reasonably familiar with metabolic pathways!

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Why does lactic acid build up in muscles? And why does it cause soreness?

“Stephen M. Roth, a professor in the department of kinesiology at the University of Maryland, explains. As our bodies perform strenuous exercise, we begin to breathe faster as we attempt to shuttle more oxygen to our working muscles.”

Duncan Cole's insight:

Good clear explanation of why muscles get sore after exercise. It isn't just down to lactic acid...

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Cellular Respiration 4 - Beta-Oxidation

http://www.handwrittentutorials.com - This tutorial is the fourth in the Cellular Respiration series. This tutorial provides an overview of Beta-Oxidation, i...
Duncan Cole's insight:

Nice tutorial on Beta-oxidation, although it goes into a little more detail than is required for a medical student.

more...
No comment yet.
Scooped by Duncan Cole
Scoop.it!

Glycolysis: An Overview

NDSU VCell Production's animation "Glycolysis: An Overview". For more information please see http://vcell.ndsu.edu/animations. Glycolysis is a series of 10 r...
Duncan Cole's insight:

An overview of glycolysis - contains some nice animations and helpful ways to visualise what is going on.  If you are just starting out learning metabolism you may need to pause frequently as the narration goes quite fast. 

 

If you follow the weblink above there are a number of other biochemistry-related videos/animations you may find helpful.

more...
No comment yet.