Avian influenza virus A(H7N9)
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Pathogenesis and transmission of avian influenza A (H7N9) virus in ferrets and mice

On 29 March 2013, the Chinese Center for Disease Control and Prevention confirmed the first reported case of human infection with an avian influenza A(H7N9) virus1. The recent human infections with H7N9 virus, totalling over 130 cases with 39 fatalities to date, have been characterized by severe pulmonary disease and acute respiratory distress syndrome (ARDS)2. This is concerning because H7 viruses have typically been associated with ocular disease in humans, rather than severe respiratory disease3. This recent outbreak underscores the need to better understand the pathogenesis and transmission of these viruses in mammals. Here we assess the ability of A/Anhui/1/2013 and A/Shanghai/1/2013 (H7N9) viruses, isolated from fatal human cases, to cause disease in mice and ferrets and to transmit to naive animals. Both H7N9 viruses replicated to higher titre in human airway epithelial cells and in the respiratory tract of ferrets compared to a seasonal H3N2 virus. Moreover, the H7N9 viruses showed greater infectivity and lethality in mice compared to genetically related H7N9 and H9N2 viruses. The H7N9 viruses were readily transmitted to naive ferrets through direct contact but, unlike the seasonal H3N2 virus, did not transmit readily by respiratory droplets. The lack of efficient respiratory droplet transmission was corroborated by low receptor-binding specificity for human-like α2,6-linked sialosides. Our results indicate that H7N9 viruses have the capacity for efficient replication in mammals and human airway cells and highlight the need for continued public health surveillance of this emerging virus.

  


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Avian Flu Diary: Jiangsu China Reports 1st Novel H7N4 Human Infection

Avian Flu Diary: Jiangsu China Reports 1st Novel H7N4 Human Infection | Avian influenza virus A(H7N9) | Scoop.it
Jiangsu Province - Credit Wikipedia #13,246 It's been several years since we've seen a new novel flu subtype jump to
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HK CHP Notified Of 1 H7N9 Case In Mainland China (Yunnan Province)

#12,939 Hong Kong's CHP today is reporting their notification of the first H7N9 case since September 15th, and th
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China: Yunnan reports one human H7N9 AIV case in Kunming

Via Flu in China, a December 2 report from the HFPC of Yunnan: China: Yunnan reported one human H7N9 AIV case in Kunming. According to the HFPC of Yunnan province on 2nd Dec 2017, one human H7N9 AIV cas
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China - NHFPC announces 2 H7N9 avian flu cases and 0 deaths for September 2017 - October 12, 2017 - previously known - FluTrackers News and Information

General Situation of National Statutory Infectious Diseases in September
http://www.nhfpc.gov.cn/jkj/xhtml/images/sm.jpg (http://www.nhfpc.gov.cn/jkj/s3578/201710/b62e94434b2f4643b816ad3ffe7b3a2c.shtml#)http://www.nhfpc.gov.cn/jkj/xhtml/images/big.jpg
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China Reports Two Deaths From H7N9 Bird Flu - Virology

The first fatalities among China’s avian flu cases came after two people in the province of Anhui have died of the bird flu infection. Anhui has so far reported five … source
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China - CHP announces a new H7N9 avian flu case in Liaoning province - September 15, 2017 - FluTrackers News and Information

CHP has just announced followings. CHP reported a new case of H7N9 avian flu in Lianoning Province. Hong Kong's Center for Health Protection (CHP) today (September 15) announced that they received a notification from the National HFPC informing an
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HK CHP Notified Of 1 H7N9 Case On The Mainland - Jiangsu Province

Jiangsu Province - Credit Wikipedia #12,736 While the number of H7N9 cases reported out of China has dropped markedl
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HK CHP Notified Of 2 H7N9 Cases In Xinjiang

#12,717 It has been a couple of weeks since our last H7N9 report from China, but today the NHFPC has reported tw
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H7N9 Zaozhuang Shandong Cluster Raises Concerns

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One H7N9 death reported in Central China - China - Chinadaily.com.cn

A resident of Central China's Hunan province died of H7N9 flu infection, said provincial authorities on Tuesday.
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CHP notified of human case of avian influenza A(H7N9) in Xinjiang

The Centre for Health Protection (CHP) of the Department of Health is today (July 7) monitoring a notification from the National Health and Family Planning Commission that on
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#China, one new #human case of #H7N9 #influenza reported in #Xinjiang (#HK CHP, Jul 7 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
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China report 6 additional human H7N9 'bird flu' cases in past week - Outbreak News Today

The National Health and Family Planning Commission of China reported six additional human cases of avian influenza A(H7N9) during the week of June 23 to 29. The three male and three female patients, aged from 4 to 72, had onset from June 11 to 23. Four of them are from Yunnan and one each from Guizhou and Shanxi. Among …
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Hong Kong CHP Notified Of H7N9 Case In Xinjiang

Hong Kong CHP Notified Of H7N9 Case In  Xinjiang | Avian influenza virus A(H7N9) | Scoop.it
#13,059 Things have been unexpectedly quiet on the H7N9 front in China this winter, with today's report only th
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#HK CHP notified of #human case of #avian #influenza A(#H7N9) in #Yunnan (Dec. 2 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
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H7N9 bird flu is spreading in Asia, experts (quietly) warn

Via The New York Times: Bird Flu Is Spreading in Asia, Experts (Quietly) Warn. Excerpt: While trying to avoid alarmism, global health agencies are steadily ratcheting up concern about bird flu in Asia. Bird viruses that can infect human
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H7N9 influenza is both lethal and transmissible in animal model for flu – media

For the first time, Kawaoka says, his team has identified an influenza virus strain that is both transmissible between ferrets (the best animal model proxy for human influenza infections) and lethal, both in the animal originally infected and in otherwise healthy ferrets in close contact with these infected animals.
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Four new cases of H7N9 bird flu reported in China - Virology

Sign up for a free trial of News Direct’s animated news graphics at http://newsdirect.nma.com.tw/Reuters.aspx For story suggestions please contact … source
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WHO: Human infection with avian influenza A(H7N9) virus - China

WHO has published Human infection with avian influenza A(H7N9) virus – China. Excerpt: On 4 August 2017, the National Health and Family Planning Commission of China (NHFPC) notified WHO of one additional laboratory-confirmed case of human infection with avia
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China reports H7N9 avian flu death in Jiangsu - Outbreak News Today

The China National Health and Family Planning Commission has reported an additional human case of avian influenza A(H7N9) in Jiangsu. The male patient, aged 58, in Zhenjiang has died. He had exposure to a live poultry market before onset. LISTEN: H7N9 avian influenza in China: Should we be worried? Since 2013, 1,561 human cases have been reported with all …
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H7N9 Longgang Shenzhen Case Confirmed In Guangdong

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HK CHP Notified Of A Single H7N9 Case In Jiangsu Province

Jiangsu Province - Credit Wikipedia #12,629 For the third week in a row China's NHFPC reports a single new H7N9 cas
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#China, #Beijing reported twenty seven #human cases of #H7N9 #influenza during fifth wave (Jul 11 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
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Yunnan Province Reports 4 Recent H7N9 Cases

#12,583 Until February of this year, Yunnan Province had never reported a human H7N9 infection (see Yunnan: 2n
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